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49 results about "Microangiopathy" patented technology
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Microangiopathy (or microvascular disease, or small vessel disease) is an angiopathy (i.e. disease of blood vessels) affecting small blood vessels in the body. It can be contrasted to macroangiopathy, or large vessel disease.
Therapeutic compounds
InactiveUS20050256310A1High plasma concentrationHigh activityOrganic active ingredientsSenses disorderMedicineDiabetic complication
The invention provides compounds of formula (I), prodrugs and stereoisomers thereof, and the pharmaceutically acceptable salts of the compounds, prodrugs, and stereoisomers, wherein R1, R2, R3, HET, n, Q, X, Y, and Z are as described herein; compositions thereof; and uses thereof in treating diabetic complications including diabetic neuropathy, diabetic nephropathy, diabetic microangiopathy, and the like.
Owner:PFIZER INC
Coffee cherry compositions and methods for their use in the treatment of diabetes and diabetes related disorders
Compositions of coffee cherry, methods for their use in the treatment of diabetes and diabetes-related complications, and methods for manufacture of the compositions are disclosed. The compositions find use in the treatment of a variety of diabetes-related conditions including disorders relating to impaired vascular function. Methods for the treatment of macroangiopathies and microangiopathies, including diabetic retinopathy, are disclosed.
Owner:VIKHRIEVA NINA
Apolipoprotein a-i mimics
Provided are peptides, compositions thereof, and methods for treating or preventing dyslipidemia, a cardiovascular disease, endothelial dysfunction, a macrovascular disorder, or a microvascular disorder.
Owner:CERENIS THERAPEUTICS HOLDINGS SA
Therapeutic uses of inhibitors of RTP801
ActiveUS20100272722A1Treat and prevent ototoxicityLow ototoxicitySenses disorderNervous disorderMedicineHearing disorder
Owner:ATUGEN AG
Waveform characteristic point based method for analyzing volume pulse wave pattern and detection device
The invention relates to a waveform characteristic point based method for analyzing a volume pulse wave pattern and a detection device, belonging to the field of electronic medical instruments. In the waveform characteristic point based method for analyzing a volume pulse wave pattern, the collection environment comprises a pulse wave pattern collection device and a computer, wherein the pulse wave pattern collection device is used for obtaining a digitalized volume pulse wave pattern and transmitting the wave pattern data to the computer and the analysis of the wave pattern is completed in the computer; the waveform characteristic point based method for analyzing a volume pulse wave pattern comprises the steps of: dividing the whole wave pattern into two parts of an ascending branch and a descending branch from the maximum point of the wave pattern; respectively acquiring the area characteristic quantity parameters of the two parts; and observing the relationship between the area of the parts and the area of the whole wave pattern to finally obtain the parameter. Shown in the research, the ascending branch and the descending branch of the volume pulse wave pattern respectively represent different physiology processes and the characteristic parameter obtained by the method represents the physiology states in detail. The pulse pattern analysis method and the device thereof have the prompting function for microangiopathy.
Owner:BEIJING UNIV OF TECH +1
Treatment of endothelial dysfunction in diabetic patients
ActiveUS20080214434A1High densitySenses disorderNervous disorderEndothelial dysfunctionDiabetic patient
A method for the treatment of endothelial dysfunction in a diabetic patient, including both diabetes induced macrovascular disorders and diabetes induced microvascular disorders, comprises administration, preferably parenteral administration, to the patient of an effective amount of high density lipoprotein (HDL).
Owner:CSL LTD
Aspongopus amide A and composition thereof, and application thereof in pharmacy and food
The invention relates to a novel-structure dopamine tripolymer aspongopus amide A extracted from insect Chinese medicine aspongopus capable of warming the middle-jiao and invigorating yang, a pharmaceutical composition containing the aspongopus amide A, and application thereof in preparing medicines and health food for treating diabetic nephropathy or chronic nephropathy. The clinical application of insect collateral-dredging theory proves that collaterals are related to pathological changes of blood capillaries. The aspongopus amide A has the functions of obviously inhibiting high-saccharide induced kidney mesenteric cell secretory cell epimatrix and inflammatory factor, and is a Smad3 phosphorylation inhibitor capable of obviously inhibiting TGF-beta1-induced Smad3 phosphorylation and Smad3 expression. The signal route of the TGF-beta / Smad3 is the main pathology of mediated organ fibrosis, which indicates that the compound has application value in chronic nephropathy, including diabetic nephropathy, renal fibrosis and the like.
