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207 results about "Neuritis" patented technology
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Neuritis (/njʊəˈraɪtɪs/) is inflammation of a nerve or the general inflammation of the peripheral nervous system. Symptoms depend on the nerves involved but may include pain, paresthesia (pins-and-needles), paresis (weakness), hypoesthesia (numbness), anesthesia, paralysis, wasting, and disappearance of the reflexes.
Pattern analysis of retinal maps for the diagnosis of optic nerve diseases by optical coherence tomography
Methods for analyzing retinal tomography maps to detect patterns of optic nerve diseases such as glaucoma, optic neuritis, anterior ischemic optic neuropathy are disclosed in this invention. The areas of mapping include the macula centered on the fovea, and the region centered on the optic nerve head. The retinal layers that are analyzed include the nerve fiber, ganglion cell, inner plexiform and inner nuclear layers and their combinations. The overall retinal thickness can also be analyzed. Pattern analysis are applied to the maps to create single parameter for diagnosis and progression analysis of glaucoma and optic neuropathy.
Owner:USC STEVENS UNIV OF SOUTHERN CALIFORNIA
Peptide composition
InactiveUS8343500B2Simplify the development processReduce capacityNervous disorderPeptide/protein ingredientsDiseaseMHC class I
Owner:APITOPE TECH BRISTOL
Cytomodulating peptides and methods for treating neurological disorders
InactiveUS20040186052A1Reducing neural cell deathReduce cell deathNervous disorderPeptide/protein ingredientsNeuritisNeuro degeneration
Compositions and methods are provided for inhibiting neuronal cell death and the loss of neuronal contacts resulting from acute and chronic neurological disorders, including neurodegenerative and neuroinflammatory diseases. The subject compositions and methods utilize RDP-58 compositions capable of providing a direct neuroprotective effect on neuronal cells in conjunction with the inhibition of autoimmune and inflammatory processes.
Owner:SANGSTAT MEDICAL
Substituted amides
Owner:MERCK SHARP & DOHME LLC
Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's disease, familial Alzheimer's disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.
Owner:UNIVERSITY OF PITTSBURGH
Pattern analysis of retinal maps for the diagnosis of optic nerve diseases by optical coherence tomography
Methods for analyzing retinal tomography maps to detect patterns of optic nerve diseases such as glaucoma, optic neuritis, anterior ischemic optic neuropathy are disclosed in this invention. The areas of mapping include the macula centered on the fovea, and the region centered on the optic nerve head. The retinal layers that are analyzed include the nerve fiber, ganglion cell, inner plexiform and inner nuclear layers and their combinations. The overall retinal thickness can also be analyzed. Pattern analysis are applied to the maps to create single parameter for diagnosis and progression analysis of glaucoma and optic neuropathy.
Owner:USC STEVENS UNIV OF SOUTHERN CALIFORNIA
Method for the in vitro diagnosis of alzheimer's disease using a monoclonal antibody
The invention relates to a method for the in vitro diagnosis of Alzheimer's disease using a monoclonal antibody. Said antibody can bind at least to amino acids 12-16 of the β-amyloid peptide, specifically detecting the neuritic plaques which are characteristic of Alzheimer's disease, without detecting diffuse plaques which are not defining characteristics of the disease. Within the neuritic plaques, the monoclonal antibody can detect a different sub-group in the composition of the different deposited isoforms of the β-amyloid peptide, which is associated with the disease progression stage. In addition, the antibody can bind to isoforms of the β-amyloid peptide in biological fluids such as urine. As a result, the inventive monoclonal antibody, the cell lines that produce said antibody and compositions containing same can be used in the in vitro diagnosis of Alzheimer's disease and in determining the disease progression stage.
