92 results about "Functional change" patented technology

A method and system are provided for determining a condition of a selected region of epithelial tissue. At least two current-passing electrodes are located in contact with a first surface of the selected region of the tissue. A plurality of measuring electrodes are located in contact with the first surface of the selected region of tissue as well. Electropotential and impedance are measured at one or more locations. An agent may be introduced into the region of tissue to enhance electrophysiological characteristics. The condition of the tissue is determined based on the electropotential and impedance profile at different depths of the epithelium, tissue, or organ, together with an estimate of the functional changes in the epithelium due to altered ion transport and electrophysiological properties of the tissue.

Methods and systems are provided for determining a condition of an organ, or epithelial or stromal tissue, for example in the human breast. The methods incorporate sonophoresis, the application of ultrasonic energy, in order to condition tissue for testing and enhance test measurements. A plurality of electrodes are used to measure surface and transepithelial electropotential and impedance of breast tissue at one or more locations and at several frequencies, particularly very low frequencies. An agent may be introduced into the region of tissue to enhance electrophysiological characteristics. Pressure, drugs and other agents can optionally be applied for enhanced diagnosis. Tissue condition is determined based on the electropotential and impedance profile at different depths of the epithelium, stroma, tissue, or organ, together with an estimate of the functional changes in the epithelium due to altered ion transport and electrophysiological properties of the tissue. Devices for practicing the disclosed methods are also provided.

A non-invasive apparatus system for monitoring autonomic nervous system, and its uses in monitoring autonomic nervous system functional change side effects caused by drugs and monitoring the aging of autonomic nervous system and tracing therapeutic effect thereof.

A method and system for analysis of fluorescence emission spectroscopy data and fluorescence lifetime imaging microscopy data are described. A unique Laguerre expansion can be found for fluorescence intensity decays of arbitrary form with convergence to a correct solution faster than with conventional methods. The Laguerre expansion technique includes expansion coefficients highly correlated with intrinsic fluorescence lifetimes, allowing direct characterization of fluorescence dynamics. For complex systems, conventional analysis of fluorescence intensity decay in terms of discrete exponential components can not readily provide a true representation of underlying fluorescence dynamics. Utilizing the Laguerre expansion technique, an alternative non-parametric method for analysis of time-resolved fluorescence data from various systems is described, facilitating characterization and discrimination of a sample. An ultra-fast method for analysis of fluorescence lifetime imaging is also described, facilitating real-time analysis of compositional and functional changes in samples, at a microscopic or macroscopic level.

Human and mammalian skin undergoes a variety of changes associated with chronological aging. Various environmental factors, disease states and genetic disorders may accelerate both the appearance of aging skin and also the structural and functional changes associated with aging skin. Ultraviolet radiation from the sun is one of the classic known and well-defined means of accelerating or worsening the aging of the skin and this is frequently termed photoaging. Other environmental factors, such as oxidative stress, free radicals, environmental toxins such as ozone and cultural customs or habits such as tobacco smoking are other known probe accelerators in photo aging skin. A wide variety of other factors known and unknown contribute to accelerated or premature aging of the skin. This invention discusses methods where electromagnetic radiation, in particular, light, can be used to photobiomodulate the activity of living cells to delay, diminish, retard or even reverse the structural and functional effects of aging of the skin and other living cells and tissues. In particular methods described for improving the appearance, structure, function of aging skin, including up and down regulating the genotypic markers for the phenotype of aging skin.

The invention discloses a software testing method, device and system. The method comprises the following steps: receiving a testing request of a software to be tested; acquiring the information of two different versions of the software to be tested, achieving differential comparison to acquire differential data, building functional change functions of the differential data and saving the functional change functions in a database; retrieving functional application functions of test cases saved in a tagged database; according to the matching between the built function change functions of the differential data and the retrieved functional application functions of the test cases saved in the tagged database, building the corresponding relation between the differential data and the test cases; determining the test cases of the software to be tested; and testing the software to be tested according to the determined test cases. According to the invention, the accuracy and the performability in software testing are improved.

