49 results about "Left coronary artery" patented technology

A prosthetic aortic valve is designed to be implanted in the natural aortic annulus and to extend into the ascending aorta to a point short of the right and left coronary arteries. Blood leakage around the valve is prevented by tension in one or more circumferential cords drawing annular tissue into sealing contact with an external sealing ring on the valve body. The security of the valve's attachment to a patient is assured with a plurality of interrupted sutures between a semirigid flange on the valve outer surface and the patient's aortic commissures and / or the patient's ascending aortic wall. The sutures are preferably attached to posts or cleats on the semirigid sewing flange, the flange being spaced apart from the valve inlet by the sealing ring.

A vibrator for use in enhancement of pre-hospital coronary thrombolysis comprising a vibration source operable to generate vibration at a frequency in the range of 1-1000 Hz with at least a pair of oscillatory contacts spaced to enable simultaneous seating to the anatomic left and right of the sternum (such as to match the geometry of the right and left coronary arteries) of a patient in need of coronary thrombolysis. The preferred vibrator is operable to emit vibration in the low frequency sonic range (at least 20 Hz) with an amplitude of about 1 mm-15 mm (and more preferably greater than 2 mm), such as to provide an effective transthoracic tool for acute coronary thrombolysis applications. In a variation, greater than a pair of contacts are utilized to provide oscillatory contact at differing intercostal space levels (in order to maximize vibratory penetration to the heart which is variably situated depending on the patient's anatomy).

The invention provides a method and a device for dividing a coronary artery. The method comprises the following steps: (1) determining the position of an aorta in an original image, and performing reinforced filtering on the original image, thereby obtaining a reinforced filtered image; (2) obtaining the starting areas of a left coronary artery and a right coronary artery according to the position of the aorta, the original image and the gray scale of the reinforced filtered image; (3) dividing the reinforced filtered image based on at least one preset dividing threshold, obtaining a candidate area which corresponds with the preset threshold, and determining the candidate areas of the left coronary artery and the right coronary artery according to the candidate area and the starting areas of the left coronary artery and the right coronary artery; and (4) according to the position relationship between the aorta and the candidate areas of the left coronary artery and the right coronary artery, respectively screening the candidate areas of the left coronary artery and the right coronary artery, connecting the screened candidate areas with the starting areas, and obtaining the left coronary artery and the right coronary artery. The method and the device provided by the technical solution of the invention can wholly, accurately and automatically extract the left coronary artery and the right coronary artery, thereby facilitating qualitative and quantitative analysis and treatment for diseases of angiocardiopathy by a doctor.

The invention discloses a spherical space division-based coronary artery automatic segmentation and anatomic marking method. The method comprises the following steps of (1) performing image preprocessing: obtaining a coronary artery segmentation image and a central line; (2) performing a pruning operation; (3) defining a spherical center and a spherical space; (4) executing a division rule of left and right coronary arteries; (5) executing a left coronary artery anatomic naming algorithm; and (6) executing a right coronary artery anatomic naming algorithm. According to the method, a spherical coordinate system is established by taking a vessel divergence point as the spherical center through utilizing characteristics of a heart-shaped inverted cone, and the blood vessel is located and dissected in the spherical space according to anatomic shapes of branch segments of the coronary arteries and a geometric structure relationship among the anatomic shapes, so that the purposes of automatic segmentation and anatomic marking are achieved; the problems of relatively long calculation time, relatively high algorithm complexity and inaccurate branch matching caused by incapability of exhausting coronary artery distribution types in an existing coronary artery automatic segmentation and anatomic marking method are solved; and compared with a method for matching the extracted blood vessel with a prior model, the spherical space division-based coronary artery automatic segmentation and anatomic marking method has the advantages that the time is shortened, the marking is accurate, and more segments can be identified and marked.

Systems and methods to provide end to end stabilization support to the operational catheter and reduce the need to stabilize or push from the lateral wall of the aorta during coronary interventions. This reduces the potential for stroke from plaque breaking off the wall of the aorta during intervention procedures. A support and stabilization wire having one end at the femoral percutaneous access and the second end at a radial percutaneous access is established for end to end stabilization. A bifurcated catheter having a wide lumen for procedural catheters and a narrow lumen for the support wire or catheter is advanced over the support wire to the aortic arch. A procedural catheter and a variety of different shaped guide wires may be deployed from the wide lumen of the bifurcated catheter into the right or left coronary artery to accommodate a range of aortic anatomical considerations during the coronary interventions.

