104 results about "Cerebral embolism" patented technology

A compound represented by the general formula (1):Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4  (1)wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a groupin which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof.The compound is useful as an agent for preventing and / or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

The invention discloses a double-frequency ultrasonic multi-dimensional focused noninvasive cerebrovascular thrombolytic system, which is characterized in that: a craniocerebral vertical positioning ring is worn for image detection and acquisition of positioning image data; the position and treatment position of a focus can be determined by using a medical image three-dimensional reconstruction technique; a multi-dimensional low-power low-frequency ultrasonic transducer is placed on the same cut face of a focus of cerebral embolism to form a stable ultrasonic cavitation effect is formed in the thrombus or the focus of the cerebral embolism; a medium-frequency and / or high-frequency focused ultrasound transducer is used to radiate the thrombus by a focused ultrasonic focal point from a position on the same cut face of body surface which is most close to the focus, the focused ultrasonic waves are focused with high power, high sound intensity and high accuracy and are intermittently emitted in a pulse modulation ultrasonic wave mode in a short time to form an instant unstable ultrasonic cavitation effect in the thrombus to induce blasting in the thrombus, so that the thrombus is disintegrated and dissolved quickly; and while the thrombus is quickly and effectively dissolved, the inner wall of the blood vessel and surrounding normal brain tissues are not damaged, so in-vitro noninvasive thrombolytic effect is achieved.

A Chinese medicine in the form of injection for treating the acute stage of ischemic apoplexy and cerebral embolism is prepared from 3 Chinese-medicinal materials; red sage root, red peony root and grass-leaved sweetflag rhizome. Its advantage is high curative effect.

The present invention relates to one kind of cardiac and cerebral vascular diseases treating compound medicine. The notoginseng total saponin dispersing tablet is prepared with the material includes notoginseng total saponin, lactose, mannitol, crosslinked polyvinyl pyrrolidone, ethanol and magnesium stearate. The preparation process includes 100-mesh sieving, weighing the above-mentioned raw materials, mixing, moistening with ethanol, palletizing, drying, tableting and other steps. The compound medicine has high preventing and treating effect on apoplexy, hemiplegia, cerebral infarction, cerebral embolism, etc.

A compound represented by formula (1):Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4  (1)[wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 represents the following group:(wherein Q5 is an alkylene group having 1 to 8 carbon atoms, or the like); and T0 and T1 are carbonyl groups or the like], a salt thereof, a solvate thereof, or an N-oxide thereof.The compound is useful as an agent for preventing and / or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after artificial valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

The present invention is medicine composition for treating cerebral ischemia and its medicinal application. The medicine composition has ginsenoside and salvianolic acid as main components. It can reduce the cerebral infarction area obviously, reduce behavior disorder caused by cerebral tissue necrosis obviously, and reach the aim of treating cerebral blood supply insufficiency, cerebral thrombosis, cerebral embolism, cerebral vascular spasm, senile dementia, etc.

By introducing hepatocyte growth factor (HGF) gene and / or vascular endothelial growth factor (VEGF) gene into the subarachnoid space in humans, cerebrovascular disorders such as cerebrovascular obstruction, cerebral infarction, cerebral thrombosis, cerebral embolism, stroke, cerebral bleeding, moyamoya disease, cerebrovascular dementia, and Alzheimer's dementia can be effectively treated or prevented.

The invention provides aporphine and oxoaporphine compounds that have endothelial nitric oxide synthase (eNOS) maintaining or enhancing activities and may be used to manufacture a medicaments for preventing or treating ischemic diseases in human and mammal, and the ischemic diseases may include ischemic cerebral apoplexy, ischemic cerebral thrombosis, ischemic cerebral embolism, hypoxic ischemic encephlopathy, ischemic cardiac disease or ischemic enteropathy etc.

The present invention discloses total notoginseng saponin liposome and its preparation. The total notoginseng saponin liposome contains total notoginseng saponin 5-30 wt%, filming material 50-80 wt%, additive 1-10 wt% and some other supplementary material. It may be prepared into transdermal preparation, aerosol, oral liquid, eye preparation, tablet or capsule; is used in treating apoplexy, hemiplegia, atherosclerotic thrombotic cerebral infarction, cerebral embolism, etc.; and has excellent medicinal application foreground.

