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185 results about "Periodontal tissue" patented technology

The tissues that are involved in periodontal diseases are the gums, which include the gingiva, periodontal ligament, cementum, and alveolar bone. The gingiva is a pink-colored mucus membrane that covers parts of the teeth and the alveolar bone.

Methods and articles for regenerating bone or peridontal tissue

There are numerous medical situations involving deficiencies of living bone or periodontal tissue and where increase of living bone or periodontal tissue mass is desired. Methods are described wherein a configured, shell-like device that is capable of being penetrated by living cells and tissues, is implanted into the body of a mammal in such a way as to establish a space, the space being at least partly, bounded by the device. The configuration of the device is such that the configuration of the established space is essentially the same as the configuration of living bone or periodontal tissue that is desired for treatment of the tissue deficiency. At least one protein from the Transforming Growth Factor-Beta Superfamily of proteins is placed within the established space for the purpose of stimulating the growth of living bone or periodontal tissue within the established space. A kit for the generation of living bone or periodontal tissue, comprised of the components mentioned above, is also disclosed.
Owner:WL GORE & ASSOC INC

Composition and method for the repair and regeneration of cartilage and other tissues

InactiveUS20060029578A1Add supportImprove coagulation/solidificationBiocideOrganic active ingredientsAbnormal tissue growthRepair tissue
The present invention relates to a new method for repairing human or animal tissues such as cartilage, meniscus, ligament, tendon, bone, skin, cornea, periodontal tissues, abscesses, resected tumors, and ulcers. The method comprises the step of introducing into the tissue a temperature-dependent polymer gel composition such that the composition adhere to the tissue and promote support for cell proliferation for repairing the tissue. Other than a polymer, the composition preferably comprises a blood component such as whole blood, processed blood, venous blood, arterial blood, blood from bone, blood from bone-marrow, bone marrow, umbilical cord blood, placenta blood, erythrocytes, leukocytes, monocytes, platelets, fibrinogen, thrombin and platelet rich plasma. The present invention also relates to a new composition to be used with the method of the present invention.
Owner:SMITH & NEPHEW ORTHOPAEDICS

Nanofibrous nonwoven membrane of silk fibroin for guided bone tissue regeneration and manufacturing method thereof

The present invention relates to a membrane for guided bone tissue regeneration and, more particularly, to a membrane for guided bone tissue regeneration having a structure that silk fibroin nanofibers obtained by removing sericin from silk fibers are formed as a nonwoven, and a manufacturing method thereof. A membrane for guided bone tissue regeneration according to the present invention has a predetermined strength, biocompatibility, and biodegradability, and may maintain a sustained drug release system, when drugs are added in the manufacturing process. Additionally, a membrane for guided bone tissue regeneration according to the present invention may be modified corresponding to the condition of usage, because a thickness of the membrane may be adjusted by controlling fineness of nanofibers, compactness of nanofibers, and pore size of a multiporous structure may be adjusted, in a nonwoven manufacturing process. A nanofibrous membrane for guided bone tissue regeneration according to the present invention is manufactured by freezing rapidly, drying a silk fibroin solution obtained by removing sericin from silk fibers, and by electrospinning after dissolving the dried silk fibroin in an electrospinning solvent. The membrane according to the present invention has excellent adhesion and air permeability, and is thereby effective in regeneration of damaged periodontal tissues.
Owner:SEOUL NAT UNIV R&DB FOUND

Bone graft and scaffolding materials immobilized with osteogenesis enhancing peptides on the surface

The present invention relates to a bone graft material and a scaffold for tissue engineering applications, which have an osteogenesis-promoting peptide immobilized on the surface. More particularly, the invention relates to a bone graft material and a scaffold for tissue engineering applications, which have a cell adhesion-inducing peptide and / or tissue growth factor-derived peptide immobilized on the surface. By the osteogenesis-promoting peptide immobilized on the surface, the inventive bone graft material and scaffold for tissue engineering applications can promote the transition, proliferation and differentiation of cells associated with regeneration, and eventually maximize the regeneration of tissue. Moreover, the peptide immobilized on the surface has low molecular weight, indicating a reduced risk of immune responses upon its application in the body, and can be present in a stable form within the body, thus showing lasting effects. Accordingly, the peptide makes it expedient to perform surgical operations for the regeneration of periodontal tissue, alveolar bone and other bone tissues, and will show high therapeutic effect.
Owner:SEOUL NAT UNIV R&DB FOUND

