129 results about "Severe pain" patented technology

A grooved electrode adapted for interfacing cellular matter is provided. The grooved electrode includes grooves adapted for electrically interfacing the grooved electrode with cellular matter growing along the body of the grooved electrode. Further, the grooved electrode includes a wireless transponder adapted to electrically interface with cellular matter and to relay such interactions via RF signals. The RF signals received by the wireless transponder are modulated in response to electrical signals generated by the cellular matter, which are detected by the transponder. The grooved electrode may be implanted within peripheral nerves for treating various neurological conditions, which may include nerve rehabilitation and prosthetic actuation, severe pain, obstructive sleep apnea and so forth.

A grooved electrode adapted for interfacing cellular matter is provided. The grooved electrode includes grooves adapted for electrically interfacing the grooved electrode with cellular matter growing along the body of the grooved electrode. Further, the grooved electrode includes a wireless transponder adapted to electrically interface with cellular matter and to relay such interactions via RF signals. The RF signals received by the wireless transponder are modulated in response to electrical signals generated by the cellular matter, which are detected by the transponder. The grooved electrode may be implanted within peripheral nerves for treating various neurological conditions, which may include nerve rehabilitation and prosthetic actuation, severe pain, obstructive sleep apnea and so forth.

The invention provides an improved electrotransport drug delivery system for analgesic drugs, namely fentanyl and sufentanil. The fentanyl / sufentanil is provided as a water soluble salt (eg, fentanyl hydrochloride) dispersed in a hydrogel formulation for use in an electrotransport device (10). In accordance with one aspect of the invention, the concentration of fentanyl / sufentanil in the donor reservoir (26) solution is above a predetermined minimum concentration, whereby the transdermal electrotransport flux of fentanyl / sufentanil is maintained independent of the concentration of fentanyl / sufentanil in solution. In accordance with a second aspect of the present invention, the donor reservoir (26) of the electrotransport delivery device (10) is comprised of silver and the donor reservoir (26) contains a predetermined “excess” loading of fentanyl / sufentanil halide to prevent silver ion migration with attendant skin discoloration. In accordance with a third aspect of the present invention, a transdermal electrotransport delivered dose of fentanyl / sufentanil is provided which is sufficient to induce analgesia in (eg, adult) human patients suffering from moderate-to-severe pain associated with major surgical procedures.

The invention is directed to compounds of Formula (I) useful as delta and mu opioid receptor modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.

The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.

The invention discloses an adjustable knee joint rehabilitation device with a massage function. The adjustable knee joint rehabilitation device comprises a main body part, a pair of angle adjusting parts, a pair of reciprocating driving parts and a pair of leg fixing parts, wherein the main body part comprises an L-shaped base, a sitting plate, side plates and a fixing seat. By turning a rotatinghandle, an arc-shaped strip drives the shank to overturn upwards, when severe pain is felt at the knee joint, turning of the rotating handle is stopped, that is, namely leg bending angle adjustment iscompleted, the reciprocating driving parts drive a ']'-shaped sliding block to reciprocate upwards and downwards to drive the arc-shaped strip to overturn a specified angle, accordingly the shank isbent at a proper angle, the knee joint is exercised by reciprocated bending at the bending angle, the recovery of the knee joint of a patient is facilitated, and the exercise enthusiasm of the patientis improved. In addition, a piston is driven to move left and right in the piston barrel through a hinged rod II and a piston rod to enable an air bag to expand or contract for shank massage, the blood circulation is improved, and the muscle atrophy of the shank is prevented.

The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.

A traditional Chinese medicine for curing subacute thyroiditis belongs to a traditional Chinese medicine for curing swollen masses goiter. The components contain: 15g of Chinese thorowax root, 15g of baical skullcap root, 15g of pinellia tuber, 15g of Chinese angelica,15g of turmeric root tuber, 15g of zedoray rhizome, 15g of turtle shell, 15g of radix semiaquilegiae, 15g of weeping forsythia capsule, 15g of seaweed, 15g of lucid ganoderma, 15g of tree peony bark, 20g of common selfheal fruit-spike, 20g of bulbus fritillariae thunbergii, 20g of figwort root, 20g of spreading hedyotis herb, 20g of roasted himalayan teasel root, 20g of prepared flowery knotweed root, 30g of milkvetch root, 30g of heterophylly falsesatarwort, 30g of oyster and 10g of dried leech; the invention has the auxiliary prescriptions that: for severe heat, the common selfheal fruit-spike is added to 30g of, and 10g of common anemarrhena rhizome is added; for severe pain, 10g of platycodon root, 10g of blackberrylily rhizome and 10g of paris root are added. The compatibility of the traditional Chinese medicine is simple; the medicine used in the prescription is fully natural herbal medicine, which is easy to collect and use; the preparation method is simple; the effects for taking and curing are good; the cost of the medicine is low, and the medicine is in particular suitable for the people living in remote villages far from towns; the cost is low for curing the people suffering from subacute thyroiditis, which solves the problem that the local area lacks medical conditions to cure the disease because of low household income and poor living condition.

