47results about How to "Reduce bleeding rate" patented technology

An elastomeric gel-filled prosthetic implant having a shell made of a single gel barrier layer. The barrier layer is formed of a homogeneous silicone elastomer capable of sterically retarding permeation of the silicone gel through the shell and having a bleed rate that is less than about 40% of the bleed rate of current shells which use a sandwiched construction with an internal barrier layer. Further, the barrier layer shell is made of a material that exhibits a wet strength that is comparable to or greater than current shells. The silicone elastomer may be a polydimethyl siloxane, and the substituted chemical group is a diphenyl group with a minimum mole percent of at least 13%. The implant may be designed for breast reconstruction or augmentation such that the shell is accordingly shaped. The shell wall thickness is at least 0.254 mm (0.010 inches), and desirably about 0.456 mm (0.018 inches). The implant shell may be made by dip-forming, spray-forming, or rotational molding. The exterior may be smooth or textured.

This invention discloses a high-performance lignin-based water reducer with high degree of sulfonation and high molecular weight and its preparation method. This water reducer exhibits an excellent water-reducing performance, its water-reducing rate of this lignin-based water reducer reaches 25% at a dosage of 0.70 wt %, which is higher than that of the naphthalene-based water reducer and the sulfonated lignin water reducer prepared by oxidation and sulfonation of alkali lignin, and 28-days compressive strength ratio of the concrete with this water reducer to the concrete without this water reducer is up to 150:100. Furthermore, the water reducer of present invention will not be crystallized in winter, and the concrete iron won't be corroded. The water reducer of the present invention makes the concretes having a low bleeding rate, excellent properties of workability, anti-freeze and anti-carbonization.

The invention provides a circumcision device and belongs to the field of medical instruments. The circumcision device comprises a functional assembly and an actuating unit assembly. The functional assembly comprises a first shell, a glans penis sleeve, a nail plate, a pull rod, a nail box, a scalpel and an ejector. The actuating unit assembly comprises a second shell, a gun core, a screw, a nut push rod and a first elastic part. The nail plate is arranged at the edge of the glans penis sleeve. The outer side of the glans penis sleeve is connected with the pull rod. The nail box is arranged on the inner side of one end of the first shell. The scalpel is located on the inner side of the nail box. The end, away from the glans penis sleeve, of the scalpel is connected with the ejector. A through hole is formed in the middle of the ejector. The pull rod penetrates through the through hole. The end, away from the glans penis sleeve, of the pull rod is connected with the gun core. The screw is arranged outside the gun core. The nut push rod is in threaded connection with the screw. One end of the screw is connected with the second shell. The ejector is pushed by the nut push rod to move. A button is arranged at the end, away from the pull rod, of the gun core. The circumcision device is simple in structure, convenient to use and capable of improving surgery efficiency and stability.

The invention provides a pharmaceutical composition containing active procyanidins and prasugrel or the pharmacologically acceptable salt thereof. The procyanidins and the prasugrel are used in a combined manner, a more effective method for curing thrombotic diseases is found, after trail for many times, the prasugrel and the procyanidins (an extract of traditional Chinese medicine) are creatively and effectively combined together, the effect of applying the procyanidins to inhibit the thrombosis in a combined manner is discovered unexpected in the process of applying the prasugrel to cure the thrombotic diseases, and not only the anticoagulant effect of the prasugrel is free from the influence of the procyanidins, but also a good effect is achieved in the aspect of reducing the adverse reaction of bleeding after the use of the prasugrel and the procyanidins in a combined manner, therefore, the risk of bleeding is greatly reduced when the advantages of good anticoagulant activity and fast effect of the prasugrel during the antiplatelet aggregation are fully exerted, the risk of bleeding of the prasugrel during the antiplatelet aggregation is effectively reduced and the adverse reaction of the prasugrel is greatly reduced.

An elastomeric gel-filled prosthetic implant having a shell made of a single gel barrier layer. The barrier layer is formed of a homogeneous silicone elastomer capable of sterically retarding permeation of the silicone gel through the shell and having a bleed rate that is less than about 40% of the bleed rate of current shells which use a sandwiched construction with an internal barrier layer. Further, the barrier layer shell is made of a material that exhibits a wet strength that is comparable to or greater than current shells. The silicone elastomer may be a polydimethyl siloxane, and the substituted chemical group is a diphenyl group with a minimum mole percent of at least 13%. The implant may be designed for breast reconstruction or augmentation such that the shell is accordingly shaped. The shell wall thickness is at least 0.254 mm (0.010 inches), and desirably about 0.456 mm (0.018 inches). The implant shell may be made by dip-forming, spray-forming, or rotational molding. The exterior may be smooth or textured.

