46results about How to "Analgesic effect" patented technology

The invention discloses a new compound indomethacin 5-efudix methyl ester and agent and preparing method, whose chemical names is 1-(4-chlorobenzene formyl)-5-methoxyl-2-methyl indole-3-acetate (5-fluorine-3, 4-dihydrogen-2, 4-dioxo-1 (2H)-pyrimidinyl) methyl ester, wherein the compound is reacted by 5-FU and formaldehyde to produce intermediate 1,3-dimethylol-5-FU, which combines IDM to form the product as tablet or capsule with acceptable medical carrier or excipient.

The invention relates to an adjustable spinal brace, which is multi-adjustable for conservative treatment of low back pain. The brace comprises an anterior abdominal pad and a posterior frame interconnected by a connection means. In accordance with the invention, the connection means comprises lateral iliac rolls to be positioned at the top of the pelvis bone (crista iliaca) and straps to be connected to the anterior abdominal pad. The posterior frame has a lumbar pad provided with pressure setting means for adjusting the applied pressure. The spinal brace is adjustable to enable an accurate magnitude and position of the pressure to correct the curvature of the spine, especially in the lumbar area. At the same time, the design of the brace is open at the lateral sides, which allows for lateral bending and normal movement of arms and legs.

A rabbit skin containing biologically active substances is obtained by the process including vaccinating rabbit skin tissues with vaccinia virus, feeding a rabbit vaccinated with vaccinia virus, killing the rabbit when its skin tissues are sufficiently inflamed, and skinning the rabbit. The rabbit skin of the present invention can be used for preparing drugs and health foods.

The invention discloses a traditional Chinese medicine composition for treating gout. The traditional Chinese medicine composition for treating gout is prepared from the following raw materials in parts by weight: 8-12 parts of salvia miltiorrhiza, 6.75-12 parts of polygonum cuspidatum, 6.75-9 parts of radices sileris, 6.75-12 parts of gentiana macrophylla, 9-12 parts of scutellaria baicalensis, 4.5-8 parts of rhizoma corydalis, 4.5-8 parts of cassia twig and 6.75-12 parts of medlar. The traditional Chinese medicine composition for treating gout, which is provided by the invention, has remarkable anti-inflammatory and abirritation effects, is capable of remarkably lowering the content of blood uric acid, good in treatment effect on gout, short in treatment period, low in cost, and free from obvious toxic and side effects and adverse reactions, and provides a new choice for clinic.

The invention discloses a formula of traditional Chinese medicines for treating soft tissue injury and a method for preparing a preparation thereof. The formula comprises the following six traditional Chinese medicines in parts by weight according to mixture ratio: 3-9 parts of ceratostigma willmottianum, 1-5 parts of hyacinth bletilla, 1-5 parts of Gaultheria yunnanensis, 0.1-0.5 part of dragon's blood, 0.5-2 parts of turpentine and 0.3-2 parts of borneol which are prepared into an externally-applied traditional Chinese medicine preparation. The prepared externally-applied traditional Chinese medicine preparation is a spraying agent, a tincture, a liniment or a film coating agent. The result of experiments shows that the invention has the advantages of no irritability, no hypersensitivity, quick acting of the medicines, obvious effects of promoting the restoration of the injured soft tissues, resisting inflammation and relieving pain and the like. The preparation prepared by the invention enriches the active components of the medicines highly, has convenient carrying and use and accurate use dose and overcomes the defects of low content of effective components, difficult quality control, poor stability and the like.

The invention discloses a traditional Chinese medicinal preparation for treating gout and a preparation method thereof. The traditional Chinese medicine is prepared from the following raw materials in part by weight: 1 to 30 parts of longhairy antenoron herb, 1 to 20 parts of clematis root, 1 to 20 parts of piper wallichii, 1 to 20 parts of lysimachia trientaloides hemsl, 1 to 20 parts of siphonostegia chinensis, 1 to 20 parts of oriental waterplantain rhizome and 1 to 10 parts of plantain herb. The traditional Chinese medicinal preparation is prepared from seven natural Chinese medicinal herbs, has the effects of clearing heat and eliminating stagnation and eliminating blood stasis and removing pain, has obvious anti-inflammatory effect and analgesic activity, and has good effects of treating acute gouty arthritis and various diseases during critical gout, difficult recurrence, and no obvious toxic or side effect or untoward effect.