A method and system provides for electrophysiological data analysis in a networked processing environment. The method and system includes receiving, via a networked connection, electrophysiological data of a patient and electronically performing, via at least one network processing device, a data analysis on the electrophysiological data. The method and system includes generating at least one report based on the data analysis, wherein the at least one report includes determination of one or more intervention options for the patient and therein transmitting the report to a recipient device across the network connection for utilization with the patient. The results of the report direct the user to apply from within the same system non-invasive brain stimulation, neurofeedback, and biofeedback modalities. Re-assessment can occur from within the same system following the training or modulation of electrophysiology and thereby generate a comparison report showing functional changes from the provided intervention or combined interventions.

In accordance with embodiments, there are provided techniques for managing functionality changes of an on-demand database system. The techniques facilitate implementing changes to the database system while minimize work flow reductions to users of the database system. To that end, one embodiment of the present invention delays implementation of the changes to provide users of the system an opportunity to adjust behavioral interaction with the database. In accordance with another embodiment of the present invention, users may implement the functional changes to determine any adverse impact on work flow, before the functional changes become permanent. In another embodiment, the user may be afforded an opportunity to selectively enable and disable the functionality changes before the duration expires.

A non-invasive apparatus system for monitoring autonomic nervous system, and its uses in monitoring autonomic nervous system functional change side effects caused by drugs and monitoring the aging of autonomic nervous system and tracing therapeutic effect thereof.

A method and system for analysis of fluorescence emission spectroscopy data and fluorescence lifetime imaging microscopy data are described. A unique Laguerre expansion can be found for fluorescence intensity decays of arbitrary form with convergence to a correct solution faster than with conventional methods. The Laguerre expansion technique includes expansion coefficients highly correlated with intrinsic fluorescence lifetimes, allowing direct characterization of fluorescence dynamics. For complex systems, conventional analysis of fluorescence intensity decay in terms of discrete exponential components can not readily provide a true representation of underlying fluorescence dynamics. Utilizing the Laguerre expansion technique, an alternative non-parametric method for analysis of time-resolved fluorescence data from various systems is described, facilitating characterization and discrimination of a sample. An ultra-fast method for analysis of fluorescence lifetime imaging is also described, facilitating real-time analysis of compositional and functional changes in samples, at a microscopic or macroscopic level.

A universal linker structure is provided, in which a functional group and activating leaving group are placed on a tether, allowing the placement of an electrophile at the end of any nucleic acid sequence. The electrophile on the tether can react with a second nucleic acid carrying a nucleophile when the two nucleic acids are hybridized near one another, resulting in release of the leaving group, and creation of a functional change. The linker can be designed to destabilize the ligation product without slowing the rate of reaction. This lowers product inhibition, and the target DNA or RNA can become a catalyst for isothermally generating multiple signals for detection. This enhanced signal is demonstrated in solution experiments and in solid supported assays. The universal linkers of the present invention are simple and inexpensive to prepare, and can be appended to any polynucleotide in automated steps on a standard DNA synthesizer.

Human and mammalian skin undergoes a variety of changes associated with chronological aging. Various environmental factors, disease states and genetic disorders may accelerate both the appearance of aging skin and also the structural and functional changes associated with aging skin. Ultraviolet radiation from the sun is one of the classic known and well-defined means of accelerating or worsening the aging of the skin and this is frequently termed photoaging. Other environmental factors, such as oxidative stress, free radicals, environmental toxins such as ozone and cultural customs or habits such as tobacco smoking are other known probe accelerators in photo aging skin. A wide variety of other factors known and unknown contribute to accelerated or premature aging of the skin. This invention discusses methods where electromagnetic radiation, in particular, light, can be used to photobiomodulate the activity of living cells to delay, diminish, retard or even reverse the structural and functional effects of aging of the skin and other living cells and tissues. In particular methods described for improving the appearance, structure, function of aging skin, including up and down regulating the genotypic markers for the phenotype of aging skin.

Human and mammalian skin undergoes a variety of changes associated with chronological aging. Various environmental factors, disease states and genetic disorders may accelerate both the appearance of aging skin and also the structural and functional changes associated with aging skin. Ultraviolet radiation from the sun is one of the classic known and well-defined means of accelerating or worsening the aging of the skin and this is frequently termed photoaging. Other environmental factors, such as oxidative stress, free radicals, environmental toxins such as ozone and cultural customs or habits such as tobacco smoking are other known probe accelerators in photo aging skin. A wide variety of other factors known and unknown contribute to accelerated or premature aging of the skin. This invention discusses methods where electromagnetic radiation, in particular, light, can be used to photobiomodulate the activity of living cells to delay, diminish, retard or even reverse the structural and functional effects of aging of the skin and other living cells and tissues. In particular methods described for improving the appearance, structure, function of aging skin, including up and down regulating the genotypic markers for the phenotype of aging skin.

