241 results about "Anthranilic acid" patented technology

An N-acyl anthranilic acid derivative represented by general formula (1) or a salt thereof is useful for prevention or treatment of diseases associated with excessive production of collagen. (In the formula, R¹ represents a carboxyl group or the like; R² represents a hydrogen atom or the like; R³ represents an optionally substituted aryl group or the like; X¹ represents a carbonyl group; X² represents a bonding hand; X³ represents a bonding hand; X⁴ represents a bonding hand or the like; and A represents an optionally substituted phenyl group or the like.)

A polishing composition comprises: at least one compound selected from tetrazole compounds and derivatives thereof and anthranilic acid compounds and derivatives thereof; abrasive particles comprising associative abrasive particles; and an oxidizing agent.

The invention provides a rubber composition for golf balls which includes (A) a base rubber containing a polybutadiene having a cis-1,4 bond content of at least 60 wt %, (B) an unsaturated carboxylic acid and/or a metal salt thereof, and (C) an anthranilic acid derivative of the general formula

wherein R¹ and R² are each independently a hydrogen atom or a hydrocarbon group of 1 to 20 carbons, m is an integer from 1 to 4, and n is an integer from 1 to 3, with the proviso that if m and/or n is 2 or more, each occurrence of R¹ and R² may be the same or different. The golf ball rubber composition of the invention enables a high-quality molded and crosslinked product having a suitable hardness and a high resilience to be obtained.

The invention provides a preparation method and application of an anti-soil polymer. The prepared polymer is used as a dispersant for a hydraulic cementing agent and/or an aqueous dispersion for potential hydraulic cementing agent and has good anti-soil performance. The preparation method the anti-soil polymer comprises a step of subjecting polyether macromonomer A with a special structure, monomer B containing a phosphoric acid or phosphorous acid group, optional monomer D and aldehyde C to condensation polymerization so as to prepare the anti-soil polymer, wherein the monomer D is selected from the group consisting of phenol, aniline, p-/o-aminobezene solfonic acid, p-/o-hydroxybenzoic acid, p-/o-aminobenzoic acid, p-/o-hydroxyezene solfonic acid, p-/o-toluidine and p-/o-methylphenol, a mol ratio of the polyether macromonomer A to the monomer B to the monomer D is 1: (0.5-12): (0-8.0), and a mol ratio of the polyether macromonomer A to the monomer B and the monomer D is 1: (0.5-12.0).

The anthranilic acid derivative or the salt thereof represented by the general formula

wherein R¹ and R² are hydrogen atom, or the like; R³ is a phenyl, cycloalkyl or bicyclic heterocyclic group which may be substituted, or the like; R⁴ is a phenyl, cycloalkyl or pyridyl group which may be substituted, or the like; X¹ is an alkylene or alkenylene group which may be substituted or a bond; X² is the general formula -X³-X⁴- or -X⁴-X³-, wherein X³ is a sulfur atom, an imino group or a bond, or the like; X⁴ means an alkylene or alkenylene group which may be substituted or a bond; is useful for a remedy such as rheumatoid arthritis, osteoarthritis and carcinoma, because it shows MMP-13 production inhibitory effect.

The present invention relates to a method for causing sodium sulfide or a mixture of sodium sulfide and sulfur to react with diazonium salt formed by diazotizing anthranilic acid, wherein the Na/S atomic ratio as calculated on the basis of the employed sodium sulfide and sulfur is adjusted to within the range of 1.33 to 2.0 during the reaction. Thus is made practicable the manufacture of thiosalicylic acid in a high yield without going through the individual route of isolating and reducing dithiosalicylic acid.

