199 results about "Agkistrodon acutus" patented technology

The invention discloses a medicament for treating rheumatism and rheumatoid disease, which is prepared from 50 kinds of Chinese medicinal herbs including pubescent angelica root, Clematis chinensis, Sichuan aconite root, Ligusticum wallichii, achyranthes and cyathula root, zanthoxylum piperitum, rhizoma dioscoreae, prepared aconite root, notopterygium root, white-stiff silkworm, safflower, gastrodia tuber, myrrh, frankincense, drynaria, tiger bone, earthworm, agkistrodon acutus, hooked uncaria, large-leaf gentian root and cinnamon twig through steps of drying the raw materials herbs, disintegrating into 120 mesh fines, sieving, mixing proportionally, carrying out germicidal treatment, making powders, watered pills, honeyed pills or capsules.

The invention relates to a plaster for treating rheumatism which is prepared from 40 traditional Chinese medicinal materials including syngnathus, pubescent angelica, angelica, agkistrodonbungarus minimus, peach kernel, safflower, phellodendron, radix sileris, catnip, asarum, pinellia ternate, yazao, erhua, forsythia, pangolin, nux vomica, rhizoma gastrodiae, panax notoginseng, papaya, hyssop, cortex eucommiae, cassia twig, olibanum, myrrh, angelica, coptis, notopterygium, fritillaria, sophora, whole worm, centipede, dragon's blood, radix auckladiae, realgar, musk, clove, borneol, astragalus, sesame oil and guangdan. The plaster has special curative effect for treating intractable rheumatism, and has advantages of quick result, short treatment period, high cure rate and low cost.

The invention relates to incubation and cultivation methods of agkistrodon acutus. An incubation method comprises the following steps of: egg selection and incubation, wherein the incubation comprises the following technical points of: a, controlling the incubation temperature to be 26-30 DEG C; b, controlling the relative incubation humidity to be 88-96 percent; c, incubating for about 23 days; and d, checking eggs timely, and processing mucid eggs: checking the eggs through lighting once a day to see whether mildew or fertilization occurs or not, and processing timely so as to avoid affecting other eggs. A cultivation method comprises the following steps of: feeding of the eggs, overwinter cultivation of the of agkistrodon acutus, and feeding and management of the of agkistrodon acutus. The incubation and cultivation methods of the agkistrodon acutus have high snakelet incubation survival rate, and fast agkistrodon acutus growth, and are suitable for large-scale artificial breeding.

The invention discloses a method utilizing a fermentation bed pool to raise agkistrodon acutus. The method includes the steps of placing the agkistrodon acutus into the fermentation bed pool, opening sliding doors every three to seven days from the next week, using new fermentation bed padding to cover excrement on the surface of fermentation bed padding, spraying EM bacterial liquid on the surface of the fermentation bed padding after 10-15 days when the snake is placed, and carrying out harrow-turning treatment on the fermentation bed padding after 15-30 days when the snake is placed. The fermentation bed pool is low in cost and simple to manufacture. The snake pool is simple in structure and reasonable in design. A snake house is complete in configuration, and environment is convenient to control. The mode utilizing the fermentation bed pool to raise the agkistrodon acutus facilitates health environment control, prevents harmful germs from breeding, and lowers risks of daily operation and cultivation.

The invention relates to a Chinese medicinal capsule for treating chronic infectious arthritis and rigid rachitis and process for preparation, wherein the raw materials include agkistrodon acutus, black-tail snake, black ants, ginseng, asaryl, scorpion, earthworm, large-leaf gentian root, seed of nuxvomica, dried rehmannia root, eucommia bark and epimeddium.

The invention provides a traditional Chinese medicine preparation for treating liver cancer, comprising the following raw medicines in parts by weight: 10-20 parts of acanthopanax, 10-20 parts of oldenlandia diffusa, 10-20 parts of radix astragali, 10-20 parts of cambogia, 10-20 parts of glossy privet fruit, 10-20 parts of white atractylodes rhizome, 10-20 parts of radix polygoni multiflori preparata, 10-20 parts of oriental wormwood, 10-20 parts of turmeric, 10-20 parts of selfheal, 10-20 parts of umbellate pore fungus, 10-20 parts of magnolia vine fruit, 10-20 parts of curcuma zedoary, 10-20 parts of tuckahoe, 10-20 parts of eclipta, 10-20 parts of root of red-rooted salvia, 10-20 parts of white peony root, 10-20 parts of barbed skullcap herb, 10-20 parts of baical skullcap root, 10-20 parts of epimedium, 1-10 parts of toad venom and 1-10 parts of scorpion. The traditional Chinese medicine preparation for treating liver cancer has the beneficial effects of prolonging the life time of inoperable patients, playing an adjuvant treating effect on patients treated mainly by operation, radiation treatment and chemo-treatment, and having certain curative effects on liver cancer-specific backgrounds of liver diseases such as hepatitis and liver cirrhosis.