The invention discloses a medicine for curing podagra, which is prepared by the raw materials with the weight proportions as follows: 15-25 parts of giant knotweed rhizome, 8-15 parts of salvia miltiorrhiza, 6-12 parts of rheum officinale, 12-17 parts of cuttlebone, 12-17 parts of isatis root, 12-17 parts of greater bunet root, 10-14 parts of herba scutellariae barbatae and 6-15 parts of radix bupleuri. The medicine for curing podagra provided by the invention has obvious effects on anti-inflammation and abirritation, can obviously lower the blood uric acid content and the activity of xanthine oxidase in livers, also can protect kidney and improve the organism condition, has excellent therapeutic effect on podagra; the therapeutic effect is excellent, the adverse reaction is little, the toxic side effect is not obvious, and the medicine is obviously better than the anti-podagra medicines clinically used at present.

The invention discloses medicinal usage of the compound 4-o-methyl-benzenesulfonyl-2(3H)-benzoxazolone and pharmaceutically acceptable salts thereof, specifically application of the compound and the pharmaceutically acceptable salts thereof in preparing non-steroidal anti-inflammatory and analgesic medicines. According to analgesic and anti-inflammatory tests on mice, after normal administration, the mice have obviously enhanced ability in fighting pain; compared to similar medicines, the compound and the pharmaceutically acceptable salts thereof have a more obvious analgesic effect, have a good inhibition effect on inflammation reactions of animals caused by various factors, and have hypotoxicity according to results of toxicity tests. In a word, the compound 4-o-methyl-benzenesulfonyl-2(3H)-benzoxazolone and the pharmaceutically acceptable salts thereof have the characteristics of good anti-inflammatory and analgesic activity and hypotoxicity, can be industrially synthesized, are cheap, and can be used individually or jointly with other pharmaceutically acceptable pharmaceutic adjuvants to prepare non-steroidal anti-inflammatory and analgesic medicines, thereby providing a novel means and method for clinical treatment of diseases caused by inflammatory pains and opening up a new direction for clinical administration.

The invention discloses a traditional Chinese medicine preparation for treating cholecystitis and gallstones and a preparation method thereof. The main pharmaceutical raw materials and the proportioning by weight are as follows: 18-80 parts of Szechuan lovage rhizome, 18-80 parts of Chinese thorowax, 18-80 parts of costus root, 28-140 parts of yellow croaker ear-stone, 18-80 parts of immature bitter orange, 18-80 parts of officinal magnolia bark, 28-140 parts of Chinese angelica, 18-80 parts of golden thread and 18-80 parts of liquoric root. The preparation method comprises: 1. medicinal materials are washed, wherein, the Chinese angelica is processed with wine, and the yellow croaker ear-stone is calcined; 2. the yellow croaker ear-stone is dried and smashed into medicine powder; 3. the other medicinal materials are dried and smashed into the medicine powder, water is added for soaking, filtrate generated by two times of decoction is merged, an extract is obtained, and the extract is concentrated to thick paste which is further smashed; 4. the medicine powder of the step 2 and the step 3 is mixed; 5. excipients are added for preparing capsules, tablets and so on. The traditional Chinese medicine preparation has significant therapeutic and analgesic effects for cholecystitis and gallstones, obvious efficacy, short treatment cycle and low recurrence rate.