The present invention, which addresses the needs described above, resides in an apparatus and method for coupling vascular apertures to a blood supply vessel in a manner that minimizes the time and operator dependent inconsistency in performing vascular anastomoses. In the coronary setting, this concept is fast and can be applied to both conventional and minimally invasive operative techniques. In the preferred embodiment, the present invention relates to an apparatus and method for facilitating end-to-side vascular anastomoses procedure, whereby the present invention acts as a coupling apparatus between a first, blood supplying hollow organ, e.g. the LIMA, radial artery, or a saphenous vein and the side wall of second hollow organ, typically one of the major coronary arteries, such as the left coronary artery (LCA), right coronary artery (RCA) or the circumflex (CX).

The invention discloses an automatic segmentation and naming method of cardiac coronary artery vessels. The method comprises the steps of: S1, extracting vessel center lines of a cardiac coronary artery 3D image, and defining three-dimensional coordinates of each point in the vessel center lines; S2, identifying a left coronary artery and a right coronary artery from the cardiac coronary artery vessels; S3, identifying RCA, R-PDA and R-PLB from the identified right coronary artery; S4, identifying LM, LAD and LCX from the identified left coronary artery; S5, identifying OM1, OM2 and OM3 from the identified LCX; S6, identifying D1, D2 and D3 from the identified LAD; and S7, identifying RI from the identified LAD and LCX. According to the method, an identification algorithm in each step is improved on the basis of center line data of the cardiac coronary artery vessels, and needed target blood vessels can be accurately and automatically identified from tens to hundreds of vessels and accurately named.

A method of cardiac radiological examination for coronarography comprises the steps of:a) introducing contrast medium simultaneously in the left coronary artery and in the right coronary artery from the aortic root and, in parallel,b) acquiring a sequence of dynamic images of the propagation of the contrast medium in the left and right coronary arteries with a displacement of the image plane, during the acquisition of said images, along a determined trajectory (E28). The contrast medium can be introduced in a cyclic manner during the acquisition of dynamic images, each cycle of introduction corresponding to a phase of closure of the aortic valve in the cardiac rhythm. 3D and 4D images with optimal efficiency can be obtained in the use of contrast medium. An injection device for producing the above cycles is synchronized with the introduction of the contrast medium.

The present invention relates to a cardiovascular diagnostic system which enables early detection of cardiovascular diseases and defines their causes. Unlike known electrocardiographs, the cardiovascular diagnosis system can further measure elastic coefficient of blood vessels (the degree of arteriosclerosis), blood vessel compliance, blood flow, and blood flow resistance and velocity in blood vessel branches of the right and left coronary arteries. The elastic coefficient shows organic changes to blood vessels. The compliance shows organic and functional changes of blood vessels simultaneously. The blood flow shows blood flow resistance.

The invention provides a device for analyzing cardiovascular and cerebrovascular characteristics and blood characteristics and a detecting method, belonging to the field of medical equipment. The device comprises a pressure pulse wave sensor, a carotid artery and vertebral artery rheogram inductance electrode, an electrocardiogram inductance electrode, a cardiophonogram sensor, a signal receiver, a main processor and an in-out part. The device can realize the cardiovascular and cerebrovascular noninvasive detection, and biomechanically analyzes each branched blood vessel of the cardiovascular and cerebrovascular system by measuring the blood pressure and the blood flow volume of a left cervical vertebra artery, a right cervical vertebra artery, a cerebrum front artery, a cerebrum middle artery, a cerebrum back artery, a left coronary artery and a right coronary artery, obtains biomechanics indexes such as the elasticity coefficient, the compliance, the blood resistance, the blood flow volume and the like of each branched blood vessel of the cardial blood vessel and the brain blood vessel, has an important significance for the early diagnosis of the myocardial infarction and the cerebral thrombosis by taking as equipment for the cardiography, the magnatic resonance imaging MRI, the CT and the like and supplementary equipment between the TCD and the ECG.