Owner:KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
Application of pseudo-ginseng and extract thereof in preparing medicament for curing and/or preventing diabetic microangiopathies
ActiveCN101700265AImprove high viscosity stateImprove hypoxia toleranceMetabolism disorderUrinary disorderPANAX NOTOGINSENG ROOTPanax notoginseng extract
The invention relates to a new application of pseudo-ginseng, pseudo-ginseng extract, panax notoginseng saponins, and panax notoginseng saponins composite, namely, a new application in preparing medicament for curing and / or preventing diabetic microangiopathies.
Owner:许淑清
Apolipoprotein A-I mimics
Provided are peptides, compositions thereof, and methods for treating or preventing dyslipidemia, a cardiovascular disease, endothelial dysfunction, a macrovascular disorder, or a microvascular disorder.
Owner:CERENIS THERAPEUTICS HOLDINGS SA
Treatment of diabetes and diabetic complications with NHE-1 inhibitors
This invention relates to methods of treating or preventing type 2 diabetes, diabetic neuropathy, diabetic cardiomyopathy, cataracts, diabetic retinopathy, foot ulcers, diabetic microangiopathy, diabetic macroangiopathy, diabetic ischemia reperfusion injury, diabetic cardiac ischemia reperfusion injury and / or insulin resistance syndrome (IRS) in mammals, particularly in humans, by administering a sodium-hydrogen exchanger type 1 (NHE-1) inhibitor or a pharmaceutical composition containing such an inhibitor. This invention also relates to combinations comprising NHE-1 inhibitors and a second pharmaceutical agent, said combinations being useful in treating type 2 diabetes, IRS, diabetic neuropathy, diabetic cardiomyopathy, cataracts, diabetic retinopathy, foot ulcers, diabetic ischemia reperfusion injury, diabetic cardiac ischemia reperfusion injury, diabetic microangiopathy and / or diabetic macroangiopathy.
Owner:PFIZER INC
Medicinal composition for treating diabetes chronic complication and preparation method of effective component
A Chinese medicine for preventing and treating the chronic complications of diabetics, such as the diabetic nephrosis, eye diseases and microangium disease, is prepared from rhubarb, scutellaria root and medical additive through extracting the free anthraquinone from rhubard, extracting scutelloside from scutellaria root, and post-processing. Said extracting process is also disclosed.
Owner:SICHUAN INST OF CHINESE MATERIA MEDICA
Alkyl pyrazine phenolsulfonate and its preparation method and use
The invention relates to alkyl pyrazine dobesilate monohydrate compounds or their hydrates having formula (I), wherein R is C1-C5 alkyl, a is an integer of 1-5, b is an integer of 1-4, m and n are identical or different, the preparing process is also disclosed. The medicament can be used for the preventing and treating blood capillary pathology of diabetic retina, kidney, peripheral nerve and skin pruritus, and for preventing and treating angina pectoris, myocardial infarction, cerebral embolism, lacuna brain infarction, brain thrombogenesis and brain blood supply insufficiency.
Owner:于学敏
Vaccinium bracteatum thunb extract and application thereof
InactiveCN105963337AHigh activityImprove high oxidative stressMetabolism disorderFood ingredient functionsHigh concentrationVaccinium bracteatum
The invention provides a vaccinium bracteatum thunb extract and an application thereof. Diabetic retinopathy is one of the serious complications of diabetes, which is an ocular fundus lesion with specific change as well as the most important expression of microangiopathy caused by diabetes. The vaccinium bracteatum thunb extract provided by the invention is prepared by the following steps: heating and extracting vaccinium bracteatum thunb with ethanol of certain concentration; concentrating the extract and adsorbing with a macroporous adsorption resin column; washing with water for removing impurities; eluting with a high-concentration ethanol solution; and concentrating the eluent and drying to obtain the vaccinium bracteatum thunb extract. The pharmacodynamics study indicates that the vaccinium bracteatum thunb extract provided by the invention can be used for preparing a medicine or food for preventing and treating diabetic retinopathy and realizes a remarkable prevention or treatment effect. The invention provides a new way of searching for a new medicine for treating diabetic complications.
