126 results about "Coronary angiography" patented technology

A self-contained and hand-held power-assisted syringe is provided which is suitable for the controlled injection of fluid material during medical procedures such as coronary angiography procedures which utilize small-bore and small sized guide catheter systems. The present invention provides a greater degree of injection power on-demand than was previously possible in a portable and hand-held syringe; and it can deliver larger volumes of radiopaque contrast medium at greater pressures than was previously possible using a conventional manual syringe. The power assisted syringe, along with all components necessary for its effective use and operation, may be pre-packaged and steriled within a single container and then disposed of after use.

The present invention provides an apparatus and a method for identifying the risk of a clinical condition in a human or animal by correlating Near Infrared (NIR) absorbance spectral data with one or several parameters including a concentration of one or more substances in the skin, a concentration of one or more substances in skin plus subdermal tissue, a score derived from one or more clinical tests like a stress test on a treadmill, coronary angiography, or intravascular coronary ultrasound. The method determines the concentration of a compound in the skin of a human or animal and comprises the steps of placing a part of the skin against a receptor, directing electromagnetic radiation (EMR) from the near-infrared spectrum onto the skin, measuring a quantity of EMR reflected by, or transmitted through, the skin with a detector; and performing a quantitative mathematical analysis of the quantity of EMR to determine the concentration of the compound, for example free and esterfied cholesterol. An example of a clinical condition is cardiovascular disease.

The present invention provides an apparatus and a method for identifying the risk of a clinical condition in a human or animal by correlating Near Infrared (NIR) absorbance spectral data with one or several parameters including a concentration of one or more substances in the skin, a concentration of one or more substances in skin plus subdermal tissue, a score derived from one or more clinical tests like a stress test on a treadmill, coronary angiography, or intravascular coronary ultrasound. The method determines the concentration of a compound in the skin of a human or animal and comprises the steps of placing a part of the skin against a receptor, directing electromagnetic radiation (EMR) from the near-infrared spectrum onto the skin, measuring a quantity of EMR reflected by, or transmitted through, the skin with a detector; and performing a quantitative mathematical analysis of the quantity of EMR to determine the concentration of the compound, for example free and esterfied cholesterol. An example of a clinical condition is cardiovascular disease.

The invention relates to a realization method for an interactive coronary artery virtual angioscope, which pertains to the technical field of medical imaging and aims at solving the visible problem of making a diagnosis and giving treatment of coronary artery. The technical proposal is that the realization method obtains the three-dimensional model of blood vessels by means of combining three-dimensional geometrical feature information of lumen by a nearly orthorhombic X-ray visualization picture of coronary artery with the data of the section of lumen by lumen endobronchial ultrasonography, then adopts virtual reality modeling language to interactively describe the model of blood vessels and realizes the visualization of coronary artery in the endoscope roaming mode. The realization method realizes interactive visit and display of the three-dimensional model of blood vessels and provides an ideal platform for the research on the development of coronary atherosclerosis pathological changes, the visible diagnosis and treatment of coronary heart diseases, the involvement in the evaluation of curative effect, and the like, and the training of medical personnel.

A 4D reconstruction method of the vascular axis of coronary artery, which belongs to the field of medical detection technology, comprises following steps: constructing the projection models of an X-ray angiography system at two angles according to X-ray coronary artery angiogram sequences at two angles, deducing the geometric transformation relationship between the two angle images, 3D reconstructing the sampled points of interested blood vessels selected by hand in the image of the first moment, connecting the reconstructed points to obtain a broken line, acquiring the 3D axis of the blood vessel at the first moment by snake transformation with respect to the broken line as the initial position, and acquiring 3D vascular axis in each subsequent moment in the image sequence by snake transformation with respect to the 3D vascular axis of the previous moment as the initial position, thus completing the 4D reconstruction of the vascular axis in the entire sequence. The method can greatly reduce the uncertainty and the error due to the operation of operators, thus improving the repeatability of the result and achieving convenient operation and high efficiency.