The invention provides a pharmaceutical composition containing active procyanidins and clopidogrel or the pharmacologically acceptable salt thereof. The procyanidins and the clopidogrel are used in a combined manner, a more effective method for curing thrombotic diseases is found, after trail for many times, the clopidogrel and the procyanidins (an extract of traditional Chinese medicine) are creatively and effectively combined together, the effect of applying the procyanidins to inhibit the thrombosis in a combined manner is discovered unexpected in the process of applying the clopidogrel to cure the thrombotic diseases, and not only the anticoagulant effect of the clopidogrel is free from the influence of the procyanidins, but also a good effect is achieved in the aspect of reducing the adverse reaction of bleeding after the use of the clopidogrel and the procyanidins in a combined manner, therefore, the risk of bleeding is greatly reduced when the advantages of good anticoagulant activity and fast effect of the clopidogrel during the antiplatelet aggregation are fully exerted, the risk of bleeding of the clopidogrel during the antiplatelet aggregation is effectively reduced and the adverse reaction of the clopidogrel is greatly reduced.

The invention discloses argatroban injection for resisting thrombus. The argatroban injection contains 0.5mg / mL of argatroban, 0.1-0.4mg / mL of nitroglycerin and 30-80mg / mL of D-sorbierite. The argatroban injection is good in stability, has obvious effect in resisting thrombopoiesis, simultaneously reduces bleeding danger of the argatroban and obviously reduces the bleeding rate.

The invention discloses argatroban injection for resisting thrombus. The argatroban injection contains 0.5mg / mL of argatroban, 0.1-0.4mg / mL of nitroglycerin and 30-80mg / mL of D-sorbierite. The argatroban injection is good in stability, has obvious effect in resisting thrombopoiesis, simultaneously reduces bleeding danger of the argatroban and obviously reduces the bleeding rate.

The invention discloses a medicinal composition containing clopidogrel and aspirin. The medicinal composition is characterized by comprising the clopidogrel and the aspirin serving as active ingredients, wherein the medicinal composition is prepared in the dose unit that every unit dose of preparation contains 75mg of active ingredients; and both ingredients exist in a free state or pharmaceutically acceptable salt forms. The invention discloses application of the composition to preparation of medicaments for treating an acute non-disabling cerebrovascular disease. The invention has the advantages that: 1, a patient can be easily and conveniently treated by using an oral medicament and has high compliance; and 2, compared with single use of aspirin, the technical scheme of the invention is of great benefit to the patient with the acute non-disabling cerebrovascular diseases without increasing the bleeding rate.

The invention provides a pharmaceutical composition containing active carbazochrome sodium sulfonate and clopidogrel or the pharmacologically acceptable salt thereof. The invention aims to invent a more effective and low adverse-reaction method for curing thrombotic diseases by using the combined medication of the carbazochrome sodium sulfonate and the clopidogrel. After conscientious trail of the patent applicant for many times, the effect of applying the carbazochrome sodium sulfonate to inhibit the thrombosis in a combined manner is discovered unexpected in the process of applying the clopidogrel to cure the thrombotic diseases, the anticoagulant effect of the clopidogrel is not abated but increased, and the very good synergistic effects are achieved after the combination of the carbazochrome sodium sulfonate and the clopidogrel, therefore, the risk of bleeding is greatly reduced when the advantages of good anticoagulant activity and fast effect of the clopidogrel during the antiplatelet aggregation are fully exerted, the risk of bleeding caused by the clopidogrel is greatly reduced and the compliance of patients is enhanced.

