Calcium magnesium injectable bone cement and preparation method and application thereof

A bone cement, calcium and magnesium technology, applied in medical science, prosthesis, etc., can solve the problems of reducing the injectability of calcium phosphate bone cement, dispersing or washing away the slurry, prolonging the curing time, etc., and achieving strong collapse resistance , fast curing speed, and easy operation

Active Publication Date: 2010-10-13
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The first object of the present invention is to overcome the poor collapse resistance of the existing water-phase injectable calcium phosphate bone cement, the slurry is easily dispersed or washed away by the blood surge in the operation area, and the injectability of the calcium phosphate bone cement is reduced. Insufficient such as prolonging the curing time, providing a product for forming injectable calcium magnesium bone cement

Method used

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  • Calcium magnesium injectable bone cement and preparation method and application thereof
  • Calcium magnesium injectable bone cement and preparation method and application thereof
  • Calcium magnesium injectable bone cement and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Weigh 10 g of composite calcium phosphate salt powder (composition is calcium hydrogen phosphate, tetracalcium phosphate and hydroxyapatite) with a particle size less than 10 μm as solid phase powder;

[0037] Weigh 0.48g of white dextrin and 0.48g of disodium hydrogen phosphate, pour them into a beaker equipped with 6g of deionized water, stir fully so that white dextrin and disodium hydrogen phosphate are fully dissolved in deionized water, and obtain a solidified solution;

[0038] Pour the solidified liquid into the solid phase powder, disperse evenly in the vessel, and mix evenly with a special mixing knife to obtain the aqueous phase injectable calcium phosphate bone cement.

[0039] Examples 2-12 Repeat the experimental steps of Example 1, the difference lies in the experimental conditions, as shown in Table 1.

[0040] The experimental condition of table 1 embodiment 2~12

[0041]

[0042] Table 2 shows the performance test results of the aqueous phase injec...

Embodiment 13

[0048] Weigh 0.5g of composite calcium phosphate salt powder (composition is calcium hydrogen phosphate, octacalcium phosphate and hydroxyapatite) with a particle size of less than 10 μm, and 9.5g of magnesium phosphate powder, and dry mix to form a solid phase powder; weigh white dextrin 1.2g, 1.04g of disodium hydrogen phosphate, poured into a beaker containing 6g of deionized water, fully stirred to fully dissolve white dextrin and disodium hydrogen phosphate into the deionized water to obtain a solidified solution;

[0049] Pour the solidification solution prepared above into the solid phase powder, disperse it evenly in the vessel, and mix it evenly with a special mixing knife to obtain a water-phase injectable calcium-magnesium bone cement (fa-ICMB) with high-efficiency collapse resistance and rapid solidification.

[0050] Examples 14-24 repeated the experimental steps of Example 13, the difference lies in the experimental conditions, as shown in Table 3, and the perform...

Embodiment 25

[0057] Weigh 5 g of composite calcium phosphate salt powder (composition is calcium hydrogen phosphate, octacalcium phosphate and calcium pyrophosphate) with a particle size less than 10 μm, 5 g of magnesium phosphate powder, and dry mix to form a solid phase powder;

[0058] Weigh 1.2 g of white dextrin and 1.04 g of disodium hydrogen phosphate, pour them into a beaker containing 6 g of deionized water, and stir fully so that white dextrin and disodium hydrogen phosphate are fully dissolved in deionized water to obtain a solidified solution;

[0059] Pour the solidified liquid prepared above into the solid phase powder, disperse evenly in the container, and mix evenly with a special mixing knife to obtain the water phase injectable calcium-magnesium bone cement fa-ICMB with high-efficiency anti-collapse and fast curing.

[0060] Examples 26-37 repeated the experimental steps of Example 25, the difference lies in the experimental conditions, as shown in Table 5, and the perform...

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Abstract

The invention discloses a product used for forming calcium magnesium injectable bone cement, comprising solid phase powder obtained by uniformly mixing composite phosphoric acid calcium salt and magnesium phosphate powder as well as curing solution obtained by dissolving dextrin and hydrophosphate in water. The invention also discloses a calcium magnesium injectable bone cement and preparation method and application thereof. The curing solution and solid phase powder in the product are uniformly mixed and blended into paste, thus obtaining water phase high efficiency scattering-resistant rapid curing bone cement capable of being injected with calcium magnesium and injectable product used for preparing bone tissue wound repairing. The invention is low in cost of raw materials, preparation method is simple, the obtained calcium magnesium injectable bone cement has strong scattering-resistance and rapid curing speed.

Description

technical field [0001] The invention belongs to the field of medical repair materials, and relates to a product for forming an injectable calcium-magnesium bone cement, an injectable calcium-magnesium bone cement and its preparation method and application, in particular to a product for forming an aqueous phase with high efficiency and anti-collapse A fast-curing injectable calcium-magnesium bone cement product, a water-phase high-efficiency anti-collapse rapid-curing injectable calcium-magnesium bone cement and its preparation method and application. Background technique [0002] Some common clinical fractures, such as distal radius fractures, tibial plateau fractures, calcaneal fractures, vertebral compression fractures, etc., only need closed reduction and percutaneous injection of bone repair materials to repair the defect, avoiding open surgery It simplifies the operation process, reduces iatrogenic soft tissue injury and approach-related complications, does not damage ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/12
Inventor 刘昌胜陈芳萍魏杰
Owner EAST CHINA UNIV OF SCI & TECH
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