The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.

Superior buffered formulations and their kits for treating lower urinary tract symptoms and disorders are provided in the invention. In particular superior buffered formulations have demonstrated improvement for treating lower urinary tract symptoms of patients experiencing severe pain and / or urgency of the bladder and associated areas of the lower urinary tract.

The invention discloses a traditional Chinese medicine combination for treating bone injury and fracture, which is characterized by comprising oral medicines and external-use medicines, wherein the oral medicines comprise the following active pharmaceutical ingredients: astragalus, angelica sinensis, barrenwort, herba cistanche, pseudo-ginseng, achyranthes root, safflower, cortex eucommiae, salvia miltiorrhiza, rhizomadrynariae, yam, fructus psoralea, sambucus williamsii hance, woodwardia japonica, prepared radix rehmanniae, lumbricus and white peony root; and the external-use medicines comprise various active pharmaceutical ingredients: myrrh, fructus evodiae, teasel, pseudo-ginseng, safflower, rhizoma ligustici wallichii, nux vomica, toad skin, centipede, notopterygium and herba lycopodti. The traditional Chinese medicine combination activates osteoblasts of endosteum and periosteum at the bone injury and fracture site to rapidly calcify, thereby having special efficacy to promote the generation a new bone. The traditional Chinese medicine combination is suitable for treating various bone injuries and fractures, has high cure rate, relieve severe pains of the bone injury and fracture of mass patients without using strong analgesics, can promote bone callus to rapidly form and has the effects of relieving flatulence and pains, eliminating blood stasis and promoting tissue regeneration and growth of the bone callus.

The present invention relates to a video analysis-based newborn pain expression identification method. According to the present invention, by introducing a deep learning method based on a three dimensional convolutional neural network and applying to the newborn pain expression identification work, the expressions when the newborns are in the peaceful and crying states and the expressions, such as the mild pain, the severe pain, etc., caused by the painful operations can be identified effectively, and a new path is provided for developing a newborn pain automatic assessment system. Concretely, by introducing the three dimensional convolutional neural network, and using a 3D convolution kernel to extract the time domain and spatial domain features of the video fragments, the tedious operation of extracting the features artificially is avoided, the extracted features are preferable, and the newborn pain expressions are learned and identified automatically on a deep learning platform. Compared with a conventional artificial assessment mode, the video analysis-based newborn pain expression identification method is more objective and accurate, and saves a lot of manpower resources.

The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.

The invention is directed to compounds of Formula (I) useful as delta and mu opioid receptor modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.

Mucositis is the result of a complex process of interactive biologic phenomena that take place in both the epitelium and the submucosa, often leading to severe pain and increased risk of dangerous syste f48 mic infections. Mucositis is often a side effect during chemotherapy and radiation therapy. The benzamidine derivatives herein described are particularly effective for treating and preventing mucositis since they are acting simultaneously at the several phases that characterize this disease. Data supplied from the esp@cenet database

The invention relates to a medical rolling translation stretcher, which comprises rolling straps 1, driving shafts 2, an inner support frame 3, a tension adjusting device 4, drive motor modules 5, side power assisting handles 6, an electric end handle 7, a manual end handle 8, an open bearing support arm 9, an end bearing support arm 10, manual drivers 11 and a rolling strap protection supporting plate 12. The medical rolling translation stretcher can be used to transfer and transport special nursing patients, acute and severe patients, postoperative patients, and field wounded patients needing emergency treatment securely, conveniently and quickly. With the adoption of the medical rolling translation stretcher, the patients can be transported automatically by a rolling translation method, so that the labor intensity of medical care personnel can be relieved; man power and time are saved; in addition, the dignity of the patients is kept; the suffering of the patients is reduced; and the transport complication is avoided.