Owner:CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)
Peripheral nerve field stimulator curved subcutaneous introducer needle with wing attachment specification
An apparatus for use in peripheral nerve field stimulation (PNFS) whereby a plurality of curved introducer needles, of varying curvatures, are provided to permit the physician to best locate the region of oligodendrocytes that contain the A Beta fibers by matching the lumbar lordosis. A wing device is also provided that is attachable to the hub of the curved needle introducer which gives the physician better ability to maneuver the needle during insertion as well as permitting tenting of the skin. The invention benefits a large number of painful disorders arising from pathology in the cervical, thoracic, and lumbar spine. In addition, this invention can also help a large number of other conditions including but not limited to failed back surgery syndrome / post-laminectomy pain, occipital / suboccipital headaches, scar pain, post herpetic neuralgia pain, mononeuritis multiplex, and pain following joint surgery (e.g., knee, hip, shoulder).
Owner:ADVANCED NEUROMODULATION SYST INC
Thioflavin derivatives for use in the antemortem diagnosis of Alzheimers disease and in vivo imaging and prevention of amyloid deposition
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's Disease, familial Alzheimer's Disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.
Owner:UNIVERSITY OF PITTSBURGH
Substituted 2,3-diphenyl pyridines
Novel compounds of the structural formula (I) are antagonists and / or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson s disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
Owner:MERCK SHARP & DOHME CORP
Chinese traditional medicine for treating facial paralysis, facial spasm and trifacial neuralgia
A traditional Chinese medicine for treating facial paralysis, facial spasm, trigeminal neuralgia prepared from preserved batryticated silkworm powder 60-120g, buthus martensi kirsch powder 40-80g, giant typhonium tuber powder 55-110g, Chinese angelica root powder 58-115g, milk vetch root powder 60-120g, rhizome of Sichuan lovage powder 50-100g, white mustard seed powder 10-50g, ledebouriella root powder 60-120g, dahurian angelica root powder 64-110g, rhizoma Gastrodiae powder 75g, notopterygium root powder 55-95g, and licorice powder 15-40g.
Owner:游国峰
Methods for the treatment and prevention of inflammatory diseases
The invention includes processes mainly for the treatment of a inflammatory diseases, such as inflammatory bowel disease, arthritis, atherosclerosis, asthma, allergy, inflammatory kidney disease, circulatory shock, multiple sclerosis, chronic obstructive pulmonary disease, skin inflammation, periodontal disease, psoriasis and T cell-mediated diseases of immunity, including allergic encephalomyelitis, allergic neuritis, transplant allograft rejection, graft versus host disease, myocarditis, thyroiditis, nephritis, systemic lupus erthematosus, and insulin-dependent diabetes mellitus. The processes involve treating a patient with a pharmaceutical composition containing an active ingredient that inhibits the activity of sphingosine kinase.
Owner:APOGEE BIOTECHNOLOGY CORP
Substituted pyrimidines
Owner:MERCK SHARP & DOHME CORP
NGF-Fc fusion protein and preparation method thereof
InactiveCN105273087AImprove stabilityExtended half-lifeNervous disorderPeptide/protein ingredientsDiseaseNervous system
The invention belongs to the technical field of biological engineering, and relates to an NGF-Fc fusion protein and a preparation method thereof. The method comprises the following steps: constructing a human immune globulin IgG Fc and nerve growth factor (NGF) fusion gene expression vector through a genetic engineering means, transferring to a mammal cell to make the transferred mammal cell highly express and produce NGF-Fc fusion proteins, purifying, identifying and carrying out biological activity detection. The expression vector transferred mammal cell constructed in the invention can express bioactive NGF-Fc fusion proteins, so the expression level can be 150mg / L or above, and the obtained protein has good stability and long half life, and can be used to prepare drugs for treating Alzheimer's disease, diabetic peripheral neuropathy, Parkinson's disease, facial neuritis, craniocerebral trauma, trauma of spinal cord, acute cerebrovascular disease, encephalatrophy and other neurological diseases, and peripheral nerve injury acute cerebral vascular central nerve injuries induced by chemical drugs.