The invention provides a Chinese patent medicine for treating rheumatoid arthritis, which is characterized in that the medicine comprises the following components by weight: 8-12 parts of ephedra sinica, 8-12 parts of Chinese mugwort leaves, 12-18 parts of zaocys dhumnades, 12-18 parts of agkistrodon acutus, 8-12 parts of frankincense, 8-12 parts of angelica dahurica, 45-55 parts of clematis roots, 8-12 parts of rhizoma homalomena, 8-12 parts of root-bark of Chinese hydrangeavine, 27-33 parts of common clubmoss herb, 27-33 parts of millettia dielsiana, 12-18 parts of notopterygium incisum, 12-18 parts of pubescent angelica, 12-18 parts of achyranthes, 9-15 parts of angelica, 9-15 parts of menispermaceae, 12-18 parts of cassia twig, 9-15 parts of pawpaw, 12-18 parts of kudzu roots, 12-18 parts of pangolin, 45-55 parts of ants, 18-22 parts of radix astragali, 12-18 parts of bighead atractylodes rhizome, 75-85 parts of fructus eucalypti robustae, 12-18 parts of cherokee roses, and 12-18 parts of licorice. The Chinese patent medicine of the present invention has the efficacy of dispelling wind and dissipating binds, freeing channels and promoting qi, activating blood and dissolving stasis, dispersing blood stasis and detumescence; the plurality of traditional Chinese medicine components can complement each other, dredge circulatory disturbance, and repair damaged joints. The invention can regulate body endocrine, and maintain internal hormone balance. The invention has significant curative effect, and has no toxic or side effect.

Purified multivalent and lyophilized antivenin and a use method belong to antibody immunity serums that aim at more than two antigens. The invention aims at preparing the multivalent antivenin by a plurality of lyophilized antivenins and the use method. The invention is characterized in that: the antigen-binding fragment F(ab)2 has 60 to 80 percent of lyophilized antiserum, the unit is mg per person, 342.5 to 1035 of vipers, 1177 to 3182 of agkistrodon acutus, 456 to 666 of adders, 1419 to 2128 of king cobras, 220 to 331 of coral snakes, 880 to 1320 of gold banded kraits, 3188 to 4782 of cobras are combined; the optimized combination is as follows: 635 of vipers, 1959 of agkistrodon acutus, 561 of adders, 1774 of king cobras, 276 of coral snakes, 1100 of gold banded kraits and 3985 of cobras. Blood circulation snake venom antiserum and nerves snake venom antiserum are respectively filled and measured. The use method is as follows: the antivenin that is diluted by sodium chloride and an anti-allergic agent, such as chlorphenamine maleate, are injected into muscle or a vein. The antivenin is prepared by only seven antivenins, and can effectively and in time treat injuries caused by various poisonous snakes in our country when the antiserum is directly injected in condition of the undetermined variety of poisonous snakes, and the invention reaches the advanced world level of the antivenin.

The present invention relates to a Chinese medicine preparation, in particular to an external Chinese medicine combined with warming moxibustion for dispelling wind chill and pathogenic dampness. The present invention is made from the crude drugs with the following weight portions: 4 to 6g of saffron, radix notoginseng and liquorice respectively, 8 to 14g of angelica, chuanxikong rhizme, motherwort herb, white peony, prepared rehmannia rhizome, corktree bark, rhizoma atractylodis, largehead atractylode, notopterygium root , pubescent angelica root, cortex eucommiae, radix saposhinikoviae, grassleaf sweetflag rhizome and acanthopanax root respectively, 13 to 17g of danshen, 1 to 3g of Buthus martensi kirsch and agkistrodon acutus and 1 to 2g of centipede; all the crude drugs are added with 500ml water and cooked into paste. The medicine, as an external Chinese medicine combined with warming moxibustion, is coated on the acupoints of human body in acupuncture, and utilizes the physical stimulus of moxibustion hyperthermia and the pharmacological action of warmly dredging channels and collaterals of Chinese mugwort leaf, as well as the characteristics of ''qi and blood will circulate in warmness but coagulate in coldness''. The present invention has immediate effects of warmly dredging channels and collaterals, harmonizing qi and blood, activating the collaterals, dispelling wind and eliminating dampness, and dispelling cold and relieving pain through acupoint administration combined with the warm effect of warming moxibustion.

