157 results about "Spondarthritis" patented technology

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 2′,4′-dichloro-biphenyl-4-yl-hydroxy-ketones and related compounds (collectively referred to herein as “DCBP compounds”), and more particularly to compounds selected from compounds of the following formula and pharmaceutically acceptable salts, solvates, and hydrates thereof:wherein: n is independently 1, 2, 3, or 4; W is independently —C(═O)—, —CH(OH)—, or —C(═NOROX)—; ROX is independently —H or C1-3alkyl; J is independently: —H, —RE1, —C(═O)—RE2, —C(═O)—O—RE3, —C(═O)—O—S(═O)2ORE4, —C(═O)—(CH2)n—C(═O)ORE5, —C(═O)—(CH2)n—NRNE1RNE2, —C(═O)—(CH2)n—NRNE3—C(═O)RE6, —C(═O)—(CH2)n—C(═O)—NRNE4RNE5, or —P(═O)(ORE7)(ORE8); wherein each of RE1, RE2, RE3, RE4, RE5, RE6, and RE7 is independently: —H, C1-3alkyl, -Ph, or —CH2-Ph. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment and / or prevention, for example, of inflammation and / or joint destruction and / or bone loss; of disorders mediated by excessive and / or inappropriate and / or prolonged activation of the immune system; of, inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activation in rheumatoid arthritis, osteoporosis, cancer associated bone disease, Paget's disease and the like.

Humanized antibodies specifically binding to hTNF-a are prepared from a mouse monoclonal antibody by the CDR (complementarity determining region) grafting method, and they show an antigen binding affinity similar to the origninal mouse monoclonal antibody and significantly low immunogenicity. Therefore, the humanized antibodies can be effectively used for treating a hTNF-a-related disease such as rheumatoid arthritis, Crohn's disease, psoriatic arthritis, psoriasis, septicemia, asthma, Wegener's granulomatosis, inflammation, and ankylosing spondylitis.

The problem of the present invention is to provide a compound having a superior RORγt inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like. The present invention relates to a compound represented by the formula (I):[wherein each symbol is as described in the DESCRIPTION] or a salt thereof, which has an RORγt inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like.

The invention relates to a method for rapidly detecting a human leucocyte antigen B27 (HLA-B27) and an in-vitro diagnosis kit, which belong to the technical field of medical biology. In the kit, a pair of HLA-B27 specific primers and a specific fluorescent probe are adopted for rapidly detecting the HLA-B27. In the kit, the pair of HLA-B27 specific primer and the specific fluorescent probe can beused for rapidly and accurately detecting HLA-B27 genes in samples such as human peripheral blood and the like, and the kit has the advantages of high specificity, high sensitivity, time saving, labor saving, low cost, high flux and the like, and can be applied to auxiliary diagnosis of multiple spondyloarthropathies which severely endanger human health such as clinical ankylosing spondylitis, Reiter syndrome, psoriatic arthritis, ulcerative colitis accompanying arthropathy, acute anterior tract uveal, and the like.

The invention relates to a traditional Chinese medicine and a preparation method thereof, in particular to a medicament for treating ankylosing spondylitis and a preparation method of the medicament. The medicament for treating ankylosing spondylitis comprises teasel roots, east asian tree fern rhizome, epimedium, eucommia, processed aconite, cassia twig, drynaria, raw rehmannia roots, red paeony roots, coix seeds, common clubmoss herb, white muscardine silkworm, notopterygium and heracleum, divaricate saposhnikovia roots and achyranthes bidentata. The preparation method includes: proportionally mixing the ingredients, soaking the mixture in cold water for 1 hour, boiling with strong fire prior to decocting with soft fire for 20 minutes, pouring out the liquid medicine, then adding water over the traditional Chinese medicine, decocting to boil prior to decocting with soft fire for 15 minutes, and uniformly mixing the two liquid medicines. Usage of the medicament includes: drinking twice a day by oral administration and taking twenty times for a treatment course during administration. The preparation method has the advantages of capability of treating both the symptoms and the root causes, high safety, little side effect, reliable curative effect and acceptability to patients.

