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Porous fibrous membrane material for periodontal repair and preparation method thereof

A technology of porous fiber and membrane materials, which is applied in the field of porous fiber membrane materials for periodontal restoration and its preparation, which can solve problems such as inappropriate degradation time, poor compatibility, and weak bioabsorption, and achieve favorable adhesion and low cost. Low, the effect of promoting periodontal repair

Active Publication Date: 2017-11-07
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the problems of weak bioabsorption, poor compatibility, and unsuitable degradation time of existing periodontal restoration products, the present invention prepares a periodontal restoration porous fiber membrane material capable of promoting periodontal tissue regeneration, so that it has the ability to promote periodontal tissue regeneration. It can well repair alveolar bone defects and has a good application prospect in the field of periodontal restoration.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] 1) PCL and gelatin are dissolved in 10ml of hexafluoroisopropanol at a mass ratio of 1:1, that is, 0.4g of PCL and 0.4g of gelatin to form a mixed solution with a mass volume percentage of 8%. After the solute is uniformly dispersed, add 0.16 % acetic acid solution, that is, 16 μl was stirred overnight, and after the system was uniformly mixed, a spinning solution was formed;

[0017] 2) The electrospinning condition is a voltage of 13KV, a flow rate of 2ml / h, a receiving distance of 15cm, and a spinning time of 1h. After vacuum drying for 5 days, a nano-scale fine-pore fiber membrane with uniform structure is formed; 3) Get chitosan (~200mPa.s) 2g and add 100ml deionized water, add the acetic acid solution of 1ml again, form the chitosan solution that mass volume percent is 2%, add 1.4g nano-hydroxyapatite afterwards, continue to stir until The solution is uniform, sonicated for 10 minutes to form a uniform and stable solution;

[0018] 4) Take the vacuum-dried electr...

Embodiment 2

[0021] 1) PCL and gelatin are dissolved in 10ml of hexafluoroisopropanol at a mass ratio of 2:3, that is, 0.4g of PCL and 0.6g of gelatin to form a mixed solution with a mass volume percentage of 10%. After the solute is uniformly dispersed, add 0.2 % acetic acid solution, that is, 20 μl was stirred overnight, and after the system was mixed evenly, a spinning solution was formed;

[0022] 2) The electrospinning conditions are a voltage of 15KV, a flow rate of 2ml / h, a receiving distance of 13cm, a spinning time of 2h, and vacuum drying for 5 days to form a nano-scale fine-pore fiber membrane with uniform structure;

[0023] 3) Add 2g of chitosan (~200mPa.s) into 100ml of deionized water, then add 1ml of acetic acid solution to form a chitosan solution with a mass volume percentage of 2%, then add 1g of nano-hydroxyapatite and continue stirring Until the solution is uniform, sonicate for 10 minutes to form a uniform and stable solution;

[0024] 4) Take the vacuum-dried electr...

Embodiment 3

[0027] 1) PCL and gelatin are dissolved in 5ml of hexafluoroisopropanol at a mass ratio of 3:2, that is, 0.3g of PCL and 0.2g of gelatin to form a mixed solution with a mass volume percentage of 10%. After the solute is uniformly dispersed, add 0.2 % acetic acid solution, that is, 10 μl was stirred overnight, and after the system was mixed evenly, a spinning solution was formed;

[0028] 2) The electrospinning conditions are voltage 12KV, flow rate 2ml / h, acceptance distance 15cm, spinning time 2h, and vacuum drying for 5 days to form a nano-scale fine pore fiber membrane with uniform structure;

[0029] 3) Add 2 g of chitosan (~200 mPa.s) into 100 ml of deionized water, then add 1 ml of acetic acid solution to form a chitosan solution with a mass volume percentage of 2%, then add 0.4 g of nano-hydroxyapatite, and continue Stir until the solution is uniform, ultrasonic for 10 minutes to form a uniform and stable solution;

[0030] 4) Take the vacuum-dried electrospun membrane...

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PUM

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Abstract

The invention discloses a porous fibrous membrane material for periodontal repair and a preparation method thereof. The porous fibrous membrane material is formed by compounding PCL, gelatin, chitosan and nanometer hydroxyapatite through the preparation by using a static spinning technology and a freeze-drying technology. The composite material is used for periodontal repair, solves the problems of low biological absorptivity, low compatibility, improper degrading time and the like of the existing periodontal repair product, has the effect of promoting the periodontal tissue regeneration, can be used for well repairing alveolar bone defects and has good application prospects in the field of periodontal repair.

Description

Technical field [0001] The invention relates to a porous fiber membrane material for periodontal restoration and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] Periodontal disease is a chronic inflammatory disease that can eventually lead to periodontal tissue defect or tooth loss, thus endangering human oral health. Periodontal disease is caused by cross-infection of a series of periodontal pathogenic bacteria, which can cause gingival inflammation, and gradually lead to periodontal soft tissue damage and bone tissue defect. At present, the induced tissue regeneration membrane, as a barrier membrane, can effectively prevent the periodontal soft tissue from growing to the bone defect and provide sufficient space for bone tissue regeneration; the induced bone regeneration technology can stimulate the formation of new bone, guide bone regeneration, and repair the defect. alveolar bone. However, some current commerc...

Claims

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Application Information

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IPC IPC(8): A61L27/58A61L27/56A61L27/50A61L27/18A61L27/22A61L27/20A61L27/12
CPCA61L27/12A61L27/18A61L27/20A61L27/222A61L27/50A61L27/56A61L27/58C08L67/04C08L5/08
Inventor 王淑芳张琳张娜董云生
Owner NANKAI UNIV
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