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Preparation method of hydrogel dressing containing honeysuckle flower and Chinese wolfberry fruit extracts

A technology of wolfberry extract and honeysuckle, applied in medical science, bandages, etc., can solve the problems of low mechanical properties of hydrogel and insufficient bactericidal effect, and achieve the effects of promoting wound healing, increasing antibacterial effect, and improving mechanical properties

Inactive Publication Date: 2018-11-02
界首市龙鑫生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, in the prior art, regarding the application of Lycium barbarum extract to hydrogel medical dressings, there are still problems that the hydrogel has low mechanical properties and its bactericidal effect is not outstanding enough.

Method used

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  • Preparation method of hydrogel dressing containing honeysuckle flower and Chinese wolfberry fruit extracts

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Experimental program
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Effect test

Embodiment 1

[0017] A preparation method of a hydrogel dressing containing honeysuckle and wolfberry extracts, comprising the following steps:

[0018] (1) Wash 8 parts of honeysuckle, 10 parts of wolfberry, and 1 vitamin C in parts by weight with distilled water to remove surface dust and impurities, then put them into a freeze dryer, and freeze-dry them at -20°C for 1 hour. , taken out, ground into powder, placed at room temperature for 1h, then put into distilled water at 40°C, treated with 60Hz ultrasonic for 2h, then soaked for 3h, filtered, and the filtrate was evaporated to reduce the volume to 1 / 4 of the original volume to obtain the extract spare;

[0019] (2) Put 10 parts of hectorite into a vacuum drying box, dry at 50°C for 3 hours, take it out, add it to distilled water with 10 times its volume, stir at 400 rpm for 1 hour, add the extract obtained in step (1), and continue Stir for 1h to obtain a mixed solution;

[0020] (3) In a nitrogen atmosphere, add 40 parts of the modi...

Embodiment 2

[0025] A preparation method of a hydrogel dressing containing honeysuckle and wolfberry extracts, comprising the following steps:

[0026] (1) Rinse 10 parts by weight of honeysuckle, 12 parts of wolfberry, and 2 parts of vitamin C with distilled water for 2 times to remove surface dust and impurities, and then put them into a freeze dryer and freeze-dry at -25°C 2h, take out, grind into powder, place at room temperature for 2h, then put into distilled water at 50°C, use 70Hz ultrasonic treatment for 3h, then soak for 4h, filter, and evaporate the filtrate to reduce the volume to 1 / 3 of the original volume to obtain extraction liquid backup;

[0027] (2) Put 10-20 parts of hectorite into a vacuum drying box, dry at 60°C for 4 hours, take it out and add it to distilled water with 15 times its volume, stir at 600 rpm for 2 hours, and add the extract obtained in step (1). , continue to stir for 2h to obtain a mixed solution;

[0028] (3) In a nitrogen atmosphere, add 45 parts o...

Embodiment 3

[0033] A preparation method of a hydrogel dressing containing honeysuckle and wolfberry extracts, comprising the following steps:

[0034] (1) Rinse 15 parts by weight of honeysuckle, 15 parts of wolfberry, and 2 parts of vitamin C with distilled water for 2 times to remove surface dust and impurities, then put them into a freeze dryer and freeze-dry at -30°C 3h, take out, grind into powder, leave at room temperature for 2h, then put into distilled water at 60°C, use 80Hz ultrasonic treatment for 3h, then soak for 5h, filter, and evaporate the filtrate to reduce the volume to 1 / 3 of the original volume to obtain extraction liquid backup;

[0035] (2) Put 20 parts of hectorite into a vacuum drying box, dry at 70°C for 5 hours, take it out and add it to distilled water with 20 times its volume, stir at 800 rpm for 2 hours, add the extract obtained in step (1), and continue Stir for 2h to obtain a mixed solution;

[0036] (3) In a nitrogen atmosphere, add 50 parts of the modifi...

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Abstract

The invention discloses a preparation method of hydrogel dressing containing honeysuckle flower and Chinese wolfberry fruit extracts. The synergistic effect of the Chinese wolfberry fruit and honeysuckle flower extracts and nanometer zinc oxide is utilized; on one hand, the extracts are wrapped at the periphery of the nanometer zinc oxide, so that the extracts can stably exist; on the other hand,Chinese wolfberry fruits and honeysuckle flowers have the effects of protecting cells and promoting cell multiplication; the obvious antibacterial activity and anti-inflammatory effects are realized;meanwhile, the pharmacological actions of regulating the blood sugar, reducing the lipid, resisting the mutagenesis, resisting the senility, resisting the anoxia, regulating the endocrine hormone andthe like are achieved; when being applied to application dressing, the extracts can be synergistic with the nanometer zinc oxide; the antibacterial effect of the hydrogel dressing is enhanced; meanwhile, the wound healing is promoted, and the anti-inflammatory effect is achieved; when the nanometer zinc oxide is used for modifying a chitosan solution, the mechanical performance of the hydrogel dressing is improved; meanwhile, the antibacterial effect is enhanced.

Description

technical field [0001] The invention belongs to the technical field of medical dressings, and in particular relates to a preparation method of a hydrogel dressing containing honeysuckle and wolfberry extracts. Background technique [0002] Hydrogel is a high molecular polymer with a three-dimensional structure, which is formed by cross-linking of hydrophilic high molecular compounds, which can swell in water and retain a large amount of water without dissolving. Hydrogels are widely used in biomedical fields such as tissue fillers and artificial skin due to their good biocompatibility. Lycium barbarum is a plant belonging to the Solanaceae family with a cultivation history of nearly 500 years. [0003] Lycium barbarum contains a variety of nutrients, such as rich carbohydrates, proteins, fats, alkaloids, amino acids, taurine, carotenoids, etc., with high nutritional value and medicinal health effects. In 1988, the Ministry of Health of my country officially announced that ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0057A61L26/0066A61L26/008A61L2300/404A61L2300/41A61L2300/45C08L5/08
Inventor 饶建军
Owner 界首市龙鑫生物科技有限公司
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