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Injectable bone cement and preparation method thereof

A bone cement and injection technology, applied in medical science, prosthesis, etc., can solve problems such as insufficient strength, mismatch between degradation and absorption and bone regeneration rate, and achieve improved injectability, good biocompatibility and degradability sexual effect

Inactive Publication Date: 2015-05-27
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Artificial bone graft materials prepared from a single material generally have problems such as insufficient strength, mismatch between degradation and absorption, and bone regeneration rate. Therefore, two or more materials are selected to prepare bone graft materials, and compounded according to a certain ratio to learn from each other. , improve the physical, chemical and biological properties of the material, and it is possible to obtain an ideal artificial bone repair material

Method used

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  • Injectable bone cement and preparation method thereof
  • Injectable bone cement and preparation method thereof
  • Injectable bone cement and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Bone cement composite powders include α-calcium sulfate hemihydrate, tetracalcium phosphate and polyethylene glycol diacrylate powder. At room temperature, weigh 3.996g (99.9%) calcium sulfate hemihydrate and 0.004g (0.1%) polyethylene glycol diacrylate, and mix them uniformly; measure 2 mL of 0.01% mercaptolated hyaluronic acid aqueous solution, and The solid phase powder (liquid-solid ratio is 0.5mL / g) was stirred and mixed for 2 minutes, and the injectable time was about 3.5 minutes.

[0029] The cured bone cement was placed in SBF solution for 12 hours, dried and ground for XRD characterization, as shown in the attached figure 1 As shown, the main component of the cured bone cement is calcium sulfate dihydrate, indicating that calcium sulfate hemihydrate quickly turns into calcium sulfate dihydrate during the curing process.

Embodiment 2

[0031] Preparation of bone cement composite powder: at room temperature, weigh 3.992g (99.8%) calcium sulfate hemihydrate and 0.008g (0.2%) polyethylene glycol diacrylate, mix uniformly; Mix 2 mL of thiolated hyaluronic acid aqueous solution with solid phase powder (liquid-solid ratio: 0.5 mL / g) for 2 minutes, and the injection time is about 4 minutes.

[0032] Carry out phase analysis to cured product according to embodiment 1, and carry out scanning electron microscope observation to the sample after curing, as attached figure 2 As shown, the cured bone cement is distributed in columnar shape.

Embodiment 3

[0034] Preparation of bone cement composite powder: at room temperature, weigh 3.984g (99.6%) calcium sulfate hemihydrate and 0.016g (0.4%) polyethylene glycol diacrylate, mix well; Mix 2 mL of thiolated hyaluronic acid aqueous solution with solid phase powder (liquid-solid ratio: 0.5 mL / g) for 2 minutes, and the injection time is about 4 minutes.

[0035] Carry out phase analysis and scanning electron microscope observation to cured product according to embodiment 2, and carry out compressive strength test to the bone cement sample degraded 14 days, compressive strength test sample is cylindrical (Φ 6mm * 12mm, as attached image 3 shown), the average compressive strength is 5.90Mpa (as attached Figure 4 shown). After curing, soak the bone cement in SBF solution, which has good collapse resistance.

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Abstract

The invention relates to an injectable bone cement and preparation method thereof. The injectable bone cement comprises powder and curing liquid, wherein the powder is composited of calcium sulfate hemihydrate and polyethylene glycol diacrylate, and the curing liquid is sulfhydrylated hyaluronic acid aqueous solution or sulfhydrylated chitosan aqueous solution. The preparation method comprises the following steps of: preparing the powder of calcium sulfate hemihydrate and polyethylene glycol diacrylate inproportion; adding the curing liquid according to the liquid-to-solid ratio of 0.4-1.0mL / g, mixing and stirring evenly, and curing at room temperature to form the injectable bone cement. Sulfhydrylated hyaluronic acid and sulfhydrylated chitosan are liable to form intramolecular and intermolecular disulfide bonds under neutral condition and have higher degree of crosslinking and viscoelasticity; thus, injectable property, collapse resistance and mechanical property of the bone cement are improved. Meanwhile, the bone cement provided by the invention also has good biocompatibility and biodegradablity, and can be used for filling and repair for various bone defects. The injectable bone cement and the preparation method thereof are used in the field of tissue engineering and medicine.

Description

technical field [0001] The invention relates to an injectable bone cement for human hard tissue repair and a preparation method, which is mainly used in the fields of biomedical materials and the like. Background technique [0002] Loss and damage of bone tissue is a common clinical disease. Common methods for repairing bone defects generally include autologous bone grafting, allogeneic bone grafting, and artificial bone repair. Autologous bone can induce new bone growth without immune rejection, and has high safety. It is considered the "gold standard" of bone transplantation, but the amount of autologous bone is extremely limited, and the bone harvesting area requires increased surgical trauma and additional blood loss. Prone to corresponding complications, causing secondary injury to the patient. Allogeneic bone grafting is a good supplement to autologous bone grafting, but there are still problems such as lack of source, immune rejection, and the risk of spreading dise...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/02A61L27/18A61L27/20
Inventor 李银霞李朝阳赵瑾崔振铎杨贤金
Owner TIANJIN UNIV
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