109 results about "Injectable bone" patented technology

An injectable mixture for substituting bone tissue in situ comprises: A) a two-component powder / liquid bone cement which upon mixing forms a self-hardening cement paste; and B) a third component consisting of a liquid which essentially is non-miscible with the cement paste and which is suitable to be washed out after hardening of said mixture in situ, resulting in a porous bone substituting material; and C) an X-ray contrast agent which is an organic substance. The injectable bone substitute material for bone augmentation has adaptable mechanical properties, an optimal radio-opacity without any inorganic X-ray contrast agent and therefore good biocompatibility.

Methods for performing spinal fusions using an injectable calcium phosphate-based bone substitute are provided. The injectable bone substitute is injected into the anterior portion of an interbody space and allowed to solidify in vivo. The injectable bone substitute has a minimum compression strength of 10 MPa after setting for about 30 minutes and preferably solidifies to a compression strength of 25 MPa within 24 hours of injection. Optionally, the posterior portion of the interbody space is fixed using a metallic implant selected from rods and pedicle screws or plates and pedicle screws by attachment thereof to adjacent vertebrae.

The invention concerns injectable bone filling cements, in particular hydraulic calcium phosphate cements, the latter being prepared from at least two initial liquid or pasty constituents comprising each a species reactive in solution or in suspension, the solidification process being initiated when said constituents are being mixed.

An injectable bone mineral substitute material composition with the capability of being hardened in a body fluid in vivo, which comprises at least one calcium phosphate component and at least one calcium sulfate component as a dry mixture mixed with an aqueous liquid, and at least one accelerator, the at least one calcium sulfate component being particulate hardened calcium sulfate, which has a specified particle size that is in order to confer injectability to the composition. The invention also concerns the bone mineral substitute material produced from the composition as well as methods and uses thereof.

The invention refers to an injectable composition for a bone mineral substitute material, which comprises a dry powder mixed with an aqueous liquid. The powder comprises a first reaction component comprising a calcium sulphate hemihydrate with the capability of being hardened to calcium sulphate dihydrate when reacting with said aqueous liquid; a second reaction component, which comprise a calcium phosphate with the capability of being hardened to a calcium phosphate cement when reacting with said aqueous liquid; and at least one accelerator for the reaction of said first and / or second reaction component with said aqueous liquid. A method of producing an injectable bone mineral substitute material is also provided, wherein the composition is mixed in a closed mixing and delivery system for delivery.

The invention concerns injectable bone filling cements, in particular hydraulic calcium phosphate cements, the latter being prepared from at least two initial liquid or pasty constituents comprising each a species reactive in solution or in suspension, the solidification process being initiated when said constituents are being mixed.

The invention discloses an injectable bone repair hydrogel and preparation method thereof. The hydrogel is prepared according to the following steps: carrying poly-dopamine (PDA) modified calcium phosphate particles on degradable natural polymers with aldehyde group in an immobilized way, and then mixing the degradable natural polymers with amino group and the degradable natural polymers carrying the PDA modified calcium phosphate particles in an immobilized way and having an aldehyde group to generate Schiff base reaction. The hydrogel disclosed by the invention is formed by the Schiff base reaction of natural polymers in physiological conditions, does not release heat violently, cannot cause damage of peripheral tissues in clinical application, and is applicable to clinical born repair materials.

A biodegradable polyurethane scaffold that includes a HDI trimer polyisocyanate and at least one polyol; wherein the density of said scaffold is from about 50 to about 250 kg m−3 and the porosity of the scaffold is greater than about 70 (vol %) and at least 50% of the pores are interconnected with another pore. The scaffolds of the present invention are injectable as polyurethane foams, and are useful in the field of tissue engineering.

The present invention relates to an injectable bone cement for filling bones with mechanical properties equivalent to those of vertebral spongy bone comprising 70 to 99 wt. % of an acrylic polymer combined with an inorganic type radiopaque compound and 1 to 30 wt. % of calibrated hydrophilic flexible solid particles, said calibrated hydrophilic flexible solid particles being chosen from gelatin, poly(glycerol sebacate) or a mixture thereof.A bone cement according to the invention is particularly intended for vertebroplasty, kyphoplasty or cementoplasty.