The present invention relates to a cardiovascular diagnostic system which enables early detection of cardiovascular diseases and defines their causes. Unlike known electrocardiographs, the cardiovascular diagnosis system can further measure elastic coefficient of blood vessels (the degree of arteriosclerosis), blood vessel compliance, blood flow, and blood flow resistance and velocity in blood vessel branches of the right and left coronary arteries. The elastic coefficient shows organic changes to blood vessels. The compliance shows organic and functional changes of blood vessels simultaneously. The blood flow shows blood flow resistance.

The invention relates to a commercial multi-functional change exchange machine and an exchange method thereof. The change exchange machine comprises a main controller, an interactive touch screen (1), a monitoring pick-up head (2), a state display device (3), a paper money inlet slot (4), a coin inlet slot (5), a standby interface (6), a receipt printing device (7), a coin output slot (8), a paper money output slot (9), and a scanning device (10). The machine has the following beneficial effects: the machines can be applied to all corners of the city and thus exchanged money amount is increased; and the exchange ways contains network-bank-based ways like the alipay-based way and the wechat-payment-based way and the like, and the O2O type network management platform is introduced, so that usage of future product owners can be realized. The machine can be applied to all self-service supermarkets, shopping malls or leisure sites and the like; users can use the third-party payment accounts like the alipay accounts and wechat payment accounts to carry out payment; and thus the users can carry out no-hypostatic-money consumption or carry out account transferring during exchange.

The invention discloses a real-time human body gesture supervised training correction system based on quaternion. The system comprises a depth-indexing video collection device used for collecting the depth image information of a trainee, a human body gesture analyzing and processing module used for analyzing and processing the main joint information of the trainee, an electrocardio information collection device used for collecting and transmitting the electrocardio information of the trainee, and a human body metal state analyzing and processing module used for obtaining the information such as nervous degree, fatigue degree and emotion change of the trainee by analyzing and processing the heart rate, the breathing frequency and the like of the trainee. The real-time human body gesture supervised training correction system based on quaternion can meet the requirements of self training, assistive training and professional teachers on carrying out digitalized correction and supervising on the metal state or functional change of the trainee in real time, and is applicable to all the fields requiring supervised training correction on a human body gesture.

Disclosed is a real-time wireless measurement and control system for engineering vehicle state. The system comprises two parts of a vehicle terminal and a remote supervising center. A remote communication is made by using a 2.4 G point-to-point wireless transmission module with a power amplifier, achieving on-site data collecting to the engineering vehicle, motion controlling of the vehicle operating, real-time remote monitoring, status displaying, parameter setting, record keeping, and further back-end data processing. The debugging is not restricted by the on-site space and material conditions of the engineering vehicles. Using the 2.4 G wireless module with a power amplifier can achieve the data transmission without any barriers within 1 km. All the data detected directly or indirectly of the whole vehicle can be real-time monitored and displayed. The system has the function of historical data record keeping, and provides the possibility for further analysis and diagnosis. Provide interfaces based on needs. Authorize users personalization to set certain operating parameters. In this way, the debugging efficiency is improved and the debugging environment is improved greatly. The upper computer monitoring software develops using a Labview, making it simple and convenient to change and adjust the function.

To provide a semiconductor integrated circuit in which a clock signal supplied to each flip-flop will not be adversely affected when a functional change is made using a spare flip-flop. The semiconductor integrated circuit includes a plurality of main flip-flops which contribute to a predetermined function, a plurality of spare flip-flops, and a clock tree synthesis circuit that generates a clock signal which is adjusted for synchronizing the plurality of main flip-flops and the plurality of spare flip-flops and supplies the adjusted clock signal to the plurality of main flip-flops and the plurality of spare flip-flops.

