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Microcapsule adrenomedullary cell for curing malignant, tumor pain and its preparing method

A technology for malignant tumors and adrenal glands, which is applied in the fields of biochemical equipment and methods, animal cells, anti-tumor drugs, etc., to achieve obvious analgesic effect, immune isolation effect, and high survival rate.

Inactive Publication Date: 2003-04-09
TIANJIN CITY THIRD CENT HOSPITAL
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  • Summary
  • Abstract
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AI Technical Summary

Problems solved by technology

However, whether it is allogeneic or xenogeneic adrenal medullary cell transplantation, the recipient will have immune rejection of the donor cells, especially in xenogeneic cell transplantation.

Method used

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Embodiment Construction

[0009] The microencapsulated adrenal medullary cells for treating malignant tumor pain in the present invention are ACA microcapsules adrenal medullary cells or APA microcapsules adrenal medulla cells formed by ACA microcapsules or APA microcapsules embedding human or animal adrenal medulla cells , The molecular weight cut-off of the microcapsules is 0.8-97.4KD. In order to ensure that the microcapsules can securely embed the adrenal medulla cells and ensure that the microcapsules have good permeability, the diameter of the microcapsules can be 250-500μm, and the amount of encapsulation (that is, the number of adrenal medulla cells embedded in each microcapsule) Number) can be (1-8)×10 2 , The wall thickness of the microcapsule can be 33.1±3.5μm, and the diameter of the microcapsule mesh can be 0.75±0.62μm.

[0010] The preparation method of microencapsulated adrenal medulla cells for treating malignant tumor pain in the present invention mainly includes 5 steps of isolation, cult...

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Abstract

The microcapsule adrenomedullary cell for curing malignant tumor pain consists of ACA microcapsule or APA microcapsule embedded human or animal adrenomedullary cell and the microcapsule entrapped molecular weight is 68-97.4 KD. The microcapsule adrenomedullary cell for curing malignant tumor pain is prepared through five steps of: separation of adrenomedullary cell from human or animal adrenal gland, short period culture in culture liquid, microencapsulation of adrenomedullary cell with ACA or APA, freeze storing in liquid nitrogen and restoring temperature in 37 deg.C before use. The microcapsule adrenomedullary cell for curing malignant tumor pain is transplanted to under human arachnoid of tumor patient to produce obvious pain relieving effect and immune isolation.

Description

Technical field [0001] The invention relates to a microcapsule adrenal medulla cell for clinical treatment of malignant tumor pain and a preparation method thereof. Background technique [0002] Therefore, the incidence of malignant tumors is higher and the cure rate is lower, and its long-term efficacy is worse. Therefore, most patients with malignant tumors will have varying degrees of chronic pain in the late stage, which seriously affects the quality of life of the patients. Long-term use of morphine and other analgesics will not only cause dependence on patients, but also produce serious side effects; and intrathecal injection of morphine is not only expensive, but also complicated and prone to complications. Therefore, the medical community has long been committed to finding alternative methods for clinical treatment of malignant tumor pain. [0003] A large number of studies have shown that the adrenal medullary cells of humans or animals have the function of secreting cat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61P29/00A61P35/00C12N5/071
Inventor 李涛杜智宋继昌方淑昌周道标孙以鲁孙绵方
Owner TIANJIN CITY THIRD CENT HOSPITAL
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