The invention discloses a product used for forming calcium magnesium injectable bone cement, comprising solid phase powder obtained by uniformly mixing composite phosphoric acid calcium salt and magnesium phosphate powder as well as curing solution obtained by dissolving dextrin and hydrophosphate in water. The invention also discloses a calcium magnesium injectable bone cement and preparation method and application thereof. The curing solution and solid phase powder in the product are uniformly mixed and blended into paste, thus obtaining water phase high efficiency scattering-resistant rapid curing bone cement capable of being injected with calcium magnesium and injectable product used for preparing bone tissue wound repairing. The invention is low in cost of raw materials, preparation method is simple, the obtained calcium magnesium injectable bone cement has strong scattering-resistance and rapid curing speed.

The invention relates to a composition for injectable cement, comprising a mineral sold phase, a separate liquid phase and, optionally, microparticles of a biocompatible and biodegradable polymer. The mineral solid phase comprises a mixture of powders with the molar composition: (CP)6 (CaO)y (SrCO3)z, [CP being CaHPO42H2O, CaHPO4, Ca1-xSrxHPO4, an equimolar mixture of bis(Ca(H2PO4)2, H2O and CaO, or a mixture of two or three of said compounds] and y+z=4?1. The liquid phase comprises pure apyrogeneic water or a saline aqueous solution with pH 4 to 9. The ratio L / P [volume of liquid phase / mass of solid mineral phase] is at least 0.4 ml / g. The above is of application as bone replacement.

The invention relates to an injectable porous high-strength bone repair material. The material can reach a bone defect part through injection and is quickly solidified to repair bone defect. The material mainly comprises a solid phase and a liquid phase, wherein the solid phase consists of polyphosphoric acid calcium salt, alpha-calcium sulfate hemihydrate and reinforced fiber; and the liquid phase is one or mixed solution of more of citric acid, sodium phosphate, sodium hydrogen phosphate, deionized water, normal saline, blood from a patient and the like. The injectable bone material has good liquidity and clinically satisfactory injectability, collapse resistance and high strength.

The present invention relates to an injectable bone regeneration material containing a bone formation enhancing peptide, and more particularly, to an injectable bone regeneration material, in which a bone formation enhancing peptide essentially containing one and more amino acid sequences among SEQ ID NO: 1 to SEQ ID NO: 28 is bonded or mixed to a gel-forming base material selected from the group consisting of chitosan, alginic acid, silk fibroin, propylene glycol, propylene glycol alginic acid, poloxamer, chondroitin sulphate, and the combination thereof. The injectable bone regeneration material according to the present invention can increase differentiation of bone marrow stromal cells and osteoblasts into bone tissue, thus maximizing tissue regeneration by a peptide capable of promoting differentiation of bone tissue and periodontal tissue regeneration. The injectable bone regeneration material is in the form of a gel, and thus can be applied to a surface of various medical devices such as implant etc., and can be mixed with bone graft particles to apply, so that it can increase a treatment effect of existing medical devices to maximize a tissue regeneration effect.

The invention relates to injectable bone cement containing strontium and a preparation method of the injectable bone cement. The injectable bone cement comprises solid phase and liquid phrase, wherein the solid phrase comprises polymethylmethacrylate, calcium sulfate hemihydrate, tetracalcium phosphate, strontium hydrogenphosphate, barium sulfate and benzoyl peroxide; the liquid phrase comprises a methyl methacrylate monomer, N,N dimethyl paratoluidine and hydroquinone; the preparation method of the injectable bone cement comprises the following steps: mixing solids and liquids at a mass ratio of 2 to 1; stirring uniformly by using a bone cement mixing and stirring system; using an injecting system to inject the bone cement; in the injectable bone cement containing the strontium, the calcium sulfate hemihydrate, the tetracalcium phosphate and the strontium hydrogenphosphate are distributed uniformly; after the injectable bone cement is implanted into a body, calcium ions and strontium ions are degraded and released gradually in the body to form a honeycomb structure and guide cells to ingrow, so that joint connection is formed so as to prevent looseness; the compressive strength of the prepared injectable bone cement containning the strontium are higher than 50 MPa. The injectable bone cement containing the strontium can be used in fracture fixation caused by osteoporosis and the like and bone defect filling.