The invention relates to a preparation method of snake skin active peptide, in particular to snakes such as black snake, pit viper, red snake, coral snake, cobra, king snake, five step snake, pine snake, tiger tail snake, Chinese water snake, etc. The fresh snake skin is used as the raw material, after cleaning → mincing → refining → adjusting the material concentration → adjusting the material temperature → adding protease enzymatic hydrolysis → centrifugal filtration → deenzyme → nanofiltration desalination concentration → ultrafiltration purification → freeze drying and other technological processes , to obtain snake skin active peptide. More than 90% of the molecular weight of the product is distributed between 200-5000Dalton, of which 200-2000Dalton (2-10 peptide) accounts for more than 75%, and it also contains docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) It has good water solubility, excellent moisture absorption and moisturizing function, good acid and heat stability. It can be used in the fields of medicine and health food production.

The invention refers to a ThrombinLikeEnzyme, called Haemocoagulase Acutus, in brief Halase, separated and purified from Agkistrodon acutus midew. It also refers to the usage of the drug of curing haemorrhagic disease made by using Halase. Halase is a glycoprotein composed of double sub-groups, connected by bisulfur bond. On N end, determining result of 15 amino acid sequences as follows: A sub-group: DCPSDWSSYEGHCYK; Bsub-group: DCSSGWSS- YEGHCYK. Molecular weight: 29076.1Da, equipotential point 5.78, and containing 1.89%-1.95% neutral hexose. Take Halase and excipient dextrose to add in injection water to dissolve, filter and sterilize, make split charging, and freeze-dry to obtain white injecting Halase powder injection. Halase is a new haemostatic drug.

The invention relates to a pharmaceutical composition for adjuvant therapy of cancers and a preparation method thereof. The pharmaceutical composition of the invention comprises the following traditional Chinese medicine raw material herbs: radix astragali, gen-seng, radix codonopsis, bighead atractylodes rhizome, poria cocos, sculellaria barbata, oldenlandia diffusa, glaucescent fissistigma roots, scorpion, centipede, radices trichosanthis, rhizoma sparganii, curcuma zedoary, licorice, and the like, has the efficacy of breaking blood, removing blood stasis, softening hardness and dissipating binds, is applicable to adjuvant therapy of various cancers, and has significant curative effect after years of clinical application.

The invention discloses a Chinese medicinal composition for drug rehabilitation which comprises the following constituents (by weight portions): corydalis tuber 150-300 parts, root of Dahurain angelica 50-130 parts, red peony root 20-100 parts, black slice of aconite 20-100 parts, rhizome of Sichuan lovage 20-100 parts, herba patriniae 30-100 parts, Chinese angelica root 50-100 parts, rheum officinale 30-100 parts, licorice root 30-100 parts, cow-bezoar 1-10 parts, secretio bufonis 0.1-2.5 parts, borneol 0.5-1.0 part, agkistrodon acutus 1-4 parts, buthus martensi kirsch 1-10 parts, deer placenta 5-30 parts, fine Chinese caterpillar fungus 20-100 parts, American ginseng 15-40 parts.

The invention relates to a Chinese medicinal powder for treating waist and leg pains, which is prepared form 28 kinds of Chinese medicinal herbs including cornus officinalis, epimeddium, east Asian tree fern rhizome, dipsacus root, drynaria, eucommia bark, Loranthus mulberry mistletoe, Clematis chinensis, large-leaf gentian root, pawpaw, cortex acanthopanacis, agkistrodon acutus, Kusnezoff monkshood root, homalomena rhizoma, achyranthes and cyathula root, frankincense, pubescent angelica root, notopterygium root, buthus martensi karsch, Chinese angelica root, gastrodia tuber, white atractylodes rhizome, atractylodes rhizome, root of red rooted saliva, dried body of ground beetle, prepared rhizome of rehmannia and mulberry twigs.

The present invention is Agkistrodon acutus venon 36KD single-stranded hemocoagulase and its preparation process, and aims at providing single-stranded Agkistrodon acutus venon hemocoagulase with high potency and low toxicity. SDS-PAGE electrophoresis shows that the hemocoagulase has molecular weight of 36KD+/-2KD, single color zone, and at least 90 % homogeneity with the N end sequence of the single-stranded amino acid shown in SEQ ID No. 1. The preparation process includes dissolving Agkistrodon acutus venon in Tris-HCl buffering solution (pH8.0) and dialysis; adding the supernatant to Metal Sepharose F.F affinity chromatographic column and collecting the penetrating peak component; adding the penetrating peak component to DEAE-Sepharose F.F ion exchange column and collecting active peak component; separating in Superdex 75 column and Sephacryl S-100 column; desalting in Sephadex G-25 column; sterilizing and freeze drying.