Owner:HAINAN ASIA PHARM CO LTD
Flavonoid new chemical entity, composition and use
PendingCN105837646AEasy to slideEasy to makeAntibacterial agentsOrganic active ingredientsArthritisMicroangiopathy
The invention provides a flavonoid new chemical entity, which has little moisture absorption and good storage stability, and is applicable to preparation of food or health food or drugs for reduction of capillary fragility, treatment or prevention of chronic venous insufficiency, hemorrhoid, scurvy, venous lower limb ulcer, premenstrual syndrome, diabetics' microangiopathy and secondary upper limb lymphedema, cardiovascular diseases, blood glucose and lipid regulation, antisepsis and inflammation reduction, virus resisting, cancer resisting, immunity adjustment, radiation protection, liver protection, rheumatoid arthritis or arthritis resisting, ulcer resisting, phlegm eliminating, asthma relieving, black spots, freckles, free radical resistance, and oxidation resistance.
Owner:刘力
Pharmaceutical composition of containing puerarin and leaves of hawthorn
InactiveCN101049356AMeet urgent clinical needsReduce preloadOrganic active ingredientsMetabolism disorderDiseasePuerarin
A medical composition in the form of injection or orally taken solid or liquid for treating coronary heart disease, angina pectoris, hypertension, cerebrovascular disease, hemicrania, diabetes, etc is proportionally prepared from kakonein and hawthorn leaf flavone.
Owner:JIANGYIN TIANJIANG PHARMA
Piperidine derivatives useful for treatment of diebetes
Owner:TORRENT PHARMA LTD
Traditional Chinese medicine composition for treating diabetes and its complications and preparation method thereof
InactiveCN105521431ASignificant effectLow priceSenses disorderAnthropod material medical ingredientsDiseaseSide effect
The invention discloses a traditional Chinese medicine composition for treating diabetes and its complications and a preparation method thereof. The composition is mainly composed of following medicinal materials: Bombyx Batryticatus, Rhizoma Sparganii, Radix Astragali, Fructus Corni, Radix Trichosanthis, Rhizoma Atractylodis, Rhizoma Curcumae and Fructus Tribuli. The composition is mainly used for treating diabetes and various complications, including diabetes macrovascular complications (coronary heart disease, hypertension and cerebrovascular disease), diabetic microangiopathy (diabetic nephropathy and diabetic ocular fundus pathology), diabetic peripheral neuropathy and the like and has significant clinical therapeutic effect without significant side effect; as the composition is substantially made with medicinal and edible drugs specified in Chinese pharmacopoeia, the composition also has the advantages of low price, good safety and the like.
Owner:史载祥
Topical drug for treatment and/or prevention of diabetic neuropathy, microangiopathy and diabetic and non diabetic ulcers and wound infection
The various embodiments herein provide a topical drug composition for the treatment of diabetes-related complications. According to one embodiment herein, the composition comprises of a compound belonging to a group of chemicals containing borates. Boric acid is used as the base material of the drug. Boric acid is dissolved in saline 0.9% or half saline serum or water, distilled water or boiled water to obtain a boric acid solution with given concentration. The best concentration is 3-5% solution. Alcohol at preset concentration is added to the boric acid solution. According to another embodiment, a method is provided for preparing a topical drug composition for the treatment of diabetes-related disorders.
Owner:JAVID MIHAN JAFARI
Treatment of endothelial dysfunction in diabetic patients
A method for the treatment of endothelial dysfunction in a diabetic patient, including both diabetes induced macrovascular disorders and diabetes induced microvascular disorders, comprises administration, preferably parenteral administration, to the patient of an effective amount of high density lipoprotein (HDL).
Owner:CSL LTD
Methods and compositions related to transplant-associated thrombotic microangiopathy
InactiveCN106999559AMicrobiological testing/measurementAntibody medical ingredientsOncologyMicroangiopathy
Embodiments described herein relate to evaluating risk of transplant-associated thrombotic microangiopathy. Disclosed herein are methods for determining the risk of developing transplant-associated thrombotic microangiopathy, as well as the likely severity of the outcome. Some embodiments include selecting and administering a treatment for transplant-associated thrombotic microangiopathy in subjects identified as having elevated risk.