The present invention relates to a traditional Chinese medicine with the effects of activating blood circulation, dredging collaterals, strengthening sinews and bones, which can be prepared into the granules, tablets and capsules by malaytea scurfpea fruit, himalayan teasel root, drynaria rhizome of fortune, radix rehmanniae glutinosae, radix rehmanniae preparata, white paeony root, cassia twig, vinegar quenching pyrite, stir-fried myrrh, incised notopterygium rhizome, doubleteeth pubescent angilica root, prepared common monkshood mother root, epimedium herb, prepared kusnezoff monkshood root, stiff silkworm, common anemarrhena rhizome, ground beetle, twotooth achyranthes root, garden balsam stem, ephedra herb, east Asian tree fern rhizome, divaricate saposhnikovia root and the excipients. The preparation method is that: the water is added in the traditional Chinese medicines for boiling for 2 times, 5 times amount of water is added at the first time for boiling for 50 minutes, then the medicines are filtered; 4 times amount of water is added at the second time for boiling for 30 minutes, then the medicines are filtered; the filtrates are merged and prepared into the clear paste with the relative density of 1.15 to 1.17 at 85 DEG C by vacuum pressure reduction concentration, then the clear paste is cooled down, 4 times amount of ethanol is added, the supernatant liquid is taken and filtered after leaving for 24 hours, the ethanol is recovered and concentrated to the thick paste with the relative density of 1.32 to 1.35 at 50 DEG C, the thick paste is mixed with appropriate amount of excipients to be prepared into the granules, tablets and capsules. The present invention is in line with a variety of requirements of current medication, the dosage is accurate, the application is convenient, the carry, transportation and the storage are convenient, the bioavailability is high and the present invention has no obvious adverse taste of the drugs.

The invention relates to a Chinese medicinal composition for treating a pelvic inflammatory disease and a preparation method thereof, and belongs to the field of Chinese medicaments. The Chinese medicinal composition is prepared from the following 13 Chinese medicaments: Chinese angelica, red paeony root, common burreed rhizome, zedoary, Szechwan chinaberry fruit, nutgrass galingale rhizome, rhizoma corydalis, swordlike atractylodes rhizome, cinnamomvine, amur corktree bark, glabrous greenbrier rhizome, moghania root and chinaroot greenbrier. The Chinese medicinal composition has the effects of regulating vital energy, dissolving stasis, relieving pain, drying damp and strengthening spleen, has obvious effects of activating blood, dissolving stasis and killing pain, and has obvious antibacterial activity. The Chinese medicinal composition is mainly used for hypogastric swollerpain, or sharp pain or lumbosacral portion psychroalgia, abnormal leucorrhea and the like caused by acute and chronic pelvic inflammatory diseases, appendagitis, endometritis, chronic cervicitis and the like. Compared with the prior art, the Chinese medicinal composition has the advantages of reasonable formula, obvious curative effect, no toxic or side effects and portability and is favorable for clinical application.

A Chinese medicine for treating acute or chronic pharyngolaryngitis, pharyngalgia, pharyngoxerosis, etc is prepared from 5 Chinese-medicinal materials including honeysuckle flower, myrobalan seed, scrophularia root, asarum herb, etc.

This invention described various formula composite of Scutellaria baicalensis for various diseases and conditions. The formula takes the advantage of our recent discovery of Scutellaria baicalensis can inhibit cyclooxygenase-2 (COX-2) activity and expression, resulting in decrease of prostaglandin synthesis. COX-2 is involved in many biological processes, such as inflammation, pain, carcinogenesis, etc. Combination of Scutellaria baicalensis with lycopene can be used for cancer prevention, especially smoking induced. Combination of Scutellaria baicalensis with glucosamine and chondroitin can be used for arthritis. Finally, this invention disclosed various method to prepare this formula and composition.

The invention discloses an application of a caulis sinomenii extract and a rhizoma imperatae extract in preparing an oral care product. The application is that the caulis sinomenii extract and the rhizoma imperatae extract are used as active components for analgesia and hemostasis to be added into an oral care health-care product in a compound form in a process for preparing the oral care product. Compared with the prior art, the oral care product has a remarkable analgesia and hemostasis effect.