Methods for the treatment of periodontal disease

The disclosure provides methods for the treatment and prevention of periodontal disease. In preferred embodiments, the invention provides for local treatment of periodontal tissues with a pharmaceutical composition including an immune response modifier (IRM) selected from the group of immune response modifiers comprising imidazoquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, imidazonaphtyridine amines, oxazoloquinoline amines, thiazoloquinoline amines and 1,2-bridged imidazopyridine amines.
Owner:COLEY PHARMA GRP INC

Method of treatment for and prevention of periodontal disease

The method of treatment for a periodontal tissue exhibiting a periodontal disease or periodontal condition in a diagnosed patient is disclosed. The method has the steps of activating an acoustic shock wave generator or source to emit acoustic shock waves; and subjecting the periodontal tissue, or the entire periodontal region of the patient to the acoustic shock waves stimulating said tissue, wherein the tissue is positioned within a path of the emitted shock waves. The method of treatment may further have the steps of administering one or more medicaments prior, during or after subjecting the patient to acoustic shock waves or testing the bacterial count or viability of the treated tissue or region of the diagnosed patient after exposure to one or more acoustic shock wave treatments; or subjecting a tissue or organ to a surgical procedure to remove or repair some or all of any defects or degenerative tissues. The method of treatment is for prevention of periodontal disease and may be used with debridement. The treatment is particularly useful in eradicating and inhibiting periodontal biofilms.
Owner:SOFTWAVE TISSUE REGENERATION TECH LLC

Preparation method of biodegradable diaphragm for promoting regeneration of periodontal tissue

The invention relates to a preparation method of a biodegradable diaphragm for promoting regeneration of periodontal tissue, belonging to the field of biological regeneration medicine. In the invention, polylactic acid, polycaprolactone, polylactic acid-glycollic acid copolymer, collagen, modified chitosan and other biodegradable synthetic polyester polymers or natural biodegradable high molecular materials are used as raw materials to prepare a thin-film material with a nano structure through the electrostatic spinning process, and then, various growth factors are loaded on the thin-film material through the supermolecule loading technology. The diaphragm for reparative regeneration of the periodontal tissue, which is prepared by the method of the invention, has good biocompatibility and can realize the purposes of inhibiting inflammation and inducing regeneration of the periodontal tissue through the controlled release of the loaded growth factors.
Owner:TONGJI UNIV

Multipotent postnatal stem cells from human periodontal ligament and uses thereof

The invention generally relates to postnatal periodontal ligament stem cells and methods for their use. More specifically, the invention relates in one aspect to postnatal periodontal ligament multipotent stem cells, use of the cells to generate periodontium, differentiation of the cells and methods of tissue cryopreservation.
Owner:NAT INST OF HEALTH REPRESENTED BY THE SEC OF THE DEPT OF HEALTH & HUMAN SERVICES NAT INST OF HEALTH +1

Double-layer composite regeneration film and making method thereof

The invention relates to a double-layer composite regeneration film and a making method thereof. The regeneration film comprises a compact layer and a loose layer, the compact layer is formed through compounding a degradable high-molecular fiber web with a collagen film, or with collagen and nano-silver particles, or with collagen and a medicine having a treatment effect, and the loose layer is formed by treating one or more selected from chitosan, silk fibroins, keratoprotein and collagens as a matrix material. The preparation method mainly comprises a step of preparing the fiber strengthened compact layer, a step of preparing the loose layer, and a step of preparing a guide film through compounding. The regeneration film has the advantages of good biocompatibility and mechanical performances, biodegradability, low immune rejection response, simple operation and the like, and can be widely used for restoring tissues, especially bone tissues and periodontal tissues.
Owner:SHENZHEN LANDO BIOMATERIALS

Dental Carrier

A dental carrier comprises a thermoplastic carrier. The thermoplastic carrier has a pattern structure. After heating the thermoplastic carrier, the thermoplastic carrier is provided with a user to be impressed by teeth or alveolar ridge for forming teeth or alveolar ridge model of the user. Compared to the prior art, the dental carrier of the present invention can provide the dental medicament contained in the pattern structure to be precisely applied and hold onto the treatment area and the medicament can be evenly coated on the teeth, root, or periodontal tissue for the treatment of teeth. When the dental carrier is not used to carry medicament, the pattern structure can improve the mechanical strength and fitness of the dental carrier to be used as a biteplate, orthodontic retainer, periodontal dressing for treatment or protection or mouth guard in sports.
Owner:TAIPEI MEDICAL UNIV +1

Dental implant insertion set and manufacturing method thereof

Disclosed is a dental implant insertion set including a crown; a fixture which has a hex hole formed therein and of which an insertion angle is set so that the hex hole is aligned corresponding to an arrangement angle of the crown; a guide stent including a stent body formed with a profile set through the three-dimensional procedure guide image to be fixed while covering the periodontal tissue; and an abutment having a hex protrusion formed at a lower portion thereof to be matched with and fixed into the hex hole, such that the crown is aligned and fixed.
Owner:DIO

Composition for preventing or treating periodontal diseases comprising extract from Achyranthis radix or Ulmus cortex

The present invention provides a composition for preventing or treating periodontal diseases comprising an extract of Achyranthis radix, Ulmus cortex or a mixture thereof which inhibits the productions of superoxide, prostaglandin, and interleukin (IL-1.beta.) which are inducers for periodontal diseases and inhibits the enzyme activity of collagenase which decomposes collagen protein which is a substrate for the periodontal tissues, and at the same time promotes collagen protein synthesis, thereby treating periodontal diseases efficiently.
Owner:LG HOUSEHOLD & HEALTH CARE LTD

Applications of mesenchymal stem cell and genetically modified mesenchymal stem cell

InactiveCN103585177AExcellent restorative treatmentPeptide/protein ingredientsDigestive systemBone tissuePeriodontal tissue
The invention relates to applications of a mesenchymal stem cell and a genetically modified mesenchymal stem cell, especially relates to applications of a mesenchymal stem cell and a genetically modified mesenchymal stem cell in preparation of products for treating periodontal disease, repairing periodontal bone tissue or soft tissue defect and / or promoting regeneration of periodontal tissue. The invention further relates to a composition containing the mesenchymal stem cell and / or the genetically modified mesenchymal stem cell, and a cell patch. According to the invention, prosthodontic treatment effect of MSC (Mesenchymal Stem Cells) from different sources on the periodontal bone defect and periodontitis soft tissue is proved successfully, and a strong evidence for expanding seed cell source is provided; meanwhile, the application also proves that the prosthodontic treatment effect of MSC modified by an HGF (Hepatocyte Growth Factor) gene on periodontal bone defect and periodontitis soft tissue is superior to that of simple MSC, and shows that HGF and MSC can play a role in cooperation in prosthodontic treatment of periodontal bone tissue or soft tissue defect and / or promoting regeneration.
Owner:BEIJING STOMATOLOGY HOSPITAL CAPITAL MEDICAL UNIV +1

Method and apparatus for periodontal diagnosis

A technique for obtaining information regarding a state of periodontal tissue involves deriving a substantially whole curve measure of similarity of an observed bandshape of an isolated spectral component attributed to water within the infrared region. Subtle variations in the bandshape of the water bands have been found to correlate with inflammatory periodontal diseases and using whole curve measures such as weighted integrals or measure of fit parameters these variations can be detected and used to classify periodontal tissues.
Owner:NAT RES COUNCIL OF CANADA

Method for in situ solidification of blood-polymer compositions for regenerative medicine and cartilage repair applications

The present invention relates to a method for repairing or regenerating tissues in a patient such as cartilage, meniscus, ligament, tendon, bone, skin, cornea, periodontal tissues, abscesses, resected tumors, cardiac tissues and ulcers. The method comprises the step of administering simultaneously or sequentially a pro-coagulant factor and an effective amount of a polymer composition comprising a biocompatible polymer and blood or a component thereof. When the polymer composition is in contact with the pro-coagulant factor it is converted into a non-liquid state such that the polymer composition will adhere to the site in need of repair to effect repair of the tissue and / or regeneration thereof.
Owner:PIRAMAL HEALTHCARE CANADA

Biocompatible Membrane and Process for Producing the Same

The present invention provides a biocompatible membrane which has a configuration that conforms well to an affected part and can be used in fields such as dentistry, oral surgery, orthopedics, etc., by a compatible membrane production process in which a biocompatible material is subjected to a lamination forming process or a powder electrostatic coating process. Examples of lamination forming processes include (a) selective laser sintering, (b) powder adherence, (c) fused deposition molding, (d) laminated object manufacturing, and (e) optical molding. The biocompatible membrane is useful as, for example, a tissue regeneration membrane or a bone regeneration membrane for periodontal tissue, bone tissue, and like tissue regeneration treatment.
Owner:SUNSTAR SUISSE SA

Periodontal disease detection system and method

InactiveUS20160270716A1Enhance the imageAccurate and repeatable periodontal measurementSurgeryEndoscopesDisease areaDisplay device
Intra-oral imaging apparatus and / or method embodiments can provide digital dental reflectance images used to identify selected areas of interest (AOI) within a dental region of interest (ROD having selected image characteristics for both hemo-globin's total concentration and oxygenation level. In one embodiment, reflectance images can determine relative total hemoglobin using at least a wavelength band that includes an isobestic wavelength for absorption coefficients of oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb). In one embodiment, intra-oral imaging apparatus and / or method embodiments can use reflectance images of a dental region at least at three wavelengths; a control logic processor for processing the reflectance images to determine relative tHb and its relative oxygenation level and / or identify disease areas having periodontal tissues condition; and a display for displaying periodontal tissues or a visual indication of the areas having selected imaging characteristic determined by the reflectance images.
Owner:CARESTREAM DENTAL TECH TOPCO LTD

Cultured Periodontal Membrane Cell Sheet, Process for Producing the Same and Method of Use Thereof

A cultured periodontal ligament cell sheet is produced by a process comprising culturing cells on a cell culture support composed of a base material whose surface is coated with a temperature-responsive polymer having an upper limit or lower limit critical dissolution temperature in water of 0 to 80° C. under specified conditions, (1) regulating the temperature of a culture fluid to the upper limit critical dissolution temperature or higher or to the lower limit critical temperature or lower, (2) allowing a cultured periodontal ligament cell sheet resulting from the culturing to adhere to a carrier and (3) detaching the sheet intact together with the carrier. This cultured periodontal ligament cell sheet has a syndesmotic microstructure, exhibits extremely high bioadherence to the dental root surface and realizes high density transplantation of target cells and positive reconstruction of periodontal tissues. Moreover, through lamination of cell sheets to be transplanted and donation of a three-dimensional polarity, highly efficient reconstruction of an adhesion apparatus can be accomplished and clinical application thereof to moderate periodontitis, severe peridontitis, gingival recession and the like is highly promising.
Owner:CELLSEED

Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration

ActiveUS20100196854A1Effective recoveryChallenging taskDental implantsTeeth fillingBone structureTooth regeneration
A method for reconstructing a functional tooth by using a carrier loaded with a plurality of mesenchymal stem cells including at least one of a stem cell derived from Apical Papilla (SCAP), Periodontal Ligament Stem Cells (PDLSC), and Dental Pulp Stem Cells (DPSC). The mesenchymal stem cell loaded carrier is planted into a site within a subject's oral cavity to form a bio-root upon which a crown may be affixed, The mesenchymal stem cells will develop new periodontal tissues to stabilize the bio-root. Methods disclosed herein are particularly beneficial for subjects lacking good bone structures for conventional crown treatments.
Owner:UNIV OF SOUTHERN CALIFORNIA

Cell-guiding fibroinductive and angiogenic scaffolds for periodontal tissue engineering

InactiveUS20120171257A1Maximum levelSuperior periodontal regeneration resultPeptide/protein ingredientsSkeletal disorderBiopolymerCell migration
Disclosed are methods for producing cell-guiding fibroinductive and angiogenic tissue engineering scaffolds composed of biodegradable and biocompatible natural biopolymers, synthetic polymers and / or their combination, incorporating growth and differentiation factors, growth hormone and chemoattractants, with interconnected pores and channels-containing microarchitecture inducing the regenerative cell migration, adhesion, proliferation and differentiation from the healthy tissues surrounding the periodontal defects, thereby facilitating the functional periodontal tissue regeneration. The methods for the application of the cell-guiding fibroinductive and angiogenic scaffolds in the surgical treatment of periodontal tissue defects resulted from destructive periodontal diseases are also provided.
Owner:INANC BULEND +1

Method of manufacturing guide stent of dental implant

Disclosed is a method of manufacturing a guide stent of a dental implant. The method includes a first step of obtaining a three-dimensional image of periodontal tissue in a mouth of a patient through an CT scan and a three-dimensional exterior image corresponding to the three-dimensional image through an oral scan; a second step of matching the three-dimensional image and the three-dimensional exterior image through a difference amp which overlaps the three-dimensional image and the three-dimensional exterior image and outputs a matching degree between the images, and obtaining a three-dimensional procedure guide image; and a third step of manufacturing a stent body having a through hole corresponding to a preset implant implantation position according to the obtained three-dimensional procedure guide image.
Owner:DIO

Injectable bone regeneration gel containing bone formation enhancing peptide

The present invention relates to an injectable bone regeneration material containing a bone formation enhancing peptide, and more particularly, to an injectable bone regeneration material, in which a bone formation enhancing peptide essentially containing one and more amino acid sequences among SEQ ID NO: 1 to SEQ ID NO: 28 is bonded or mixed to a gel-forming base material selected from the group consisting of chitosan, alginic acid, silk fibroin, propylene glycol, propylene glycol alginic acid, poloxamer, chondroitin sulphate, and the combination thereof. The injectable bone regeneration material according to the present invention can increase differentiation of bone marrow stromal cells and osteoblasts into bone tissue, thus maximizing tissue regeneration by a peptide capable of promoting differentiation of bone tissue and periodontal tissue regeneration. The injectable bone regeneration material is in the form of a gel, and thus can be applied to a surface of various medical devices such as implant etc., and can be mixed with bone graft particles to apply, so that it can increase a treatment effect of existing medical devices to maximize a tissue regeneration effect.
Owner:NANO INTELLIGENT BIOMEDICAL ENG +1

Preparation method of specific extracellular matrix ECM of periodontium and application thereof

The invention relates to a preparation method of a specific extracellular matrix ECM of periodontium. The preparation method comprises the following steps: 1) separating and culturing a human periodontal ligament cell; and 2) preparing the specific extracellular matrix ECM of periodontium; applying the specific extracellular matrix ECM of periodontium and applying the specific extracellular matrix ECM of periodontium as a human periodontal ligament stem cell in in-vitro amplification; and promoting directional differentiation of the ECM. The preparation method is simple and can remarkably promote in-vitro amplification and directional differentiation of the periodontal ligament stem cell.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