Disclosed herein is a medical imaging technique that uses a fluorinated nanoparticle contrast agent for imaging of an interior portion of a body. The fluorinated nanoparticles preferably comprise nontargeted intravascular fluorocarbon or perfluorocarbon nanoparticles. The interior body portion may be a patient's vasculature, and the medical imaging is preferably noninvasive MR angiography, which may encompass (either for 2D imaging or 3D imaging) MR coronary angiography, MR carotid angiography, MR peripheral angiography, MR cerebral angiography, MR arterial angiography, and MR venous angiography. Coils tuned to match to the 19F signal can be used, or dual tuned coils for 19F and 1H imaging can be used. Clinical field strengths (e.g. 1.5 T) and clinical doses may be used while still providing effective images.

A method for acquiring the motion information of coronary artery, which belongs to the field of medical detection technology, is used for solving the problem in acquiring the motion information of heart. The technical scheme is that a 3D motion estimation method based on elastic registration is adopted after achieving 3D reconstruction of branch skeleton of main blood vessels at each moment in X-ray coronary artery angiogram sequences; the motion of blood skeleton is transformed to be matched with skeleton lines at continuous time moments; the motion vector and the motion trajectory of each blood skeleton point in cardiac cycle are calculated; and the motion information including global and the local motion parameters of the coronary artery in the cardiac cycle is extracted according to the estimated motion vector of each blood skeleton in the image sequence. The method has the advantages of high accuracy in extracting the motion information of blood vessels, convenient operation and high work efficiency.

A self-contained and hand-held power-assisted syringe is provided which is suitable for the controlled injection of fluid material during medical procedures such as coronary angiography procedures which utilize small-bore and small sized guide catheter systems. The present invention provides a greater degree of injection power on-demand than was previously possible in a portable and hand-held syringe; and it can deliver larger volumes of radiopaque contrast medium at greater pressures than was previously possible using a conventional manual syringe. The power assisted syringe, along with all components necessary for its effective use and operation, may be pre-packaged and steriled within a single container and then disposed of after use.

A method for using 3D printing technology produces personalized biomimetic drug-eluting coronary stent and the product thereof. The process of manufacturing stent, based on coronary angiography imaging data, measures the diameter of diseased coronary and conducts 3D reconstruction. A personalized stent for each patient according to diameter, length, and morphological characteristics of target vessel that suited to the lesion is produced. The coronary stent is formed from biodegradable poly-L-lactic acid (PLLA) or other materials. The stent is modeled by 3D printing and then coated with polymers carrying antiproliferative drug to reduce restenosis (the polymers is a mixture of antiproliferative drug and PDLLA at a ratio of 1:1). The biomimetic drug-eluting coronary stent produced by 3D printing technology is personalized stent for each patient according to different characteristics of diseased coronary, reduces the incidence of vascular injury, thrombosis, dissection and other complications caused by stent and vessel diameter mismatch.

A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia following percutaneous transluminal coronary angiography. The local delivery of the drugs or agents provides for increased effectiveness and lower systemic toxicity.

The invention relates to a matching method for three-dimensional coronary angiography reconstruction, which belongs to the crossing field of digital image processing and medical imaging, and aims to meet the special requirements on the auxiliary detection and the surgical navigation of angiocardiopathy in clinical medicine. The method comprises two steps, i.e. model guidance contrastographic picture vessel segment matching and contrastographic picture puncta vasculosa matching. The matching method uses a multi-scale vascular tree model so as to better guide vascular matching, simultaneously can well solve the problem of individual difference, and improves the matching precision of vessel segments and puncta vasculosa through the method of iterative matching and largest declination of searching potential energy. The matching method for three-dimensional coronary angiography reconstruction can obtain very good angiography matching results, thereby solving the difficult problems in the automatic three-dimensional reconstruction by the multi-view angiography map.

