186 results about "Sacroiliitis" patented technology

The present invention relates to compounds of Formula (I),

methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.

The anthranilic acid derivative or the salt thereof represented by the general formula

wherein R¹ and R² are hydrogen atom, or the like; R³ is a phenyl, cycloalkyl or bicyclic heterocyclic group which may be substituted, or the like; R⁴ is a phenyl, cycloalkyl or pyridyl group which may be substituted, or the like; X¹ is an alkylene or alkenylene group which may be substituted or a bond; X² is the general formula -X³-X⁴- or -X⁴-X³-, wherein X³ is a sulfur atom, an imino group or a bond, or the like; X⁴ means an alkylene or alkenylene group which may be substituted or a bond; is useful for a remedy such as rheumatoid arthritis, osteoarthritis and carcinoma, because it shows MMP-13 production inhibitory effect.

The invention relates to a plaster used for treating rheumatism, rheumatoid disease and various hyperosteogeny, which consists of 35 kinds of Chinese medicine materials, including nux vomica, unprocessed radix aconiti, unprocessed wild aconite, clematis chinensis, Chuanmugua, radix cyathulae, common culbmoss herb, Chuanduan, divaricate sapshnikovia root, cassia twig and ephedra, etc. The plaster has the functions of eliminating dampness, dispelling cold, activateing collaterals, promoting blood circulation by removing blood stasis, reducing swelling and resolving masses. Therefore, the plaster has the good effects on rheumatism, rheumatoid disease, prolapse of lumbar intervertebral disc, cervical spondylosis, gonarthritis, hyperosteogeny and hyperplasia of mammary glands and no toxicity and side effects. In addition, curative effect is quick, the course of treatment is short and cure rate is high.

The present invention relates to a compound represented by the formula [I]

wherein X¹, X² and X³ are each an optionally substituted CH or a nitrogen atom, and any one of X¹, X² and X³ is a nitrogen atom, X⁴ is an optionally substituted CH, R¹ is an optionally substituted phenyl group or an optionally substituted heterocyclic group, and R² is an optionally substituted pyridin-4-yl group, an optionally substituted pyridine-N-oxide-4-yl group or an optionally substituted pyrimidin-4-yl group, or a salt thereof. The compound has superior p38 MAP kinase inhibitory activity and MMP-13 production inhibitory activity, and is useful as an agent for the prophylaxis or treatment and the like of an inflammatory disease, an autoimmune disease, a debilitating disease, an osteoarticular degenerative disease, a neurodegenerative disease, a vascular disease, a neoplastic disease or an infectious disease.

The present disclosure is directed to modulators of cyclooxygenase (COX) enzymes and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of the severity and duration of non-specific pain, tension-type pain, headache, migraine, lower back pain, sciatica, dental pain, muscular pain, pain associated with acute soft tissue injuries, bursitis, tendonitis, lumbago, periarthritis, tennis elbow, sprains, strains, muscular problems associated with sports injuries, muscular problems associated with accidents, period pain, primary dysmenorrhoea, acute sore throat pain, osteoarthritis, rheumatoid arthritis, cancer, any disorder requiring analgesic response, any disorder requiring anti-inflammatory response, any disorder requiring antipyretic response, any conditions mediated by cyclooxygenase, cystic fibrosis, dementia, Alzheimer's disease, and/or conditions mediated by levels of β-amyloid are described.

The present invention relates to compounds of Formula (I),

methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.

The invention encompasses a method for diagnosing an arthritic condition and a gastrointestinal inflammatory disorder in a companion animal. The invention also encompasses a method for identifying ingredients for a pet food composition that are suitable for preventing, ameliorating the symptoms of, or treating an arthritic condition or gastrointestinal inflammatory disorder.