The invention provides a novel synthetic method of a bis-benzoxazine ketone ultraviolet absorbent, and belongs to the technical field of fine chemical engineering. The method comprises the following steps: A, stirring, anhydrides, used as raw materials, of o-aminobenzoic acid and (o-, m-, p-) phthaloyl dichloride or (o-, m-, p-)phthalic acid for a certain time in a non-polar solvent; B, adding chemical dehydrating agent or physical dehydrating agent in a reaction system without separating, slowly heating and refluxing for a certain time to obtain (o-, m-, p-)substituted bis-benzoxazine ketone ultraviolet absorbent; wherein the stirring time in the step A is not less than 1 hour, the refluxing time is 5-10 hours in the step B, the chemical dehydrating agent used in the step B is various dehydrating agents reacted with the water, including but not limited to alkaline calcium oxide, soda lime, acidic concentrated sulfuric acid, concentrated phosphoric acid, polyphosphoric acid, phosphorus pentoxide, thionyl chloride, acetic anhydride and the like, neutral molecular sieve, water-absorbent, anhydrous cupric sulfate and the like; the physical dehydrating agent comprises but not limited to non-protonic solvent such as benzene, methylbenzene, xylene and the like. The method provided by the invention has the advantages of being simple in operation flow, low in cost, simple in equipment, and suitable for the scale industrial production.

The present invention relates to the field of microbiology, and discloses an L-tryptophan fermentation strain and a method for fermentation production of L-tryptophan by using the L-tryptophan fermentation strain. According to the present invention, the L-tryptophan fermentation strain with the preservation number of CGMCC No.7941 has anthranilic acid tolerance; and compared with the original strain, the strain of the present invention has the better anthranilic acid tolerance, and can make the more anthranilic acid be converted into the tryptophan, such that the high concentration tryptophan can be accumulated so as to increase the yield and the production efficiency of the L-tryptophan and meet the large-scale industrial production of the L-tryptophan.

The invention discloses a synthesis method for 2,3,6,7-triptycene tetracarboxylic dianhydride. The method comprises the following steps of: 1) preparing 2,3,6,7-tetramethylanthracene from o-xylene and benzyl alcohol or methylene chloride under the catalysis of anhydrous aluminum trichloride; 2) diazotizing the 2,3,6,7-tetramethylanthracene, anthranilic acid and amyl nitrite to generate a crude product 2,3,6,7-tetramethyl triptycene; 3) performing chromatographic separation on the crude product 2,3,6,7-tetramethyl triptycene, and flushing the separated 2,3,6,7-tetramethyl triptycene by using a mixed eluting agent to obtain 2,3,6,7-tetramethyl triptycene; 4) oxidizing the 2,3,6,7-tetramethyl triptycene in a mixed solvent consisting of potassium permanganate, pyridine and water under a reflux condition to generate 2,3,6,7-triptycene tetracarboxylic acid; and 5) refluxing and dehydrating the 2,3,6,7-triptycene tetracarboxylic acid in acetic anhydride to generate the 2,3,6,7-triptycene tetracarboxylic dianhydride. The method has the characteristics of readily available and low-cost raw materials, high yield and high product purity.

The invention relates to a novel tryptanthrin (indole[2,1-b] quinazoline-6,12-diketone) derivative, a synthetic method and a medicinal application thereof. A general structural formula is as follows (see the description). The novel tryptanthrin derivative is synthesized through biomimetic synthesis, the general chemical structural formula of the novel derivative is shown in Figure 1, wherein in the formula, R,R1,R2,R3 are halogen, nitro, amido, hydroxy, alkyl, alkoxy and aryl, R1is morpholine, piperidine, N-methylpiperidine, N-ethylpiperidine, isonipecotic acid, piperazine, 1-(2-pyridyl) piperazine, dimethylamine, diethylamine, 1-(2-ethoxy) piperazine and 1-(2-furoyl) piperazine, and an o-aminobenzoic acid derivative reacts with an indole quinone derivative in solvents of methylbenzene, methyl alcohol, ethyl alcohol, dichloromethane, isopropanol and the like, so as to prepare the novel tryptanthrin derivative. The novel tryptanthrin derivative which has a good inhibiting effect and a good antibacterial effect on cancer cells is preliminarily screened through an MTT experiment and an antibacterial experiment, and the medicine has pharmacological effects in the aspects of tumor resistance, antibiosis and inflammation diminishing.

