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350 results about "Electro physiology" patented technology

Method for measuring heart electrophysiology

A mapping catheter is positioned in a heart chamber, and active electrode sites are activated to impose an electric field within the chamber. The blood volume and wall motion modulates the electric field, which is detected by passive electrode sites on the preferred catheter. Electrophysiology measurements, as well as geometry measurements, are taken from the passive electrodes and used to display a map of intrinsic heart activity.
Owner:ST JUDE MEDICAL ATRIAL FIBRILLATION DIV

System and method for magnetic-resonance-guided electrophysiologic and ablation procedures

InactiveUS7155271B2Increased resolution and reliabilityImprove accuracySurgical instrument detailsDiagnostic recording/measuringMr guidanceMr contrast agent
A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures is disclosed. The system in its preferred embodiment provides an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures. The invention is particularly applicable to catheter ablation, e.g., ablation of atrial fibrillation. In embodiments which are useful for catheter ablation, the combined electrophysiology and imaging antenna catheter may further include an ablation tip, and such embodiment may be used as an intracardiac device to both deliver energy to selected areas of tissue and visualize the resulting ablation lesions, thereby greatly simplifying production of continuous linear lesions. The invention further includes embodiments useful for guiding electrophysiologic diagnostic and therapeutic procedures other than ablation. Imaging of ablation lesions may be further enhanced by use of MR contrast agents. The antenna utilized in the combined electrophysiology and imaging catheter for receiving MR signals is preferably of the coaxial or “loopless” type. High-resolution images from the antenna may be combined with low-resolution images from surface coils of the MR scanner to produce a composite image. The invention further provides a system for eliminating the pickup of RF energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance. Other ablative methods can be used such as laser, ultrasound, and low temperatures.
Owner:THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

Closed-loop micro-control system for predicting and preventing epilectic seizures

The invention provides a micro-control neuroprosthetic device and methods for predicting and controlling epileptic neuronal activity. The device includes a detection system that detects and collects electrophysiological information comprising action potentials from single neurons and ensembles of neurons in a neural structure such as an epileptogenic region of the brain in a subject. An analysis system included in the neuroprosthetic device evaluates the electrophysiological information and performs a real-time extraction of neuron firing features from which the system determines when stimulus intervention is required. The neuroprosthetic device further comprises a stimulation intervention system that provides stimulus output signals having a desired stimulation frequency and stimulation intensity directly to the neural structure in which abnormal neuronal activity is detected. The analysis system further analyzes collected electrophysiological information during or following stimulus intervention to assess the effects of the stimulation intervention and to provide outputs to maintain or modify the stimulation intervention.
Owner:UNIV OF FLORIDA RES FOUNDATION INC

Helically shaped electrophysiology catheter

An electrophysiology (EP) device suitable for ablating tissue within a patient's body lumen. The EP device of the invention generally comprises an elongated shaft having a distal shaft section with a helical shape and at least one electrode on an exterior portion thereof. One aspect of the invention comprises a method of performing a medical procedure, such as treating a patient for atrial arrhythmia, by forming a lesion using an EP device embodying features of the invention.
Owner:SICHUAN JINJIANG ELECTRONICS SCI & TECH CO LTD

System for Automatic Medical Ablation Control

A system provides heart ablation unit control. The system includes an input processor for acquiring electrophysiological signal data from multiple tissue locations of a heart and data indicating tissue thickness at the multiple tissue locations. A signal processor processes the acquired electrophysiological signal data to identify location of particular tissue sites of the multiple tissue locations exhibiting electrical abnormality in the acquired electrophysiological signal data and determines an area of abnormal tissue associated with individual sites of the particular sites. An ablation controller automatically determines ablation pulse characteristics for use in ablating cardiac tissue at an individual site of the particular tissue sites in response to the acquired data indicating the thickness of tissue and determined area of abnormality of the individual site.
Owner:PIXART IMAGING INC

Method and system for detecting electrophysiological changes in pre-cancerous and cancerous tissue

A method and system are provided for determining a condition of a selected region of epithelial tissue. At least two current-passing electrodes are located in contact with a first surface of the selected region of the tissue. A plurality of measuring electrodes are located in contact with the first surface of the selected region of tissue as well. Electropotential and impedance are measured at one or more locations. An agent may be introduced into the region of tissue to enhance electrophysiological characteristics. The condition of the tissue is determined based on the electropotential and impedance profile at different depths of the epithelium, tissue, or organ, together with an estimate of the functional changes in the epithelium due to altered ion transport and electrophysiological properties of the tissue.
Owner:EPI SCI LLC