Methods and devices for performing intravascular endarterectomy. Methods includes intravascularly advancing a catheter having a carbon dioxide delivering distal end past a plaque-occluded vessel site, passing the distal end between the plaque and vessel wall. Other methods include intravascularly advancing paddles between plaque and vessel walls, including ultrasonic imaging paddles, ultrasonic vibrating paddles, and mechanically vibrating paddles. Some methods include providing intravascular devices having radially expandable jaws or paddles, and advancing those jaws or paddles along vessel walls to separate plaque from vessel walls. Still other methods include providing an anchoring guide catheter adapted to establish a suction grip around the left coronary artery ostium, and to use the anchored guide catheter to support intravascularly introduced endarterectomy devices operating on plaque in the left main coronary artery. One method utilizes retroperfusion of the coronary arteries to allow the anchoring guide catheter to remain in position for longer periods. Scissors-type expanding devices and stents for use after endarterectomy procedures are also provided.

The invention provides a bending adjusting handle and a bending adjustable catheter with the bending adjusting handle. The bending adjustable catheter comprises a catheter body, the bending adjustinghandle and at least two traction parts, wherein at least two bending adjustable sections arranged at an interval are arranged at the remote end of the catheter body; the bending adjusting handle comprises a driving mechanism and a control mechanism connected with the driving mechanism; the remote end of each traction part is connected with one of the bending adjustable sections; and the near end of each traction part is connected with a secondary sliding part of the driving mechanism of the bending adjusting handle. By manipulating the bending adjusting handle, the bending adjustable sectionscan be simultaneously driven to be bent to form different composite bending shapes, or one bending adjustable section is separately driven to be bent to finely adjust the bending shape of the corresponding bending adjustable section, so that operations such as a left coronary artery intervention operation and a right coronary artery intervention operation with different requirements on morphologies of the remote end of the bending adjustable catheter can be performed by using one same bending adjustable catheter, and individual differences of physiological anatomical structures of lumens of different paints can be met.

The invention discloses a valved homograft conduit, which comprises an artificial blood vessel and an artificial valve. The artificial blood vessel is provided with a near end to a heart and a far end to the heart, and the artificial valve is located at the near end to the heart of the artificial blood vessel. A left opening and a right opening are arranged on the lateral wall of the artificial blood vessel at the positions close to the artificial valve, and the positions of the left opening and the right opening correspond to openings of a left coronary artery and a right coronary artery. The valved homograft conduit further comprises a hard homograft conduit which is communicated with the artificial blood vessel and is ligatured with an aorta through a ligation belt, wherein the hard homograft conduit comprises a hard homograft conduit of the near end to the heart, the hard homograft conduit of the near end to the heart is located between the left opening, the right opening and the far end to the heart and is close to the near end to the heart of the artificial blood vessel. A space is formed between the ligation position and an aortic valve, and blood not only is supplied to a whole body along the artificial blood vessel, but also flows into the space through the openings, and further is supplied to the left coronary artery and the right coronary artery. The openings and the coronary arteries are not needed to be sutured, and the bleeding probability of an anastomotic stoma is reduced.

The invention discloses a coronary artery recognition method and device. One embodiment of the method comprises the following steps: acquiring two quasi-center lines of a coronary artery; calculatingthe minimum distance from each measurement point on the two quasi-center lines to the left ventricle, the left atrium, the right ventricle and the right atrium respectively to obtain a first distance,a second distance, a third distance and a fourth distance correspondingly; sorting the first distance, the second distance, the third distance and the fourth distance corresponding to each measurement point from small to large; selecting left coronary artery feature points and right coronary artery feature points from all the measurement points on the two quasi-center lines based on the sorting result of each measurement point, and counting the number of the left coronary artery feature points and the right coronary artery feature points on each quasi-center line; and determining whether thecoronary artery corresponding to the quasi-center line is the left branch or the right branch based on the number of the left coronary artery feature points or the number of the right coronary arteryfeature points. Therefore, the accuracy of coronary artery left and right branch identification is improved.