Owner:CHILDRENS HOSPITAL MEDICAL CENT CINCINNATI
Medicinal composition for treating diabetes chronic complication and preparation method of effective component
A Chinese medicine for preventing and treating the chronic complications of diabetics, such as the diabetic nephrosis, eye diseases and microangium disease, is prepared from rhubarb, scutellaria root and medical additive through extracting the free anthraquinone from rhubard, extracting scutelloside from scutellaria root, and post-processing. Said extracting process is also disclosed.
Owner:SICHUAN INST OF CHINESE MATERIA MEDICA
Medicine for treating early microangiopathy of diabetes mellitus and preparation method thereof
InactiveCN103055028AReduce lesionsDegree of reductionMetabolism disorderCardiovascular disorderSide effectSemen
The invention relates to a medicine for treating early microangiopathy of diabetes mellitus and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. The medicine disclosed by the invention is prepared from the following raw medicines in parts by weight: 15-30 parts of Astragalus mongholicus, 14-20 parts of lucid ganoderma, 12-30 parts of glossy privet fruit, 12-18 parts of radix rehmanniae, 12-20 parts of semen cassia, 12-20 parts of rhizoma atractylodis, 9-15 parts of the root of red-rooted salvia, and 6-12 parts of prepared rheum officinale. The traditional Chinese medicine composition disclosed by the invention has the effects of tonifying qi, nourishing yin, tonifying kidney, nourishing liver, dispersing blood stasis and dredging collaterals, has a good effect of preventing and treating early microangiopathy of diabetes mellitus, is capable of obviously lightening early microangiopathy degree of diabetes mellitus, and has the functions of improving microcirculation and hemorheology, adjusting body immunity and the like; and furthermore, the medicine disclosed by the invention is safe and free from toxic and side effects.
Owner:ZHEJIANG CHINESE MEDICAL UNIVERSITY
Traditional Chinese medicine composition and preparation method and application thereof
ActiveCN103656161AGood effectGood for treating diabetesMetabolism disorderUnknown materialsDiabetes mellitusSmoked Plum
The invention provides a traditional Chinese medicine composition and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines: smoked plum, coptis chinensis, root of rehmannia, radix ophiopogonis / lotus plumule, donkey-hide gelatin, astragalus membranaceus, Chinese yam, radix scrophulariae and rhizoma atractylodis. The traditional Chinese medicine composition can be used for preparing medicines for preventing or treating diabetic microangiopathy and diabetes mellitus.
Owner:宋健平 +1
Sugar control composition containing quinoa and preparation method thereof
PendingCN112826014APrevent diseaseImprove metabolic disordersFood ingredient functionsInsulin responseReceptor
The invention discloses a sugar control composition containing quinoa and preparation method thereof. The preparation method comprises the following steps: respectively weighing the following components in percentage by mass: 25-40% of quinoa, 10-20% of purple rice, 10-20% of white kidney beans, 10-20% of oats and 10-20% of walnuts, the sum of the mass percentages of the components being 100%; in the formula, vitamin B1 in the quinoa and coarse cereals in the formula can maintain normal glycometabolism and nerve conduction functions of diabetic patients, and can help diabetic patients to maintain capillary health and avoid microangiopathy; so that the composition is capable of improving the kidney cell metabolism disorder caused by hypertension, wherein magnesium can better help the blood sugar of the diabetic patient to be converted into energy, and meanwhile insulin response is improved. In addition, the n-3 series of polyunsaturated fatty acids in the walnuts can help and enhance cell activity, then increase insulin receptors, make insulin very sensitive, increase blood sugar consumption and convert blood sugar into glycogen.