The invention provides a cancer pain plaster composed of nux vomica, Hindu datura flower, pendulous monkshood root, dried Chinese toad skin, paniculate swallowwort root or herb, yanhusuo tuber, panax notoginseng, and an auxiliary material of borneol. One plaster comprises, preferably, 1.0g of nux vomica, 1.0g of Hindu datura flower, 1.0g of pendulous monkshood root, 1.0g of dried Chinese toad skin, 1.0g of paniculate swallowwort root or herb, 2.0g of yanhusuo tuber, 1.0g of panax notoginseng, and the auxiliary material of borneol. According to the technology, authentic pure traditional Chinese medicines are selected, and scientific formulation and rigorous production process are adopted. The materials are refined, and effect is concentrated. An effect can be provided after 20min of application, and a pain-relieving effect can last for 24h. Therefore, a substantial pain-relieving effect can be provided for continuous cancer pain. Especially, the plaster has relieving and stopping effects against long-term severe pains. When the plaster is repeatedly applied, no toxic or side effect is provided, and addiction is prevented. The plaster causes no irritation or allergy to skins, and is suitable to be used against various pains caused by various cancer primary tumors and metastases. With the plaster, patient pain can be relieved, symptoms can be relieved, and substantial pain relieving effects and concentrated pain relieving functions such as blood circulation activating, stasis removing, collateral dredging, qi regulating, and stagnation eliminating are provided.

The invention discloses a preparation with the function of treating gastric ulcer caused by peptic gastric ulcer and a preparation method thereof. The formulation is prepared by 14 traditional Chinese medicine bulk drugs including astragalus root, prepared rhizome of rehmannia, bighead atractylodes rhizome, pseudo-ginseng, rhizoma corydalis, bletilla striata, elecampane, daemonorops draco, cinnamon, frankincense, ramulus acaciae, calcined flute, centipede and deerhorn gelatin, and extractives of the traditional Chinese medicine bulk drugs. The formulation plays roles of Warming Yang, tonifying spleen and activating Qi, nourishing flood, removing blood stasis, promoting tissue regeneration and alleviating pain and is used for treating gastric cavity secret anguish, warming and massage enjoyment, paroxysm or aggravation with cold and cool or fatigue, severe pain with limosis, pain relief with eating food and abdomen bloating after a meal which are caused by peptic ulcer deficiency-cold as well as limb cooling, fatigue, inappetence, loose stool and clear water or pantothenic acid vomiting and chronic gastritis caused by Helicobacter pylori. The invention also discloses a preparation method and a quality control method of the preparation.

Analgesic formulations to be applied topically that are reported to relieve moderate to severe pain due to tendonitis, fibromyalgia, shingles, insect bites and bee stings, ACL, arthritis, and sinus headaches. In many cases, test subjects report immediate pain relief with a single application and complete pain elimination with only a few applications. The formulations are in a coconut oil base which is skin friendly. The primary active ingredient is wrightia tinctoria, which when combined with other ingredients, causes the formulation to exhibit a synergistic effect on pain relief unexpected from using the ingredients alone or in combination.

The invention discloses a traditional Chinese composition for treating gastric ulcer, gastrorrhagia, and gastric perforation. The active ingredients of the medicine are prepared by the following components according to the parts by weight: 10-25 parts of alpine salamander, 10-25 parts of cuttlebone 10-20 parts of aspongopus, 10-25 parts of rhizoma pleionis, 10-20 parts of bletilla striata, 10-20 parts of corydalis tuber, and 7-15 parts of honey-fried licorice root. Alpine salamander, cuttlebone and aspongopus are taken as monarch drugs; rhizoma pleionis and corydalis tuber are taken as ministerial drugs; bletilla striata is taken as an adjuvant drug; honey-fried licorice root is taken as a conductant drug; all medicines are combined and supplements each other. The medicine can effectively treat gastric ulcer, gastrorrhagia and gastric perforation caused by gastric ulcer, and is applied clinically. Hundreds of patients with symptoms such as unpalpable gastric cavity and tingle, severe pain after eating, hematemesis, hemafecia, ulcer, hemorrhage, excrement black, perforation and the like all get satisfactory treatment effect by using the composition. The composition is safe, convenient to use, and difficult to replase, has no side effect, short treatment period and popularization value, and is applied to series of diseases of gastric ulcer.