The invention relates to a method for preparing chitosan / hydroxyapatite composite microspheres, and belongs to the field of preparation technologies of biomedical materials. According to the method, chitosan, calcium nitrate and disodium hydrogen phosphate are taken as raw materials, and an in-situ synthesis technology is adopted for preparing the chitosan / hydroxyapatite (HA) composite microspheres. The method comprises the following steps: dropping a prepared calcium nitrate / chitosan solution into an oil phase containing Span 85 to form a water-in-oil type emulsion; adding a disodium hydrogen phosphate solution and uniformly stirring; dropping a glutaraldehyde water solution for cross-linking; finally regulating the pH value of a system through sodium hydroxide; performing dehydration, centrifugation, washing and drying to get a composite microsphere product. The chitosan / HA composite microspheres prepared by the method disclosed by the invention have the advantages of regular sphericity, narrow particle size distribution and high dispersivity, and can be used for effectively avoiding the problem of agglomeration of nano-HA particles during the preparation process of a traditional emulsification method, and be used as a medicine carrier or an injectable bone tissue repair material.

The invention belongs to the field of biomaterial preparation and biomedical application, and particularly relates to a fibroin bone cement biological adhesive with excellent wet state adhesion and immediate high strength mechanical properties and a preparation method thereof. According to the preparation method, polyphenols / hydroxyapatite or polyphenols / calcium phosphate is introduced into a fibroin solution system to prepare the fibroin bone cement biological adhesive with super strong adhesion. The adhesive has excellent wet state adhesion, and the novel injectable bone cement adhesive is provided for bone and joint hard tissue injury caused by trauma and pathological diseases. The adhesive can also be used as a hemostatic adhesive material for tissues such as skins, organs, blood vessels, nerves, muscles and mucous membranes.

The present invention relates to a biodegradable fibrin based composition for injection into osseous defects or voids, which can be the result of osteoporosis, surgery, bone cysts, tumor removal or traumatic bone injury.

The invention relates to an injectable composite bone material and a preparation method thereof, and belongs to the technical field of biomaterial. The injectable composite bone material is prepared from collagen stroma nanocrystal calcium phosphate and semi-hydrated calcium sulphate powder by mixing, while sterilized medical water is prepared from the injectable composite bone material according to a certain ratio of liquid to solid, so that the liquid phase and the solid phase can be mixed evenly to prepare the injectable composite bone material during use. The material and the method introduce semi-hydrated calcium sulphate into nanocrystal calcium phosphate / collagen composite material with a natural bone classification structure and characteristics to prepare an injectable bone repair material so as to realize performance complementation, not only can maintain the characteristics of the imitated natural bone structure, but also endow new injectable performance to the materials, thereby having wider application range.

The invention provides a preparation method of an injectable bone repair material. The injectable bone repair material comprises alpha-calcium sulfate hemihydrate, bone meal particles, biodegradable polymers, a nucleating agent and a curing solution. After the injectable bone repair material is cured, the compression strength can reach about 30Mpa, the porosity can reach 43.7%, and the pore diameter can be as high as 20-100 micrometers. The curing time of the injectable bone materials is between 7 min and 125 min. Therefore, the injectable bone repair material provided by the invention is suitable for clinical application for minimally invasive bone repair.

The invention relates to graphene oxide modified bone cement and a preparation method. The graphene oxide modified bone cement comprises powder and solidifying liquid, wherein the powder is formed by compounding calcium sulfate hemihydrate and hydroxyapatite doped with 5-10% of strontium, and the solidifying liquid is a graphene oxide aqueous solution. The preparation method comprises the following steps: proportionally preparing the powder of calcium sulfate hemihydrate and hydroxyapatite doped with 5-10% of strontium; adding the solidifying liquid according to a liquid-solid ratio of 0.5mL / g and mixing; stirring uniformly; and solidifying at room temperature to obtain injectable bone cement. The graphene oxide has good mechanical property and can be highly dispersed in an aqueous solution or organic solvent; and by adding the graphene oxide, the mechanical property of the bone cement can be enhanced. The bone cement material prepared by the method has the characteristics of strong collapse resistance, good injectable property and high strength and also has good biocompatibility and biodegradability. The bone cement can be used for filling and repairing various bone defects and is applied to the fields of tissue engineering and medicine.

