Coronary artery microcirculation detection and coronary artery analysis system

Abstract

The invention discloses a coronary artery microcirculation detection and coronary artery analysis system. A diagnosis method which is based on a CT perfusion imaging technology and is used for safely, rapidly and effectively evaluating coronary artery microvascular functions is established through fluid mechanics, and a rapid, accurate and non-invasive coronary artery microcirculation function evaluation method is established for disease diagnosis and treatment and treatment strategy guidance. In combination with the achievement of a team on CT-FFR research and development in recent years, the invention aims to establish a CT perfusion scanning-based coronary artery microcirculation function evaluation method CT-IMR, evaluate the diagnosis accuracy through clinical verification and develop a non-invasive method for accurately and quickly evaluating the coronary artery microcirculation function by virtue of CT iconography, so that the clinical requirements are met, and a brand-new non-invasive IMR system is found. Compared with an existing method, the system has the advantages of being non-invasive, rapid, accurate, safe, economical and the like, and the non-invasive IMR system can detect cases with only coronary artery microangiopathy and can also detect cases with combined coronary artery macrovascular diseases.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to a coronary microcirculation detection and coronary analysis system. Background technique [0002] According to the 2018 "China Cardiovascular Disease Report", the prevalence and mortality of cardiovascular disease in my country continue to rise, and it has been listed as one of the leading causes of death for Chinese residents for many years. Among them, the mortality rate caused by coronary artery disease is close to Half. Coronary artery disease, including coronary heart disease (coronary atherosclerotic heart disease and coronary spasm disease) and coronary microvascular disease (coronary microvascular disease, CMVD), seriously threatens the health of the people, and the resulting cardiovascular events (including cardiac death, myocardial infarction, heart failure, etc.) Circulation has become one of the main goals of coronary heart disease treatment. Especially for pat...

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Problems solved by technology

But in fact, this "most effective" method is still unable to distinguish the changes in radioactive activity caused by coronary macrovascular disease or microvascular disease. Therefore, when using this method to evaluate coronary microvascular function in some patients with coronary macrovascular disease Very limited and cannot be diagnosed accurately

Moreover, the human body needs to take in a certain amount of radioactive isotopes during the examination process, which often makes many patients daunting. In addition, the examination is expensive and time-consuming. It often takes several hours to complete a case of examination, which cannot meet the needs of a large number of patients in a limited time.

In the process of coronary angiography, the perfusion and clearance of the contrast agent in the myocardium can be roughly judged by visually observing the myocardial microcirculation, but it cannot be accurately measured, and the subjectivity is high, so the accuracy and accuracy of the diagnosis cannot be guaranteed. specificity

The coronary microcirculation resistance index (IMR) measured by the temperature dilution method through the pressure guide wire during coronary angiography is considered to be the gold standard for invasive detection of coronary microcirculation dysfunction, but this method is harmful to the human body. Certain trauma, and there is a risk of coronary complications during the examination, and it is expensive, and it is difficult for patients to accept repeated examinations within a certain period of time, so it is not suitable to use this method to evaluate the treatment effect and screen effective therapeutic drugs, so it is urgent A safe, effective, rapid and affordable non-invasive examination method for early diagnosis of coronary microvascular disease, to guide the selection of treatment options, and to screen effective therapeutic drugs

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