The invention belongs to the technical field of medicaments and provides active ingredients of Chinese herbal medicine camptosorus sibiricus and an extraction method and use of the same. The extraction method comprises a water extraction method, an alcohol extraction method, a macroporous resin purification method and a solvent extraction method. The main active ingredients of an extract obtained by the method are total flavonoids, total momordica saponins and total organic acids, wherein the content of the total flavonoids is 1 to 35 percent, the content of the total momordica saponins is 1 to 25 percent and the content of the total organic acids is 1 to 3 percent. The invention also provides a method for preparing the camptosorus sibiricus into a proper formulation directly or by mixing with solid or liquid commonly used for preparations of the type in pharmaceutics. The active ingredients of the camptosorus sibiricus and the preparation thereof have functions of treating thromboangiitis obliterans, nephritis, traumatism and bleeding, metrorrhagia, neurodermitis, hemiplegia caused by cerebral embolism and diabetes-related complications. The extraction method is simple, easy to implement and low in cost. And the extract obtained is free from toxic and side effects.

The invention discloses healthcare tea capable of tonifying qi, tonifying spleen and tonifying kidneys. The healthcare tea consists of nine Chinese herbal medicine materials including lentinula edodes, astragalus, fried Chinese yam, radix codonopsis, fruits of Chinese wolfberry, tangerine peel, siraidia grosvenorii, liquorice and red jujubes. The healthcare tea has the advantages of tonifying qi, tonifying spleen and tonifying kidney, being short in period, treating diseases fundamentally, avoiding relapse, being convenient to take, suitable for being used in four seasons, low in cost, reasonable in formula, low in price, high in cure rate, and the like, can prevent the occurrence of skin diseases and various cancers, and has a relatively good auxiliary curative effect for hypertension, hyperlipaemia, diabetes mellitus and cardiogenic cerebral embolism sequelae. Besides, the healthcare tea is prepared from non-toxic pure ecologic medicine materials and food materials, and is free from any toxic and side effects.

The invention relates to a therapeutic medicine for cerebral embolism sequela, in particular, a therapeutic medicine for treating cerebral embolism sequela and a preparation method thereof which solve problems of poor cure effect, slow efficiency and the like existed in the prior art. Calculated by weight parts, the medicine is a medicament made from raw materials as follows: 70-100 parts of lumbricus, 30-50 parts of leech, 80-100 parts of ligusticum wallichii, 50-80 parts of Chinese angelica, 50-80 parts of uncaria rhynchophylla, 50-80 parts of peach kernel, 30-50 parts of red flower, 50-100 parts of gastrodia elata, 40-80 parts of caulis spatholobi, and 30-50 parts of radix salvia miltiorrhiza. The preparation method comprises the steps of: firstly, drying the raw materials, crushing to form fine powder of 100-200 meshes and sieving; then after mixing according said proportion, sterilizing and mixing uniformly to make into the medicament in a plurality of dosage forms, such as water-bindered pills, tablets, honey boluses or capsules. The medicine for treating cerebral embolism sequela disclosed by the invention is composed of natural animals and plants, so the medicine has a mild medicine property as well as no toxic side effect and adverse effect, is suitable for patients who are at different ages, suffer from stroke sequela and have different physic conditions to take for a long term in a stage of recovery.

A compound represented by the following formula (1): Q1—Q2—To—N(R1)—Q3—N(R2)—T1—Q4  (1) [wherein, R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may have a substituent, or the like; Q2 is a single bond or the like; Q3 represents the following group: —C(R3a)(R4a)—{C(R3b)(R4b)}m1—{C(R3c)(R4c)}m2—{C(R3d)(R4d)}m3—{C(R3e)(R4e)}m4—C (R3f)(R4f)— (in which, R3a to R4e represent hydrogen or the like); T0 represents a carbonyl group or the like; and T1 represents —COCONR— or the like]; or salt thereof, solvate thereof, or N-oxide thereof. The compound is useful as a preventive and / or therapeutic agent for cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

The invention belongs to medical technical field and discloses nasal mucosa medication agent of tetramethylpyrazine and the preparation method. The agent contains tetramethylpyrazine, pharmaceutical excipient and absorption enhancer. The weight percentage is 1:0.1 to 100:0.1 to 10. The tetramethylpyrazine includes tetramethylpyrazine prepared in various methods and salts of tetramethylpyrazine. Formula dosage of tetramethylpyrazine is put into absorption enhancer and additional pharmaceutical solutions of suitable concentration prepared in advance to produce nasal mucosa medication agent, such as nasal drops, spray, aerosol, microsphere agent, liposomes, etc. Via the special physiological structure of nasal cavity, the agent medicates via nasal mucosa and allows tetramethylpyrazine bypasses the blood-brain barrier to enhance the distribution of medicine in brain tissue. The drug can be used to treat migraine, cerebral ischemia, cerebral embolism and emergencies such as angina pectoris, coronary heart disease, myocardial infarction, etc, and the drug has the advantages of complete and rapid absorption, high treating effects, high stability, and few side effects.

