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Method for extracting analgesic effective component of osthole from buchtorm libanotis root

A technology of osthole and extract, which is applied in the direction of medical preparations containing active ingredients, non-central analgesics, plant/algae/fungus/moss components, etc., which can solve the problems of lack of quantitative indicators for quality control

Inactive Publication Date: 2011-04-06
XI AN JIAOTONG UNIV
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Problems solved by technology

The research on the analgesic active ingredients of Changchun Qi has not yet been reported in the literature, and the "Chinese Pharmacopoeia" (2005 edition) and local standards have not been included. At the same time, the quality control of Changchun Qi medicinal materials in the market lacks quantitative indicators.

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  • Method for extracting analgesic effective component of osthole from buchtorm libanotis root

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example example 1

[0010] Example 1: The present invention is a method for extracting and separating the analgesic active ingredient-osthole from the ether extract of the coarse powder of Changchun seven medicinal materials produced in Taibai, Shaanxi. The preferred method is as follows: first take the coarse powder of Changchun seven medicinal materials, extract with 6 times the amount of ether under reflux, filter, and then use 6 times the amount of ether to reflux extract once, filter, combine the two extracts, discard the drug residues, Obtain the ether extract, after reclaiming the ether solvent, the residue obtained is the ether extract; the ether extract is separated twice with a silica gel chromatographic column: for the first time, gradient elution is carried out with a chloroform-methanol solvent system, and the chloroform-methanol ( 20:0) eluent, the extract after solvent recovery from the eluent is used for the second column chromatographic separation; the second time gradient elution...

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Abstract

The invention provides a method for abstracting analgesia effective ingredient that is cnidium fruit from libanotis buethorimensis, comprising refluxing abstracting coarse powder of libanotis buethorimensis medicinal materials with ether, and filtrating; refluxing abstracting the marc with ether again to obtain the residue which ether extract after filtrating and combining the twice extract, discarding the marc, reclaiming ether dissolvent; mixing the libanotis buethorimensis with the ether extract onto the silica-gel chromatographic column, gradient eluting with chloroform-methanol dissolvant and petroleum ether-ethyl acetate system in turns, reclaiming the dissolvant to obtain the extract; standing the extract to separate out lark powder-formed precipitate, obtaining the precipitate after filtrating; recrystallizing the precipitate with petroleum ether-ethyl acetate repeatedly to obtain the white needle crystalline of cnidium fruit. The method performs activity screening for the different abstraction part of libanotis buethorimensis by using analgesic effect as pharmacodynamics index, separates and identifies out cnidium fruit as the analgesia effective ingredient of libanotis buethorimensis.

Description

technical field [0001] The invention relates to a method for extracting medicine, in particular to a method for extracting osthole, an effective analgesic ingredient, from Changchun Qiqi. Background technique [0002] It has been reported in the literature that osthole has analgesic and anti-inflammatory effects (Hu Jie, Chen Gang. Experimental research on the anti-inflammatory and analgesic effects of osthole [J]. Hunan Journal of Traditional Chinese Medicine. 2007, 23 (1): 82-83.), And the analgesic effect and the research results of the analgesic effect of Changchun Qi extract (Shi Juan, Wang Yunxia, ​​Bian Min, etc. Experimental research on the analgesic effect of Changchun Qi extract [J]. Chinese Journal of Modern Applied Pharmacy. 2006, 23 (2): 100-102.) coincides with; Changchun Seven, also known as Yanfeng, is the dry root and rhizome of Libanotis buchtormensis (Fisch) DC.] of Umbelliferae Libanotis buchtormensis (Fisch) DC. , analgesic, invigorating the spleen and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/16A61P29/00A61K36/23
Inventor 石娟朱彗凝容梦荣
Owner XI AN JIAOTONG UNIV
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