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Application of R-ketamine in treatment on depression at acute stage

A technology for ketamine and depression, which is applied in the application field of R-ketamine in the treatment of acute depression, can solve problems such as side effects and dissociation symptoms, and achieve a long-lasting, fast onset, and good clinical application value. Effect

Inactive Publication Date: 2018-03-23
WUXI MENTAL HEALTH CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Another noteworthy issue is the psychoactive side effects and addictive potential of ketamine treatment in a small number of depressed patients, including dissociative symptoms, psychotic symptoms, etc.

Method used

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  • Application of R-ketamine in treatment on depression at acute stage
  • Application of R-ketamine in treatment on depression at acute stage
  • Application of R-ketamine in treatment on depression at acute stage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: R-ketamine antidepressant curative effect experiment

[0029] 1.1 Materials and methods

[0030] 1.1.1 Experimental animals

[0031] Male adult C57BL / 6 mice, 8 weeks old (body weight 20-25 g, Japan SLC, Hamamatsu, Japan) and adult CD1(ICR) mice, 13-15 weeks old (body weight more than 40 g, Japan SLC, Japan Hamamatsu pine, Japan). Animals were housed at constant temperature with a 12-h light / dark cycle (lights on at 07:00-19:00 hrs), with free access to food and water.

[0032] 1.1.2 Experimental materials

[0033] PCPA chloropropionate hydrochloride (300 mg / kg, 5-HT synthesis inhibitor) was purchased from Sigma-aldrich (St. Louis, USA).

[0034] 1.1.3 Chronic social defeat stress (CSDS) depression model

[0035] C57BL / 6 mice were exposed to different CD1-challenged cages for 10 min per day for a total of 10 days. At the end of each day's stressful stimulation, the CD1 mice and the invading C57BL / 6 mice were housed on opposite sides of the cage, separ...

Embodiment 2

[0049] Example 2: Comparison of antidepressant efficacy between R-ketamine and (2R,6R)-hydroxynorketamine

[0050] 2.1 Materials and methods

[0051] 2.1.1 Experimental animals

[0052] Male adult C57BL / 6 mice, 8 weeks old (body weight 20-25 g, Japan SLC, Hamamatsu, Japan) and adult CD1(ICR) mice, 13-15 weeks old (body weight more than 40 g, Japan SLC, Japan Hamamatsu pine, Japan). Animals were housed at constant temperature with a 12-h light / dark cycle (lights on at 07:00-19:00 hrs), with free access to food and water.

[0053] 2.1.2 Experimental materials

[0054] (2R,6R)-hydroxynorketamine (2R,6R-hydroxynorketamine, R-HNK) was purchased from Sigma-aldrich Company (St. Louis, USA).

[0055] 2.1.3 Chronic social defeat stress (CSDS) depression model

[0056] C57BL / 6 mice were exposed to different CD1-challenged cages for 10 min per day for a total of 10 days. At the end of each day's stressful stimulation, the CD1 mice and the invading C57BL / 6 mice were housed on opposi...

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Abstract

The invention relates to application of R-ketamine in treatment on depression at an acute stage and belongs to the technical field of medicines. R-ketamine is applied to treatment on depression at anacute stage, the medicine is administrated in an intravenous injection mode, the dosage is 0.5 mg / kg, and the administration frequency is once a week. R-ketamine provided by the invention has a very unique anti-depression function, the anti-depression function of R-ketamine is different from those of similar substances such as ketamine or S-ketamine, and R-ketamine is rapid in effect taking, longin lasting time, and free of adverse reaction such as dissociation symptoms or addiction, and has very good clinical application values.

Description

technical field [0001] The invention relates to the application of R-ketamine in the treatment of acute depression, and belongs to the technical field of medicines. Background technique [0002] Depression (Major depression, MDD) is a common mental illness with low mood as the main manifestation, resulting in the loss of social function and quality of life of patients, often leading to other physical diseases and even death of patients. The World Health Organization lists depression as the fourth most disabling disease in the world, and predicts that by 2020, depression will become the second most disabling disease. The treatment of depression mainly includes psychotherapy, physical therapy and drug therapy. Psychotherapy has certain requirements for patients' comprehension and comprehension ability, and the treatment period is long and the cost is high, which limits its use. Physiotherapy, such as electroconvulsive therapy, requires general anesthesia and will seriously a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/137A61P25/24
CPCA61K31/137
Inventor 张凯
Owner WUXI MENTAL HEALTH CENT
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