A method of inhibiting the inflammatory process, the method comprising administering to a mammal suffering from inflammation a therapeutically effective amount of a pharmaceutical composition comprising a compoundwhere:R is a C1-C10 alkylene group, in which, when the number of carbon atoms is at least 2, there are optionally 1 or 2 non-adjacent double bonds; 1 to 3 non-adjacent methylene groups are optionally replaced by NR1 (where R1 is H, alkyl, or acyl), O, or S; and 1 or 2 methylene groups are optionally replaced by a carbonyl or hydroxymethylene group and pharmaceutically acceptable esters or salts of the compounds and wherein the inflammatory process results from a disease selected from the group consisting of ulcerative colitis, endotoxic shock, rheumatoid arthritis, juvenile arthritis, osteoarthritis, psoriasis, Crohn's disease, inflammatory bowel disease, multiple sclerosis, insulin dependent diabetes mellitus, gout, psoriatic arthritis, reactive arthritis, vital or post-viral arthritis and ankylosing spondylarthritis.

The invention discloses application of health care nourishment used for cervical spondylosis, rachitis and arthritis and a preparation method. According to quintessence theory of traditional Chinese medicine, the nourishment varies with each individual, through outstanding proportion, the nourishment is made by more than eight medical and edible dual-purpose traditional Chinese medicine ingredients, various types of probiotics and oligopeptide serving as main ingredients, and prebiotics, carbohydrate, amino acid, multiple vitamins and multiple minerals serve as auxiliary ingredients. According to the nourishment, the medical and edible dual-purpose ingredients are selected, nutrient microelements are added by utilizing advanced scientific preparation technology, the functions of promoting blood circulation to remove blood stasis, relieving pain, disinfecting, resisting inflammatory, dredging collaterals, nourishing liver and kidney and promoting regeneration and repair of tissues are achieved, and the nourishment has the functions of prevention and health care to the patients who suffer from cervical spondylosis, rachitis and arthritis.

Humanized antibodies specifically binding to hTNF-α are prepared from a mouse monoclonal antibody by the CDR (complementarity determining region) grafting method, and they show an antigen binding affinity similar to the original mouse monoclonal antibody and significantly low immunogenicity. Therefore, the humanized antibodies can be effectively used for treating a hTNF-α-related disease such as rheumatoid arthritis, Crohn's disease, psoriatic arthritis, psoriasis, septicemia, asthma, Wegener's granulomatosis, inflammation, and ankylosing spondylitis.

The invention discloses application of mesenchymal stem cells in preparation of products for treating rheumatoid arthritis. The invention provides application of the mesenchymal stem cells or cell preparations of the mesenchymal stem cells in preparation of drugs for treatment of rheumatoid arthritis. The preparation method of the cell preparations includes the following steps: adopting a tissue block in a Warton zone of the umbilical cord as a raw material, and preparing the umbilical cord mesenchymal stem cells so as to obtain the cell preparations, wherein a low-serum culture medium is adopted in the preparation process. The cell preparations are suitable for cell therapy of rheumatoid arthritis and other diseases related to rheumatoid arthritis, wherein complications and diseases withsimilar pathogenesis of the diseases related to rheumatoid arthritis include rheumatoid vasculitis, pneumonia, osteoarthritis, rheumatoid heart disease, ankylosing spondylitis, gout, eye diseases, kidney diseases, urinary system infection, Cushing's syndrome, oral ulcers and other diseases. A great application value is provided for treatment of rheumatoid arthritis and related diseases.

The invention provides a full-nutritional formula food, a specific full-nutritional formula food or a non-full-nutritional formula food for patients with ankylosing apondylitis. The formula is on the basis of the requirements of general principles of formula food with special medical use, is combined with the constitutive characters of the patients with ankylosing apondylitis, is integrated with the advanced research results of physiology, medicine, nutriology, clinical application and the like of Harvard University at present, and is developed according to the traditional Chinese medicine essence theory (with the main principle of homology of three internal organs including liver, spleen and kidney) of 'reinforcing middle energizer to reside the dispelling Qi' and 'balancing aftercare'. The product takes multiple medicine and food dual-purpose traditional Chinese medicine extract essences, multiple probiotics and oligopeptides as main raw materials, and takes prebiotics, carbohydrate, amino acid, multi-vitamins and mineral substances as auxiliary materials and is prepared by mixing the main raw materials and the auxiliary materials, thus being used as a single nutrition source to meet the demand for nutrition of the patients with ankylosing apondylitis, and also having the effects of invigorating the circulation of blood and removing stasis, activating meridians to stop pain, strengthening the body resistance to eliminate pathogenic factors, diminishing inflammation and relieving pain, warming kidney and supporting Yang, nourishing and strengthening bones and improving immunity.

The present invention relates to compounds of Formula (I),methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury / loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.