Owner:FUDAN UNIV
Method for the in vitro diagnosis of alzheimer's disease using a monoclonal antibody
InactiveUS7932048B2Easy extractionEasy to detectNervous disorderImmunoglobulins against animals/humansNeuritisMonoclonal antibody
The invention relates to a method for the in vitro diagnosis of Alzheimer's disease using a monoclonal antibody. Said antibody can bind at least to amino acids 12-16 of the β-amyloid peptide, specifically detecting the neuritic plaques which are characteristic of Alzheimer's disease, without detecting diffuse plaques which are not defining characteristics of the disease. Within the neuritic plaques, the monoclonal antibody can detect a different sub-group in the composition of the different deposited isoforms of the β-amyloid peptide, which is associated with the disease progression stage. In addition, the antibody can bind to isoforms of the β-amyloid peptide in biological fluids such as urine. As a result, the inventive monoclonal antibody, the cell lines that produce said antibody and compositions containing same can be used in the in vitro diagnosis of Alzheimer's disease and in determining the disease progression stage.
Owner:CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)
Ninjurin-1 modulation and uses thereof
ActiveUS20100310568A1Relieve symptomsReduce tissue damageNervous disorderPeptide/protein ingredientsMedicineInflammation
Methods, uses, agents and compositions useful for the prevention, treatment and / or diagnosis of neuroinflammatory conditions such as multiple sclerosis and spinal cord injury based on the modulation of nerve injury-induced protein-1 (Ninjurin-1) are disclosed.
Owner:VAL CHUM PARTNERSHIP
Peptide composition
InactiveUS20080200368A1Simplify the development processReduce capacityNervous disorderPeptide/protein ingredientsDiseaseMHC class I
There is provided a method for selecting a tolerogenic peptide by selecting a peptide which is capable of binding to an MHC class I or II molecule without further processing. There is also provided a peptide selected by such a method and its use in a pharmaceutical composition and a method to treat and / or prevent a disease. The present invention also relates to a composition which comprises the following myelin basic protein (MBP) peptides: MBP 30-44; MBP 83-99; MBP 131-145; and MBP 140-154. The composition may be used to treat a disease, in particular multiple sclerosis and / or optical neuritis and the invention also relates to such uses and methods.
Owner:APITOPE TECH BRISTOL
Substituted furo[2,3-b]pyridine derivatives
Novel compounds of the structural formula (I) are antagonists and / or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
![Substituted furo[2,3-b]pyridine derivatives](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/3ed63723-40f5-4ba6-aa1b-8315990b9ddc/US20050272763A1-20051208-C00001.png "Substituted furo[2,3-b]pyridine derivatives")
![Substituted furo[2,3-b]pyridine derivatives](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/3ed63723-40f5-4ba6-aa1b-8315990b9ddc/US20050272763A1-20051208-C00002.png "Substituted furo[2,3-b]pyridine derivatives")
![Substituted furo[2,3-b]pyridine derivatives](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/3ed63723-40f5-4ba6-aa1b-8315990b9ddc/US20050272763A1-20051208-C00003.png "Substituted furo[2,3-b]pyridine derivatives")
Owner:MERCK SHARP & DOHME CORP
Use of epidermal growth factor for the morphofunctional restoration of peripheral nerves in diabetic neuropathy
ActiveUS20100136062A1Eliminate neuropathic painFree from painNervous disorderPeptide/protein ingredientsAnesthetic AgentMicrosphere
The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and / or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anaesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.
Owner:CENT DE ING GENETICA & BIOTECNOLOGIA
Respiratory muscle trainer
InactiveCN103816647AAchieve the purpose of rehabilitationGymnastic exercisingDiseaseRespiratory disease
The invention relates to a respiratory muscle trainer in an abdomen pressurization form and utilizing a spring meter to display tensile force. The respiratory muscle trainer comprises an abdominal belt, a rubber ball used for pressurization and inflation and the spring meter. A user can inflate air into an air bag in the abdominal belt by squeezing the rubber ball according to conditions thereof, certain uniform pressure is generated on the abdomen, and the spring meter can help a user to detect respiratory muscle strength. The respiratory muscle trainer is a full-function training apparatus special for respiratory muscles, and can be used for enhancing contractility and endurance of the respiratory muscles. The respiratory muscle trainer is controllable in training intensity, adjustable and precise in effect and free of limits of seasons, climates, sites and body postures, is applicable to fitness crowd and exercise in the rehabilitation period of pulmonary chronic respiratory diseases and the like; senile respiratory muscle strength reduction is prevented; respiration force of athletes is strengthened; respiratory therapy for neuritis, myasthenia, pleural adhesion and postoperative pulmonary atelectasis is realized; respiratory function training and the like of normal people is realized.
