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Use of agonists of formyl peptide receptor 2 for treating dermatological diseases

a technology of formyl peptide receptor and agonist, which is applied in the direction of phosphorous compound active ingredients, peptide/protein ingredients, drug compositions, etc., can solve the problems of hampered pharmaceutical utility of lipoxin a4 and its analogs, and achieve the effects of reducing inflammation, reducing drug side effects, and reducing side effects

Inactive Publication Date: 2014-09-11
ALLERGAN INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention is about a type of molecule called FPR2 agonists that can reduce inflammation in the skin. These molecules can be applied in a variety of ways, such as creams or lotions, and can be taken by injection or orally. They have been shown to be effective in treating skin conditions like rosacea, sunburn, and acne. The molecules can also be used to promote skin healing and reduce inflammation caused by certain proteins. Overall, the invention provides a useful tool for developing new treatments for dermatological diseases.

Problems solved by technology

Pharmaceutical utility of lipoxin A4 and its analogs are hampered by inherent physicochemical properties of the natural poly-olefinic natural product.

Method used

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  • Use of agonists of formyl peptide receptor 2 for treating dermatological diseases
  • Use of agonists of formyl peptide receptor 2 for treating dermatological diseases
  • Use of agonists of formyl peptide receptor 2 for treating dermatological diseases

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Embodiment Construction

[0012]The present invention relates to a method for treating dermatological inflammation and dermatological diseases in a subject in need of such treatment, which comprises administering a pharmaceutical composition comprising a therapeutically effective amount of at least one agonist of Formyl peptide receptor 2 (FPR2).

[0013]In another aspect, the invention provides the use of at least one agonist of FPR2 for the manufacture of a medicament for the treatment of a dermatological inflammation disease or condition mediated by FPR2 in a mammal

[0014]In another aspect, the invention provides a method for treating dermatological inflammatory diseases, which comprises administering a pharmaceutical composition comprising a therapeutically effective amount of at least one agonist of FPR2 as disclosed in U.S. patent application Ser. No. 13 / 668,835, provided that the compounds have binding activity at the FPR2 receptor.

[0015]In another aspect, the invention provides the use of at least one co...

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Abstract

The present invention relates to a method for treating dermal inflammation and dermal diseases by local or systemic delivery, in a subject in need of such treatment, which comprises administering a pharmaceutical composition comprising a therapeutically effective amount of at least one agonist of Formyl peptide receptor 2 (FPR2).

Description

RELATED APPLICATIONS[0001]This application claims the benefit of U.S. Provisional Patent Application Ser. No. 61 / 773,778 filed Mar. 6, 2013, the disclosure of which is hereby incorporated in its entirety by reference.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The present invention relates to a method for treating dermal inflammation and dermal diseases by local or systemic delivery, in a subject in need of such treatment, which comprises administering a pharmaceutical composition comprising a therapeutically effective amount of at least one agonist of Formyl peptide receptor 2 (FPR2).[0004]2. Summary of the Related Art[0005]The formyl peptide receptor (FPR) family belongs to the seven transmembrane domain G-protein-coupled receptor (GPCR) family. This family includes 3 members in humans and one member of this family FPR2 (also known as FPRL-1, ALXA4) is expressed predominantly on inflammatory cells such as monocytes and neutrophils, as well as on T cells and has...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07F9/40C07C275/42C07D223/10C07C235/82C07D401/06C07D261/12C07D405/14C07D235/02C07D409/06C07D405/06C07D257/04C07D233/80C07D217/24
CPCC07F9/40C07C235/82C07C275/42C07D217/24C07D223/10C07D233/80C07D409/06C07D257/04C07D261/12C07D401/06C07D405/06C07D405/14C07D235/02A61K31/196A61K31/197A61K31/405A61K31/4166A61K31/42A61K31/662A61P17/12A61P17/02A61P35/00A61P17/18A61P17/10A61P17/04A61P17/14A61P17/06A61P17/16A61P17/08A61K31/17A61K9/0014A61K31/167A61K31/192A61K31/4045A61K31/41A61K31/4174A61K31/4178A61K31/4184A61K31/472A61K31/4725A61K31/55A61K31/683
Inventor BEARD, RICHARD L.DONELLO, JOHN E.VISWANATH, VEENAHSIA, EDWARD
Owner ALLERGAN INC
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