The invention discloses a saury Maillard peptide with uric acid reducing activity as well as a preparation method and an application thereof. The preparation method comprises steps as follows: mincing saury, adding water, heating and stirring the mixture, adjusting the pH value to 4.2, performing centrifugal separation, and taking a precipitate; adding water, protease and monomer amino acid to the precipitate, adjusting the pH value to 7.0, adding reducing sugar after hydrolysis for a reaction, performing centrifugation, and taking a supernatant, that is, a saury Maillard peptide liquid; performing spray drying on the peptide liquid to obtain dried saury Maillard peptide powder. With the adoption of the method, the Maillard peptide is prepared under the continuous action of enzymolysis and a Maillard reaction, the production technology process is simplified, the production cycle is shortened, the production cost is reduced, the uric acid reducing effect of the prepared target Maillard peptide is significant, and rat animal experiments indicate that the uric-acid-reducing Maillard peptide prepared with the method can significantly reduce the blood uric acid level of rats and has a certain protection effect on kidney functions of the rats.