The invention relates to an image analysis method, computer equipment and a storage medium. The image analysis method comprises the steps of: acquiring coordinates of coronary artery origin points ina coronary artery angiography image to be analyzed according to the coronary artery angiography image to be analyzed and a preset origin point detection model, wherein the coordinates of the coronaryartery origin points comprise the coordinates of the left coronary artery origin point and the coordinates of the right coronary artery origin point; acquiring an ascending aorta segmentation image corresponding to the coronary angiography image to be analyzed according to the coronary angiography image to be analyzed, and extracting a central line of an ascending aorta of the ascending aorta segmentation image; analyzing the coronary angiography image to be analyzed according to the coordinates of the left coronary artery origin point, the coordinates of the right coronary artery origin pointand the central line of the ascending aorta to obtain an analysis result, wherein the analysis result is used for representing whether the coronary artery origin in the coronary angiography image tobe analyzed is abnormal or not. By adopting the image analysis method, the efficiency of analyzing whether the coronary artery origins in the coronary angiography image to be analyzed is abnormal or not can be improved.

The invention discloses function and application of a Caspase activation and recruitment domain 3 (Card3) gene in a coronary atherosclerotic heart disease. The Card3 gene knockout mice and heart specific Card3 transgenic mice are taken as objects, and a research is carried out on a myocardial infarction model caused by blocking mice heart ramus descendens anterior arteriae coronariae sinistrae. The result proves that compared with WT mice, the cardiac infarction proportion, and the degrees of myocardial hypertrophy and fibrosis of the Card3 gene knockout mice are obviously inhibited, and the cardiac function is obviously improved; the phenotype of the Card3 transgenic mice is contrary to that of the Card3 gene knockout mice. Consequently, the Card3 gene can promote and increase development and progression of the coronary atherosclerotic heart disease, the Card3 can be used as a drug target for screening the drugs for treating the coronary atherosclerotic heart disease, and the inhibitor of the Card3 can be applied to preparation of a drug for treating the coronary atherosclerotic heart disease.

The embodiment of the invention discloses a CT image processing method and device. The method comprises the steps that a CT image is acquired, and the parameters of the CT image coronary arteries in the CT image are identified and determined, wherein the CT image coronary arteries includes a CT image left coronary artery and a CT image right coronary artery; the CT image coronary artery types of the CT image coronary arteries are determined according to the parameters of the CT image coronary arteries, wherein the CT image coronary artery types include a left advantage and a right advantage; different segments different from a preset coronary artery model are determined according to the preset CT image coronary artery model; and the parameter indexes of the different segments are calculated according to a preset score table. According to the CT image processing method and device, different segments different from the preset coronary artery model are determined according to the preset CT image coronary artery model, different parts can be automatically identified and different characteristics can be analyzed so that the scoring difficulty can be reduced and scoring time can be shortened; besides, the parameter indexes of the different segments are calculated according to the preset score table so that user reference is facilitated, and the accuracy of the scoring result can be enhanced.

The invention belongs to the field of pharmacy, and relates to a new application of a compound GSK-J1 HCL to pharmacy, in particular to an application of a histone demethylase JMJD3 inhibitor GSK-J1 HCL to preparation of a medicine for treating myocardial fibrosis. Through an established myocardial fibrosis model caused by a mouse left coronary artery ligation operation and an Ang II induced NRCFs in-vitro myocardial fibrosis model experiment, a result shows that the GSK-J1 HCL has a regulation and control effect on myocardial fibrosis by inhibiting expression of JMJD3 to reduce collagen content and reducing expression of fibrosis related protein. The compound GSK-J1 HCL (C22H23N5O2.HCL) and the related inhibitor thereof can be used for preparing the medicine for preventing and treating myocardial fibrosis diseases.

The invention discloses an application of signal regulatory protein alpha (SIPR alpha, SHPS-1) genes in coronary atherosclerotic heart diseases, belonging to the field of function and application of genes. Mice of which the SHPS-1 genes are knocked out and cardiac-specific SHPS-1 transgenic mice are adopted as experimental subjects; MI (myocardial infarction) models are formed by blocking LAD (left anterior descending coronary artery) of the hearts of the mice, and the result shows that compared with WT (wild type) control mice, the cardiac infarction proportion, cardiac hypertrophy and degree of fibrosis of the mice of which the SHPS-1 genes are knocked out, subjected to an MI operation, are obviously inhibited, and the cardiac functions of the mice are obviously improved; the cardiac infarction proportion, cardiac hypertrophy and degree of fibrosis of the cardiac-specific SHPS-1 transgenic mice are obviously increased, and the cardiac functions of the mice are obviously worsened, so that the result shows that the SHPS-1 genes can promote and worsen the occurrence and development of the coronary atherosclerotic heart diseases; SHPS-1 can be used as a medicament target for screening medicaments which are used for treating the coronary atherosclerotic heart diseases; an inhibitor of SHPS-1 can be used for preparing the medicaments for treating the coronary atherosclerotic heart diseases.