A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia following percutaneous transluminal coronary angiography. The local delivery of the drugs or agents provides for increased effectiveness and lower systemic toxicity.

The invention relates to an elastic registration method of a CAG image sequence, comprising that single pixel and 8-connectino skeleton of main vascular branches are extracted from each frame of the CAG image and are expressed as ordered sets of pixel points; and a preset registration error function is set to a minimum value to find corresponding relations between two vascular skeleton point sets in adjacent time points. In the invention, the preset registration error function is used to carry out elastic registration for each adjacent frame in an X-ray coronary angiography image sequence, in order to find corresponding relations between vascular angiography skeleton points. The method creates conveniences for acquiring information of the coronary in a cardiac cycle movement and deformation, for further analyzing condition of hearts movement, and for reconstructing the coronary vessels in a dynamic three-dimension manner.

The invention provides an X-ray radiography image blood vessel segmentation and recognition method and device, and the method comprises the steps: inputting a coronary angiography image into an encoder in a blood vessel segmentation and recognition network, and outputting a feature map of the coronary angiography image; inputting the feature map output by the encoder into a segmentation decoder and an identification decoder in the blood vessel segmentation and identification network respectively, outputting a segmentation result of the coronary angiography image through the segmentation decoder, and outputting an identification result of the coronary angiography image through the identification decoder; wherein the blood vessel segmentation and identification network is obtained by training based on coronary angiography image samples, predetermined segmentation results of the coronary angiography image samples and predetermined blood vessel type tags. According to the method, more accurate recognition and segmentation results can be obtained by using the trained blood vessel segmentation and recognition network.

The application relates to an intracavitary image-based method, device and system for calculating a fractional flow reserve (FFR) and a computer storage medium. The method for acquiring the fractionalflow reserve comprises the steps of: S1, acquiring image data related to a coronary artery blood vessel, and building a corresponding 3D vessel model by processing the image data, wherein the image data related to the coronary artery blood vessel includes intracavitary image data and coronary angiography image data; S2, calculating a blood flow equation according to the 3D vessel model and a fluid dynamics approach so as to obtain distribution of hemodynamic parameters of coronary arteries of a region expressed by the 3D vessel model; and S3, performing calculation according to the hemodynamic parameters acquired in the step S2 to obtain the fractional flow reserve. The method, the device and the system can acquire the FFR of coronary arteries of a patient by accurate calculation.

A method of cardiac radiological examination for coronarography comprises the steps of:a) introducing contrast medium simultaneously in the left coronary artery and in the right coronary artery from the aortic root and, in parallel,b) acquiring a sequence of dynamic images of the propagation of the contrast medium in the left and right coronary arteries with a displacement of the image plane, during the acquisition of said images, along a determined trajectory (E28). The contrast medium can be introduced in a cyclic manner during the acquisition of dynamic images, each cycle of introduction corresponding to a phase of closure of the aortic valve in the cardiac rhythm. 3D and 4D images with optimal efficiency can be obtained in the use of contrast medium. An injection device for producing the above cycles is synchronized with the introduction of the contrast medium.

The application provides a method and device for conveniently measuring evaluation parameters of coronary arteries and a system. The method comprises: measuring pressure Pd of the narrow distal end ofa coronary artery and / or inlet pressure Pa of the coronary artery through a pressure guide wire; performing coronary angiography on the coronary artery measured; selecting first and second position angiographic images of the coronary artery measured; segmenting a segment of the coronary artery from the proximal end and the distal end, and performing three-dimensional modeling to obtain a coronaryartery three-dimensional vascular model; injecting a contrast medium to obtain average time Ta in which the contrast medium passes from an inlet of the segment to an outlet; acquiring time Tmax in which the contract medium passes from the inlet of the segment to the outlet in maximum expanded state according to a hydromechanics equation; acquiring evaluation parameters of the coronary artery. Modeling can be performed according to angiographic images of any moment in a cardiac cycle; three-dimensional modeling is convenient; injection time of a dilator is shortened; the measuring process is simple; test results are accurate.