The present invention belongs to the field of pharmaceutical technology and relates to transdermal Ligustrazine plaster and its preparation. It has Ligustrazine phosphate or Ligustrazine as active medicinal component and consists of medicine storing back, adhering layer, release controlling film, back lining layer and protective layer. It is superior to available Ligustrazine preparation forms inmedicine releasing are, transdermal rate and lasting release time, and has the features of determined curative effect, stable quality, high safety, etc. Animal experiments show that the plaster can retard the effect of ischemic to cerebral damage, inhibit thrombosis caused by tissue damage, prevent and treat cerebral embolism and maintain balanced medicine density in blood for 24 hr; and has light irritation to skin, no irritability and no toxic reaction.

The invention relates to a monascus compound preparation capable of regulating pressure and lipid and improving arteriosclerosis, coronary heart disease and cerebral embolism. The preparation is prepared through the following steps: fermenting ginseng and gingko leaves in a liquid state to obtain ginseng fermentation liquor and gingko fermentation liquor, culturing monascus 9901 bacterium or 9906strain in a liquid state, and adding water into the ginseng fermentation liquor, the gingko fermentation liquor and grains to prepare a solid-state culture medium; grafting and performing solid statefermentation to initially obtain a monascus strain; sterilizing malt juice or potato juice, sugar and agar to prepare a plate; grafting and culturing to prepare a pure monascus strain; preparing a strain enlarged culture fluid; grafting and performing strain enlarged culture; culturing in a shaker; performing sterilization grafting and culturing on the ginseng extract, the gingko extract and a solid fermentation nutrient solution; sterilizing, baking, crushing and uniformly mixing the fermented solid culture to obtain monascus fine powder; and preparing the preparation according to a corresponding preparation process of the preparation. The non-citrinin high-color value functional monascus produced by adopting a liquid-state fermentation technology in the invention has the advantages of low cost, edible safety, tiny toxic or side effect, stable and reliable curative effect and short course of treatment.

The invention provides a traditional Chinese medicine compound used for treating cardiovascular and cerebrovascular diseases, which is made of the following components by weight ratios: 5-25 portions of red sage root, 5-25 portions of astragalus root, 5-25 portions of pseudostellaria root, 3-23 portions of polygala aureocauda dunn, 3-23 portions of shepherds purse, 1-6 portions of notoginseng, 3-23 portions of oldenlandia, 3-23 portions of eucommia bark, 3-23 portions of prepared rehmannia root, and 1-6 portions of prepared licorice. The components of the traditional Chinese medicine compound can produce synergetic effect, thus treating the cardiovascular and cerebrovascular diseases with high efficiency. Clinical control studies prove that the traditional Chinese medicine compound has the total effective rate of 96.9% on treating cerebral embolism and the total effective rate of 100% on treating hypertension. Also, the traditional Chinese medicine compound has the advantages of quick effect and good and lasting curative effect.

The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is an optionally substituted lower alkyl group, an optionally substituted lower alkoxy group, an optionally substituted lower alkenyl group, a cycloalkyl group or a lower acyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom or a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same and an intermediate thereof. These compounds are useful as preventives or remedies for various diseases such as brain infarction, cerebral thrombosis, cerebral embolism, TIA, cerebral vascular jerk, Alzheimer's diseases, myocardial infarction, heart attack, heart failure, thrombosis, pulmonary infarction and pulmonary embolism.

The invention discloses a traditional Chinese medicine for treating wind-cold numbness, which comprises the following components in part by weight: 1 to 2 parts of Chinese angelica, 1 to 2 parts of szechuan lovage rhizome, 1 to 2 parts of divaricate saposhnikovia root, 1 to 2 parts of tuber fleeceflower root, 1 to 2 parts of erythrina indica lam, 1 to 2 parts of incised notopterygium rhizome, 1 to 2 parts of pubescent angelica root, 1 to 2 parts of tall gastrodia tuber, 1 to 2 parts of common monkshood mother root, 1 to 2 parts of kusnezoff monkshood root, 1 to 2 parts of frankincense, 1 to 2 parts of myrrh, 1 to 2 parts of suberect spatholobus stem and 1 to 2 parts of glossy privet fruit. A preparation method of the traditional Chinese medicine comprises the following steps of: mixingthe components, and grinding the mixture into fine powder, and processing the fine powder to form honeyed pills, water honeyed pills and capsules. The traditional Chinese medicine has the effects of promoting blood circulation, removing blood stasis, stopping pain, promoting integral blood circulation, eliminating blood stasis and promoting tissue regeneration, and has the good curative effect on diseases such as modern rheumatic and rheumatoid arthritis, cervical vertebra syndrome, scapulohumeral periarthritis, obstructive vasculitis, phlebeurysma, cerebral embolism sequelae, hemiplegia and the like, which are caused by anemofrigid-damp arthralgia.

