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A gradient material for guiding periodontal hard and soft tissue regeneration and its preparation method

A gradient material, soft tissue technology, applied in tissue regeneration, spinning solution preparation, additive processing, etc., can solve problems such as loss of ability to maintain space, religious restrictions on disease transmission, achieve high cell affinity, and avoid the risk of disease transmission , the effect of improving the mechanical strength

Active Publication Date: 2021-10-08
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current clinical use of commercialized collagen-based guided tissue regeneration membranes (Bio-Gide, Bio-Mend, etc.) also has defects: (1) Loss of the ability to maintain space due to its rapid degradation behavior; (2) Collagen is mostly derived from mammals Organs or tissues, such as pig skin, beef Achilles tendon, etc., have the risk of potential disease transmission and religious restrictions

Method used

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  • A gradient material for guiding periodontal hard and soft tissue regeneration and its preparation method
  • A gradient material for guiding periodontal hard and soft tissue regeneration and its preparation method
  • A gradient material for guiding periodontal hard and soft tissue regeneration and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0052] A preferred embodiment of the present invention provides a method for preparing a gradient material to guide periodontal hard and soft tissue regeneration. The raw materials include: fish collagen from Sangon Biotechnology Co., Ltd., hexafluoroisopropanol from Aladdin Company, Shandong Jinan Daigang Biological Co., Ltd. The polylactic acid-glycolic acid of Technology Co., Ltd., the specific steps are as follows:

[0053] Step 1: Weigh 0.06g of nano-hydroxyapatite and disperse it in 2mL of hexafluoroisopropanol, and use an ultrasonic cell pulverizer to ultrasonically disperse for 1 hour;

[0054] Step 2: Weigh 0.02g fish collagen and add it to the dispersion obtained in step 1, shake it with a constant temperature oscillator for 10 minutes;

[0055] Step 3: Weigh 0.4g of polylactic acid-glycolic acid and add it to the mixed solution obtained in step 2, and shake it in a constant temperature oscillator at 25°C for 2 hours to obtain a spinning solution;

[0056] Step 4: U...

Embodiment 2

[0067] A preferred embodiment of the present invention provides a method for preparing a gradient material to guide periodontal hard and soft tissue regeneration. The raw materials include: fish collagen from Sangon Biotechnology Co., Ltd., hexafluoroisopropanol from Aladdin Company, Shandong Jinan Daigang Biological Co., Ltd. The polylactic acid-glycolic acid of Technology Co., Ltd., the specific steps are as follows:

[0068] Step 1: Weigh 0.06g of nano-hydroxyapatite and disperse it in 2mL of hexafluoroisopropanol, and use an ultrasonic cell pulverizer to ultrasonically disperse for 1h;

[0069] Step 2: Weigh 0.02g fish collagen and add it to the dispersion obtained in step 1, shake it with a constant temperature oscillator for 10 minutes;

[0070] Step 3: Weigh 0.4g of polylactic acid-glycolic acid and add it to the mixed solution obtained in step 2, and shake it in a constant temperature oscillator at 25°C for 2 hours to obtain a spinning solution;

[0071] Step 4: Ultra...

experiment example 1

[0082] In the experiment, the composite fiber membrane of nano-hydroxyapatite / fish collagen / polylactic acid-glycolic acid was prepared by electrospinning method. The specific steps are as follows:

[0083] Step 1: Weigh 0.06g of nano-hydroxyapatite and disperse it in 2mL of hexafluoroisopropanol, and use an ultrasonic cell pulverizer to ultrasonically disperse for 1h;

[0084] Step 2: Weigh 0.02g fish collagen and add it to the dispersion obtained in step 1, shake it with a constant temperature oscillator for 10 minutes;

[0085] Step 3: Weigh 0.4g of polylactic acid-glycolic acid and add it to the mixed solution obtained in step 2, and shake it in a constant temperature oscillator at 25°C for 2 hours to obtain a spinning solution;

[0086] Step 4: Ultrasonically disperse the spinning solution obtained in Step 3 for 30 minutes again with an ultrasonic cell pulverizer;

[0087] Step 5: Prepare the nano-hydroxyapatite / fish collagen / polylactic acid-glycolic acid composite fiber ...

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Abstract

The invention discloses a gradient material for guiding periodontal hard and soft tissue regeneration and a preparation method thereof. The gradient material of the invention is constructed by combining electrospinning technology with biological 3D printing technology. Due to the microporous structure of the electrospinning fiber membrane It can prevent gingival fibroblasts from migrating to the root surface to act as a mechanical barrier, and at the same time facilitate the transmission of nutrients and metabolic substances; due to the high designability of the structure and shape of the 3D printed scaffold layer, the alveolar bone can be personalized according to clinical needs repair. The preparation process of the method is simple and stable, integrates periodontal guiding tissue regeneration membrane and alveolar bone repair scaffold material, and has the potential to realize clinical customized treatment. The gradient material has a good effect of guiding hard and soft tissue repair in vivo, and can be better applied to synchronous regeneration and repair of alveolar bone and periodontal tissue.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a gradient material for guiding periodontal hard and soft tissue regeneration and a preparation method thereof. Background technique [0002] Guided Bone Regeneration (GBR) technology uses a barrier membrane to prevent the migration of gingival epithelium to the root surface, thereby creating enough space for the reconstruction and regeneration of damaged alveolar bone. Guided tissue regeneration technology provides a new strategy for adjuvant treatment of periodontal diseases and promotion of bone tissue regeneration. Traditional non-degradable GBR membranes need to be removed by secondary surgery, which will increase the risk of infection and patient pain, so they are gradually eliminated; collagen-based degradable membranes have a risk of disease transmission because their collagen components are mostly derived from mammalian tissues, and There is the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/46A61L27/56A61L27/58D01F1/10D01F6/92D04H1/435D04H1/728
CPCA61L27/46A61L27/56A61L27/58D01F6/92D01F1/10D04H1/728D04H1/435A61L2430/12A61L2430/34C08L89/00C08L67/04D01D5/0038D01D1/02D01F6/84C08L89/06A61L31/127A61L31/146A61L31/16A61L2400/12B33Y80/00C08K2003/325C08L75/04C08L5/08C08K3/32B29K2067/046D01D5/0084D10B2331/04B29K2073/00B29K2067/043D01D5/003B29K2075/00B32B37/144D10B2331/30D01F6/625B29K2005/00D10B2331/10B29K2067/04D10B2331/041
Inventor 李吉东金蜀鄂李玉宝左奕袁琛
Owner SICHUAN UNIV
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