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Gradient material for guiding regeneration of periodontal hard and soft tissues and preparation method of gradient material

A gradient material and soft tissue technology, applied in tissue regeneration, spinning solution preparation, additive processing, etc., can solve the problems of religious restrictions on disease transmission, loss of ability to maintain space, etc., to avoid the risk of disease transmission, high cell affinity , high biocompatibility effect

Active Publication Date: 2019-08-20
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current clinical use of commercialized collagen-based guided tissue regeneration membranes (Bio-Gide, Bio-Mend, etc.) also has defects: (1) Loss of the ability to maintain space due to its rapid degradation behavior; (2) Collagen is mostly derived from mammals Organs or tissues, such as pig skin, beef Achilles tendon, etc., have the risk of potential disease transmission and religious restrictions

Method used

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  • Gradient material for guiding regeneration of periodontal hard and soft tissues and preparation method of gradient material
  • Gradient material for guiding regeneration of periodontal hard and soft tissues and preparation method of gradient material
  • Gradient material for guiding regeneration of periodontal hard and soft tissues and preparation method of gradient material

Examples

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Comparison scheme
Effect test

Embodiment 1

[0052] A preferred embodiment of the present invention provides a method for preparing a gradient material to guide periodontal hard and soft tissue regeneration. The raw materials include: fish collagen from Sangon Biotechnology Co., Ltd., hexafluoroisopropanol from Aladdin Company, Shandong Jinan Daigang Biological Co., Ltd. The polylactic acid-glycolic acid of Technology Co., Ltd., the specific steps are as follows:

[0053] Step 1: Weigh 0.06g of nano-hydroxyapatite and disperse it in 2mL of hexafluoroisopropanol, and use an ultrasonic cell pulverizer to ultrasonically disperse for 1 hour;

[0054] Step 2: Weigh 0.02g fish collagen and add it to the dispersion obtained in step 1, shake it with a constant temperature oscillator for 10 minutes;

[0055] Step 3: Weigh 0.4g of polylactic acid-glycolic acid and add it to the mixed solution obtained in step 2, and shake it in a constant temperature oscillator at 25°C for 2 hours to obtain a spinning solution;

[0056] Step 4: U...

Embodiment 2

[0067] A preferred embodiment of the present invention provides a method for preparing a gradient material to guide periodontal hard and soft tissue regeneration. The raw materials include: fish collagen from Sangon Biotechnology Co., Ltd., hexafluoroisopropanol from Aladdin Company, Shandong Jinan Daigang Biological Co., Ltd. The polylactic acid-glycolic acid of Technology Co., Ltd., the specific steps are as follows:

[0068] Step 1: Weigh 0.06g of nano-hydroxyapatite and disperse it in 2mL of hexafluoroisopropanol, and use an ultrasonic cell pulverizer to ultrasonically disperse for 1 hour;

[0069] Step 2: Weigh 0.02g fish collagen and add it to the dispersion obtained in step 1, shake it with a constant temperature oscillator for 10 minutes;

[0070] Step 3: Weigh 0.4g of polylactic acid-glycolic acid and add it to the mixed solution obtained in step 2, and shake it in a constant temperature oscillator at 25°C for 2 hours to obtain a spinning solution;

[0071] Step 4: U...

experiment example 1

[0082] In the experiment, the composite fiber membrane of nano-hydroxyapatite / fish collagen / polylactic acid-glycolic acid was prepared by electrospinning method. The specific steps are as follows:

[0083] Step 1: Weigh 0.06g of nano-hydroxyapatite and disperse it in 2mL of hexafluoroisopropanol, and use an ultrasonic cell pulverizer to ultrasonically disperse for 1 hour;

[0084] Step 2: Weigh 0.02g fish collagen and add it to the dispersion obtained in step 1, shake it with a constant temperature oscillator for 10 minutes;

[0085] Step 3: Weigh 0.4g of polylactic acid-glycolic acid and add it to the mixed solution obtained in step 2, and shake it in a constant temperature oscillator at 25°C for 2 hours to obtain a spinning solution;

[0086] Step 4: Ultrasonically disperse the spinning solution obtained in Step 3 for 30 minutes again with an ultrasonic cell pulverizer;

[0087] Step 5: Prepare the nano-hydroxyapatite / fish collagen / polylactic acid-glycolic acid composite fi...

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Abstract

The invention discloses a gradient material for guiding regeneration of periodontal hard and soft tissues, and a preparation method of the gradient material. The gradient material is constructed by combining an electrostatic spinning technology with a biological 3D (three dimensional) technology. A micropore structure of an electrostatic spun fibrous membrane can prevent gingival fibroblasts frommigrating to a root surface to play a mechanical barrier role and facilitate transmission of nutrition and metabolism substances; and individualized repair of alveolar bone can be achieved according to clinical requirements since a structure and a shape of a 3D printing scaffold layer are highly designable. The method is simple and stable in preparation technology, and the gradient material integrates a periodontal guided tissue regeneration membrane and an alveolar bone repair scaffold material and has a potency to achieve clinical customized treatment. The gradient material has a good effectof guiding the repair of the hard and soft tissues in vivo and can be better applied to the synchronous regeneration and repair of the alveolar bone and the periodontal tissues.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a gradient material for guiding periodontal hard and soft tissue regeneration and a preparation method thereof. Background technique [0002] Guided Bone Regeneration (GBR) technology uses a barrier membrane to prevent the migration of gingival epithelium to the root surface, thereby creating enough space for the reconstruction and regeneration of damaged alveolar bone. Guided tissue regeneration technology provides a new strategy for adjuvant treatment of periodontal diseases and promotion of bone tissue regeneration. Traditional non-degradable GBR membranes need to be removed by secondary surgery, which will increase the risk of infection and patient pain, so they are gradually eliminated; collagen-based degradable membranes have a risk of disease transmission because their collagen components are mostly derived from mammalian tissues, and There is the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/46A61L27/56A61L27/58D01F1/10D01F6/92D04H1/435D04H1/728
CPCA61L27/46A61L27/56A61L27/58D01F6/92D01F1/10D04H1/728D04H1/435A61L2430/12A61L2430/34C08L89/00C08L67/04D01D5/0038D01D1/02D01F6/84C08L89/06A61L31/127A61L31/146A61L31/16A61L2400/12B33Y80/00C08K2003/325C08L75/04C08L5/08C08K3/32B29K2067/046D01D5/0084D10B2331/04B29K2073/00B29K2067/043D01D5/003B29K2075/00B32B37/144D10B2331/30D01F6/625B29K2005/00D10B2331/10B29K2067/04D10B2331/041
Inventor 李吉东金蜀鄂李玉宝左奕袁琛
Owner SICHUAN UNIV
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