The microcapsule adrenomedullary cell for curing malignant tumor pain consists of ACA microcapsule or APA microcapsule embedded human or animal adrenomedullary cell and the microcapsule entrapped molecular weight is 68-97.4 KD. The microcapsule adrenomedullary cell for curing malignant tumor pain is prepared through five steps of: separation of adrenomedullary cell from human or animal adrenal gland, short period culture in culture liquid, microencapsulation of adrenomedullary cell with ACA or APA, freeze storing in liquid nitrogen and restoring temperature in 37 deg.C before use. The microcapsule adrenomedullary cell for curing malignant tumor pain is transplanted to under human arachnoid of tumor patient to produce obvious pain relieving effect and immune isolation.

The invention discloses Chinese herbal medicine for treating herpes progenitalis. The Chinese herbal medicine is prepared by the following 12 kinds of Chinese herbal medicine: felwort, baical skullcap root, Chinese thorowax root, indigowoad root, rhizome smilacis glabrae, semen plantaginis, alisma, raw pearl barley, rehmannia root, purslane, figwort, and radix glycyrrhizae. The Chinese herbal medicine has the efficacy of cooling blood, detoxication, improving dampness, clearing filthy, tonifying Yin and promoting saliva, is suitable for treating herpes progenitalis, comprises components which are compatible with one another, takes effect quickly, has a high cure rate with a low rate of relapse, is easy to prepare, has a low cost, and adopts pure natural plants as constituent herbs, thereby having no toxic or side effects and being safe to take.

The present invention is related to an active substance of Hericium erinaceus having a pain-relieving effect, and a pharmaceutical composition including the active substance. The active substance is prepared using the following steps: (a) inoculating a mycelium of H. erinaceus on an agar plate and incubating at 15-32° C. for 8-16 days; (b) inoculating the incubated H. erinaceus mycelia from step (a) into a medium in a flask and incubating at 20-30° C. and pH 4.5-6.5 for 3-5 days; (c) inoculating the incubated H. erinaceus mycelia from step (b) into a medium in a fermentation tank and incubating at 24-32° C. and pH 4.5-5.5 for 8-16 days to obtain a fermented medium of the H. erinaceus mycelia; and (d) desiccating the fermented medium of the H. erinaceus mycelia from step (c) to obtain the powder of the H. erinaceus mycelia, which is further purified and isolated to obtain a novel compound of H. erinaceus.

A Chinese medicine in the form of tablets for treating metrorrhagia caused by uterine ring is prepared from 8 Chinese-medicinal materials including cyperus tuber, cat-tail pollen, lucid ligustrum fruit, white peony root, etc through parching cyperus tuber in wine to obtain volatile oil and aromatic liquid, extracting others in alcohol, concentrating, baking, adding auxilies, and tabletting. Its advantages are high curative effect and no toxic by-effect.

The invention relates to a capsule for treating rheumatism and rheumatoid arthritis, which is prepared from the following components in parts by weight: 3-20 parts of safflower, 1-10 parts of hirudo, 2-20 parts of pawpaw, 2-20 parts of, pangolin, 1-15 parts of nux vomica, 2-20 parts of radix salviae miltiorrhizae, 2-20 parts of white pepper, 2-20 parts of frankincense, 2-20 parts of myrrh, 3-20 parts of corydalis tuber, 2-15 parts of himalayan teasel root, 2-15 parts of radix cyathulae, 2-15 parts of rhizoma sparganii and 3-20 parts of radix linderae. The preparation method of the capsule comprises the following steps: processing partial active pharmaceutical ingredients, airing, grinding the 6 active pharmaceutical ingredients and 8 active pharmaceutical ingredients into 200-mesh powder,evenly mixing, and encapsulating, wherein each capsule weighs 0.35g. The capsule has permeability, and can quickly eliminate joint sore, numbness, heating and other symptoms. The capsule can promote blood circulation of the affected part, quickly absorb inflammatory secretion, nourish the cartilage, balance the synovia secretion and restore the affected joint and surrounding soft tissues, so thatthe joint can regain normal physiological functions. The capsule can regulate the organic immunity, enhance the capacity for resisting invasion of wind, cold, dampness and other exogenous pathogenic factors, and prevent recurrence. The capsule has the advantages of quick effect taking, good curative effect, no side effect and high safety and reliability, and is convenient to use; and the effective rate is 98%.

