37 results about "Mental nerve" patented technology

A compound represented by general formula (I):a salt thereof, a solvate thereof, or a prodrug thereof wherein all symbols are as defined in the specification has an antagonistic activity against CXCR4 and is therefore useful as a preventive and / or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, systemic erythematosus, retinopathy, macular degeneration, pulmonary fibrosis, transplanted organ rejection, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiac / vascular disease (for example, arteriosclerosis, myocardial infarction, stenocardia, cerebral infarction, chronic arterial occlusive disease, etc.), metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), a preventive and / or therapeutic agent for cancerous diseases or infections, or an agent for regeneration therapy.

The present invention relates to a compound represented by formula (I-0):wherein symbols in formula have the same meanings as described in the present specification, a salt thereof, an N-oxide thereof or a solvate thereof or a prodrug thereof, and medical use thereof. The compound of the present invention has an antagonistic activity against CXCR4 and is therefore useful as a preventive and / or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, transplanted organ rejection, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, and cancerous disease (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy.

The present invention relates to a compound represented by formula (I-0):wherein symbols in formula have the same meanings as described in the present specification, a salt thereof, an N-oxide thereof or a solvate thereof or a prodrug thereof, and medical use thereof.The compound of the present invention has an antagonistic activity against CXCR4 and is therefore useful as a preventive and / or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoidarthritis, arthritis, retinopathy, pulmonary fibrosis, transplanted organ rejection, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy.

The invention relates to a composition with the plant estrogen-like effects, and the composition is prepared by the following pharmaceutical raw materials by weight percentage: 12-64 percent eucommia bark and 6-38 percent malaytea scurfpea fruit. The traditional Chinese medicine composition has the plant estrogen-like effects and can bi-directionally regulate the estrogen level of human body, delay the arrival of menopause and be applicable to improving the perimenopausal syndrome of women: menstrual disorders, vasomotor symptoms (flushes and hot flushes), mental and neurological disorders (depression, anxiety, excitability and insomnia), cardiovascular and cerebrovascular symptoms (hypertension, hyperlipidemia, heart palpitations, atherosclerosis, coronary heart disease, senile dementia, and the like), bone and joint symptoms (osteoporosis, arthralgia, and the like), symptoms of urogenital tract and other diseases.

Compositions for supporting healthy memory and optimizing mental energy and methods for improving, preventing, and treating mental disorders or deterioration. The compositions of the invention can be formulated as nutritional or dietary supplements.

The present invention relates to an antipruritic agent comprising a nociceptin antagonist as an active ingredient. The nociceptin antagonist can be used as a preventive or remedy for diseases associated with itching (for example, atopic dermatitis and urticaria), local pruritus cutaneous caused by insect excretion and secretion, nodular prurigo, kidney dialysis, diabetes, blood disease, liver disease, kidney disease, incretion and metabolic disorder, viscera malignant tumor, hyperthyroidism, autoimmune disease, multiple sclerosis, neurologic disease, psychoneurosis, allergic conjunctivitis, spring catarrh, atopic keratoconjunctivitis, or itching caused by excess use of laxuries and drugs because it has excellent scrtaching behavior suppressing effect, that is, antiitching effect and antipruritic effect.

The invention discloses a compound with phosphodiesterase 4D and acid sphingomyelinase inhibitory activity. The compound has good PDE4D / ASM double-target inhibitory activity and can be used for preventing and / or treating diseases associated with the phosphodiesterase 4D and the acid sphingomyelinase, and the diseases particularly include inflammatory diseases, autoimmune diseases such as dermatitis, atopic dermatitis, psoriasis and multiple sclerosis, cardiovascular diseases such as atherosclerosis and ischemia reperfusion injury, hepatic diseases such as non-alcoholic steatohepatitis, alcoholic steatohepatitis and hepatic fibrosis, mental and neurological diseases such as depression and anxiety disorder, neurodegenerative diseases such as Alzheimer's diseases, respiratory system diseasessuch as chronic obstructive pulmonary diseases, cystic fibrosis, pulmonary fibrosis, pulmonary edema and lung injury and metabolic diseases such as diabetes.

Soymilk is provided which can prevent or alleviate menopausal disorders, and is highly safe with no risk of side effects even with long-term intake thereof. This soymilk is made from germinated soybeans, and is used for alleviating or preventing the vasomotor disorder-like symptoms and psychoneuropathic disorder-like symptoms associated with menopausal disorders. Furthermore, this soymilk is labeled with a notice specifying that the soymilk is to be used for alleviating or preventing the vasomotor disorder-like symptoms and psychoneuropathic disorder-like symptoms of menopausal disorders.

The invention discloses a composition containing wolfberry fruit, chrysanthemum flower and theanine for relieving asthenopia, and belongs to the field of the healthy medicine. The invention provides the composition for reliving asthenopia, and active ingredients thereof are prepared from wolfberry fruit, chrysanthemum flower and theanine. The trial result of the people shows that the composition not only aims at asthenopia eye local symptom, but also can obviously improve the psychoneural symptom caused by asthenopia in different degrees, such as attention-deficit disorder and memory deterioration; the effect of relieving the asthenopia is obvious, and the extensive market prospect is provided.

The invention discloses a traditional Chinese medicine preparation for treating climacteric syndrome of women. The preparation is prepared from raw materials and auxiliary materials. The raw materials comprise the following components in parts by weight: 31-40 parts of cibotium barometz, 25-35 parts of salvia miltiorrhiza, 18-24 parts of curcuma zedoary, 18-24 parts of trifid sopubia herb, 15-25 parts of telegraph plants, 25-33 parts of habenaria dentate, 32-46 parts of fried spina date seed and 12-20 parts of angelica sinensis. The traditional Chinese medicine preparation disclosed by the invention can effectively improve the level of estradiol of women with climacteric syndrome and alleviate vasomotor symptom, autonomic imbalance and psychosomatic manifestations.