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Composite bone material capable of being injected and preparation method thereof

A technology of bone material and collagen, applied in the field of injectable composite bone material and its preparation, can solve the problem of inability to meet the needs of minimally invasive in situ surgery, and achieve the effect of a wide range of applications

Inactive Publication Date: 2009-06-24
BEIJING ALLGENS MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the nanocrystalline calcium phosphate / collagen composite material is in a solid form, which cannot meet the needs of minimally invasive in situ surgery. For example, the preparation of injectable bone repair materials based on the nanocrystalline calcium phosphate / collagen composite material can maintain the imitation of natural bone structure. Features, and endow the material with new injectable properties, with a wider range of applications

Method used

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  • Composite bone material capable of being injected and preparation method thereof
  • Composite bone material capable of being injected and preparation method thereof
  • Composite bone material capable of being injected and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] (1) Dissolve 20g of collagen sol in 300ml of 0.5M acetic acid solution, slowly add 11ml of 1mol / l Na 2 HPO 4 and 18.3ml1mol / lCaCl 2 , while stirring with a magnetic stirrer; then slowly add 0.5ml of 1mol / l NaOH solution dropwise until the pH value is 7; let the solution stand for 1 day, remove the supernatant, centrifuge to separate the precipitate, and wash it repeatedly with deionized water After three times, put it into a freeze drier for drying, and make a dry powder after grinding. (See Figure 1a, Figure 1b, Figure 1c)

[0029] (2) Take by weighing 100 grams of calcium sulfate dihydrate, 0.25 grams each of sodium citrate and aluminum sulfate, add in the hydrothermal reaction solution, then add 567ml of water, at a reaction temperature of 120 ° C, a pressure of 0.15 MPa, and a stirring speed of 400 rpm React for 6 hours under certain conditions, then filter to obtain precipitate, bake in an oven at 120°C for 2-3 hours, and then put it in an oven at 90°C overnight...

Embodiment 2

[0032] (1) Dissolve 30g of collagen sol in 300ml of 0.5M acetic acid solution, slowly add 11ml of 1mol / l Na 2 HPO 4 and 18.3ml 1mol / lCaCl 2 , while stirring with a magnetic stirrer; then slowly add 0.5ml 1mol / l NaOH solution dropwise until the pH value is 7; let the solution stand for 5 days, remove the supernatant, centrifuge to separate the precipitate, and wash it repeatedly with deionized water After three times, put it into a freeze drier for drying, and make a dry powder after grinding.

[0033] (2) Take by weighing 200 grams of calcium sulfate dihydrate, 0.50 grams each of sodium citrate and aluminum sulfate, add in the hydrothermal reaction kettle, then add 1134ml of water, at a reaction temperature of 110 ° C, a pressure of 0.1 MPa, and a stirring speed of 200 rpm React for 5 hours under certain conditions, then filter to obtain precipitate, bake in an oven at 120°C for 2-3 hours, and then put it in an oven at 90°C overnight, grind to obtain a dry powder, which is c...

Embodiment 3

[0036] (1) Dissolve 8g of collagen sol in 300ml of 0.1M nitric acid solution, slowly add 10ml of 1mol / l (NH 4 ) 2 HPO 4 and 10ml 1mol / lCaCl 2, while stirring with a magnetic stirrer; then slowly add 0.5ml 1mol / l NaOH solution dropwise to pH 7; let the solution stand for 4 days, remove the supernatant, centrifuge to separate the precipitate, and wash it three times with deionized water Afterwards, put it into a freeze dryer for drying, and make a dry powder after grinding.

[0037] (2) Weigh 300 grams of calcium sulfate dihydrate, 0.75 grams each of sodium citrate and aluminum sulfate, add in the hydrothermal reaction kettle, then add 1701ml of water, at a reaction temperature of 130°C, a pressure of 0.2MPa, and a stirring speed of 500 rpm React for 8 hours under certain conditions, then filter to obtain precipitates, bake in an oven at 120°C for 2-3 hours, and then put it in an oven at 90°C overnight, and grind to obtain a dry powder, which is calcium sulfate hemihydrate po...

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Abstract

The invention relates to an injectable composite bone material and a preparation method thereof, and belongs to the technical field of biomaterial. The injectable composite bone material is prepared from collagen stroma nanocrystal calcium phosphate and semi-hydrated calcium sulphate powder by mixing, while sterilized medical water is prepared from the injectable composite bone material according to a certain ratio of liquid to solid, so that the liquid phase and the solid phase can be mixed evenly to prepare the injectable composite bone material during use. The material and the method introduce semi-hydrated calcium sulphate into nanocrystal calcium phosphate / collagen composite material with a natural bone classification structure and characteristics to prepare an injectable bone repair material so as to realize performance complementation, not only can maintain the characteristics of the imitated natural bone structure, but also endow new injectable performance to the materials, thereby having wider application range.

Description

technical field [0001] The invention belongs to the field of biomaterial science, and in particular relates to an injectable composite bone material and a preparation method thereof. Background technique [0002] Osteoporosis is one of the major diseases that threaten human health. At present, vertebral body collapse and fractures caused by osteoporosis still lack effective treatment methods, which have become medical problems that need to be solved urgently. In recent years, a new minimally invasive technique—percutaneous vertebral augmentation has been applied clinically, and its curative effect is definite in preventing vertebral fractures and restoring vertebral body height. The injectable self-curing bone repair material used in this technology is an in situ bone tissue regeneration repair material, which meets the requirements of minimally invasive surgical techniques, with small tissue damage, no damage to the blood supply of the repair area, easy operation, Much att...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/02
Inventor 崔菡胡堃刘茜
Owner BEIJING ALLGENS MEDICAL SCI & TECH
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