The present invention relates to a Chinese medicine prescription preparation for effectively curing the diseases of coronary heart disease and angina pectoris. Said Chinese medicine prescription preparation is made up by using the Chinese medicinal materials of cinnamon bark and decumbent corydalis tuber through a certain preparation process. Said Chinese medicine prescription preparation has the functions of promoting blood circulation, removing blood stasis, supplementing qi and stopping pain.

The invention relates to a traditional Chinese medicine compound preparation for treating uterine fibroid and breast hyperplasia and a preparation method thereof. The compound traditional Chinese medicine preparation takes sparganium, curcuma rhizome, laminaria japonica, alga, tarragon, Chinese angelica, Poria cocos, seed of Job's tears, zhebeinine, Radix Astragali, motherwort and achyranthes root as active components, and is the medically acceptable oral preparation with pharmaceutical adjuvant. The preparation is prepared by a traditional Chinese medical science theory dialectical treatment variation principle, under an integral idea guidance, treatment accords with symptom, different diseases can be treated by employing same treatment methods, different diseases are treated with same method, good curative effect can be obtained, and the traditional Chinese medicine compound preparation is the ideal medicine for treating uterine fibroid and breast hyperplasia.

The invention belongs to the technical field of Chinese herbal compound preparations for preventing or treating cold. A Chinese herbal compound disclosed by the invention comprises the following Chinese medicine raw materials in parts by weight: 1-40 parts of incised notopterygium rhizome, 1-20 parts of dahurian angelica root, 1-50 parts of indigowoad leaves, 1-50 parts of baical skullcap root, 1-30 parts of lightyellow sophora root and 1-30 parts of common cnidium fruit. The Chinese herbal compound preparation disclosed by the invention integrates the effects of dispelling exopathogens with pungent, relieving the exterior syndrome with drugs pungent in flavor and cool in property and clearing fever and detoxicating into a whole, is different from a single exterior-resolving or fever-clearing agent in the past, advocates defending the exterior by firstly sweating and expelling pathogenic factors and combining cold with warm, is good in defervescence effect and has significant clinical effects when being clinically used for treating symptoms of influenza and common cold, including symptoms, such as fever or high fever, aversion to cold, muscular soreness, nasal congestion, runny nose, sore throat, itchy throat, red tongue with thin and white or thin and yellow fur and the like.

The invention relates to a traditional Chinese medicine compound preparation for treating uterine fibroid and breast hyperplasia and a preparation method thereof. The compound traditional Chinese medicine preparation takes sparganium, curcuma rhizome, laminaria japonica, alga, tarragon, Chinese angelica, Poria cocos, seed of Job's tears, zhebeinine, Radix Astragali, motherwort and achyranthes root as active components, and is the medically acceptable oral preparation with pharmaceutical adjuvant. The preparation is prepared by a traditional Chinese medical science theory dialectical treatment variation principle, under an integral idea guidance, treatment accords with symptom, different diseases can be treated by employing same treatment methods, different diseases are treated with same method, good curative effect can be obtained, and the traditional Chinese medicine compound preparation is the ideal medicine for treating uterine fibroid and breast hyperplasia.

The invention discloses a sarcococca ruscifolia stapf granule, and a preparation method and application of the sarcococca ruscifolia stapf granule, and belongs to the technical field of granule preparation. The preparation method of the sarcococca ruscifolia stapf granule includes the following steps that the whole plant of sarcococca ruscifolia stapf is dried, and crushing, water-alcohol extraction, concentration, mixing with sucrose, granulating and drying are conducted; and the prepared sarcococca ruscifolia stapf granule has obvious anti-ulcer and analgesic pharmacological effects. The sarcococca ruscifolia stapf granule is researched and developed, the further development and utilization of products related to sarcococca ruscifolia stapf medicinal materials are facilitated, the research and development of the sarcococca ruscifolia stapf granule are of great significance for the development of characteristic medicinal materials of Guangxi and the development of products with high technology and high added value, market competitiveness can be improved, and potential and inestimable social and economic benefits are generated.