The present invention is a kind of Chinese medicine preparation prepared with safflower, drynaria rhizome, leatherleaf milletia and clematis root in certain weight proportion, and through organic solvent extraction or direct crushing and other conventional steps. The Chinese medicine preparation may be prepared into liniment, tincture, ointment, plaster and other externally applied preparation forms. Its is used in treating pain caused by hyperosteogeny, protrusion of lumbar intervertebral disc, cervical spondylopathy, etc. through being applied to the pain spot, and has high curative effect.

A glove for reducing lateral subluxation of the first carpometacarpal joint that includes a glove body, and a strap portion carried by the glove body. The strap portion extends from a proximal end portion of the glove, and has a length sufficient to allow the strap to be looped around the thumb, to provide dorsal-radial tension on the thumb near the distal end of the first metacarpal in order to reduce lateral subluxation at the first carpometacarpal joint. An attachment element is also provided for securing a distal end of the strap portion to a mutually engaging attachment element secured to the glove body.

The invention discloses granules for relieving the stasis of blood and removing the obstruction of vital energy and blood flow in the chest. The granules are prepared from 35-42g of giant mistletoe, 35-42g of pubescent angelica root, 35-42g of radix gentianae macrophyllae, 35-42g of radix sileris, 28-35g of pawpaw, 7-11g of wild ginger, 35-42g of eucommia bark, 35-42g of radix cyathulae, 22-28g oftripterygium wilfordii, 42-52g of caulis lonicerae, 42-52g of caulis sinomenii, 35-42g of caulis piperis kadsurae, 35-42g of wooly datchmanspipe herb, 57-67g of astragalus root, 28-35g of tuckahoe, 35-42g of angelica, 28-35g of rhizoma ligustici wallichii, 35-42g of white peony root, 42-52g of radix salviae miltiorrhizae, 15-23g of scaly anteater, 28-35g of cassia nomame thorn and 12-20g of licorice (moxibustion). The preparation method of the granules comprises the following steps: adding water into the twenty two traditional Chinese medicines, decocting for 1.5 hours for the first time anddecocting for 1 hour for the second time by adding water, merging decoction, filtering, decompressing and concentrating filtrate into thick paste with the relative density of 1.35-1.40 (60 DEG C), decompressing and drying, and pulverizing into fine powder; taking the fine powder, adding an amount of sucrose powder, dextrin and ethanol, preparing granules and subpackaging. The granules are convenient to take, have the effects of tonifying the liver and the kidney, strengthening the bone and tendons, relieving the stasis of blood, removing pathologic wind and relieving pains and have very goodcurative effect to rheumatoid arthritis, tetanic dorsal column inflammation, sacroiliitis and the like.

Disclosed is an externally applied pure Chinese medicine for treating spondylitis ankylopoietica and arthritis, which comprises the following Chinese medicinal materials (by weight portion), musk 2-35, wild aconkite root 2-30, Clematis chinensis 2.5-40 and seed of nuxvomica 2-40.

The invention discloses a pharmaceutical composition for treating orthopaedic diseases, especially the injection of the pharmaceutical composition and its preparation, the medicament is prepared from bone extract of pig's limbs and sweet melon seeds extract through conventional methods for injection preparation.

The present invention relates to a method for preparing a cartilage product comprising a protein hydrolysate with a degree of hydrolysis comprised between 0.5% and 3.0%, at least one glycosaminoglycan and at least one growth factor. The present invention also relates to the cartilage product obtainable through said method. Said cartilage product is useful in the treatment or prevention of wounds, ulcers, burns, psoriasis, osteoarthritis, synovitis, osteoporosis, osteopenia, diseases of the tendons and ligaments, periodontal diseases, signs of skin aging, the harmful effects of ultraviolet radiation exposure or stretch marks.

The invention discloses a medicine for treating rheumatoid arthritis and ankylosing spondylitis and its preparation method, which is mainly prepared from Clematis chinensis, arisaema tuber, cantharis, semen strychni, ledebouriella root, cassia twig and camphor by a predetermined weight ratio, the medicament fits for external use by patients.

The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament (OPLL), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, PXE, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.