The invention discloses a composition for treatment of high blood pressure / rheumatoid arthritis, which comprises the following 54 Chinese herbs: radix aconiti preparata, dipsacus root, radix glycyrrhizae, ginseng, rhizoma drynariae, semen cuscutae, radix rehmanniae recens, olibanum, myrrh, radix puerariae, poria cocos, radix angelicae pubescentis, parasitic loranthus, gentiana macrophylla, radix sileris, manchurian wildginger, angelica sinensis, paeoniflorin, ligusticum wallichii, fried eucommia ulmoides, cordyceps sinensis, lyceum chinensis, angelica polyclada, rhizoma atractylodis macrocephalae, rhizoma polygonati, cynomorium songaricum, peach kernel, agkistrodon, desertiving cistanche, colla corni cervi, semen brassicae, radix achyranthis bidentatae, borneo camphor, shaved cinnamon bark, oakum, fried fructus meliae toosendan, corydalis tuber, fried pangolin, radix paeoniae alba, fried rhizome cyperi, radix aconiti carmichaeli, pericarpium citri reticulatae viride, ant, pericarpium citri reticulatae, schisandra chinensis, rhizome dioscoreae, ramulus uncariae cum uncis, cortex phellodendri, rhizoma atractylodis, rhizoma zingeberis, radix clematidis, peppermint, semen celosiae and semen momordicae, and the materials are unique. The invention also discloses medical liquor prepared by the composition and a preparation method and an application thereof, which has a good effect on treatment of high blood pressure and rheumatoid arthritis.