The invention belongs to the field of health products and discloses meal replacement powder for assisting blood pressure lowering and a preparation method of the meal replacement powder for assisting the blood pressure lowering. The meal replacement powder for assisting the blood pressure lowering is prepared from the following components in parts by weight: 50-80 parts of soya beans, 10-30 parts of agarics, 10-30 parts of lentinula edodes, 5-15 parts of cassia seeds, 20-40 parts of hawthorn fruits, 30-50 parts of tomatoes, 50-80 parts of Chinese yam, 50-80 parts of corns, 30-50 parts of kudzu vine roots and 25-35 parts of lucid ganoderma. The meal replacement powder prepared by adopting the preparation method disclosed by the invention can meet the daily feeding nutrient ingredient and energy needs of low heat, low fat, low cholesterol, low sugar, low salt, high protein, high vitamin and an appropriate amount of trace elements of a hypertensive patient, and also can be used for regulating the blood pressure by virtue of pesticide effect ingredients to comprehensively achieve effects of decreasing blood pressure and protecting health; and meanwhile, the selected directly-edible materials are safe, effective, free of toxic and side effects, beneficial to being eaten by the hypertensive patient at any time, and capable of effectively preventing the elevation of blood pressure.