The invention discloses a coronary artery projection image generation method and device and a computer readable medium. One embodiment of the method comprises the following steps: acquiring a coronaryartery computed tomography angiography (CTA) sequence image; carrying out segmentation processing on the coronary artery CTA sequence image to generate two connected region images; identifying the two connected region images to generate a left coronary artery three-dimensional segmentation image and a right coronary artery three-dimensional segmentation image; and performing image projection processing on the left coronary artery three-dimensional segmented image and the right coronary artery three-dimensional segmented image to generate a left coronary artery tree two-dimensional image and aright coronary artery tree two-dimensional image. According to the invention, the left coronary artery CTA sequence image can be processed by the artificial intelligence model to generate the left coronary artery three-dimensional segmentation image and the right coronary artery three-dimensional segmentation image; therefore, maximum density projection is generated for the left coronary artery tree and the right coronary artery tree, interference of other tissues or blood vessel branches on coronary arteries is eliminated, and doctors can observe related problems of disease diagnosis such asblood vessel bifurcation, calcification or stenosis.

The invention belongs to the field of pharmacy and relates to novel application of a compound EPZ5676 in pharmacy, in particular to application of a compound EPZ567 (C30H42N8O3) and a related inhibitor thereof in preparing a drug for preventing and treating myocardial fibrosis diseases. According to the application, a model experiment for myocardial fibrosis caused by left coronary artery ligationoperation of mice and a TGF-beta induced aCFs in vitro myocardial fibrosis model experiment are established; the results show that the content of collagen is reduced by inhibiting the expression of DOT1L through the EPZ5676, and the regulation action of expression of fibrosis-related protein on myocardial fibrosis is reduced; the compound EPZ5676 inhibits a fibrosis effect of primary myocardial fibroblasts. The compound EPZ5676 and the related inhibitor thereof can be used for preparing a drug for preventing and treating the myocardial fibrosis diseases.

Disclosed herein is a catheter for a left coronary artery having a distal end for being introduced into an opening of the left coronary artery from an artery of an arm. The catheter can include a catheter main body including a main body portion of a substantially linear shape in a natural state thereof and a curved portion extending from the main body portion to form a portion that extends to the distal end and has a curved shape in a natural state thereof.

The invention provides a preparation method and an evaluation system of animal models of syndrome of blood stasis caused by myocardial ischemia and syndrome of blood stasis caused by myocardial ischemia and deficiency of vital energy, belonging to the technical field of research on syndrome of traditional Chinese medicine for preparing and evaluating disease and syndrome combined animal models. The animal model of syndrome of blood stasis caused by myocardial ischemia is created by putting an Ameroid constriction ring in the coronary artery. 1 to 8 weeks later after operating on an animal pattern, the processes of dynamic observation, physicochemical index detection, electrocardiogram, ultrasonic cardiogram and coronary radiography are carried out, and 4 weeks after the operation, the animal pattern accords with the diagnosis of syndrome of blood stasis caused by myocardial ischemia. The animal model of syndrome of blood stasis caused by myocardial ischemia and deficiency of vital energy is prepared by ligating left coronary artery. 30 days later after operating on another animal pattern, the processes of dynamic observation, electrocardiogram, ultrasonic cardiogram and pathology detection are carried out, and about 7 days after the operation, the animal pattern is found to accord with the diagnosis of syndrome of blood stasis caused by myocardial ischemia and deficiency of vital energy and still support the diagnosis of syndrome of blood stasis caused by myocardial ischemia until 30 days before material drawing.

