The invention relates to a grape seed polyphenol compound chewable tablet and a preparation method thereof and belongs to the technical field of food processing. The grape seed polyphenol compound chewable tablet comprises the main components of 40 parts of grape seed polyphenol, 8-10 parts of licorice, 10-15 parts of strawberries and 5-10 parts of waxberries, wherein the strawberries and strawberries are of 20 parts in total. The grape seed polyphenol compound chewable tablet is nutritious and rich in amino acids, vitamins, polyphenols and trace elements such as calcium and iron, has effects of antioxidation, free radical scavenging and preventing free radicals from damaging to human cells so as to protect human organs and tissues and prevent diseases such as heart disease, cancer, premature aging, diabetes and arteriosclerosis which are caused by free radicals, is good in flavor, moderate in sweet and sour, bitter free and fresh and puckery taste free and sweet after-taste available after chewing, is not added with sweeteners to be healthy, simultaneously has effects of prevention and treatment of oral ulcer and anti-inflammation, and long in storage period. The preparation method is simple in process and suitable for industrial production.