The invention discloses a Chinese medicinal composition for treating damp-heat invasion blood stasis diabetic foot. Damp-heat invasion blood stasis diabetic foot comprises symptoms of red and swollen hot pain of limbs, purplish red and brightness of skin, dirty and odor fester of wounds, severe pain of lower limbs, anorexia, constipation, red tongue, yellowish and greasy coated tongue, chest pain, dark-red tongue and numb limbs. A medicine for oral administration comprises peach seed, red paeony root, Chinese angelica, gentian, root of red-rooted salvia, dahurian patrinia herb, largehead atractylodes rhizome, tuckahoe, bunge corydalis herb, zedoary, honeysuckle stem, safflower, szechuan lovage rhizome, common anemarrhena rhizome, suberect spatholobus stem, earthworm, rhubarb and astragalus; and externally applied medicament comprises dragon's blood, clematis root, honeysuckle flower, frankincense, myrrh, lightyellow sophora root, phellodendron, Sinkiang arnebia root, pubescent holly root, stir-fried garden burnet root, safflower, calcined gypsum, bletilla and plantain seed. The Chinese medicinal composition has the effects of invigorating qi and blood, promoting blood circulation to remove blood stasis, removing necrotic tissue and promoting tissue regeneration; the local micrangium barrier of the lower limbs is improved, blood circulation is promoted, and the necrotic tissue drops to fulfill the aim of tissue repair; the medicine for oral administration has the effects of controlling blood sugar effectively, regulating blood viscosity and reducing blood pressure; and the infection of feet is prevented, and the immunologic functions of human bodies are enhanced. The microcirculation of ulcer wounds can be improved effectively by the oral administration and external application of the Chinese medicines to fulfill the aim of healing the ulcer wounds.

The invention discloses an element diet with special medical purpose suitable for critical patient and patient with metabolic intestinal tract dysfunction, comprising by weight percentage: soya small peptide 17-19%, medium chain triglyceride 1.6-2.3%, soyabean oil, 1.6-2-2.3%, maltodextrin 70-72.5%, mineral matter mixture 1.6-2.0%, vitamin mixture 0.3-0.5%, tuckahoe 3.5-4.5%. The invention also discloses a preparation method of the element diet. The element die protein is from the soya small peptide very beneficial for patient digestion and absorption. According the newest DRIs standard, the vitamin, trace element and mineral matter are added beneficial for patient postoperative recovery. The tuckahoe increases the patient immunity. The element diet has features of balance, comprehensive, resonableness, convenience, immunity adjustment and provides effective ensure on postoperative recovery for critical patient and patient with metabolic intestinal tract dysfunction and surgery critical patient.

The invention discloses a traditional Chinese medicine for treating prostatitis. The traditional Chinese medicine comprises 8-12g of fish poison yam rhizome, 18-22g of rhizoma smilacis glabrae, 8-12g of gentian, 18-22g of plantain herb, 8-12g of phellodendron, 4-8g of akebia stem, 10-14g of radix bupleuri, 18-22g of unprocessed rehmannia root, 8-12g of Chinese yam, 26-34g of talcum, 18-22g of raw coix seed, 4-8g of grass-leaved sweetflag rhizome and 6-10g of fine licorice root, and aiming at patients suffering from severe pain, also comprises 12-18g of szechwan chinaberry fruit and 8-12g of spina gleditsiae. The traditional Chinese medicine has effects of disinhibiting dampness and heat, removing toxins and transforming turbidity, well treating chronic prostatitis, substantially relieving prostate symptoms, improving prostatic enlargement through lasting medicine use, eliminating frequent micturition, urgent urination, odynuria and turbid urine and reducing pain symptoms.

The invention belongs to the technical field of drugs and particularly relates to external ointment for treating gout. The external ointment is characterized by being prepared from the following raw materials in parts by weight: 10-20 parts of radix aconiti kusenzoffii, 10-20 parts of frankincense, 7-9 parts of pseudo-ginseng, 7-9 parts of flos carthami, 8-12 parts of dysosma versipellis, 8-12 parts of Chinese yams, 1-3 parts of cordyceps sinensis, 1-3 parts of dragon's blood, 1-3 parts of loofah sponges, 3-5 parts of earthworms, and 1-3 parts of Chinese angelica. The external ointment has the effects of regulating functions of livers and kidneys, balancing acid and alkali component proportion in body, promoting a metabolic function, strengthening the body immunity, relaxing the muscles and stimulating the blood circulation, dispersing blood stasis and stopping bleeding, is obvious in effect of treating gout with symptoms of muscular soreness, arthrocele, severe pains and the like, and has the characteristics of being short in course of treatment, quick in effect-taking, low in cost, free of toxic or side effect, unlikely to relapse after a heal, and the like.