The invention relates to the technical field of medicine, in particular to a cardiac thrombosis animal model and a construction method thereof. The construction method comprises the following steps: introducing a chlorophosphonate preparation into the abdominal cavity of an animal; after 0.5-2 days, carrying out ligation on the anterior descending branch of the left coronary artery of the animal in the anesthetic state; and after ligation for 0.5-2 days, introducing the chlorophosphonate preparation into the abdominal cavity of the animal again. The mouse myocardial infarction model is prepared by a method of myocardial infarction modeling, injection of a small amount of chlorophosphonate lipidosome before and after an operation and removal of macrophages in a short period, and the success rate of left ventricular thrombus formation of a modeling mouse reaches 90% or above. The method is simple and easy to implement and can be widely popularized and applied to experimental animals of various body types, the left ventricular thrombosis forming rate is high, the effect is stable, the modeling time is short, and the cardiac thrombosis animal model is closer to the pathophysiological state of left ventricular thrombosis after myocardial infarction clinically.

The invention relates to the technical field of medical devices, in particular to a dual-head coronary artery direct perfusion tube, which is composed of a handle, a left coronary artery perfusion head, a hard connecting rod, a high-density right coronary artery perfusion head and a soft perfusion tube. As that weight of the right coronary artery perfusion head is several time of that of the leftcoronary artery perfusion head, the right coronary artery perfusion head can be naturally lowered to the right coronary artery orifice and position under the action of gravity. As that double-headed coronary artery direct perfusion tube of the invention is use, the left coronary artery and the right coronary artery can be simultaneously perfusion, the perfusion time is shortened by half, the wholeoperation time is greatly shorten, the operation risk can be reduced, and great benefits are brought to the patients. The double-headed coronary artery direct perfusion tube of the invention can simultaneously perfusion the left coronary artery and the right coronary artery, thus shortening the perfusion time by half.

The invention provides a method and a device for dividing a coronary artery. The method comprises the following steps: (1) determining the position of an aorta in an original image, and performing reinforced filtering on the original image, thereby obtaining a reinforced filtered image; (2) obtaining the starting areas of a left coronary artery and a right coronary artery according to the position of the aorta, the original image and the gray scale of the reinforced filtered image; (3) dividing the reinforced filtered image based on at least one preset dividing threshold, obtaining a candidate area which corresponds with the preset threshold, and determining the candidate areas of the left coronary artery and the right coronary artery according to the candidate area and the starting areas of the left coronary artery and the right coronary artery; and (4) according to the position relationship between the aorta and the candidate areas of the left coronary artery and the right coronary artery, respectively screening the candidate areas of the left coronary artery and the right coronary artery, connecting the screened candidate areas with the starting areas, and obtaining the left coronary artery and the right coronary artery. The method and the device provided by the technical solution of the invention can wholly, accurately and automatically extract the left coronary artery and the right coronary artery, thereby facilitating qualitative and quantitative analysis and treatment for diseases of angiocardiopathy by a doctor.

The invention provides an application of ganoderma spore oil to preparation of a cardiovascular disease prevention and treatment medicine. A ligated left coronary artery induced hypertension heart disease model is used for analyzing cardiac functions by taking ventricular wall thicknesses in a contraction period and a relaxation period, inner diameter data, left ventricular ejection fraction and the like as observation indexes, results indicate that separate active components including the ganoderma spore oil extracted from ganoderma spores can improve the cardiac functions under the condition of effective dose 3g / (kg*BW), ejection fraction reaches 66.02 and approximates blank control group values, heart blood output quantity is effectively improved, particularly, left ventricular relaxation capacity is obviously changed, and the ganoderma spore oil has the function of preventing cardiovascular diseases and can be used for preparing the cardiovascular disease prevention and treatment medicine.

The invention provides an image processing method and device, and the method comprises the steps of obtaining an aorta key layer based on a coronary artery origin image, and enabling the aorta key layer to comprise an aorta region, a first coronary artery connected domain, and a second coronary artery connected domain; establishing a first preset coordinate system by taking the central point of the aorta region as an original point; based on a first coordinate axis in the first preset coordinate system, determining coordinates of a left coronary artery origin point and coordinates of a right coronary artery origin point, wherein the right coronary artery origin point is the center point of the first coronary artery connected domain, and the left coronary artery origin point is the center point of the second coronary artery connected domain; and based on the coordinate of the left coronary origin point and the coordinate of the right coronary origin point, obtaining a determination result, wherein the determination result is used for determining whether the coronary origin of the coronary origin image is abnormal. According to the technical scheme, the left coronary origin point and the right coronary origin point can be quickly and accurately positioned, and the coronary origin abnormity judgment efficiency is improved.