98 results about "Acute stage" patented technology

A method of assessing the likelihood that a person who is asymptomatic for coronary artery disease does in fact have the disease is disclosed. The levels of an atherogenic protein and acute phase reactant and optionally of anti-atherogenic protein for an individual are obtained and compared to one or more cut-points related to those substances and, based on the comparison(s), an assessment is made of the likelihood that the individual has coronary artery disease. The atherogenic protein may be OxLDL, the acute phase reactant may be C-reactive protein or fibrinogen, and the anti-atherogenic protein may be HDL.

A Chinese medicine in the form of injection for treating the acute stage of ischemic apoplexy and cerebral embolism is prepared from 3 Chinese-medicinal materials; red sage root, red peony root and grass-leaved sweetflag rhizome. Its advantage is high curative effect.

An embodiment of the invention is a shoulder dislocation acute-phase immobilization orthosis for supporting, in treatment for a shoulder dislocation, an arm in a prescribed position while the elbow is bent at a right angle in an arm hanging position. The orthosis comprises: a support frame (1) integrally formed of a lightweight hard thick-plated material, with a width approximately greater than that of the forearm, comprising: a curved portion (3) which follows the shape of the abdominal part of a body and an arm supporting side face (5) of approximately the forearm length, which is integrally extended forward from one end of the curved portion (3) via a bent portion (4) and is bent at an appointed angle; an arm supporting member(s) (6) for immobilizing the forearm, provided on the arm supporting side face (5) of the support frame (1); and a wrap-around belt (2) made of a flexible material having a width identical to that of the support frame 1, provided with a surface fastener (8) for fitting the support frame (1) to the trunk part of a body.

This invention relates to the diagnosis and / or monitoring of patients with inflammatory diseases or conditions, including systemic lupus erythematosus, particularly for diagnosis of the acute stage of the disease, including methods and kits for carrying out this activity. This disclosure presents the surprising discovery that levels of complement pathway components on reticulocytes can be used to diagnose, monitor, or predict the occurrence of acute episodes of chronic inflammatory diseases or conditions.

The present invention concerns the use of hepcidin as a marker for detecting inflammatory chronic diseases and especially for a differential diagnosis to detect inflammatory chronic diseases and / or non-inflammatory chronic diseases. The present invention also concerns a method for detecting inflammatory chronic diseases, non-inflammatory chronic diseases and / or acute phase reactions comprising the determination of hepcidin.

The invention discloses a method of fully automatically classifying and partitioning a branch retinal artery obstruction based on a three-dimensional OCT image. The method comprises the following steps: pretreatment is carried out, a graph searching algorithm is adopted to layer the retina, and each layer of the retina is leveled according to a pigment epithelium layer; an AdaBoost classifier is used for automatically classifying an acute stage and an atrophy stage of the branch retinal artery obstruction; partitioning of the acute stage of the branch retinal artery obstruction is carried out, a Bayesian posterior probability is firstly adopted to carry out initial partitioning on an obstruction area, and then based on a graph searching-graph partitioning algorithm, accurate partitioning is carried out on the obstruction area; and partitioning of the atrophy stage of the branch retinal artery obstruction is carried out, and the obstruction area for the atrophy stage is automatically partitioned through building an inner retina thickness model. The method of the invention can accurately classify and partition the branch retinal artery obstruction area, and can replace manual classifying and partitioning.

The invention belongs to the technical field of medical early warning, and discloses an early warning system and method for cerebral apoplexy. The early warning system for cerebral apoplexy comprisesan image collection module, a physiological index collection module, a main control module, an image processing module, a risk evaluation module, a warning module, a data storage module and a displaymodule. According to the system and method, through the image processing module, automatic identification and segmentation of a cerebral ischemia zone in a super-acute stage can be achieved, and the segmentation precision of the ischemia zone is improved; data preprocessing, feature selection and feature optimization are conducted through the risk evaluation module, and obtained data features aremore effective; an XGBoost method is adopted for automatically generating the risk probability that a target group of people suffer from cerebral apoplexy, community health screening can be more efficiently and conveniently conducted, and a doctor can be helped to more simply and quickly evaluate the risk that the target group of people suffer from cerebral apoplexy; health screening can be strongly pushed, so that potential users with cerebral apoplexy are more quickly found, and earlier warning is given, so that earlier and more effective treatment is conducted.

