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Application of antrodia cinnamomea in anti-benign prostatic hyperplasia medicines

A technology for prostatic hyperplasia and prostate, which is applied to drug combinations, antipyretics, anti-inflammatory agents, etc., can solve the problems of cumbersome preparation, high cost, low yield and the like, achieves simple preparation method, relieves inflammation and pain, and reduces acetic acid. The effect of twists

Inactive Publication Date: 2016-11-02
SHANGHAI JIAO TONG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention is cumbersome to prepare in the prior art and mostly involves the use of various toxic solvents such as dichloromethane, methanol, acetone, etc. The preparation process requires the use of precision instruments such as MPLC, and repeated column chromatography, high cost, low yield and other defects, An application of Antrodia camphorata in anti-prostatic hyperplasia drugs is proposed, and the preparation method is simple and fast

Method used

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  • Application of antrodia cinnamomea in anti-benign prostatic hyperplasia medicines
  • Application of antrodia cinnamomea in anti-benign prostatic hyperplasia medicines
  • Application of antrodia cinnamomea in anti-benign prostatic hyperplasia medicines

Examples

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Effect test

Embodiment 1

[0016] The present embodiment prepares a kind of Antrodia camphorata extract for the treatment of benign prostatic hyperplasia, comprising the following steps:

[0017] 1) Take the fruit body of the original medicinal material Antrodia camphorata, pick out impurities, chop or chop;

[0018] 2) Put it into a round bottom flask, add 65%-90% ethanol as an extraction solvent, and the ratio of solid to liquid is 2-3g of crude drug / 1000mL;

[0019] 3) Reflux extraction for 30-60 minutes;

[0020] 4) The extract is filtered, the extraction solvent is recovered and concentrated under reduced pressure to obtain a dry extract of the extract.

[0021] The following test shows that the Antrodia camphorata extract prepared in this example has anti-testosterone propionate-induced prostatic hyperplasia in rats.

[0022] Experimental materials: Experimental animals: 72 male SD rats, weighing 160-180g. Test drug: Finasteride suspension 0.25mg / mL (positive control group); Antrodia camphorata...

Embodiment 2

[0059] This example uses the same method as Example 1 to prepare an Antrodia camphorata extract with anti-inflammatory and analgesic effects for treating inflammation and pain associated with benign prostatic hyperplasia.

[0060] The following tests illustrate that the Antrodia camphorata extract prepared in this example has analgesic and anti-inflammatory effects.

[0061] Test animals: ICR mice, SPF grade, 18-22g, half male and half male.

[0062] experiment method

[0063] 1) mouse writhing method

[0064] ICR mice were randomly divided into 8 groups: normal saline group (NS), positive control drug aspirin group (Asp40mg / kg), Antrodia camphorata group (low-dose group: 104mg / kg, middle-dose group: 208mg / kg, high-dose group: 416mg / kg) in each group of 10, half male and half male. Mice in each group were given normal saline or corresponding drugs, and administered by intragastric administration once a day for 5 consecutive days. One hour after the last administration, eac...

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Abstract

An application of antrodia cinnamomea in anti-benign prostatic hyperplasia medicines. Dry extract of the antrodia cinnamomea is applied for preparing the anti-benign prostatic hyperplasia medicines, so that epithelial cell height of prostate is reduced, and content of ACP and DHT in serum and expression of vascular endothelial growth factor in prostate are reduced. The method in the invention is simple and quick. The antrodia cinnamomea extract has the effect of treating the benign prostatic hyperplasia, which is comparable with that of a western medicine finasteride. The antrodia cinnamomea extract also has the effect of resisting inflammation and relieving pain, can inhibit cotton pellet granuloma of mice and reduce acetic acid-induced writhing times, and can be used for alleviating inflammation and pain accompanied with the benign prostatic hyperplasia.

Description

technical field [0001] The invention relates to a technology in the field of medicine preparation, in particular to the application of Antrodia camphorata in anti-prostatic hyperplasia medicine. Background technique [0002] Benign prostatic hyperplasia (BPH) is a common disease in middle-aged and elderly men, and its incidence is increasing year by year with the aging of the population. Statistics show that the incidence rate of men aged 51 to 60 in my country is as high as 70%. The main clinical manifestations of benign prostatic hyperplasia are a series of lower urinary tract symptoms, such as frequent urination, thinner urine stream, strenuous urination, urinary retention, etc. Severe cases can lead to aggravated lower urinary tract symptoms and damage to the upper urinary tract or hydronephrosis, kidney disease, etc. functional failure (LUTS). Regarding the pathogenesis of benign prostatic hyperplasia, it is believed that benign prostatic hyperplasia is related to hor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/07A61P13/08A61P29/00
CPCA61K36/07
Inventor 李晓波管荣良周龙王梦月彭颖张远腾
Owner SHANGHAI JIAO TONG UNIV
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