The invention discloses quick-acting collateral-dredging swelling-dispersing pain-relieving tincture and a preparation method thereof. The quick-acting collateral-dredging swelling-dispersing pain-relieving tincture is mainly prepared by the steps of mixing the raw materials in parts by weight, grinding and bottling, wherein the raw materials include pine needle, berba aristolochiae mollissimae, alangium platanifolium, fructus liquidambaris, garden balsam stem, chinaroot greenbrier, beehive, hematoxylon, red paeony root, carthamus tinctorius, castor bean, aconitum pendulum, unprocessed rhizoma pinelliae, unprocessed monkshood, unprocessed radix aconiti agrestis, unprocessed arisaema consanguineum schott, unprocessed nux vomica, thunder god vine, sargent gloryvine, radix clematidis, ligusticum wallichii, frankincense, myrrh, asarum heterotropoides, camphor and borneol. The quick-acting collateral-dredging swelling-dispersing pain-relieving tincture disclosed by the invention is simple in preparation method and is capable of effectively treating various neuralgia diseases and various pyogenic infections, such as prosopalgia, vascular headache, toothache, traumatic injury, rheumatic arthritis, cervical vertebra and lumbar spondylosis.