A method having clinically sufficient degree of diagnostic accuracy for detecting the presence of coronary artery disease in a human patient from the general population and for distinguishing between the stages of the disease in that patient is disclosed. The stages are, first, the non-acute stage, which is either asymptomatic coronary artery disease or stable angina, second, the acute stage known as unstable angina, and, third, the acute stage known as acute myocardial infarction. The diseased state (as opposed to the non-diseased state) is indicated by the clinically significant presence of a first marker in a sample from the patient. The presence of one of the two acute stages, unstable angina or acute myocardial infarction, is indicated by the clinically significant presence of a second marker in a sample from the patient. The presence of the more severe acute stage known as acute myocardial infarction is indicated by the clinically significant presence of a third marker in a sample from the patient. Preferably the first marker comprises OxLDL, the second marker comprises MDA-modified LDL, and the third marker is a troponin. Preferably the OxLDL and MDA-modified LDL are detected using monoclonal antibodies that can detect the presence of those markers in undiluted human plasma at concentrations as low as 0.02 milligrams / deciliter.

The compound Chinese onion preparation for treating chronic obstructive lung disease is prepared with Chinese onion, trichosanthes peel, Chinese goldthread, immature bitter orange, cassia twig and other chinese medicine materials. The preparation process includes crushing material, ethanol extraction, depression recovery of ethanol, concentration, adding supplementary material, vacuum drying to obtain dry extract, crushing, and further steps to prepare tablet, capsule, drip pills and micro pills. The compound Chinese onion preparation has obvious functions of relieving cough, eliminating phlegm and relieving asthma, and may be used to treat chronic obstructive lung disease effectively. It is ideal medicine for COPD in acute stage and COPD in prolonged stage and chronic stage.

The invention provides a drug composition for treating depressive disorders. The drug composition is prepared by following raw materials of, by weight, 11-33 parts of bupleurum, 16.5-49.5 parts of red-rooted salvia roots, 16.5-49.5 parts of turmeric root tubers, 6-18 parts of cape jasmine fruits, 22.5-67.5 parts of wild jujube seeds, 22.5-67.5 parts of fumitories and 11-33 parts of grassleaf sweetflag rhizome. The invention further provides a preparation method and an application of the drug composition. The raw materials of the drug composition are selected according to the principle that the raw materials have effects of soothing the liver, resolving depression, promoting circulation, removing stasis, eliminating phlegm and turbidness, calming the heart and soothing the nerves, the drug composition aims at treating excess symptoms of liver depression, blood stasis and phlegm turbidness of post stroke depression (PSD) in acute stages and subacute stages, and the drug composition is explicit in drug effect and controllable and provides a new drug-using choice.

The invention discloses a medicament for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. The medicament is prepared from ginseng, radix salviae miltiorrhizae and ligustrazine according to certain weight proportion. The medicament can be prepared into any dosage forms but preferable freeze-drying powder injection, and the method comprises the following steps: extracting the ginseng and the radix salviae miltiorrhizae to obtain active components of general ginsenoside, total salvianolic acid and the like, and then adding the ligustrazine to prepare the freeze-drying powder injection. The medicament has the function of supplementing qi and activating blood circulation, is applied to treating the cardiovascular and cerebrovascular diseases, in particular to treating ischemic cerebrovascular diseases such as cerebral thrombosis, cerebral ischemia, cerebral infarction and the like, and is specifically applied to treating qi-deficiency and blood stasis syndromes during meridian acute stage of stroke, including hemiplegia, deviated mouth and tongue, aphasia, and tired hypodynamia.

The invention relates to a traditional Chinese medicine compound preparation for treating hemorrhagic apoplexy, which is formed by preparing the raw materials of rhubarb, buffalo horn, red peony root, peony bark, rehmannia root, lumbricus, radix notoginseng and Japanese sweetflag according to weight proportion. The compound preparation is medicinal decoction, a mixture, oral liquid, granules and injection. According to the long-time clinical practice of Professor Zhou Zhongying, the invention puts forward heat stasis, orifice obstruction, collateral damage and blood spill as the basic pathogenesis of the acute stage of the hemorrhagic apoplexy. Therefore, a method for removing heat from the blood and dredging the stasis of the blood is established, and the functions of removing heat from the blood and dissipating the blood stasis take the downward transportation of foods as a main part as the heat stasis and the orifice obstruction are relevant to the disturbance in the downward transportation of yangming meridians. Hence, a product for removing heat from the blood, relieving the stasis of the blood, removing the obstruction of the fu-organs and expelling the heat-evil is adopted, and the medicine is used for treating the hemorrhagic apoplexy.

