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Medicine for treating early microangiopathy of diabetes mellitus and preparation method thereof

A technology for microvascular disease and diabetes, which is applied in the field of drugs for treating early microvascular disease of diabetes and its preparation, can solve the problems of no specific treatment methods, and achieve the effects of no toxic and side effects, convenient administration, and great feasibility

Inactive Publication Date: 2013-04-24
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because its specific pathogenesis and pathological mechanism have not been fully elucidated, there is currently no effective treatment at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1) Weigh 20g of cassia seed, 12g of prepared rhubarb and 30g of Ligustrum lucidum and add water for reflux extraction. The amount of water added is 8 times the weight of cassia seed, prepared rhubarb and Ligustrum lucidum. Reflux extraction twice, the first time of reflux extraction for 2 hours , the second reflux extraction for 1.5 hours, the obtained extract was added with 90% ethanol for alcohol precipitation, and the ethanol was recovered to reach the clear paste 1;

[0027] 2) Weigh 20g of Ganoderma lucidum, 20g of Atractylodes atractylodes, 30g of Astragalus membranaceus and 15g of Salvia miltiorrhiza, crush them, pass through a 10-mesh sieve, soak in 70% ethanol overnight, add 8 times the weight of the soaking solution in 70% ethanol for percolation extraction, and collect the percolation The liquid is subjected to high-speed centrifugation at 5000 rpm, the supernatant is removed after centrifugation, and the supernatant is retained to obtain the clear paste 2;

...

Embodiment 2

[0031] 1) Weigh 12g of cassia seed, 6g of prepared rhubarb and 12g of Ligustrum lucidum and add water for reflux extraction. The amount of water added is 10 times the weight of cassia seed, prepared rhubarb and Ligustrum lucidum, and reflux extraction 4 times, each time for 1 hour, to obtain Add 95% ethanol to the extract to carry out alcohol precipitation, reclaim ethanol, and reach clear paste 1;

[0032] 2) Weigh 14g of Ganoderma lucidum, 12g of Atractylodes atractylodes, 15g of Astragalus membranaceus, and 9g of Salvia miltiorrhiza, crush them, soak them in 50% ethanol overnight, add 50% ethanol 6 times the weight of the above soaking solution for percolation extraction, collect the percolation solution, and run at 4000 rpm Centrifuge at high speed per minute, remove the supernatant after centrifugation, and keep the supernatant to obtain clear cream 2;

[0033]3) Weigh 12g of raw soil, add water for reflux extraction, the amount of water added is 15 times the weight of ra...

Embodiment 3

[0036] 1) Weigh 15g of cassia seed, 8g of prepared rhubarb and 15g of Ligustrum lucidum and add water to carry out reflux extraction. Add 90% ethanol to the extract to carry out alcohol precipitation, reclaim ethanol, and reach clear paste 1;

[0037] 2) Weigh 18g of Ganoderma lucidum, 17g of Atractylodes atractylodes, 20g of Astragalus membranaceus and 12g of Salvia miltiorrhiza, crush them, soak them in 70% ethanol overnight, add 10 times the weight of the soaking solution in 70% ethanol for percolation extraction, collect the percolation solution, and run at 6000 rpm Centrifuge at high speed per minute, remove the supernatant after centrifugation, and keep the supernatant to obtain clear cream 2;

[0038] 3) Weigh 17g of raw soil, add water for reflux extraction, the amount of water added is 25 times the weight of raw soil, reflux extraction 4 times, each time for 1 hour, the obtained extract is added with 95% ethanol for alcohol precipitation, ethanol is recovered, dried, ...

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PUM

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Abstract

The invention relates to a medicine for treating early microangiopathy of diabetes mellitus and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. The medicine disclosed by the invention is prepared from the following raw medicines in parts by weight: 15-30 parts of Astragalus mongholicus, 14-20 parts of lucid ganoderma, 12-30 parts of glossy privet fruit, 12-18 parts of radix rehmanniae, 12-20 parts of semen cassia, 12-20 parts of rhizoma atractylodis, 9-15 parts of the root of red-rooted salvia, and 6-12 parts of prepared rheum officinale. The traditional Chinese medicine composition disclosed by the invention has the effects of tonifying qi, nourishing yin, tonifying kidney, nourishing liver, dispersing blood stasis and dredging collaterals, has a good effect of preventing and treating early microangiopathy of diabetes mellitus, is capable of obviously lightening early microangiopathy degree of diabetes mellitus, and has the functions of improving microcirculation and hemorheology, adjusting body immunity and the like; and furthermore, the medicine disclosed by the invention is safe and free from toxic and side effects.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a medicine for treating early diabetic microangiopathy and a preparation method thereof. Background technique [0002] Diabetes is a common endocrine and metabolic disease. With the development of society and economy, changes in people's lifestyles and population aging, the incidence of diabetes is increasing year by year worldwide. It has become a disease after cardiovascular and tumors. , the third disease that threatens people's health and life. Diabetic microangiopathy is one of the most serious and common chronic complications of diabetes and one of the main causes of disability. How to use the advantages of traditional Chinese medicine to intervene in the process of diabetes, delay and timely treat the emergence of early microangiopathy and other complications of diabetes is a scientific and technological problem that needs to be solved ur...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61P3/10A61P9/14
Inventor 柴可夫牛永宁马纲
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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