Owner:JIANGNAN UNIV
Thioflavin derivatives for use in the antemortem diagnosis of alzheimers disease and in vivo imaging and prevention of amyloid deposition
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's Disease, familial Alzheimer's Disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.
Owner:UNIVERSITY OF PITTSBURGH
Sigma ligands for use in the prevention and/or treatment of post-operative pain
The invention refers to the use of a sigma ligand, particularly a sigma ligand of formulae (I), (II) or (III) to prevent and / or treat acute and chronic pain developed as a consequence of surgery, especially superficial and / or deep pain secondary to surgical tissue injury, and peripheral neuropathic pain, neuralgia, allodynia, causalgia, hyperalgesia, hyperesthesia, hyperpathia, neuritis or neuropathy secondary to surgical procedure.
Owner:LAB DEL DR ESTEVE SA
Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's disease, familial Alzheimer's disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.
Owner:UNIVERSITY OF PITTSBURGH
Spirocyclic amides as cannabinoid receptor modulators
Novel compounds of structural formula (I) are antagonists and / or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as psychotropic drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinsons disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as, the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
Owner:MERCK SHARP & DOHME CORP
Methods for the treatment and prevention of inflammatory diseases
Owner:APOGEE BIOTECHNOLOGY CORP
Antibodies to receptor for advanced glycation end products (RAGE) and uses thereof
InactiveUS8420083B2Block the binding of Aβ-globulomersAntipyreticAnalgesicsAntiendomysial antibodiesNeuritis
Owner:ABBVIE INC
Substituted imidazoles as cannabinoid receptor modulators
Owner:MERCK SHARP & DOHME CORP
Composition for treating pain of head, face and limbs and various tendons clonic convulsion and preparation thereof
The invention discloses a medicine composition for treating head, face and limb pain and cramps, which comprises scorpion, centipede, muscardine silkworm, aconite root, muskiness and borneol. The medicine composition of the invention has the functions of detoxication, precluding knot, meridian ducting, dispelling wind and relieving pain, relieving spasm by subduing liver-wind, dispersing stagnant fire and so on, which has remarkable effect on neuritis and blood vessel diseases resulted from wind-phlegm which blocking the meridian and viscera and Qi stagnation and blood stasis, such as face neuritis, hemifacial spasm, child MBD, intractable headache, splitting headache, limb pain and anaesthesia, cerebral arteriosclerosis, cerebral infarction, polyneuritis and so on.
Owner:黄孔新
Nano far infrared superconducting energy health care insoles
InactiveCN103989287AStrong energyBlood circulation is smooth and acceleratedInsolesDigestive systemSurface layerAdhesive
The invention discloses nano far infrared superconducting energy health care insoles. The health care insoles are composed of functional adhesive, sponge and self-heating surface layer cloth. The nano far infrared superconducting energy health care insoles can be used for treating dietetic neuritis for a long term and have a long-term health care function.
Owner:鹤山市龙腾科技有限公司
Composition comprising the extract of herbs for preventing or treating neurodegenerative disorders
InactiveUS20140044817A1Increase the amount addedPromote formationBiocideNervous disorderNeural cellMedicine
This invention relates to a pharmaceutical composition and a health functional food for preventing or improving neurodegenerative disorders comprising mixed herb extracts of Dioscorea Rhizoma and Dioscorea nipponica in a weight ratio of 3.5:1 (w / w). The herb extracts mixed Dioscorea Rhizoma and Dioscorea nipponica in a weight ratio of 3.5:1 have the synergetic effects on increasing the amount of nerve growth factor in vivo, increasing the neural cell proliferation, promoting the formation of neuritis and enhancing cognitive abilities. Thus, the herb extracts of the present invention may be used for a pharmaceutical composition and a health functional food for preventing or treating neurodegenerative disorders.
Owner:DONG A ST CO LTD
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