The invention relates to a pathology determining auxiliary device, in particular to an intra-operative pathological tissue quick extracting device which comprises a syringe, a piston, a hollow push-pull rod and a needle. The piston is arranged in the syringe, the hollow push-pull rod is fixedly connected with the tail end of the piston, the needle is arranged at the front end of the syringe, an 'H'-shaped tissue pushing mechanism which extends into the piston is arranged at the front end of the inside of the needle, and a 'T'-shaped pushing mechanism is arranged at the rear end of the hollow push-pull rod, penetrates into the hollow push-pull rod from the rear end of the hollow push-pull rod and extends to the rear end of the piston; a cavity is arranged inside the piston, a first throughhole which is communicated with the cavity is formed in the front end of the piston, and a second through hole which is communicated with the cavity is formed in the rear end of the piston. The intra-operative pathological tissue quick extracting device has the advantages that tissues can be extracted by the intra-operative pathological tissue quick extracting device in sterile environments, a seal cover can sleeve the intra-operative pathological tissue quick extracting device after the intra-operative pathological tissue quick extracting device is disinfected and can be directly pulled downin operation, and accordingly the intra-operative pathological tissue quick extracting device can be used; tissue extracting procedures are convenient and speedy, and the intra-operative pathologicaltissue quick extracting device is high in safety.

The invention relates to an endometriosis fibrosis animal model construction method and application thereof and belongs to the technical field of animal models. According to a preparation method of anendometriosis fibrosis animal model, estrogen is subcutaneously injected to neck and back of an SPF-grade BALB / c female mouse and endometrial tissue fragments are intraperitoneally injected, so thatthe endometriosis fibrosis animal model is constructed. The preparation method has the advantages that the model has high conformity with clinical pathologic characteristics of endometriosis; the model is convenient to operate, the modeling period is short and the modeling success rate is high; an efficient modeling method is provided for researches of the endometriosis. Meanwhile, the model can be used as an ideal model for exploring the pathogenesis and an effective diagnosis and treatment strategy of endometriosis fibrosis.

The invention discloses an abdominal puncture rod and a puncture outfit with electric knife and extraction balloon. The puncture rod comprises a puncture head; the puncture head is connected with thepuncture rod base through a cylindrical connecting rod; the external wall of the cylindrical connecting rod is provided with an annular groove, a first balloon and a second balloon are arranged in theannular groove, and the second balloon is positioned on the outer side of the first balloon; a first electric knife bit used for electrocoagulation is arranged on the puncture head; a second electricknife bit used for electrocoagulation is arranged on the second balloon; the cylindrical connecting rod is internally provided with a first lumen communicated with the first balloon and a second lumen communicated with the second balloon at one end; the other ends of the first lumen and the second lumen respectively extend to the puncture rod base and are respectively communicated with a first water injection joint and a second water injection joint on the puncture rod base. By filling the first balloon or filling the first balloon and the second balloon at the same time, the abdominal incision can be gradually expanded; the second electric knife bit closes an electric cutting current, and the expansion effect of the first balloon and the second balloon can be improved.

The invention relates to an implementation method for a stereotactic electroencephalogram based on a Leksell framework. The implementation method specifically comprises the steps that firstly, three-dimensional reconstruction is carried out on head MRI data; secondly, an included angle between each electrode and the cross section of the human body is set to be an angle a, and an included angle between each electrode and the median sagittal plane of the human body is set to be an angle beta; thirdly, a deep electrode imbedding plane is formulated according to examines and weighs of a preoperative assessment; fourthly, after a head frame of the Leksell framework is installed in the morning of an operation, and head MRI thin-layer chromatographic scanning is carried out; fifthly, preoperative MRI and the MRI obtained in morning of the operation are mixed in a Neurotech system; sixthly, three-dimensional coordinate values X, Y and Z of an inlet point and a far point of each electrode are worked out according to developing points of the Leksell framework on the MRI, and the unique space direction angle a value and the angle beta value of each electrode are worked out; finally, the coordinate values, the angle a direction and the angle beta direction are adjusted on the head frame of the Leksell framework, and the deep electrodes are accurately and quickly implanted to objective positions through customized operative instruments. According to the implementation method, operation is easy and convenient, and the deep electrodes can be precisely, safely, reliably and quickly implanted to the objective positions.

The invention relates to iRNA, e.g., double stranded ribonucleic acid (dsRNA), compositions targeting the Serpinc1 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of Serpinc1 and to treat subjects having a Serpinc1-associated disease, e.g., a bleeding disorder, such as a hemophilia.