The invention discloses a traditional Chinese medicinal composition for treating a hemorrhoid. The traditional Chinese medicinal composition is prepared from the following bulk drugs by weight: 8 to 10 parts of radix et rhizoma rhei, 8 to 10 parts of flos sophorae immaturi, 8 to 10 parts of radix sanguisorbae and 1 to 3 parts of borneol. Through the way, the invention provides the traditional Chinese medicinal composition for treating the hemorrhoid, and the traditional Chinese medicinal composition has the effects of clearing away heat, removing dampness, moistening intestines, relaxing the bowels, subsiding swelling,dissipating stasis and relieving pain, removing toxic substance, relieving itching, softening a hard mass, purging intense fire, dissipating blood stasis, relieving pain, cleaning the intestines, expelling the hemorrhoid, healing a sore, promoting granulation, activating blood circulation to dissipate blood stasis, cooling blood and stopping bleeding, and the like, has the characteristic of treating both symptoms and root causes, is used for obviously ameliorating the local blood circulation of a patient, is used for enabling the blood of the patient to be cool without the disadvantage of remaining the stagnation and the blood to be activated in circulation without frenetic circulation, clearing away the heat of the heart, the lung, the stomach and the intestines,promoting the blood circulation, quickening the absorption of an inflammatory substance, obviously relieving and lightening the clinical symptoms of various hemorrhoids (including an internal hemorrhoid, an external hemorrhoid and a mixed hemorrhoid) and enabling the aching feeling and the hematochezia symptom of the patient to disappear, is used for enabling the bowls to be open, and can be usedfor preventing and treating the diseases of the various hemorrhoids, acute-stage hemorrhoids (an inflammatory external hemorrhoid, a thrombotic external hemorrhoid and an incarcerated hemorrhoid) andbleeding, ache, and the like, after haemorrhoidectomy.

Disclosed herein is a method of treating a patient suffering a myocardial infarction, particularly an acute myocardial infarction, or of reducing an adverse consequence of a myocardial infarction in a patient comprising administering an antagonist of TGF-β to the patient during the acute stage of the myocardial infarction.

The invention discloses mesalazine enteric positioned controlled-release preparation, comprising a core, a controlled-release coating layer, an adhesive coating layer, and an enteric coating layer. The core includes mesalazine, hydroxyl propyl cellulose and talc powder, the controlled-release coating layer is composed of ethyl cellulose and triethyl citrate, the adhesive coating layer is made from sodium alginate, the enteric coating layer is composed of methacrylic acid and methyl methacrylate copolymer, triethyl citrate and talc powder. The invention also provides a preparation method of the enteric positioned controlled-release preparation. The preparation method is simple with controllable parameters, prepared pellets do not release in gastric acid and may release slowly for 24 hours in a dissolution medium at pH 7.5. This preparation is irritating to gastrointestinal adhesion and may be used in acute stage treatment for ulcerative colitis (inflammation accompanied ulcers) and maintenance treatment for preventing recurrence.

A method having clinically sufficient degree of diagnostic accuracy for detecting the presence of coronary artery disease in a human patient from the general population and for distinguishing between the stages of the disease in that patient is disclosed. The stages are, first, the non-acute stage, which is either asymptomatic coronary artery disease or stable angina, second, the acute stage known as unstable angina, and, third, the acute stage known as acute myocardial infarction. The diseased state (as opposed to the non-diseased state) is indicated by the clinically significant presence of a first marker in a sample from the patient. The presence of one of the two acute stages, unstable angina or acute myocardial infarction, is indicated by the clinically significant presence of a second marker in a sample from the patient. The presence of the more severe acute stage known as acute myocardial infarction is indicated by the clinically significant presence of a third marker in a sample from the patient. Preferably the first marker comprises OxLDL, the second marker comprises MDA-modified LDL, and the third marker is a troponin. Preferably the OxLDL and MDA-modified LDL are detected using monoclonal antibodies that can detect the presence of those markers in undiluted human plasma at concentrations as low as 0.02 milligrams / deciliter.

The present invention provides therapeutically active compounds and compositions as receptor antagonists and methods of use thereof. In one aspect, the compounds are useful in modulating pain, inflammation and acute phase reactions by inhibiting the PGE2 receptors including PGE2 EP1, EP2 and EP4 receptors.