The invention discloses a system for detecting whether coronary angiography has a complete occlusion lesion or not based on deep learning. A deep learning recurrent neural network is used for analyzing an overall video, a GPU (graphics processing unit) is used for accelerating calculation to obtain a detection result, the calculation delay is small, and the real-time problem of detection is solved. The system comprises a video input module, a convolutional neural network module, a coding and decoding attention module and a classification module. Particularly, the encoding and decoding attention module and the supervision algorithm thereof provided by the invention are used for generating a proper attention weight to improve the detection accuracy. The end-to-end system design achieves automation of the coronary artery complete occlusion detection process, and complex intermediate steps are not needed. Compared with other systems for detecting whether the complete occlusion lesion exists or not, the whole video instead of a single image is analyzed, the situation of misjudgment caused by the single image is reduced, and the accuracy of existence judgment of the complete occlusion lesion is remarkably improved.

The embodiment of the invention discloses a plaque recognition method and device for a coronary angiography image, equipment and a medium. The method comprises the steps of acquiring a coronary angiography image to be recognized; and inputting the coronary angiography image to be recognized into a completely trained plaque recognition model to obtain a recognition result output by the plaque recognition model, a training sample of the plaque recognition model being generated based on an unlabeled coronary angiography image and a labeled coronary non-angiography image. According to the plaque recognition method for the coronary angiography image, the plaque recognition model is trained based on the labeled coronary non-angiography image and the unlabeled coronary angiography image, so thatplaques recognized by the plaque recognition model are more accurate.

Embodiments relate to associating coronary angiography image annotations with SYNTAX score for assessment of coronary artery disease. Aspects include receiving and processing a plurality of angiogram videos from a coronary angiography study into a plurality of frames, selecting and displaying a key frame from the plurality of frames for each angiogram video in a browsing interface, and receiving a selection of one of the key frame from a user. Aspects further include displaying the angiogram video associated with the selected key frame in a video viewer interface, receiving a lesion annotation from the user for a frame of the angiogram video, and displaying a SYNTAX score questionnaire in the video viewer interface. Aspects further include annotating the frame of the angiogram video with the answers to the SYNTAX score questionnaire from the user and saving the answers to the SYNTAX score questionnaire with the annotated frame in a database.

A method for using 3D printing technology produces personalized biomimetic drug-eluting coronary stent and the product thereof. The process of manufacturing stent, based on coronary angiography imaging data, measures the diameter of diseased coronary and conducts 3D reconstruction. A personalized stent for each patient according to diameter, length, and morphological characteristics of target vessel that suited to the lesion is produced. The coronary stent is formed from biodegradable poly-L-lactic acid (PLLA) or other materials. The stent is modeled by 3D printing and then coated with polymers carrying antiproliferative drug to reduce restenosis (the polymers is a mixture of antiproliferative drug and PDLLA at a ratio of 1:1). The biomimetic drug-eluting coronary stent produced by 3D printing technology is personalized stent for each patient according to different characteristics of diseased coronary, reduces the incidence of vascular injury, thrombosis, dissection and other complications caused by stent and vessel diameter mismatch.

A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia following percutaneous transluminal coronary angiography. The local delivery of the drugs or agents provides for increased effectiveness and lower systemic toxicity.

The invention relates to a method for repairing coronary artery segmentation fracture and a device for repairing coronary artery segmentation fracture. The method comprises the following steps: obtaining a prediction output image of a coronary artery segmentation body; performing segmentation and selection of the predicted output image to obtain an effective connector and a candidate connector; Performing connectivity analysis on the effective connector and the candidate connector; if it is determined by analysis that the effective connector and the candidate connector are connectable, a corresponding connecting operation is performed to realize segmentation and fracture repair of the predicted output image. The invention utilizes the dendritic growth structure of the coronary artery, selects the effective connector and the candidate connector which may be matched with the effective connector, and can better judge the position and the state of the coronary artery rupture. Then the connectionable effective connection and candidate connection were connected to complete the repair, and the reliability of coronary angiography was improved.