The invention discloses an intraoperative pathological tissue extractor, which comprises a needle tube, a piston assembled in the needle tube, a push-pull rod for controlling the movement of the piston, and a needle head installed at the front end of the needle tube. The front end of the needle point of the needle head is circular The opening is equipped with an extraction cavity that can slide along the needle in the needle barrel of the needle, and the extraction cavity is connected with the piston through a connecting rod. The invention provides a special instrument capable of fast and convenient pathological extraction, which has simple structure, convenient operation and low cost; the circular needle end structure is designed to reduce the impact on the needle as much as possible without affecting the advance of the needle. The influence of other tissues can reduce the probability of bleeding and improve the accuracy of pathological cell collection; the setting of the connecting rod, extraction cavity and other position structures in this scheme enables all the tissues extracted at the end of the needle to enter the extraction cavity without Residing in the needle, the withdrawal chamber can be taken out directly from the back of the syringe, which greatly facilitates the tissue collection process.

A method for preventing stroke in a patient suffering from atrial fibrillation, wherein the patient has no risk factors for major bleeding events, the method comprising administering to the patient a dosage of >150 mg b.i.d. to 300 mg b.i.d. of dabigatran etexilate, optionally in the form of a pharmaceutically acceptable salt thereof.

The invention discloses a novel anastomosis system of blood vessels and a blood vessel stent. The system comprises a branched artificial blood vessel group, a stent artificial blood vessel group, a suture-free ring and an anastomosis buckle device; a main body of the branched artificial blood vessel group is a main body artificial blood vessel of a tubular structure, a main branched artificial blood vessel of a tubular structure is fixedly communicated with the upper end of the main body artificial blood vessel, and three branched blood vessels are fixedly communicated with the upper end of the main branched artificial blood vessel. By means of the system, the surgical step is simplified, the surgical difficulty is lowered, then the in-vitro time, the surgical time, the deep hypothermia circulatory arrest time and the brain protection time are greatly shortened, the surgical mortality rate is reduced, and the morbility of nervous systems and other complications is lowered at the same time. Few anastomotic stomas are involved, through buckling of the anastomosis buckle device and the suture-free ring, the bleeding probability is lowered, the mortality rate is lowered accordingly, and the success probability of operations is greatly lowered.

The present invention relates to a polymer composition comprising 100 parts by weight of an olefin-based polymer, and 0.01 to 100 parts by weight of a branched fatty acid and 0.01 to 200 parts by weight of a releasable active compound per 100 parts by weight of said olefin-based polymer.

The present invention relates to a polymer composition comprising 100 parts by weight of an olefin-based polymer, and 0.01 to 100 parts by weight of terpenoid and 0.01 to 200 parts by weight of a releasable active compound per 100 parts by weight of said olefin-based polymer.

The invention belongs to a new drug composite, in particular to a drug composite which adopts troxerutin and ADP receptor antagonist as active ingredients. In order to find a composite drug compositefor curing thrombotic diseases which can not only keep the fast and forceful anticoagulation activity, but also effectively reduce the bleeding risk, the inventor finds that using both troxerutin andADP receptor antagonist for inhibiting the thrombosis has unexpected effect and extremely good synergistic effect through serious and repeated experiments and the mixed use of the both drugs can not only increase the antithrombotic function, but also reduce the bleeding risk when using ADP receptor antagonist so that the use of both drugs has better and more effective anticoagulation activity andfaster function.

The invention discloses a balloon catheter comprising a main body and a catheter. The catheter comprises an inner tube and an outer tube. An inner balloon and an outer balloon are arranged at one end of the outer tube. A plurality of temperature sensing elements are uniformly distributed on the inner wall of the inner balloon. A plurality of mapping flexible electrodes are uniformly distributed on the outer wall of the outer balloon. An inner balloon pressure sensor and an inter-outer balloon pressure sensor are arranged in the main body. Pressure in the inner balloon is adjusted in real time by detection data from the inner balloon pressure sensor. Pressure in the space between the inner balloon and the outer balloon is monitored in real time through detection data from the inner balloon pressure sensor and the outer balloon pressure sensor. According to the balloon catheter, the mapping function and the freezing function are integrated in the same catheter, thereby saving operation time, and achieving accurate and real-time detection of temperature at an ablation part of the human body. The balloon catheter has higher safety performance, and can monitor use condition of the inner balloon, thereby further improving practicability and safety of the catheter.