A method for measuring vanadium in vanadium-nitrogen alloy belongs to the technical field of analytical chemistry. The advantages of this method lie in that the reagents used in the determination process are few in type, the time is short, the operation is simple, and the method has high precision and accuracy, and is especially suitable for the analysis of a large number of samples. The present invention adopts mixed acid to dissolve the sample, under the acidity of 12% to 25%, adding ammonium persulfate to oxidize vanadium (IV) to pentavalent, using N-phenyl-substituted anthranilic acid as an indicator, using ferrous ammonium sulfate as an indicator Standard solution titration. Chromium, manganese and cerium do not interfere with the determination.

An anthranilic acid derivative represented by the general formula (X) [wherein R¹ represents hydrogen or a carboxy-protecting group; R² represents optionally substituted phenyl, a heterocyclic group, etc.; R³ represents optionally substituted phenyl, a monocyclic heterocyclic group, etc.; X¹ represents carbonyl, etc.; X² represents optionally substituted alkylene group, a bond, etc.; X³ represents oxygen, a bond, etc.; and X⁴ represents a group represented by the general formula -X⁵-X⁶- or -X⁶-X⁵- (wherein X⁵ means oxygen, a bond, etc.; and X⁶ means optionally substituted alkylene, a bond, etc.)] or a salt of the derivative. The derivative or salt has the inhibitory activity of MMP-13 production and is hence useful as a therapeutic agent for articular rheumatism, osteoarthritis, cancer, etc.

The invention relates to a method for synthesizing Varenicline intermediate 2, 3, 4, 5-tetralin-1, 5-methylene-hydrogen-benzoazepine. The method includes the following steps: under the action of catalyst, mixing amyl nitrite with o-aminobenzoic acid solution to generate diazonium salt, then mixing the diazonium salt with cyclopentadiene, and heating to react to generate compound 1; feeding ozone into the solution of compound 1, after complete conversion, adding reducing agent to generate compound 2, then dripping the compound 2 to the mixed solution of triacetoxy sodium borohydride and benzylamine to generate compound 3 by loop closing; and hydrogenating the compound 3 under the action of palladium and carbon for debenzylation and reduction to obtain M intermediate 2, 3, 4, 5-tetralin-1, 5-methylene-hydrogen-benzoazepine. The method has the advantages of greatly simplifying the method for preparing Varenicline intermediate, being simple in production process and safe in operation, well ensuring no harm to the environment and control on production cost, increasing yield and being capable of becoming a process in great industrial production.

The invention discloses a recycling method of o-aminobenzoic acid from mother liquid or waste water, which comprises the following steps: loading weak alkaline ion exchanging resin or phenylethene-diethyl benzene strong-polar large-hole adsorbing resin in the adsorbing column; adding acid or alkaline to adjust pH value for mother liquid or waste water; assembling adsorbing column under 5-40 deg.c with flow speed at 2-4BV/h; eluting through 2-6% sodium hydroxide solution under 25-45 deg.c with flow speed at 2-3BV/h; recycling sodium o-aminobenzoic solution.

A process for preparing quinazolin-4-one or its derivative by reacting anthranilic acid or its derivative with formic acid or its derivative in the presence of ammonia, or by reacting ammonium anthranilate or its derivative with formic acid or its derivative.

The invention discloses an anthranilic acid compound, of which the structure is shown in a general formula I, wherein the definitions of substitutional groups are shown in an instruction book. The anthranilic acid compound has broad-spectrum insecticidal activity, and in particular to spodoptera exigua hubner and diamond back moth, the compound has better activity, and can also achieve good control efficiency under the condition of low dose.

The invention is concerned with novel anthranilic acid derivatives of formula (I)

wherein R¹ to R¹⁴ and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds are HM74A agonists and can be used as medicaments.

The use of anthranilic acid (2-AA) to label N-glycans prior to separation using a reversed-phase liquid chromatography (RP-LC) column under acidic conditions using formic acid is described herein. Negatively charged 2-AA offers stronger retention on the reversed phase column than 2-aminobenzamide (2-AB) in RP-LC and allows efficient ionization and detection of 2-AA labeled N-glycans. The acidic conditions used for the RP-LC leads to an efficient separation of acidic 2-AA N-glycans carrying terminal sialylation without the need for an ion-pairing reagent. The method and compositions described herein may be used with RP-nano-LC-MS and a 96-well plate sample preparation, which allows attomolar sensitivity and high throughput.