Technique for preparing verbascoside with function of curing chronic glomerulonephritis in glutinous rehmannia leaf

Abstract

The invention belongs to the technological field of the Chinese medicine, particularly relating to an extraction and separation processes of the active ingredients with the active function of treating the chronic glomerulonephritis. The mullein indican is the active compound researched and developed for many years in our research institute; the mullein indican is extracted, separated and refined from the digitalis leaf and is an active compound with the function of treating the chronic glomerulonephritis. The invention is the research result of many years held and developed by the Chinese Medicine Research Department of the Chinese Medicine Research Institute of China and is supported by the special fund of the Central Institute of the National Science and Technology Department; now the compound has been approved by the State Food and Drug Administration Bureau as the novel drug and the mechanism research of the treatment of the chronic nephritis has been completed; the pre-clinical research work includes the main pharmacodynamic experiment, the production technology experiment (including the industrialized extraction and separation processes), the quality control standard, the experiment of the affecting factors of the quality, the experiment of the long-term stability, the acute toxicity of the rat, the experiment of the long-term toxicity, the teratogenic and mutagenic experiment, the general pharmacological experiment, the pharmacokinetics experiment, and so on. The digitalis leaf is mainly produced in the Huaiqing area of the Henan province, and is also grown wild and cultivated in the Shaanxi, Hebei and other places of China.

Description

1. Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to an extraction, separation and preparation process of an active ingredient with the activity of treating chronic glomerulonephritis. Background technique [0002] Chronic glomerulonephritis is an immune disease (mainly formed by immune complexes) with a high incidence worldwide. In my country, the incidence of nephropathy is as high as 5%, of which 40% belong to immune nephropathy. The onset of glomerulonephritis is long, and the course of the disease can reach several months or even years. Rebound often occurs during the treatment process, and when it develops further, it can lead to renal failure. In terms of treatment methods in modern medicine, in addition to symptomatic and supportive therapy, the weapons of immunotherapy are still corticosteroids and immunosuppressants. In severe cases, hormone short-term shocks, quadruple therapy, anticoa...

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Problems solved by technology

[0003] Most of the traditional Chinese medicine preparations that have been marketed in recent years are compound medicines. Although they have played a certain role in clinical practice, there have been no reports of single traditional Chinese medicine drugs so far.

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