An application of antrodia cinnamomea in anti-benign prostatic hyperplasia medicines. Dry extract of the antrodia cinnamomea is applied for preparing the anti-benign prostatic hyperplasia medicines, so that epithelial cell height of prostate is reduced, and content of ACP and DHT in serum and expression of vascular endothelial growth factor in prostate are reduced. The method in the invention is simple and quick. The antrodia cinnamomea extract has the effect of treating the benign prostatic hyperplasia, which is comparable with that of a western medicine finasteride. The antrodia cinnamomea extract also has the effect of resisting inflammation and relieving pain, can inhibit cotton pellet granuloma of mice and reduce acetic acid-induced writhing times, and can be used for alleviating inflammation and pain accompanied with the benign prostatic hyperplasia.

The invention discloses a preparation method of cortex eucommiae toothpaste. The preparation method is mainly characterized in that cortex eucommiae leaves, herba taraxaci and plantain herb are prepared into drug extract; and the drug extract is mixed with toothpaste paste substrate in a proportion being (0.2 to 0.5) to 100. The preparation method has a remarkable curative effect for recurrent oral ulcer, which is also named as recurrent aphthous ulcer, as well as tooth decay and periodontal disease. The preparation method enriches utilization ways of cortex eucommiae leaves, and also providesways and research idea for developing oral nursing care toothpaste.

The invention relates to a Chinese medicinal composition for treating a pelvic inflammatory disease and a preparation method thereof, and belongs to the field of Chinese medicaments. The Chinese medicinal composition is prepared from the following 13 Chinese medicaments: Chinese angelica, red paeony root, common burreed rhizome, zedoary, Szechwan chinaberry fruit, nutgrass galingale rhizome, rhizoma corydalis, swordlike atractylodes rhizome, cinnamomvine, amur corktree bark, glabrous greenbrier rhizome, moghania root and chinaroot greenbrier. The Chinese medicinal composition has the effects of regulating vital energy, dissolving stasis, relieving pain, drying damp and strengthening spleen, has obvious effects of activating blood, dissolving stasis and killing pain, and has obvious antibacterial activity. The Chinese medicinal composition is mainly used for hypogastric swollerpain, or sharp pain or lumbosacral portion psychroalgia, abnormal leucorrhea and the like caused by acute and chronic pelvic inflammatory diseases, appendagitis, endometritis, chronic cervicitis and the like. Compared with the prior art, the Chinese medicinal composition has the advantages of reasonable formula, obvious curative effect, no toxic or side effects and portability and is favorable for clinical application.

The invention provides a method for abstracting analgesia effective ingredient that is cnidium fruit from libanotis buethorimensis, comprising refluxing abstracting coarse powder of libanotis buethorimensis medicinal materials with ether, and filtrating; refluxing abstracting the marc with ether again to obtain the residue which ether extract after filtrating and combining the twice extract, discarding the marc, reclaiming ether dissolvent; mixing the libanotis buethorimensis with the ether extract onto the silica-gel chromatographic column, gradient eluting with chloroform-methanol dissolvant and petroleum ether-ethyl acetate system in turns, reclaiming the dissolvant to obtain the extract; standing the extract to separate out lark powder-formed precipitate, obtaining the precipitate after filtrating; recrystallizing the precipitate with petroleum ether-ethyl acetate repeatedly to obtain the white needle crystalline of cnidium fruit. The method performs activity screening for the different abstraction part of libanotis buethorimensis by using analgesic effect as pharmacodynamics index, separates and identifies out cnidium fruit as the analgesia effective ingredient of libanotis buethorimensis.