113 results about "Pain medicine" patented technology

The present invention relates to compositions and methods for the administration of lipid-based vehicles to treat various disorders, including bladder inflammation, infection, dysfunction, and cancer. In various aspects, the compositions and methods of the invention are useful for prolonged delivery of drugs, e.g., antibiotics, pain treatments, and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system, and other organs or body systems. In particular, the present invention relates to liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin, and toxins, such as botulinum toxin, for the treatment of bladder conditions, including pain, inflammation, incontinence, and voiding dysfunction. Further related are methods of using these vehicles alone or in conjunction with antibodies, e.g., uroplakin antibodies, to improve duration of liposome attachment, and provide a long-term intravesical drug delivery platform. The present invention specifically relates to antibody-coated liposomes that are useful for targeting specific receptors for drug, peptide, polypeptide, or nucleic acid delivery. In one particular aspect, the present invention relates to liposomes coated with antibodies against nerve growth factor (NGF) receptor and containing NGF antisense nucleic acids, which are used as a treatment for neurogenic bladder dysfunction.

The present invention is directed to dosage forms that can be used in therapeutic methods involving the oral co-administration of a combination of at least two drugs, one of which impairs gastrointestinal absorption and one of which does not. The dosage forms are designed so that the drug impairing absorption is not released into the gastrointestinal tract of a patient until after the drugs that do not impair absorption have been released and substantially absorbed. The invention may be used in treatment of migraine using a combination of triptans and NSAIDs or in the treatment of pain using a combination of NSAIDs and opioid analgesics.

A nasal applicator for nasally administering medicinal active pharmaceutical substances and / or ingredients, in particular painkillers or analgetics, includes a dosage device for dosedly discharging the active pharmaceutical substance, dosage determining logic for determining the discharged amount of active pharmaceutical substance as well as a locking device for locking the dosage device, in particular when the determined amount of discharged active pharmaceutical substance reaches a predetermined level. The locking device for locking the discharge dosage device is controlled by an electronic control device with a patient data memory into which an individual patient's control data may be inputted via an input device for individually locking the dosage device for a specific patient.

The invention relates to a system of medical supplies for sedation and analgesia, comprising an electronically controlled drug infusion device comprising an IV drug infusion device capable of controlling sedation or analgesia drug flow to the patient, a patient health monitor for collecting and providing the relevant patient physiology condition, and an electrical controller suitable for receiving the mark of the drug infusion device and service mode mark and adjusting infusion speed on the basis of data input by the user input and from the patient health monitor; and a disposable breathing apparatus detachably connected with the drug infusion device and suitable for one-time use and comprising the service mode mark communicated with the electrically controller.