The invention discloses a traditional Chinese medicine prescription for treating acute stage of diabetic foot ulcer. The traditional Chinese medicine is prepared from the following traditional Chinese medicinal raw materials in parts by weight: 25-35 parts of dandelion, 25-35 parts of golden cypress, 25-35 parts of fructus forsythiae, 25-35 parts of semen momordicae, 10-20 parts of honeysuckle, 10-20 parts of radix angelicae, 10-20 parts of red paeony root, 10-20 parts of cortex moutan, 10-20 parts of liquorice, 10-15 parts of patrinia, 10-15 parts of pericarpium papaveris, 10-15 parts of rhizoma corydalis, 6-8 parts of cocklebur fruit, 6-8 parts of yellow wax, 6-8 parts of polygonum cuspidatum, 6-8 parts of radix ampelopsis, 10-12 parts of manystem stonecrop leaf, 10-12 parts of fructus evodiae, 40-60 parts of yellow lead and 100-120 parts of plant oil. The traditional Chinese medicine has the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, removing slough and promoting growth of tissue regeneration and relieving swelling and pain, and has good and fast effect on treatment of the acute stage of diabetic foot ulcer.

The invention discloses a method and a device for detecting an infarction area, a storage medium and equipment. The method for detecting an infarction area comprises: obtaining a cerebral parenchyma tissue part in a magnetic resonance image; according to a set surface diffusion coefficient threshold value, obtaining an infarction candidate region from the parenchyma tissue part; obtaining an infarction confirmation area in which the ratio of a diffusion weighted imaging signal to a surface diffusion coefficient is higher than a set value in the parenchyma tissue part; determining a candidate communication area communicated with the infarction confirmation area in the infarction candidate areas; and determining a target infarction area according to the diffusion weighted imaging signal value in the candidate communication area. According to the invention, infarction detection in acute and super-acute stages can be carried out, the calculation speed is high, and tumors and infarction areas with high DWI values and low ADC values can be distinguished.

The present invention discloses a dorsal disc prolapse treatment traditional Chinese medicine preparation, which comprises dipsacus asper, east asian tree fern, common floweringquine fruit, prepared rhizome of rehmannia, Chinese clematis root and rhizome, epimedium, drynaria, dodder, common achyranthes, cassia bark, white peony root, divaricate saposhnikovia, checkerberry, salvia miltiorrhiza, common clubmoss herb, lobed kudzuvine root, common macrocarpium fruit, milkvetch root, nutgrass galingale rhizome, pinellia, arisaema cum bile, ground beetle, stiff silkworm, earthworm, white mustard seed, frankincense, myrrh, manchurian wildginger herb and radix notoginseng powder. The dorsal disc prolapse treatment traditional Chinese medicine preparation has a characteristic of unique formula, has effects of blood activating, collateral dredging, wind-evil dispelling, pain relieving, soft lump loosen knot, kidney invigorating, bone and muscle strengthening, liver benefiting, spleen strengthening, qi regulating and pain relieving, can be used for treating various types of dorsal disc prolapses, provides effects for an acute stage or a chronic phase of the dorsal disc prolapsed, and provides excellent treatment effects for patients with characteristics of short disease course and severe pain, wherein the patient only requires taking the single dorsal disc prolapse treatment traditional Chinese medicine preparation without traction or other treatments. In addition, characteristics of short cure time, high cure rate, no toxic-side effect, good sciatica treatment effect and good lumbocrural pain treatment effect are provided. The present invention further discloses a preparation method for preparation pills.

A Chinese medicine in the form of capsule, or oral liquid for treating the acute stage of SARs and human fowl's influenza is prepared from 21 Chinese-medicinal materials including bezoar, borneol, coix seed, astragalus root, etc. Its preparing process is also disclosed.

The invention relates to application of R-ketamine in treatment on depression at an acute stage and belongs to the technical field of medicines. R-ketamine is applied to treatment on depression at anacute stage, the medicine is administrated in an intravenous injection mode, the dosage is 0.5 mg / kg, and the administration frequency is once a week. R-ketamine provided by the invention has a very unique anti-depression function, the anti-depression function of R-ketamine is different from those of similar substances such as ketamine or S-ketamine, and R-ketamine is rapid in effect taking, longin lasting time, and free of adverse reaction such as dissociation symptoms or addiction, and has very good clinical application values.

The invention discloses a traditional Chinese medicine composition for curing cerebral hemorrhage and a preparation method thereof. The traditional Chinese medicine composition is prepared by traditional Chinese medicinal raw materials of tall gastrodis tuber, uncaria, leech, flos sophorae, safflower, cacumen biotae, concha haliotidis, eucommia, liquorice and the like, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition provided by the invention is compact in prescription, has the efficacies of stopping bleeding and activating blood circulation, calming liver and relieving dizziness, restoring consciousness and inducing resuscitation, lowering intracranial pressure, and cleaning up intracerebral hematoma, is particularly used for patients in an acute stage and suffering from hypertensive cerebral hemorrhage, has the advantages of high efficiency and high cure rate.