The invention discloses an injectable bone repair material with a controllable magnesium ion release behavior and a preparation method of the material, relates to the field of injectable bone repair materials, and aims at developing an injectable microsphere cell carrier loaded with magnesium-containing inorganic components. Different from common microcarriers such as sephadex in a large-scale cell culture technology, microphseres are prepared from aliphatic polyester with adjustable rate of biodegradation and can be injected into defect parts in a human body together with cells performing adhesive growth on the surfaces by serving as cell carriers, and along with tissue regeneration, a polyester microsphere support is gradually degraded and absorbed by an organism and gives way to regenerated tissue. The magnesium-containing inorganic components are introduced in the microcarriers, by selecting different magnesium-containing inorganic components and changing the proportion and intakeof the magnesium-containing inorganic matter in the microspheres, the release behavior of magnesium ions is regulated and controlled, and then the bioactive microsphere type bone repair material withthe excellent osteogenesis promoting capacity is developed by means of the biological effect of the magnesium ions in the new bone formation process.

The present invention relates to injectable bone-repairing hydrogel containing exosomes of human umbilical cord mesenchymal stem cells and a preparation method of the injectable bone-repairing hydrogel, and belongs to the technical field of biomedical engineering. The hydrogel material contains exosomes of human umbilical cord mesenchymal stem cells, nano-hydroxyapatite, a hyaluronic acid-adipic dihydrazide derivative and an alginic acid derivative with an aldehyde group on a main chain. The preparation method comprises the steps of separation of human umbilical cord mesenchymal cells, extraction of exosomes, preparation of nano-hydroxyapatite, preparation of a hyaluronic acid-adipic dihydrazide derivative, preparation of composite hydrogel and the like. The injectable bone-repairing hydrogel provides a new repair method for a bone defect treatment and has a wide application prospect and an ideal repair effect.

The invention relates to strontium-containing injectable bone cement and a preparation method thereof. The strontium-calcium composite bone cement comprises the following solid phases: tetracalcium phosphate, monetite crystal whiskers, strontium hydrogen phosphate and calcium sulfate hemihydrate, and the following liquid phases: water for injection or polyvinyl alcohol, and polyethylene glycol. The solid phases and the liquid phases are separately mixed, and then solid mixture and liquid mixture are uniformly stirred and mixed in solid-liquid mass ratio of (2-3):1, so that the strontium-calcium composite bone cement is obtained. Through hydration and solidification, the final product, namely the strontium-calcium composite bone cement of calcium sulphate and strontium doped apatite, is prepared, initial strength of the bone cement can be enhanced due to needle-like morphology of monetite crystal whiskers, resistance to collapse due to water is good, degradation rate is adjustable, the bone cement does not collapse in a human body, morphology of the bone cement after solidification is of a laminate shape and rod-shaped crystals are adhered, the bone cement can be completely degraded, degradation rates of calcium sulphate and strontium-containing apatite are different, mechanical properties of the bone cement can be maintained, and repairing of coloboma in clinical application can be realized.

The invention provides an injectable bone repair material, which comprises powder and a solidification liquid, wherein the solidification liquid is prepared from a polysaccharide-dopamine graft, a buffer salt and water. The polysaccharide-dopamine graft is added to the solidification liquid of the bone repair material, so that the compatibility and the cohesiveness of bone cement and tissues and bones are strengthened, the powder and the liquid can be prevented from being scattered after being mixed and the injectable bone repair material can be manually molded. The invention further provides a preparation method of the injectable bone repair material.

The invention discloses an injectable water-absorbing and swelling bone cement, which comprises the following raw materials in percentage by weight: 0.002%-0.09% of methyl methacrylate monomers, 0.001%-0.0018% of N,N-Dimethyl-p-toluidine, 0.0015%-0.0045% of hydroquinone, 0.705%-66.6023% of methyl methacrylate-styrene copolymer, 0.12%-14.4014% of polymethyl methacrylate, 0.05%-9% of barium sulfate, 9.9%-90.1205% of water-absorbing resin fibers. The invention further provides a preparation method of the bone cement, and the preparation method specifically comprises the following step: mixing the prepared water-absorbing resin fibers with the injectable bone cement precursor to obtain injectable water-absorbing and swelling bone cement. The water-absorbing resin fibers in the injectable water-absorbing and swelling bone cement are increased in volume after absorbing water, the elastic modulus of the bone cement can be reduced, the volume contraction of PMMA bone cement in self polymerization can be offset, and the bone and prosthesis are firmly bonded.

