The invention discloses a medicine and a granule used for climacteric syndrome. The medicine comprises the following components in parts by weight: 10-30 parts of prepared rehmannia roots, 5-10 parts of radix bupleuri, 1-10 parts of tortoise-shell glue, 10-20 parts of cortex phellodendri chinensis, 10-20 parts of rhizoma anemarrhenae, 1-5 parts of rhizoma cyperi, 10-30 parts of white paeony root, 10-20 parts of herba leonuri, 2-3 parts of cassia twig, 1-10 parts of herba lycopi, 10-30 parts of cornus officinalis, 1-5 parts of red flowers, 25-35 parts of white poria, 5-10 parts of myrrh, 1-5 parts of Chinese angelica, 1-5 parts of teasel root, 1-5 parts of rhizoma corydalis, 10-20 parts of semen cuscutae and 10-30 parts of herba schizonepetae. The medicine disclosed by the invention has the effects of regulating liver and tonifying kidney, and nourishing yin to lessen fire, is mainly used for treating menopausal syndrome (menopausal disorders) which belongs to syndromes of yin deficiency of liver and kidney according to the traditional Chinese medicine differentiation, wherein the syndromes include dryness-heat flushing, dizziness and tinnitus, soreness and weakness of waist and knees or painful heel, insomnia and dreaminess, edginess and irritability.