The invention provides a pharmaceutical composition containing active carbazochrome sodium sulfonate and clopidogrel or the pharmacologically acceptable salt thereof. The invention aims to invent a more effective and low adverse-reaction method for curing thrombotic diseases by using the combined medication of the carbazochrome sodium sulfonate and the clopidogrel. After conscientious trail of thepatent applicant for many times, the effect of applying the carbazochrome sodium sulfonate to inhibit the thrombosis in a combined manner is discovered unexpected in the process of applying the clopidogrel to cure the thrombotic diseases, the anticoagulant effect of the clopidogrel is not abated but increased, and the very good synergistic effects are achieved after the combination of the carbazochrome sodium sulfonate and the clopidogrel, therefore, the risk of bleeding is greatly reduced when the advantages of good anticoagulant activity and fast effect of the clopidogrel during the antiplatelet aggregation are fully exerted, the risk of bleeding caused by the clopidogrel is greatly reduced and the compliance of patients is enhanced.

The invention relates to iRNA, e.g., double stranded ribonucleic acid (dsRNA), compositions targeting the Serpinc1 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of Serpinc1 and to treat subjects having a Serpinc1-associated disease, e.g., a bleeding disorder, such as a hemophilia.

A method for preventing stroke in a patient suffering from atrial fibrillation, wherein the patient has no risk factors for major bleeding events, the method comprising administering to the patient a dosage of >150 mg b.i.d. to 300 mg b.i.d. of dabigatran etexilate, optionally in the form of a pharmaceutically acceptable salt thereof.

The invention relates to a pathology determining auxiliary device, in particular to an intra-operative pathological tissue quick extracting device which comprises a syringe, a piston, a hollow push-pull rod and a needle. The piston is arranged in the syringe, the hollow push-pull rod is fixedly connected with the tail end of the piston, the needle is arranged at the front end of the syringe, an 'H'-shaped tissue pushing mechanism which extends into the piston is arranged at the front end of the inside of the needle, and a 'T'-shaped pushing mechanism is arranged at the rear end of the hollow push-pull rod, penetrates into the hollow push-pull rod from the rear end of the hollow push-pull rod and extends to the rear end of the piston; a cavity is arranged inside the piston, a first throughhole which is communicated with the cavity is formed in the front end of the piston, and a second through hole which is communicated with the cavity is formed in the rear end of the piston. The intra-operative pathological tissue quick extracting device has the advantages that tissues can be extracted by the intra-operative pathological tissue quick extracting device in sterile environments, a seal cover can sleeve the intra-operative pathological tissue quick extracting device after the intra-operative pathological tissue quick extracting device is disinfected and can be directly pulled downin operation, and accordingly the intra-operative pathological tissue quick extracting device can be used; tissue extracting procedures are convenient and speedy, and the intra-operative pathologicaltissue quick extracting device is high in safety.

The invention belongs to a new drug composite, in particular to a drug composite which adopts troxerutin and ADP receptor antagonist as active ingredients. In order to find a composite drug composite for curing thrombotic diseases which can not only keep the fast and forceful anticoagulation activity, but also effectively reduce the bleeding risk, the inventor finds that using both troxerutin andADP receptor antagonist for inhibiting the thrombosis has unexpected effect and extremely good synergistic effect through serious and repeated experiments and the mixed use of the both drugs can not only increase the antithrombotic function, but also reduce the bleeding risk when using ADP receptor antagonist so that the use of both drugs has better and more effective anticoagulation activity andfaster function.

The invention discloses a biopsy forceps, comprising a mounting and fixing part, a clamp head assembly and a control assembly; the clamp head assembly includes a first forceps cup and a second forceps cup; the first forceps cup and the second forceps cup pass through the mounting and fixing part The first pliers cup is formed with a first cutting part; the second pliers cup is formed with a second cutting part; the second cutting part is used to abut each other when the first pliers cup and the second pliers cup When it is used, it cooperates with the first cutting part to cut off the living tissue; the control assembly is connected with the fixing part, and is used to control the opening and closing of the first forceps cup and the second forceps cup. The invention can prevent large-area damage to surrounding tissues during the sampling process, reduce bleeding probability, and improve extraction accuracy.