The invention provides a health risk pre-warning system for a human body circulatory system. The health risk pre-warning system comprises a human body health scanning system, a circulatory system health risk pre-warning data processor and a circulatory system health risk pre-warning result displayer, wherein the human body health scanning system is used for scanning and evaluating function values of tissue and organs of the human body circulatory system; the circulatory system health risk pre-warning data processor is used for performing human body circulatory system health risk pre-warning through a human body circulatory system health risk pre-warning model; the output end of the human body health scanning system is connected with the input end of the circulatory system health risk pre-warning data processor, and the output end of the circulatory system health risk pre-warning data processor is connected with the circulatory system health risk pre-warning result displayer. Functions of the organs of the circulatory system can be comprehensively scanned in short time, functionality of the organs of the circulatory system is evaluated, and energy changes of the tissue and functional changes of the organs of a human body can be discovered in time. Potential danger factors and disease development directions can be predicted in combination with clinical index data of the circulatory system, and health risks of the circulatory system can be pre-warned early.

Methods for measuring transporter activity using budding baculoviruses that do not express endogenous transporters on their envelope have a low background level and can measure the target activity with a high sensitivity. Such methods can be used to measure functional changes due to transporter SNPs over a more extensive range of substrates, and can be applied to tailor-made therapies.

The invention provides a human body endocrine system health risk early warning system, which comprises a human body health scanning system, an endocrine system health risk early warning data processor and an endocrine system health risk early warning result display, wherein the human body health scanning system is used for scanning and evaluating the function values of each tissue and organ of a human body endocrine system; the endocrine system health risk early warning data processor uses a human body endocrine system health risk early warning model for performing human body endocrine system health risk early warning; the output end of the human body health scanning system is connected with the input end of the endocrine system health risk early warning data processor; and the output end of the endocrine system health risk early warning data processor is connected with the endocrine system health risk early warning result display. The organ function of the endocrine system is comprehensively scanned in a short time; the organ function of the endocrine system is evaluated; and the human body tissue energy change and the organ functional change are discovered in time. The potential risk factors and the disease development direction are predicted through combining endocrine system clinical index data, and the health risk of the endocrine system realizes early-stage early warning.

The invention discloses a method for separating and cultivating II-type epithelial cells of people alveolus pulmonis. By using pancreatin joint elastase to digest and separate, the II-type epithelial cells of people alveolus pelmonis are obtained through filtering, differential adhension, density gradient centrifugation and the separation and purification of Anti-CD 14 magnetic beads. The invention establishes a set of method of separating, cultivating and identifying II-type epithelial cells of people alveolus pulmonis, and the maintaining situation of the biological characteristics of the cells cultivated by the method is assessed. The capacity of obtaining II-type epithelial cells of people alveolus pulmonis with high purity through the cultivating method is certified, moreover, the biological characteristics of cells can be enduringly maintained, and the method provides possibilities for further deep research of the proliferation, differentiation, liquid transferring and synthetizing secretion of II-type epithelial cells of alveolus pulmonis as well as the functional changes of II-type epithelial cells of alveolus pulmonis in the cases of pathophysiology, such as lung injury, lung repair.

A method and system for determining a condition of a selected region of epithelial and stromal tissue, for example in the human breast. A plurality of electrodes are used to measure surface and transepithelial electropotential of breast tissue as well as surface electropotential and impedance at one or more locations and at several defined frequencies, particularly very low frequencies. An agent may be introduced into the region of tissue to enhance electrophysiological characteristics. Measurements made at ambient and varying suction and / or positive pressure applied to the epithelial tissue and / or positive pressure conditions applied to the breast are also used as a diagnostic tool. Tissue condition is determined based on the electropotential and impedance profile at different depths of the epithelium, stroma, tissue, or organ, together with an estimate of the functional changes in the epithelium due to altered ion transport and electrophysiological properties of the tissue. Devices for practicing the disclosed methods are also provided.

A System-on-Chip (SoC) may include logic blocks connected to each other and to external connections, and a hardware debug infrastructure logic connected to the logic blocks and for performing functional changes to a design layout of the SoC. The hardware debug infrastructure logic may include software re-configurable modules based upon the logic blocks obtained from substituting a mask programmable ECO base cell configured as a functional logic cell for a logic cell in the design layout.