Method and system for detecting electrophysiological changes in pre-cancerous and cancerous tissue and epithelium

Methods and systems are provided for determining a condition of an organ, or epithelial or stromal tissue, for example in the human breast. The methods incorporate sonophoresis, the application of ultrasonic energy, in order to condition tissue for testing and enhance test measurements. A plurality of electrodes are used to measure surface and transepithelial electropotential and impedance of breast tissue at one or more locations and at several frequencies, particularly very low frequencies. An agent may be introduced into the region of tissue to enhance electrophysiological characteristics. Pressure, drugs and other agents can optionally be applied for enhanced diagnosis. Tissue condition is determined based on the electropotential and impedance profile at different depths of the epithelium, stroma, tissue, or organ, together with an estimate of the functional changes in the epithelium due to altered ion transport and electrophysiological properties of the tissue. Devices for practicing the disclosed methods are also provided.
Owner:EPI SCI LLC

Medical devices incorporating carbon nanotube material and methods of fabricating same

The present invention relates generally to medical devices; in particular and without limitation, to unique electrodes and / or electrical lead assemblies for stimulating cardiac tissue, muscle tissue, neurological tissue, brain tissue and / or organ tissue; to electrophysiology mapping and ablation catheters for monitoring and selectively altering physiologic conduction pathways; and, wherein said electrodes, lead assemblies and catheters optionally include fluid irrigation conduit(s) for providing therapeutic and / or performance enhancing materials to adjacent biological tissue, and wherein each said device is coupled to or incorporates nanostructure or materials therein. The present invention also provides methods for fabricating, deploying, and operating such medical devices.
Owner:MEDTRONIC INC

Brain therapy system and method using noninvasive brain stimulation

A brain therapy system and method using noninvasive brain stimulation, comprising:a stimuli generator unit for generating a stimuli presentation program;a sensor assembly comprising a plurality of active EEG electrodes for measuring the electrophysiological activity of a patient's brain subjected to said stimuli presentation program;a data acquisition unit in communication with the sensor assembly for retrieving patient EEG signals;a data processing unit in communication with the data acquisition unit for:analyzing the patient EEG signals to obtain patient EEG data, andcomparing the patient EEG data against a normalized EEG pattern retrieved from a standardized database;selecting a stimulation protocol in dependence of said comparison;a brain stimulation unit for applying the selected stimulation protocol on the active EEG electrodes.
Owner:NEUROMETRICS

Headgear with displacable sensors for electrophysiology measurement and training

A method and system provides for headgear usable for electrophysiological data collection and analysis and neurostimulation / neuromodulation or brain computer interface for clinical, peak performance, or neurogaming and neuromodulation applications. The headgear utilizes dry sensor technology as well as connection points for adjustable placement of the bi-directional sensors for the recoding of electrophysiology from the user and delivery of current to the sensors intended to improve or alter electrophysiology parameters. The headgear allows for recording electrophysiological data and biofeedback directly to the patient via the sensors, as well as provide low intensity current or electromagnetic field to the user. The headgear can further include auditory, visual components for immersive neurogaming. The headgear may further communication with local or network processing devices based on neurofeedback and biofeedback and immersive environment experience with balance and movement sensor data input.
Owner:EVOKE NEUROSCI

Method of using dermatomal somatosensory evoked potentials in real-time for surgical and clinical management

Methods, computer systems and apparatus are provided for neurophysiological assessment, specifically evaluation of mixed and dermatomal nerve conduction latencies and amplitudes, as well as electrophysiological evaluation of spontaneous electromyogram. Software guides the user through protocol selection, electrode placement, baseline determinations, comparisons to normal data, post-manipulation comparisons, displayed warning of pathological changes, archiving of data and report generation.
Owner:NEUROPHYSIOLOGICAL CONCEPTS

Method and system for detecting electrophysiological changes in pre-cancerous and cancerous tissue

A method and system are provided for determining a condition of a selected region of epithelial tissue. At least two current-passing electrodes are located in contact with a first surface of the selected region of the tissue. A plurality of measuring electrodes are located in contact with the first surface of the selected region of tissue as well. Electropotential and impedance are measured at one or more locations. An agent may be introduced into the region of tissue to enhance electrophysiological characteristics. The condition of the tissue is determined based on the electropotential and impedance profile at different depths of the epithelium, tissue, or organ, together with an estimate of the functional changes in the epithelium due to altered ion transport and electrophysiological properties of the tissue.
Owner:EPI SCI LLC

