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Application of water extract of balsam pear

A water extract of bitter melon and a technology of bitter melon, applied in the field of biochemistry, can solve the problems of large side effects of antidepressant drugs, and achieve the effect of good effect, low cost and small side effects

Inactive Publication Date: 2019-01-18
CHINA THREE GORGES UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above defects or improvement needs of the prior art, the present invention provides a bitter melon water extract used in the preparation of antidepressant drugs, the purpose of which is to use natural bitter melon water extracts for the preparation of antidepressant drugs, thus Solve the technical problems of existing antidepressant drugs with large side effects

Method used

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  • Application of water extract of balsam pear
  • Application of water extract of balsam pear
  • Application of water extract of balsam pear

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Raw material crushing: fresh bitter gourd is dehydrated and crushed, and passed through a 300-mesh sieve to obtain superfine bitter gourd powder;

[0034] (2) warm water leaching: the balsam pear superfine powder that obtains in step (1) is solvent with distilled water, according to material water ratio 1:22, carry out low-temperature leaching, leaching temperature is at 95 ℃, leaching time 10 hours, solid Extraction solution is obtained after liquid separation;

[0035] (3) Crude: Concentrate the extract obtained in step (2) to 1:1 (ml:g), cool to room temperature, and obtain a concentrate;

[0036] (4) Refining: add 80% ethanol solution to the concentrated solution in step (3), until the alcohol content reaches 60%, refrigerate in airtight storage at 4°C for 24 hours, filter, recover ethanol from the filtrate to obtain a crude extract;

[0037](5) Add 85% ethanol solution to the crude extract obtained in step (4), until the alcohol content reaches 75%, refrigerat...

Embodiment 2

[0039] (1) Raw material crushing: fresh bitter gourd is dehydrated and crushed, and passed through a 500-mesh sieve to obtain superfine bitter gourd powder;

[0040] (2) warm water leaching: the balsam pear superfine powder that obtains in step (1) is solvent with distilled water, according to material water ratio 1:20, carry out low-temperature leaching, leaching temperature is at 90 ℃, leaching time 8 hours, solid Extraction solution is obtained after liquid separation;

[0041] (3) Crude: Concentrate the extract obtained in step (2) to 1:1.5 (ml:g), cool to room temperature, and obtain a concentrate;

[0042] (4) Refining: add 85% ethanol solution to the concentrated solution in step (3) until the alcohol content reaches 80%, refrigerate at 4°C for 48 hours, filter, and recover ethanol from the filtrate to obtain a crude extract;

[0043] (5) add 90% ethanol solution to the crude extract obtained in step (4), until the alcohol content reaches 80%, refrigerate at 4°C for 48...

Embodiment 3

[0045] (1) Raw material crushing: fresh bitter gourd is dehydrated and crushed, and passed through a 400-mesh sieve to obtain superfine bitter gourd powder;

[0046] (2) warm water leaching: the balsam pear superfine powder that obtains in step (1) is solvent with distilled water, according to material water ratio 1:18, carries out low-temperature leaching, and leaching temperature is at 85 ℃, and leaching time is 5 hours, solidifies Extraction solution is obtained after liquid separation;

[0047] (3) Crude: Concentrate the extract obtained in step (2) to 1:2 (ml:g), cool to room temperature, and obtain a concentrate;

[0048] (4) Refining: add 85% ethanol solution to the concentrated solution in step (3) until the alcohol content reaches 70%, refrigerate at 4°C for 36 hours, filter, and recover ethanol from the filtrate to obtain a crude extract;

[0049] (5) Add 90% ethanol solution to the crude extract obtained in step (4), until the alcohol content reaches 80%, refrigera...

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Abstract

The invention discloses an application of water extract of balsam pear, which is applied to the preparation of antidepressant drugs. As that water extract of the common vegetable bitter gourd is use as the raw material source of the antidepressant medicine, the bitter gourd has the unique antidepressant effect, and the beneficial effects of wide source, low cost, good effect and small side effectcan be obtained.

Description

technical field [0001] The invention belongs to the field of biochemistry, and more specifically relates to an application of bitter melon water extract. Background technique [0002] Depression is characterized by changes in mood, such as feelings of guilt or low self-worth, low energy, and loss of interest or happiness. Due to treatment resistance and high risk of suicide, depression has been recognized as one of the most prevalent public mental health problems, and according to the World Health Organization, depression is the main cause of social burden. [0003] Antidepressants refer to a group of psychiatric drugs mainly used to treat mental diseases with depression as the prominent symptom. Antidepressants are mainly used to treat depression and various depressive states. There are two common first-generation antidepressants, monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs). Due to the rapid development of new drugs, new drugs emerge in endle...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/42A61K31/715A61P25/24
CPCA61K31/715A61K36/42A61P25/24
Inventor 邓志芳高雯琪杨简彭艳张静王伟
Owner CHINA THREE GORGES UNIV
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