The invention discloses a bone disease treatment plaster. The bone disease treatment plaster comprises Smilax hypoglauca Benth, Hedyotis diffusa, Zanthoxylum nitidum, Cynanchum amplexicaule (Sieb. et Zucc.) Hemsl., Herba Patriniae, Pseudobulbus Cremastrae seu Pleiones, Cornu Bubali, Cordyceps sinensis, barbed skullcap herb, fresh dendrobium, Polygonum multiflorum, geckos, Santalum album L., Dioscorea nipponica Makino, rheum officinale, toad venom, geckos, American ginseng, Salvia miltiorrhiza, Adenophora stricta, Radix Scrophulariae, Sophora flavescens, Radix Pseudostellariae, Corn Cervi Pantotrichum, sea horses, starfishes, sea urchins, Folium Cordylines Fruticosae, Rhizoma Paridis, Rhodiola rosea, Crocus sativus, Radix Astragali, Human Placenta, pangolins, long-noded pit viper, Agkistrodon acutus, Zaocys Dhumnades, Changbai Mountain Mythic Fungus, dragon's blood, panax notoginseng, black maca, Cistanche deserticola, Radix Morindae officinalis, polygonatum rhizome, Semen plantaginis, semen cuscutae, centipedes, lumbricus, musk, rhizoma gastrodiae and whole scorpions. The bone disease treatment plaster aims at macroscopic regulation, and realizes integral conditioning and treatment through regulating the self tissue ability of a complex and open huge system and depending on the self rehabilitation ability of patients.

The invention relates to an external used medicine prepared based on traditional Chinese medicines for treating tumor, wherein powder product is prepared by taking gecko, nidus vespae, cynanchum paniculatum, astragalus mongholicus, codonopsis pilosula, rhizoma atractylodis alba, hairyvein agrimony, semen coicis, safflower carthamus, amethyst, manyleaf paris rhizome, honey-fried licorice root, toad skin, stiff silkworm, pillis ophidiae, zaocys dhumnade, agkistrodon, rhizoma corydalis, angelica sinensis, cortex albiziae, Flos Albiziae, scorpio, centipede, lumbricus, polygala tenuifolia, amber, chlorite schist, leech, gadfly, ground beeltle, manis pentadactyla, and oldenlandia diffusa, which are finely selected and cleaned with clear water, mixing uniformly, crushing to 60-80 meshes medicine powders, and sterilizing. The medicine has functions in combating poison with poison, dispelling wind and removing obstruction in the meridians, clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, smoothing the nerves, combating poison, removing stasis, tonifying Qi and strengthening healthy energy, can inhibit and kill tumor cells effectively, and has significant treating effect to tumors without toxic and side effects.

The invention discloses an angiogenesis inhibitant, which has an amino acid sequence selected from SEQ ID NO.1 and SEQ ID NO.2 and a molecular weight of 25000-35000 Dalton measured by a non-reducing SDS-PAGE (sodium dodecyl sulfate polyacrylamide gel electrophoresis) method. The purification method comprises the steps of: first dissolving agkistrodon acutus venom in a buffer solution, conducting centrifugation so as to take supernate; subjecting the obtained supernate to anion exchange chromatography so as to obtain an angiogenesis inhibitant crude solution; then coupling a monoclonal antibody secreted by a hybridoma cell strain 1B9 (CCTCC C200970) with an affinity chromatography vector so as to prepare an immune affinity chromatography column; finally purifying the crude solution with the obtained immune affinity chromatography column, thus obtaining the angiogenesis inhibitant. The angiogenesis inhibitant of the invention can be prepared into powder injections for injection, and has an anti-angiogenesis activity, especially angiogenesis related to tumor growth, and also has an obvious effect in tumor resistance and tumor metastasis resistance.

The invention relates to a medicament for external application for treating hypertension, which comprises the following active raw materials (by weight portion): notoginseng 4-10 parts, selfheal 0-6 parts, coptis root 4-10 parts, cicada skin 4-10 parts, centipede 9-20 parts, root of red rooted saliva 0-30 parts, cassia seed 0-20 parts, hooked uncaria 0-20 parts, kudzuvine root 10-20 parts, gastrodia elata 0-30 parts, dried body of ground beetle 4-10 parts, earthworm 4-10 parts, agkistrodon acutus 15-45 parts, borneol 2-6 parts, kansui root 3-5 parts, rhizoma corydalis 4-10 parts, asarum herb 5-8 parts and white mustard seed 4-10 parts. The medicament is prepared through mixing the raw materials and grinding into medicinal powder.