The invention relates to a Chinese medicinal preparation for treating a nephrotic syndrome and a preparation method. The raw materials of active ingredients of the prepared Chinese medicinal preparation consist of astragalus, eucommia bark, pyrrosia leaf, stem and leaf of assan crotalaria, pine leaf, stem and leaf of wallich pepper, rhizome of david anemone, lygodium japonicum, mosla scabra, herb of spanishneedles, rust-coloured crotalaria herb with root, gentianopsis barbata, cottonrose hibiscus root, root of cluster mallow, purple flower holly leaf and brittle falsepimpernel herb. The Chinese medicinal preparation has the effects of invigorating spleen, supplementing qi, tonifying kidney, strengthening body resistance, activating blood circulation to dissipate blood stasis, clearing heat and inducing diuresis, can be used for treating diseases such as chronic nephritis, pyelonephritis and nephrotic syndrome, has the characteristics of clear curative effect, safety, convenience, no toxic or side effect, quick response and low probability of relapse and has a total effective ratio of being over 90 percent on the treatment of the nephrotic syndrome.