48 results about "Radiographic contrast media" patented technology

An injector 20 that may be used to deliver radiographic contrast media and / or flushing solution into a patient's vascular system for the purposes such as obtaining enhanced diagnostic x-ray images. The injector includes the following features: (1) a syringe mount 26 for attachment of a syringe 28 to the injector 20; (2) display 34 and controls 90 for volume and flow rates; (3) automatic limiting of the operating pressure of the injector 20 as determined by the selection of a flow rate; (4) a syringe cradle 48 having a warming capability; (5) a purge / retract trigger 36 for control of the injection procedure having intuitive direction (i.e., forward for injecting, reverse for filing), non-contact control transmission through the housing of an injector 20 for an improved seal integrity, a speed lock, and / or the ability to change the concentration and / or flow rate of media or other fluid during an injection procedure; (6) a switch to determine when the drive ram 46 is in a “home” position; (7) a “soft” on / off power switch separate from the injector; and (8) a structure to prevent rotation of the drive ram 46 about its axis of symmetry 76. Additionally, the injector system includes software for the control of various components.

A self-contained and hand-held power-assisted syringe is provided which is suitable for the controlled injection of fluid material during medical procedures such as coronary angiography procedures which utilize small-bore and small sized guide catheter systems. The present invention provides a greater degree of injection power on-demand than was previously possible in a portable and hand-held syringe; and it can deliver larger volumes of radiopaque contrast medium at greater pressures than was previously possible using a conventional manual syringe. The power assisted syringe, along with all components necessary for its effective use and operation, may be pre-packaged and steriled within a single container and then disposed of after use.

An injector 20 that may be used to deliver radiographic contrast media and / or flushing solution into a patient's vascular system for the purposes such as obtaining enhanced diagnostic x-ray images. The injector includes the following features: (1) a syringe mount 26 for attachment of a syringe 28 to the injector 20; (2) display 34 and controls 90 for volume and flow rates; (3) automatic limiting of the operating pressure of the injector 20 as determined by the selection of a flow rate; (4) a syringe cradle 48 having a warming capability; (5) a purge / retract trigger 36 for control of the injection procedure having intuitive direction (i.e., forward for injecting, reverse for filing), non-contact control transmission through the housing of an injector 20 for an improved seal integrity, a speed lock, and / or the ability to change the concentration and / or flow rate of media or other fluid during an injection procedure; (6) a switch to determine when the drive ram 46 is in a “home” position; (7) a “soft” on / off power switch separate from the injector; and (8) a structure to prevent rotation of the drive ram 46 about its axis of symmetry 76. Additionally, the injector system includes software for the control of various components.

This invention generally relates to a barium sulfate product particularly useful as an X-ray contrast agent in preparations administered for examination of the gastrointestinal tract and to processes for making the product from naturally occurring barite ore containing barium sulfate crystals and gangue materials. The process includes treating or contacting the barium sulfate-containing particles obtained from barite ore with a fluidizing agent in a liquid medium to remove gangue materials present therein.

Methods for reducing kidney damage induced by radiographic contrast medium or another nephrotoxic drug or substance administered to or generated by a patient include reducing the temperature of the patient by positioning an endovascular heat exchange device in a blood vessel of the patient and adjusting the temperature of the device to cause a reduction in the patient's temperature. The patient's temperature may be reduced prior to, during, and / or after, the administration of the contrast medium. The methods may also include administering an anti-shivering mechanism to the patient to reduce shivering caused by the reduction in the patient's temperature. The methods may also include disrupting the laminarity of blood flow around the device to enhance the temperature exchange between the device and the blood flowing around the device. The endovascular heat exchange device may be an endovascular heat exchange catheter. The device may be a component of a system, which includes a temperature controller in communication with the endovascular heat exchange device to reduce the temperature of the patient to reduce the temperature of the patient's kidneys.

In an X-ray CT apparatus 1 and an X-ray CT method, the thickness of an object to be inspected is computed on the basis of the number of transmitted X-rays in a specific energy range set above and below the K-absorption edge of an X-ray contrast medium serving as the object to be inspected, and a CT image is reconstructed on the basis of the computed thickness of the object to be inspected. Such X-ray CT apparatus 1 and X-ray CT method can generate an X-ray CT image stably and independently of the size of the object to be inspected and of X-ray tube voltage (X-ray energy distribution).

An injector 20 that may be used to deliver radiographic contrast media and / or flushing solution into a patient's vascular system for the purposes such as obtaining enhanced diagnostic x-ray images. The injector includes the following features: (1) a syringe mount 26 for attachment of a syringe 28 to the injector 20; (2) display 34 and controls 90 for volume and flow rates; (3) automatic limiting of the operating pressure of the injector 20 as determined by the selection of a flow rate; (4) a syringe cradle 48 having a warming capability; (5) a purge / retract trigger 36 for control of the injection procedure having intuitive direction (i.e., forward for injecting, reverse for filing), non-contact control transmission through the housing of an injector 20 for an improved seal integrity, a speed lock, and / or the ability to change the concentration and / or flow rate of media or other fluid during an injection procedure; (6) a switch to determine when the drive ram 46 is in a “home” position; (7) a “soft” on / off power switch separate from the injector; and (8) a structure to prevent rotation of the drive ram 46 about its axis of symmetry 76. Additionally, the injector system includes software for the control of various components.

A method of pereparing a rediographic contrast medium containing liposomes is disclosed, comprising (a) dissolving a phospholipid and a sterol in a supercritical or subcritical carbon dioxide in the presence of a compound containing a hydroxyl group or a polyalkyleneoxide group, (b) adding thereto an aqueous solution containing an iodine compound to form micelles and (c) discharging the carbon dioxide to form liposomal vesicles enclosing the iodine compound.

In accordance with the present invention, a high intensity radiopaque contrast agent is disclosed. The agent may be coated on or incorporated within bulk materials, which may then be subsequently utilized to fabricate a radiopaque medical device. Primary effects through chemistry include higher radiopaque concentrations per unit weight of the radiopaque element or agent. Secondary effects include selective placement of the radiopaque elements which may further enhance the radiopacity of the device with reduced requirements of the radiopaque agent. Such a radiopaque contrast agent may be produced in various forms such as a dendrimer and / or incorporated as the end groups of polymeric chain. In addition one can incorporate biological and / or pharmaceutical agents in combination with the present invention.

The present invention relates to a process for the preparation of iodinated phenols; in particular; it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted phenol compounds to the corresponding 3,5-disubstituted-2,4,6-triiodophenols, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves.

A method of pereparing a rediographic contrast medium containing liposomes is disclosed, comprising (a) dissolving a phospholipid and a sterol in a supercritical or subcritical carbon dioxide in the presence of a compound containing a hydroxyl group or a polyalkyleneoxide group, (b) adding thereto an aqueous solution containing an iodine compound to form micelles and (c) discharging the carbon dioxide to form liposomal vesicles enclosing the iodine compound.

A radiopaque balloon with a composite wall having a radiopaque adhesive affixing inner and outer layers of the balloon. The radiopaque adhesive provides a radiographic image of the balloon wall with or without the use of a radiopaque contrast media to inflate the balloon. A radiographically fainter image is provided as the balloon is inflated with well-defined edges of a balloon image, and the total radiopacity of the balloon does not change as the balloon is inflated. Also, a method of imaging a balloon wall and a method of imaging a radiopaque adhesive between two layers of a balloon wall are provided.

The present invention relates to a process for the preparation of iodinated phenols; in particular; it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted phenol compounds to the corresponding 3,5-disubstituted-2,4,6-triiodophenols, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves.