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3D print scaffold material and preparation method and application thereof

A 3D printing and scaffold material technology, applied in the field of materials, can solve the problems of precise control of the external and internal structures of difficult hydrogels, and achieve the effects of promoting adhesion growth, promoting bone regeneration, and optimizing physical and chemical properties.

Active Publication Date: 2017-09-01
HOSPITAL OF STOMATOLOGY SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the traditional hydrogel preparation method is mainly through the chemical reaction or physical interaction between polymer chains, and it is difficult to achieve precise regulation of the external and internal structure of the hydrogel.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Example 1 Preparation of 3D printing scaffold material

[0066] The 3D printing scaffold material includes the following components according to the mass concentration: SDF-1 1000 μg / L, BMP2 1000 μg / L, sodium sea salt 220 mg / L, gelatin 200 mg / L and nano-hydroxyapatite particles 100 mg / L;

[0067] The preparation method of the 3D printing support material is as follows:

[0068] (1) Dissolving the sodium hectic acid, gelatin and nano-hydroxyapatite particles in double-distilled water according to the formula amount, mixing at 37° C., and stirring for 3 hours until a uniform transparent solution without precipitation is formed;

[0069] (2) Add SDF-1 and BMP2 to the transparent solution in step (1) according to the formula, place it on ice and stir for 30 minutes, pre-cool at 4°C for later use.

[0070] The prepared 3D printed scaffold material had good adhesion and growth of cells.

Embodiment 2

[0071] Example 2 Preparation of 3D printing scaffold material

[0072] The 3D printing scaffold material includes the following components according to the mass concentration: SDF-1 900 μg / L, BMP2 900 μg / L, sodium sea salt 180 mg / L, gelatin 180 mg / L and nano-hydroxyapatite particles 80 mg / L;

[0073] The preparation method of the 3D printing support material is as follows:

[0074] (1) Dissolving the sodium heptate, gelatin and nano-hydroxyapatite particles in double-distilled water according to the formula amount, mixing at 35° C., and stirring for 4 hours until a uniform transparent solution without precipitation is formed;

[0075] (2) Add SDF-1 and BMP2 to the transparent solution in step (1) according to the formula, place it on ice and stir for 20 minutes, pre-cool at 4°C for later use.

[0076] The prepared 3D printed scaffold material had good adhesion and growth of cells.

Embodiment 3

[0077] Example 3 Preparation of 3D printing scaffold material

[0078] The 3D printing scaffold material includes the following components according to the mass concentration: SDF-1 1050 μg / L, BMP2 1050 μg / L, sodium sea salt 250 mg / L, gelatin 220 mg / L and nano-hydroxyapatite particles 120 mg / L;

[0079] The preparation method of the 3D printing support material is as follows:

[0080] (1) Dissolving the sodium heptate, gelatin and nano-hydroxyapatite particles in double-distilled water according to the formula amount, mixing at 38° C., and stirring for 2 hours until a uniform transparent solution without precipitation is formed;

[0081] (2) Add SDF-1 and BMP2 to the transparent solution in step (1) according to the formula, place on ice and stir for 50 minutes, pre-cool at 4°C for later use.

[0082] The prepared 3D printed scaffold material had good adhesion and growth of cells.

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Abstract

The invention relates to a 3D print scaffold material and a preparation method and application thereof and particularly relates to a 3D print scaffold material for periodontal tissue reconstruction and a preparation method and thereof. The material comprises the following components: a stromal cell-derived factor-1 (stromal cell-derived factor-1, SDF-1) and a bone morphogenetic protein 2 (Bone Morphogenetic Proteins, BMPs). By adopting two functional molecules of SDF-1 and BMP2, endogenous stem cells are collected into a periodontal defect area, osteogenic differentiation is accelerated, periodontal tissue regeneration is accelerated, meanwhile, an individual bionic degradable polymer scaffold is designed on the basis of 3D printing, and the external form and the internal microstructure of the material is precisely controlled through a computer.

Description

technical field [0001] The invention relates to the field of materials, in particular to a 3D printing bracket material and its preparation method and application, in particular to a 3D printing bracket material for periodontal use and its preparation method. Background technique [0002] Periodontal disease is a chronic infectious disease that destroys the supporting tissues of teeth, and it is also the main cause of tooth loss in adults. In my country, 80% to 97% of adults suffer from periodontal disease to varying degrees. The main mechanism of its pathogenesis is that bacteria invade the periodontal tissue, through direct invasion and non-specific immune response of the body, causing chronic inflammation of the periodontal tissue, which in turn causes the destruction of the periodontal tissue, especially the alveolar bone, and finally leads to the loss of supporting tissue, Teeth loosen and fall out. The ultimate goal of periodontal disease treatment is to eliminate the...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/20A61L27/22A61L27/54B33Y10/00B33Y50/02B33Y70/00B33Y80/00
CPCA61L27/12A61L27/20A61L27/222A61L27/54A61L2300/414A61L2300/45A61L2430/12B33Y10/00B33Y50/02B33Y70/00B33Y80/00C08L5/04
Inventor 谭家莉林炯
Owner HOSPITAL OF STOMATOLOGY SUN YAT SEN UNIV
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