The invention discloses a medicinal composition for treating cardiovascular and cerebrovascular diseases, and a preparation method and application of the medicinal composition. The medicinal composition can prolong coagulation time, reduce cholesterol levels and contribute to reducing the formation rate of thrombus and atherosclerosis, can be used for treating cerebrovascular diseases such as cerebral ischemia, cerebral thrombosis, cerebral embolism and the like, and cardiovascular diseases such as coronary disease, hypertension, hyperlipaemia, atherosclerosis, myocardial ischemia, arrhythmia, heart failure, stenocardia, myocardial infarction and the like, particularly has good treatment effect when used for continued treatment on patients suffering the cardiovascular and cerebrovascular diseases after emergency treatment, and is a new choice for clinical medication.

The invention relates to a weight- and blood fat- reducing infusion prepared of pure Chinese medicinal herbs and the preparing process thereof, prepared of fifteen Chinese medicinal herbs such as Virgate Wormwood Herb, Oriental Waterplantain Rhizome, Cassia obtusifolia L, etc, by the following steps of: washing, drying, mixing and crushing->decocting->placing->concentrating->preparing soft material->making granules->drying->regulating granules->split-charging->checking->obtaining the finished products, and it relates pathogenesis of adiposity, high blood fat, diabetes and hihg blood pressure, improving micro circulation, increasing blood flow, improving blood viscosity, preventing cardio and cerebral embolism, anti-oxidizing, eliminating in vivo free radicals, reducing blood fat, clearing pulse, reducing blood pressure and sugar, reducing weight, thus having obvious clinical curative effect on patients with adiposity, high blood fat, diabetes and hihg blood pressure, and able to prevent diseases and senescence and prolong life.

The invention discloses a Chinese medicinal composition, its preparing process and use, wherein the preparing process consists of watering and grilling Ligusticum wallichii, root of red rooted saliva, zedoary, peach kernels and common burreed tuber three times (1-3 hours each time), merging the grilling liquids, concentrating into concrete with specific gravity of 1. 10-1. 30 (60 deg C. ), disintegrating safflower and earthworm into fine powders, charging musk and pharmaceutically acceptable medicinal auxiliary materials, and mixing with the concrete homogeneously. The composition can be used for treating cerebral embolism, arteriosclerosis, coronary disease, senile dementia, light-headedness, hemiparalysis, brain trauma and cerebral hemorrhage sequelae.

The invention provides a Chinese medicinal composition for treating hypertension, cerebral thrombus, cerebral embolism and coronary disease, wherein the raw materials include (by weight ratio) ginseng saponin 2-6 parts, notoginseng saponins 2-6 parts, ligustrazine 1-4 parts, red sage root extract 2-4 parts. The preparation process comprises mixing raw material with sterilization water for injection by a ratio of 1:2, proportionally charging notoginseng saponins, ginseng saponin, ligustrazine and red sage root extract, packing, sterilizing with heavy pressure for 30 minutes at 100 Deg C, finally storing in dry and cool places.

The invention relates to the technical field of medicine, and relates to a Chuanxiong volatile oil drop pill for treating cardiovascular and cerebrovascular diseases such as cerebral thrombosis, cerebral embolism, transient cerebral ischemia, coronary heart disease, hypertension, arteriosclerosis, and vascular vertigo. The invention adopts a steam distillation method or a subcritical fluid extraction method to prepare chuanxiong volatile oil, and fully removes water in the chuanxiong volatile oil; mixes the chuanxiong volatile oil with polyethylene glycol matrix, and adopts a dropping pill machine to produce chuanxiong volatile oil drop pills. The Chuanxiong volatile oil dripping pill prepared by the present invention does not contain water, so the Chuanxiong volatile oil is stable. Compared with the Chuanxiong volatile oil injection or oral liquid, it has good stability, high bioavailability, and is easy to store. It can effectively improve the effect of Chuanxiong volatile oil on ischemic brain. Efficacy of vascular disease.

