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Acne-removing cream and preparation method thereof

An anti-acne cream, hydroxypropyl technology, applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations and other directions, can solve the problems of inability to remove acne, prevent acne, damage the stratum corneum of the skin, speed up tissue repair, etc. Pigmentation, good acne-relief effect, pain relief effect

Active Publication Date: 2018-06-12
广州美尔生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, hormones or antibiotics (such as tetracyclines, macrolides, etc.) are generally used clinically to treat acne, but there are many side effects and drug resistance
There is also the use of physical laser therapy to treat acne. By irradiating specific wavelengths of laser light to kill acne bacilli, promote cell synthesis, and accelerate tissue repair, the inflammatory lesions of acne can be removed, but laser therapy can only be achieved from physical methods. Clear the existing acne on the surface, can not remove acne from the root, prevent acne
In addition, the existing anti-acne products on the market directly use fruit acid or salicylic acid as the active ingredient for anti-acne, which is highly irritating to the skin and will damage the stratum corneum of the skin.

Method used

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  • Acne-removing cream and preparation method thereof
  • Acne-removing cream and preparation method thereof
  • Acne-removing cream and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] This embodiment 1 provides a kind of anti-acne cream, which is composed of the following components in terms of mass percentage: 0.1% of hexamidine bis(isethionate) salt, 2% of inclusion azelaic acid , inclusion salicylic acid 2%, oat alkaloid derivatives 0.5%, phytic acid 0.1%, glyceryl stearate 1%, cetearyl glucoside 2%, isopropyl myristate 2%, C12 -15 alcohol benzoate 4%, higher alkyl C16-18 alcohol 3%, propylene glycol 5%, azone 0.5%, xanthan gum 0.3%, methylparaben 0.2%, 305 emulsifier 1%, fragrance 0.2% and the balance deionized water. The avenal alkaloid derivative is dihydroavenyl anthranilic acid.

[0029] The preparation method of this acne cream, comprises the steps:

[0030] (1) Mix higher alkyl C16-18 alcohol, glyceryl stearate, cetearyl glucoside, isopropyl myristate, C12-15 alcohol benzoate and azone and heat to dissolve to 85 °C, phase A is obtained;

[0031] (2) Add xanthan gum and methylparaben to deionized water and disperse evenly at 85°C to obtain...

Embodiment 2

[0035] This embodiment 2 provides a kind of anti-acne cream, which is composed of the following components in terms of mass percentage: 0.15% of hexamidine bis(isethionate) salt, 1.5% of inclusion azelaic acid , inclusion salicylic acid 1.5%, oat alkaloid derivatives 0.8%, phytic acid 0.2%, glyceryl stearate 1%, cetearyl glucoside 2%, isopropyl myristate 2%, C12 -15 alcohol benzoate 4%, higher alkyl C16-18 alcohol 3%, propylene glycol 5%, azone 0.5%, xanthan gum 0.3%, methylparaben 0.2%, 305 emulsifier 1%, fragrance 0.2% and the balance deionized water. The avenal alkaloid derivative is dihydroavenyl anthranilic acid.

[0036] The preparation method of this acne cream is the same as that of Example 1.

Embodiment 3

[0038] This embodiment 3 provides a kind of anti-acne cream, which is composed of the following components in terms of mass percentage: 0.2% of hexamidine bis(isethionate) salt, 1.8% of inclusion azelaic acid , inclusion salicylic acid 1.8%, oat alkaloid derivatives 1.2%, phytic acid 0.3%, glyceryl stearate 1%, cetearyl glucoside 2%, isopropyl myristate 2%, C12 -15 alcohol benzoate 4%, higher alkyl C16-18 alcohol 3%, propylene glycol 5%, azone 0.5%, xanthan gum 0.3%, methylparaben 0.2%, 305 emulsifier 1%, fragrance 0.2% and the balance deionized water. The avenal alkaloid derivative is dihydroavenyl anthranilic acid.

[0039] The preparation method of this acne cream is the same as that of Example 1.

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Abstract

The invention discloses acne-removing cream. The acne-removing cream is prepared from hexamidine diisethionate, a hydroxypropyl-beta-cyclodextrin inclusion compound of azelaic acid, a hydroxypropyl-beta-cyclodextrin inclusion compound of salicylic acid and oat alkaloid derivatives. Permeation and stripping effects of salicylic acid in the hydroxypropyl-beta-cyclodextrin inclusion compound of salicylic acid is beneficial to permeation of other components into the skin basal layer, and the hexamidine diisethionate, a hydroxypropyl-beta-cyclodextrin inclusion compound of azelaic acid are enabledto more effectively kill propionibacterium acnes to fundamentally treat acnes, and great acne removing effects are achieved. By the hydroxypropyl-beta-cyclodextrin inclusion compound of azelaic acid,oil secretion and chromatosis can be evidently reduced while antibacterial acne-removing effects are achieved, water-oil balance is effectively regulated, and acne reduction and acne mark fading are realized; by the oat alkaloid derivatives, skin irritation symptoms such as allergy and stabbing pain caused by other components can be alleviated, and swelling, itching and pains of acne affected parts can be alleviated.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to an acne-removing cream and a preparation method thereof. Background technique [0002] Acne (acne) is a common chronic hair follicle and sebaceous gland inflammatory skin disease caused by various factors. The chest and other parts rich in sebaceous glands have the highest incidence rate in adolescence. Current studies believe that the pathogenesis of acne is mainly related to the following four factors: excessive sebum secretion, hyperkeratosis at the opening of the pilosebaceous gland duct, proliferation of Propionibacterium acnes, and inflammatory response. The acne marks and pits left after acne healing will affect the patient's appearance and quality of life, and even bring psychological pressure to the patient. [0003] Propionibacterium acnes (P.acnes) is the main pathogenic bacterium that causes acne. It is a Gram-positive anaerobic short bacillus that usually resides in the ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/46A61K8/362A61K8/73A61K8/368A61K8/44A61Q19/00A61Q17/00A61P17/10A61P31/04A61P31/02
CPCA61K8/362A61K8/368A61K8/445A61K8/466A61K8/738A61K2800/56A61Q17/005A61Q19/00A61Q19/008
Inventor 成雨熙
Owner 广州美尔生物科技有限公司
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