Owner:XIAN MEDICAL UNIV
Method and detection device for analyzing volumetric pulse wave pattern based on waveform feature points
Owner:BEIJING UNIV OF TECH +1
New purpose of naodesheng extract for treating diabetes complication
ActiveCN101244134AOverall condition improvedCondition improvedMetabolism disorderPlant ingredientsDiabetic retinopathyCelsius Degree
The invention relates to a new usage of Naodesheng tablets extraction for treating diabetes complications, belonging to the technical field of the Chinese herbal medicines. The Naodesheng tablets extraction is made of the active pharmaceutical ingredients of the following parts by weights: 70 to 80 portions of notoginseng, 255 to 265 portions of kudzu root, 85 to 95 portions of safflower, 70 to 80 portions of rhizoma ligustici wallichii and 150 to 160 portions of haw. The preparation method comprises the following steps: first, mixing the whole notoginseng and half the kudzu root and crush into powder to get the notoginseng-and-kudzu root medical powder; then, extracting the remaining active pharmaceutical ingredients to get the clear cream with 1.22 to 1.25 as the relative density at 80 degrees Celsius; finally, adding the notoginseng-and-kudzu root medical powder and mixing uniformly to get the Naodesheng tablets extraction. The Naodesheng tablets extraction has obvious curative effect for treating diabetes complications caused by microangiopathy such as peripheral neuritis, diabetic retinopathy and gangrene and successfully cures patients who fail in treating diabetes complications via normal treatment.
Owner:聂文涛
Coronary artery microcirculation detection and coronary artery analysis system
The invention discloses a coronary artery microcirculation detection and coronary artery analysis system. A diagnosis method which is based on a CT perfusion imaging technology and is used for safely, rapidly and effectively evaluating coronary artery microvascular functions is established through fluid mechanics, and a rapid, accurate and non-invasive coronary artery microcirculation function evaluation method is established for disease diagnosis and treatment and treatment strategy guidance. In combination with the achievement of a team on CT-FFR research and development in recent years, the invention aims to establish a CT perfusion scanning-based coronary artery microcirculation function evaluation method CT-IMR, evaluate the diagnosis accuracy through clinical verification and develop a non-invasive method for accurately and quickly evaluating the coronary artery microcirculation function by virtue of CT iconography, so that the clinical requirements are met, and a brand-new non-invasive IMR system is found. Compared with an existing method, the system has the advantages of being non-invasive, rapid, accurate, safe, economical and the like, and the non-invasive IMR system can detect cases with only coronary artery microangiopathy and can also detect cases with combined coronary artery macrovascular diseases.
Owner:HANGZHOU FIRST PEOPLES HOSPITAL
Ophthalmic preparation and preparation method and application thereof
InactiveCN110898047AReduce solubilityImprove solubilityOrganic active ingredientsSenses disorderDiabetes retinopathyHydrolase inhibitor
The invention relates to the technical field of pharmaceutical preparations, and specifically discloses an ophthalmic preparation and a preparation method and application thereof. The active componentof the ophthalmic preparation provided by the invention is a soluble epoxide hydrolase inhibitor t-AUCB, which can effectively inhibit the expression of soluble epoxide hydrolase (sEH) and reduce theloss of retinal pericytes and improve the degree of microangiopathy, thus achieving the purpose of preventing and treating diabetic retinopathy. The ophthalmic preparation provided by the invention is a clinically-used pharmaceutical preparation, such as eye drops, an ophthalmic ointment or ophthalmic gel, etc., prepared from t-AUCB and pharmaceutically acceptable excipients. Local drug deliveryof eyes is realized, which is beneficial to improve medication compliance of patients. In addition, the preparation method of the ophthalmic preparation is simple, has strong controllability, is beneficial to realize industrial production, and has broad application prospects in the field of diabetic retinopathy prevention and treatment.
Owner:HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
Device for treatment of peripheral arterial disease and micro-angiopathy in lower limbs
ActiveUS10980705B2Easy to adaptVibration massagePhysical medicine and rehabilitationPhysical therapy
Owner:VIBRANT MEDICAL
Method of treating diabetic peripheral neuropathy through amendment of pre-neuronal diabetic coagulative micro-angiopathy and neuronal deficiency of mitochondrial ATP production, and through induction of neuronal regeneration
DPN is an intractable and tormenting neurovascular and dermal disorder.Two patients of DPN of stocking-glove pattern were treated with SAG for treatment of microvascuar coagulopathy, induction of vasodilation and possible induction of angioneogenesis; with ALC for ATP generation through mitochondrial beta-oxidation of fats; and with ALA for antioxidative stress to prevent precipitation of vascular damage and to prevent DPN recurrence. SAG+ALC was to cure maceration.Thus, SAG+ALC+ALA was effective in mitigating and curing their distresses. It shall be one of the logical and practical means of prompt DPN therapy not only to alleviate DPN but also to lead to “cure.”
Owner:OKUYAMA SHINICHI +1
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