Real-time optoacoustic monitoring with electophysiologic catheters

A system and method for opto-acoustic tissue and lesion assessment in real time on one or more of the following tissue characteristics: tissue thickness, lesion progression, lesion width, steam pop, and char formation, system includes an ablation element, laser delivery means, and an acoustic sensor. The invention involves irradiating tissue undergoing ablation treatment to create acoustic waves that have a temporal profile which can be recorded and analyzed by acoustic sampling hardware for reconstructing a cross-sectional aspect of the irradiated tissue. The ablation element (e.g., RF ablation), laser delivery means and acoustic sensor are configured to interact with a tissue surface from a common orientation; that is, these components are each generally facing the tissue surface such that the direction of irradiation and the direction of acoustic detection are generally opposite to each other, where the stress waves induced by the laser-induced heating of the tissue below the surface are reflected back to the tissue surface.
Owner:BIOSENSE WEBSTER INC

Method and system for detecting electrophysiological changes in pre-cancerous and cancerous tissue and epithelium

A method and system for determining a condition of a selected region of epithelial and stromal tissue, for example in the human breast. A plurality of electrodes are used to measure surface and transepithelial electropotential of breast tissue as well as surface electropotential and impedance at one or more locations and at several defined frequencies, particularly very low frequencies. An agent may be introduced into the region of tissue to enhance electrophysiological characteristics. Measurements made at ambient and varying suction and / or positive pressure applied to the epithelial tissue and / or positive pressure conditions applied to the breast are also used as a diagnostic tool. Tissue condition is determined based on the electropotential and impedance profile at different depths of the epithelium, stroma, tissue, or organ, together with an estimate of the functional changes in the epithelium due to altered ion transport and electrophysiological properties of the tissue. Devices for practicing the disclosed methods are also provided.
Owner:EPI SCI LLC

Method of noninvasive electrophysiological study of the heart

The invention relates to medicine, namely to cardiology, cardiovascular surgery, functional diagnosis and clinical electrophysiology of the heart. The invention consists in reconstructing electrograms, whose experimental registration requires an invasive access, by computational way on unipolar ECGs recorded at 80 and more points of the chest surface. Based on reconstructed electrograms, isopotential, isochronous maps on realistic models of the heart are constructed, the dynamics of the myocardium excitation is reconstructed and electrophysiological processes in the cardiac muscle are diagnosed. Application of the method allows one to improve the accuracy of non-invasive diagnosis of cardiac rhythm disturbances and other cardio-vascular diseases.
Owner:EP SOLUTIONS SA

Closed-loop micro-control system for predicting and preventing epileptic seizures

The invention provides a micro-control neuroprosthetic device and methods for predicting and controlling epileptic neuronal activity. The device includes a detection system that detects and collects electrophysiological information comprising action potentials from single neurons and ensembles of neurons in a neural structure such as an epileptogenic region of the brain in a subject. An analysis system included in the neuroprosthetic device evaluates the electrophysiological information and performs a real-time extraction of neuron firing features from which the system determines when stimulus intervention is required. The neuroprosthetic device further comprises a stimulation intervention system that provides stimulus output signals having a desired stimulation frequency and stimulation intensity directly to the neural structure in which abnormal neuronal activity is detected. The analysis system further analyzes collected electrophysiological information during or following stimulus intervention to assess the effects of the stimulation intervention and to provide outputs to maintain or modify the stimulation intervention.
Owner:UNIV OF FLORIDA RES FOUNDATION INC

Electrophysiologic Testing Simulation For Medical Condition Determination

A system simulates stimulation of scar tissue identified as hyper-enhanced areas in a medical image with variable luminance thresholds and categorizes partially-viable myocardium as distinct from non-viable scar tissue. A cardiac function analysis system includes a repository of imaging data representing a 3D volume comprising a patient heart. A model processor provides a model of the patient heart using the imaging data said model being for use in allocating electrical properties to model parameters determining electrical conductivity associated with image data classified as, (a) scar tissue, (b) impaired tissue and (c) normal heart tissue. The electrical properties allocated to scar tissue are different to electrical properties allocated to normal tissue. A stimulation processor simulates electrical stimulation of the patient heart using the model to identify risk of heart impairment.
Owner:NORTHWESTERN UNIV