The embodiments relate to a method and device for determining plaque deposits in coronary arteries. According to the method, a coronary angiography radiography image of a subject is obtained using an imaging modality. The obtained radiography image is calibrated for further analysis of the radiography image. Image processing techniques such as thresholding and histogram equalization are applied on the radiography image to extract vessel tree structure for analysis. Further, an inner lumen width and an outer vessel width are computed based on the processed radiography image. Further, a level of plaque deposition is determined based on the inner lumen and outer vessel dimensions. Further, the result based on the analysis is displayed to the user. The result includes the level of plaque deposits within the lumen on the vascular structure and possible risks posed by the plaque deposits to a subject.

The invention relates to a blood flow speed calculation method for the coronary artery based on a radiography image. The method comprises the following steps that a coronary artery radiography image sequence is acquired; each frame of the acquired coronary artery radiography image is divided and subjected to binaryzation, and a coronary artery tree is extracted; target blood vessel center lines are extracted from the coronary artery tree; according to the change condition of the lengths of the target blood vessel center lines of different frames, the average blood flow speed of a target bloodvessel in the filling stage is calculated through fitting.

The invention belongs to the field of medical image processing, and discloses a method and a system for quantitatively evaluating myocardial infarction on the basis of nuclide image and CT (computed tomography) coronary angiography fusion. The method includes acquiring heart PET (positron emission tomography) / CT and CTA (computed tomography angiography) data; carrying out three-dimensional DCT (discrete cosine transformation) frequency-domain interpolation on PET / CT images; acquiring heart regions in the PET / CT images and CTA images by the aid of multi-spectrum segmentation processes; acquiring left ventricular cardiac muscle regions in PET images by the aid of threshold processes; manually segmenting left ventricular cardiac muscle regions in the CTA images layer by layer; registering images; classifying pixel points according to the locations of pixel points on the registered images and tracer uptake values; inversely transforming infarction regions into original CTA spaces and dividing the volumes of left ventricular cardiac muscles from the volumes of the transformed infarction regions; three-dimensionally displaying fused images in volume rendering manners. The method and thesystem have the advantages that integral registration procedures can be fully automated, the method and the system are good in objectivity, intuitive results can be obtained, and analysis can be facilitated for clinical doctors.

The invention discloses a method for optimizing an optimal viewing angle of a multiple branch interesting blood vessel section, and belongs to the technical filed of coronary angiography. The method for optimizing the optimal viewing angle of the multiple branch interesting blood vessel section includes the following steps: S1, selecting the interesting blood vessel section with a flow direction tracking method, calculating the actual stenosis rate of the interesting blood vessel section, S2, obtaining a projection angle range A in which the projection length-reduction rate is smaller than a set threshold value, S3, projecting angles within A on the interesting blood vessel section in a two-dimensional mode, calculating a stenosis rate value, S4, selecting a stenosis rate value, wherein the difference between the stenosis rate value and the actual stenosis rate value is within a set threshold value range, the corresponding projection angle of the stenosis rate value is range B, S5, seeking out a projection angle range C in which the overlap area of the two-dimensional projection area of the interesting blood vessel section and the two-dimensional projection areas of other blood vessel sections is smaller than a certain threshold value in B, S6, obtaining a hyperplane which can divide interesting blood vessel section branches effectively, and selecting an optimal projection angle, wherein the projection direction of the optimal projection angle is orthogonal to the normal vector of the hyperplane. The optimization method of the optimal viewing angle of the multiple branch interesting blood vessel section can be applied to the projection of the multiple branch interesting blood vessel section.