The present invention discloses a dorsal disc prolapse treatment traditional Chinese medicine preparation, which comprises dipsacus asper, east asian tree fern, common floweringquine fruit, prepared rhizome of rehmannia, Chinese clematis root and rhizome, epimedium, drynaria, dodder, common achyranthes, cassia bark, white peony root, divaricate saposhnikovia, checkerberry, salvia miltiorrhiza, common clubmoss herb, lobed kudzuvine root, common macrocarpium fruit, milkvetch root, nutgrass galingale rhizome, pinellia, arisaema cum bile, ground beetle, stiff silkworm, earthworm, white mustard seed, frankincense, myrrh, manchurian wildginger herb and radix notoginseng powder. The dorsal disc prolapse treatment traditional Chinese medicine preparation has a characteristic of unique formula, has effects of blood activating, collateral dredging, wind-evil dispelling, pain relieving, soft lump loosen knot, kidney invigorating, bone and muscle strengthening, liver benefiting, spleen strengthening, qi regulating and pain relieving, can be used for treating various types of dorsal disc prolapses, provides effects for an acute stage or a chronic phase of the dorsal disc prolapsed, and provides excellent treatment effects for patients with characteristics of short disease course and severe pain, wherein the patient only requires taking the single dorsal disc prolapse treatment traditional Chinese medicine preparation without traction or other treatments. In addition, characteristics of short cure time, high cure rate, no toxic-side effect, good sciatica treatment effect and good lumbocrural pain treatment effect are provided. The present invention further discloses a preparation method for preparation pills.

The invention provides a preparation method of a cyclobenzaprine hydrochloride sustained-release tablet, and belongs to the technical field of a medicine. The cyclobenzaprine hydrochloride sustained-release tablet disclosed by the invention consists of cyclobenzaprine hydrochloride, a sustained-release material, a pore-foaming agent, a filling agent, a lubricating agent and distilled water. The cyclobenzaprine hydrochloride, as a major ingredient, has effects of relieving muscle spasm as well as accompanied severe pain in skeletal muscle and the like; and the provided sustained-release preparation is safe and effective, stable in quality, low in cost and low in administration efficiency, and the sustained-release preparation is capable of enhancing patient compliance and is capable of stably stopping pain and relieving spasm.

The invention discloses a newborn pain expression recognition method based on dual-channel feature deep learning. This method first grayscales the facial image of the newborn and extracts the local binary pattern (Local Binary Pattern, LBP) feature map; then uses a two-channel convolutional neural network to process the grayscale image and The features of the two channels of the LBP feature map are used for deep learning; finally, a softmax-based classifier is used to classify the fusion features of the two channels for expression classification, which is divided into four types of expressions: calm, crying, mild pain, and severe pain. Combining the feature information of the two channels of the gray image and its LBP feature map, this method can effectively identify calm, crying, mild pain, severe pain and other expressions, and has a certain effect on the lighting, noise and occlusion problems of newborn facial images. It has good robustness and provides a new method and approach for developing a pain expression recognition system for newborns.

The invention discloses a dysmenorrhea patch, and belongs to the field of traditional Chinese medicine. The dysmenorrhea patch is composed of the following pharmaceutical raw materials in parts by weight: 8-15 parts of angelica sinensis, 9-12 parts of ligusticum wallichii, 8-15 parts of superior cinnamon, 8-12 parts of baked ginger, 8-15 parts of myrrh, 9-12 parts of pollen typhae, 6-10 parts of radix paeoniae rubra, 10-14 parts of trogopterus dung, 5-12 parts of fenouil commun, 8-10 parts of rhizoma corydalis, 18-25 parts of motherwort, 10-12 parts of fructus toosendan, and 10-15 parts of peach kernel. The raw materials of the dysmenorrhea patch are all selected from the natural Chinese herbal medicines, and the dysmenorrhea patch is mainly used for treating premenstrual and menstrual lumbar abdomen severe pain caused by qi and blood deficiency cold and womb cold and stagnation, does not contain any hormone, does not have any stimulation to skin, and does not have any side effect; and after mixing, the pharmaceutical raw materials have a synergistic effect, and a remarkable effect is achieved in treatment of dysmenorrhea.

A pharmaceutical anti-inflammatory preparation and method for preparation and treatment of arthritis and related inflammatory conditions used for mild to severe pain for relatively long acting results. This anti-inflammatory preparation comprises anti-inflammatory corticord steroid in aqueous-like suspension, a muscle relaxant in oil-like composition, and amide anesthetic compound in aqueous-like composition and Vitamin B-12 in aqueous-like composition. It is prepared by mixing the anti-inflammatory preparation at a rate and for a time sufficient to create a suspended emulsion. The anti-inflammatory preparation is administered while in suspended emulsion by intramuscular patient injection.