System for Heart Performance Characterization and Abnormality Detection

A system for heart performance characterization and abnormality detection includes an acquisition device for acquiring an electrophysiological signal representing heart beat cycles of a patient heart. A detector detects one or more parameters of the electrophysiological signal of parameter type comprising at least one of, (a) amplitude, (b) time duration, (c) peak frequency and (d) frequency bandwidth, of multiple different portions of a single heart beat cycle of the heart beat cycles selected in response to first predetermined data. The multiple different portions of the single heart beat cycle being selected from, a P wave portion, a QRS complex portion, an ST segment portion and a T wave portion in response to second predetermined data. A signal analyzer calculates a ratio of detected parameters of a single parameter type of the multiple different portions of the single heart beat cycle. An output processor generates data representing an alert message in response to a calculated ratio exceeding a predetermined threshold.
Owner:PIXART IMAGING INC

System for Heart monitoring, Characterization and Abnormality Detection

A system analyzes and characterizes cardiac electrophysiological signals by determining instantaneous signal entropy for identifying and characterizing cardiac disorders, differentiating cardiac arrhythmias, determining pathological severity and predicting life-threatening events. A system for heart monitoring, characterization and abnormality detection, includes an acquisition device for acquiring an electrophysiological signal representing a heart beat cycle of a patient heart. A signal processor derives an entropy representative value of the acquired electrophysiological signal within a time period comprising at least a portion of a heart beat cycle of the acquired electrophysiological signal and provides an entropy value as a function of the entropy representative value and the time period. A comparator generates data representing a message for communication to a destination device in response to the entropy value exceeding a predetermined threshold.
Owner:PIXART IMAGING INC

Electrophysiological measurement method and system for positioning an implantable, hearing instrument transducer

An electrophysiological measurement method and system is provided for positioning an implantable transducer of a hearing instrument relative to a middle ear component or inner ear of a patient. The method and system employ electrophysiological measurement signals obtained in response to test signals applied to an implanted transducer. In one embodiment, the electrophysiological measurements are obtained by an electrocochleography measurement device that measures the cochlear summating potential and / or action potential responsive to test signals applied to an implanted transducer. In another embodiment, an auditory brainstem response measurement device is utilized to obtain electrical potential measurement signals responsive to test signals applied to an implanted transducer.
Owner:COCHLEAR LIMITED

Method and apparatus for visually supporting an electrophysiological catheter application in the heart by means of bidirectional information transfer

InactiveUS20070167706A1Rapid overview of positionRapid overview of extentReconstruction from projectionSurgical instrument detailsElectricityInformation transmission
Method and apparatus for visually supporting an electrophysiological catheter application in the heart by means of bidirectional information transfer The present invention relates to a method and apparatus for visually supporting an electrophysiological catheter application in the heart. For the method, 3D image data of at least the heart, which is captured using a tomographic 3D imaging method prior to execution of the catheter application, and electroanatomical 3D mapping data of at least one area of the heart to be treated, which is captured during execution of the catheter application, is provided and the electroanatomical 3D mapping data and / or at least part of the 3D image data is displayed during execution of the catheter application. The method is characterized in that, in the electroanatomical 3D mapping data and / or the 3D image data, the contour of one or more areas (3) relevant to the catheter application is captured and transferred to the other system in each case on which the areas (3) are superimposed as a single polyline (5) in the representation (2, 4) of the electroanatomical 3D mapping data and / or 3D image data. The method proposed and the associated apparatus provide the user with a rapid overview of the areas relevant to the catheter application.
Owner:SIEMENS AG

System and method for stimulation of biologic signals in a bio-electro-physiologic matrix

An implantable device for monitoring physiological changes in an organism is disclosed. The device includes a matrix positioned proximate a biological material of the organism, an irradiation device associated with the matrix for exposing the biological material to radiation, and a sensor device associated with the matrix for detecting a response of the biological material to the irradiation. The response can be used to remotely detect a characteristic of the biological material.
Owner:UNIVERSITY OF ROCHESTER

Devices and Methods for Reducing Electrical Noise in an Irrigated Electrophysiology Catheter System

An irrigation system for use with an irrigated electrophysiology catheter includes a peristaltic pump and an irrigation tube. The pump generally includes a pump clamp and a rotor, which are spaced apart to provide a tubing channel therebetween. The irrigation tube is inserted into the tubing channel. At least one of the pump clamp and the irrigation tube is treated to reduce surface adhesion therebetween. This advantageously minimizes perturbations to the double layer, which reduces a noise signal that might otherwise couple to and distort an electrogram signal.
Owner:ST JUDE MEDICAL ATRIAL FIBRILLATION DIV
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