The invention discloses a traditional Chinese medicine preparation capable of tonifying qi and yin and nourishing a liver and a kidney. The preparation is prepared by further study on rhodiola coccinea, fructus lycii, epimedium, fructus psoraleae, oyster, ginseng, achyranthes bidentata, rehmannia, prepared rehmannia, radix aucklandiae, and liquorice through a modern technology. On the basis of component analysis, the preparation has the effects of tonifying qi and yin, nourishing the liver and the kidney, strengthening tendons and bones, nourishing blood and promoting blood circulation. Pharmacodynamic experiments and clinical observation show that the preparation can improve symptoms of a consumptive disease and qi and yin deficiency, such as lumbago, asthenia, dizziness, tinnitus, insomnia, poor appetite, impotence, palpitation, amnesia, short breath, sudation, cold intolerance, frequent urination, and semiliquid stool significantly, and improve abnormal physical signs such as tender-red and faint-cyan tongue, white and greasy tongue coat, and weak, deep and thready pulse, has a beneficial function, and is beneficial on the basis of dredging, and non-greasy simultaneously. A human body has no adverse effect through detection of safety indices, and the preparation has a certain improving effect on a part of patients with abnormal liver and kidney functions. A clinical total effective rate is 93.3%; an obvious effective rate is 45%; and the preparation is safe and reliable to take.