The invention discloses application of PD149163 to preparation of medicine for treating cerebral arterial thrombosis. According to application of PD149163 to preparation of the medicine for treating cerebral arterial thrombosis, on the premise that cerebral blood flow of a focal zone is not affected in the cerebra ischemic reperfusion process, PD149163 plays a protective role in rat cerebral injury at the acute stage caused by focal cerebra ischemic reperfusion. PD149163 possibly resists to nerve cell apoptosis caused at the acute stage of cerebra ischemic reperfusion by blocking an AMPK-mTOR signal channel and inhibiting autophagy.

The invention relates to the technical field of traditional Chinese medicines and in particular relates to a novel preparation method and application of traditional Chinese medicine composition for treating cerebral infarction during acute stage and earlier restoration stage. The production process is improved on the basis of the original prescription of Chinese patent CN200310114532.X, the leeches are subjected to superfine grinding, the salvia miltiorrhiza is totally subjected to CO2 supercritical extraction, and the medicinal compositions in the medicinal materials are effectively kept through the process. Compared with clinical research, the clinical curative effect of the product subjected to process improvement on stroke (cerebral thrombosis) is obviously superior to the curative effect of the original process product; and moreover, the prepared traditional Chinese medicine composition has the effects of resisting oxidation and eliminating radicals and has a positive effect of preventing brain neuron injuries, and according to the pharmacodynamics study, the traditional Chinese medicine composition has an obvious curative effect on aged dementia (AD).

The invention discloses the use of Bitongning preparation as medicament for the treatment of gout acute stages, wherein the Bitongning preparation is prepared from pseudo-ginseng and rhizoma corydalis as the raw materials.

This invention relates to the diagnosis and / or monitoring of patients with inflammatory diseases or conditions, including systemic lupus erythematosus, particularly for diagnosis of the acute stage of the disease, including methods and kits for carrying out this activity. This disclosure presents the surprising discovery that levels of complement pathway components on reticulocytes can be used to diagnose, monitor, or predict the occurrence of acute episodes of chronic inflammatory diseases or conditions.

The invention provides a preparation method of a medicine for treating cerebral stroke and sequela thereof. Traditional Chinese medicine components of different properties are specifically extracted in a classified manner; therefore, compared with the prior art, the preparation process disclosed by the invention is more reasonable; the content of effective components of the prepared medicine is greatly increased; the medicine can be prepared into an injection; and the injection is easily used in the stroke acute stage. The traditional Chinese medicine component disclosed by the invention is prepared from the following medicinal raw materials in parts by weight: 10-40 parts of herba siegesbeckiae extract, 1-3 parts of safflower carthamus extract, and 1-3 parts of medicinal cyathula root extract.

The invention relates to a formula and a preparation method of a portable functional food for stress after a disaster. Through the formula and the preparation method of the portable functional food for stress after a disaster, it is solved that patients having post-traumatic stress disorder flashbacks, wakening caused by nightmare, selective amnesia, loss of faith in the future, and both mental diseases of anxiety and depression are badly in need of a functional food which has small toxic and side effects and can be taken for a long time with psychological counseling, wherein in an acute stage (salvation stage) of disorder, it is expected that the functional food is convenient for carrying and taking and can produce functions fast. Through the preparation method, functional components are extracted from traditional edible traditional Chinese medicines and are prepared into the portable functional food which is a thick liquid toothpaste-type portable preparation. The portable functional food which can supply energy fast, can relieve mental tension, has small toxic and side effects and can be taken for a long time can be provided after a disaster.

The patent discloses application of a tanshinone IIA nano preparation, shown as in .1 and using O-hydroxyethyl chitosan derivative as an entrapping agent, in drugs to prevent or treat cerebral ischemia, particularly nerve injury due to local cerebral ischemia, and belongs to the technical field of nerve protection drugs. The tanshinone IIA entrapped by a nano carrier can quickly pass through the blood brain barrier. Compared with tanshinone IIA, the tanshinone IIA nano preparation has better blocking action upon nerve injury in acute stage of ischemic brain injury; threshold concentration is far lower than the concentration of tanshinone IIA. In addition, it is discovered that tanshinone IIA can promote healing of post-stroke injury and can play well by stimulating regeneration of post-ischemia endogenous nerves; tanshinone IIA entrapped by the nano carrier is more active than tanshinone IIA with the same dosage. The nano preparation herein can treat stroke-caused injury.