3D print scaffold material and preparation method and application thereof

The invention relates to a 3D print scaffold material and a preparation method and application thereof and particularly relates to a 3D print scaffold material for periodontal tissue reconstruction and a preparation method and thereof. The material comprises the following components: a stromal cell-derived factor-1 (stromal cell-derived factor-1, SDF-1) and a bone morphogenetic protein 2 (Bone Morphogenetic Proteins, BMPs). By adopting two functional molecules of SDF-1 and BMP2, endogenous stem cells are collected into a periodontal defect area, osteogenic differentiation is accelerated, periodontal tissue regeneration is accelerated, meanwhile, an individual bionic degradable polymer scaffold is designed on the basis of 3D printing, and the external form and the internal microstructure of the material is precisely controlled through a computer.
Owner:HOSPITAL OF STOMATOLOGY SUN YAT SEN UNIV

Gradient material for guiding regeneration of periodontal hard and soft tissues and preparation method of gradient material

ActiveCN110141687AAchieving Synchronous RepairAll-in-one repairSurgeryPharmaceutical delivery mechanismFiberGradient material
The invention discloses a gradient material for guiding regeneration of periodontal hard and soft tissues, and a preparation method of the gradient material. The gradient material is constructed by combining an electrostatic spinning technology with a biological 3D (three dimensional) technology. A micropore structure of an electrostatic spun fibrous membrane can prevent gingival fibroblasts frommigrating to a root surface to play a mechanical barrier role and facilitate transmission of nutrition and metabolism substances; and individualized repair of alveolar bone can be achieved according to clinical requirements since a structure and a shape of a 3D printing scaffold layer are highly designable. The method is simple and stable in preparation technology, and the gradient material integrates a periodontal guided tissue regeneration membrane and an alveolar bone repair scaffold material and has a potency to achieve clinical customized treatment. The gradient material has a good effectof guiding the repair of the hard and soft tissues in vivo and can be better applied to the synchronous regeneration and repair of the alveolar bone and the periodontal tissues.
Owner:SICHUAN UNIV

Porous fibrous membrane material for periodontal repair and preparation method thereof

The invention discloses a porous fibrous membrane material for periodontal repair and a preparation method thereof. The porous fibrous membrane material is formed by compounding PCL, gelatin, chitosan and nanometer hydroxyapatite through the preparation by using a static spinning technology and a freeze-drying technology. The composite material is used for periodontal repair, solves the problems of low biological absorptivity, low compatibility, improper degrading time and the like of the existing periodontal repair product, has the effect of promoting the periodontal tissue regeneration, can be used for well repairing alveolar bone defects and has good application prospects in the field of periodontal repair.
Owner:NANKAI UNIV

Nonwoven Nanofibrous Membranes of Silk Fibroin for Guided Bone Tissue Regeneration and Their Preparation Method

The present invention relates to a membrane for guided bone tissue regeneration and, more particularly, to a membrane for guided bone tissue regeneration having a structure that silk fibroin nanofibers obtained by removing sericin from silk fibers are formed as a nonwoven, and a manufacturing method thereof.A membrane for guided bone tissue regeneration according to the present invention has a predetermined strength, biocompatibility, and biodegradability, and may maintain a sustained drug release system, when drugs are added in the manufacturing process. Additionally, a membrane for guided bone tissue regeneration according to the present invention may be modified corresponding to the condition of usage, because a thickness of the membrane may be adjusted by controlling fineness of nanofibers, compactness of nanofibers, and pore size of a multiporous structure may be adjusted, in a nonwoven manufacturing process. A nanofibrous membrane for guided bone tissue regeneration according to the present invention is manufactured by freezing rapidly, drying a silk fibroin solution obtained by removing sericin from silk fibers, and by electrospinning after dissolving the dried silk fibroin in an electrospinning solvent. The membrane according to the present invention has excellent adhesion and air permeability, and is thereby effective in regeneration of damaged periodontal tissues.
Owner:SEOUL NAT UNIV R&DB FOUND

Method for enhancing viability of periodontal tissue cells

In a method for enhancing viability of periodontal tissue cells associated with more than one tooth, the periodontal tissue cells are irradiated simultaneously by an LED (light emitting diode) module having a light emitting range covering the associated teeth, wherein the irradiating energy is between 0.1 J / cm2 and 10 J / cm2.
Owner:HO MING HUA +2
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