The invention discloses a pharmaceutical composition for treating cerebrovascular and cardiovascular diseases as well as a preparation method and application. The pharmaceutical composition has antithrombotic and anti-stasis effects, and can be used for treating cerebral ischemia, cerebral thrombosis and cerebral embolism and other cerebrovascular diseases, hypertension and coronary heart disease, hyperlipidemia, atherosclerosis, myocardial ischemia, arrhythmia, heart failure, angina and myocardial infarction and other cardiovascular diseases, especially for further treating patients with cerebrovascular and cardiovascular diseases after first aid, with relatively good treating effect; therefore, a new choice is provided for clinical medicinal application.

The invention belongs to the field of medicinal preparations and particularly discloses a method for preparing a Shuxuening injection having the effects of expanding blood vessels and improving microcirculation. The preparation method comprises the following steps of: grinding ginkgo leaves and performing the technical treatments of the ginkgo leaves, such as ethanol soakage, condensation filtration, ethanol refrigeration, resin adsorption and ethanol elution, to obtain extracting solution of ginkgo. The method can guarantee that inactive substances such as proteins and tannins are completely eliminated, the degradation of active substances is avoided, related substances in the preparation are reduced, and the finished product of the preparation has the advantages of high stability, small irritability, high solubility and stable curative effect. Clinical tests prove that the Shuxuening injection can be used for intravenous drip to treat diseases such as ischemic cardiovascular and cerebrovascular diseases, coronary heart disease, angina, cerebral embolism, cerebrovascular spasm and the like.

The invention discloses a Chinese herbal medicine with a function of tranquilizing mind by nourishing the heart. The Chinese herbal medicine is prepared from the following raw materials in parts by weight: 90-100 parts of dried longan pulp, 80-100 parts of lily, 40-50 parts of wild jujube seeds, 30-50 parts of lotus seeds, 40-50 parts of grosvener siraitia, 80-100 parts of mushroom and 30-50 parts of liquorice. The Chinese herbal medicine is prepared from non-toxic pure ecological medicines and food raw materials, thus being free from any toxic or side effect; the Chinese herbal medicine not only can be used for treating an insomniac, but also can be used as diet to take all the year round; the Chinese herbal medicine is capable of rinsing intestines and stomach, promoting digestion and relieving stasis, nourishing and nursing the five internal organs, keeping fit and preventing insomnia, and has a better auxiliary effect for obesity, hypertension, hyperlipidemia, diabetes as well as heart and cerebral embolism sequela. The nerve-calming health food has the advantages of being good in nerve-calming effect, short in period, free from bounce, convenient to take, low in price and the like.

A permeable plug may be temporarily deployed in a patient to protect blood vessels from blockage by various debris. The plug includes a body formed from a filtering material. The body is collapsible for delivery to a location in a blood vessel and expandable to a filtering configuration in which the body occupies a cross-section of the blood vessel and is held in place by its own expansive force. At least one stud is connected to the body for use in deployment of the plug within the blood vessel and retrieval of the plug from the blood vessel.

The present invention discloses a preparation method of Chinese medicine preparation for treating ischemic cardiovascular and cerebrovascular diseases. The method comprises the following steps of: extracting and refining the ginkgo leaf and szechuan lovage rhizome to obtain the extract with higher content of active ingredient, adding the extract with pharmaceutic adjuvant with a ratio of 1 : 1 - 5 and 1 : 1 - 8, mixing uniformly, and preparing into soft capsule and pills respectively. The Chinese medicine preparation has significant effect on the treatment of ischemic cardiovascular and cerebrovascular diseases, coronary heart disease, angina pectoris, cerebral embolism, cerebral vasospasm and the like, no toxic and side-effect, the production technology is simple, and the quality control of product is convenient.

The invention relates to alkyl pyrazine dobesilate monohydrate compounds or their hydrates having formula (I), wherein R is C1-C5 alkyl, a is an integer of 1-5, b is an integer of 1-4, m and n are identical or different, the preparing process is also disclosed. The medicament can be used for the preventing and treating blood capillary pathology of diabetic retina, kidney, peripheral nerve and skin pruritus, and for preventing and treating angina pectoris, myocardial infarction, cerebral embolism, lacuna brain infarction, brain thrombogenesis and brain blood supply insufficiency.