The invention discloses injectable bone cement with an antioxidation characteristic as well as a preparation method and application thereof. The bone cement consists of powder and liquid, wherein the powder consists of phosphate, sulfate and beta-carotene powder; the liquid consists of one or more of sodium citrate, sodium hydrogen phosphate and deionized water. The bone cement is prepared by using the preparation method which comprises the following steps: (1) uniformly mixing phosphate, sulfate, beta-carotene powder and a dispersing agent according to a mass ratio, wherein beta-carotene is 0.1-1% of the total mass and the dispersing agent is 0.01-0.3% of the total mass; (2) adding the solidified liquid to stir uniformly, wherein the proportion of the addition of the solidified liquid to the powder mixture prepared in the step (1) is 1.5-2.0 g / mL. The prepared bone cement has the characteristics of being injectable and high in strength, is capable of automatically and rapidly solidifying under physiological environment, and has good bioactivity, antioxidation characteristic and bone cell inducing characteristic.

The invention relates to an injectable bone cement and preparation method thereof. The injectable bone cement comprises powder and curing liquid, wherein the powder is composited of calcium sulfate hemihydrate and polyethylene glycol diacrylate, and the curing liquid is sulfhydrylated hyaluronic acid aqueous solution or sulfhydrylated chitosan aqueous solution. The preparation method comprises the following steps of: preparing the powder of calcium sulfate hemihydrate and polyethylene glycol diacrylate inproportion; adding the curing liquid according to the liquid-to-solid ratio of 0.4-1.0mL / g, mixing and stirring evenly, and curing at room temperature to form the injectable bone cement. Sulfhydrylated hyaluronic acid and sulfhydrylated chitosan are liable to form intramolecular and intermolecular disulfide bonds under neutral condition and have higher degree of crosslinking and viscoelasticity; thus, injectable property, collapse resistance and mechanical property of the bone cement are improved. Meanwhile, the bone cement provided by the invention also has good biocompatibility and biodegradablity, and can be used for filling and repair for various bone defects. The injectable bone cement and the preparation method thereof are used in the field of tissue engineering and medicine.

The present invention relates to an injectable bone regeneration material containing a bone formation enhancing peptide, and more particularly, to an injectable bone regeneration material, in which a bone formation enhancing peptide essentially containing one and more amino acid sequences among SEQ ID NO: 1 to SEQ ID NO: 28 is bonded or mixed to a gel-forming base material selected from the group consisting of chitosan, alginic acid, silk fibroin, propylene glycol, propylene glycol alginic acid, poloxamer, chondroitin sulphate, and the combination thereof. The injectable bone regeneration material according to the present invention can increase differentiation of bone marrow stromal cells and osteoblasts into bone tissue, thus maximizing tissue regeneration by a peptide capable of promoting differentiation of bone tissue and periodontal tissue regeneration. The injectable bone regeneration material is in the form of a gel, and thus can be applied to a surface of various medical devices such as implant etc., and can be mixed with bone graft particles to apply, so that it can increase a treatment effect of existing medical devices to maximize a tissue regeneration effect.

An injectable bone mineral substitute material composition with the capability of being hardened in a body fluid in vivo, which comprises at least one calcium phosphate component and at least one calcium sulfate component as a dry mixture mixed with an aqueous liquid, and at least one accelerator, the at least one calcium sulfate component being particulate hardened calcium sulfate, which has a specified particle size that is in order to confer injectability to the composition. The invention also concerns the bone mineral substitute material produced from the composition as well as methods and uses thereof.

The invention provides a stem cell-loaded injectable bone repair adhesive for highly bionic active bone tissues. The stem cell-loaded injectable bone repair adhesive is composed of hydrogel with a multiple hybrid cross-linked network structure and stem cells distributed in the hydrogel with the multiple hybrid cross-linked network structure. The bone repair adhesive has an interpenetrating networkstructure after freeze drying. A high polymer material with carboxyl and catechol functional groups is subjected to oxidation self-crosslinking, the high polymer material with carboxyl and catechol functional groups and a high polymer material with amino and carboxyl are subjected to Michael addition reaction, phenolic hydroxyl groups on the high polymer material with carboxyl and catechol functional groups and calcium ions dissociated from micron-sized spherical hydroxyapatite are chelated to form the multiple hybrid cross-linked network structure, and the micron-sized spherical hydroxyapatite is uniformly distributed in the multiple hybrid cross-linked network structure. The bone repair adhesive can promote adhesion and proliferation of stem cells while improving the tissue adhesion, and enhance angiogenesis and osteogenesis of stem cells.