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Medicament for treating cardiovascular and cerebrovascular diseases and preparation method thereof

A technology of a drug and a composition, applied in the field of traditional Chinese medicine, can solve problems such as difficult treatment of cerebrovascular disease, and achieve the effects of high bioavailability, rapid action, and prevention and treatment of reperfusion injury

Active Publication Date: 2009-10-28
ZHEJIANG WECOME MEDICINE IND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, anti-reperfusion injury after cerebral ischemia has become the key point in the treatment of cerebral ischemia. There are many clinical treatment methods and drugs, and antiplatelet drugs, anticoagulants, thrombolytic agents, vasodilators, and brain protective agents are generally used. etc., but almost none of the therapies and drugs have achieved positive curative effect, and most of them can only improve one aspect of complex lesions. The complex pathophysiological process has brought many difficulties to the treatment of ischemic cerebrovascular disease

Method used

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  • Medicament for treating cardiovascular and cerebrovascular diseases and preparation method thereof
  • Medicament for treating cardiovascular and cerebrovascular diseases and preparation method thereof
  • Medicament for treating cardiovascular and cerebrovascular diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] Ginseng 1000g

[0084] Danshen 5000g

[0085] Ligustrazine hydrochloride (calculated as Ligustrazine) 80g

[0086] Made 1000 pieces. Each tube contains 1g of ginseng, 5g of salvia miltiorrhiza, and 80mg of ligustrazine hydrochloride (calculated as ligustrazine).

[0087] a) Reflux extraction of 1000g ginseng with 8 times the amount of 65% ethanol for 3 times, each time for 1.5 hours, combine the 3 extracts, concentrate under reduced pressure to recover ethanol, and put it on the macroporous resin D101 column at a flow rate of 0.5 times the volume of the resin per hour Adsorption, add 1 times the volume of the resin to wash the resin with purified water, elute with 75% ethanol at a flow rate of 0.5 times the volume of the resin per hour, collect the 75% ethanol eluate, recover the ethanol, add an appropriate amount of water to dissolve, and use a molecular weight cut-off of 5000 for the aqueous solution Ultrafiltration membrane ultrafiltration, collect the ultrafiltra...

Embodiment 2

[0092] Ginseng 3000g

[0093] Danshen 10000g

[0094] Ligustrazine hydrochloride (calculated as Ligustrazine) 20g

[0095] Made 1000 pieces.

[0096] The preparation method is the same as in Example 1. Among them, 209g of effective fractions of salvianolic acid, 72g of effective fractions of total ginsenosides and 76g of mannitol were obtained.

Embodiment 3

[0098] Ginseng 6000g

[0099] Danshen 5000g

[0100] Ligustrazine hydrochloride (calculated as Ligustrazine) 20g

[0101] Made 1000 pieces.

[0102] The preparation method is the same as in Example 1. Among them, 129g of effective fractions of salvianolic acid and 125g of effective fractions of total ginsenosides were obtained, and the dosage of mannitol was 69g.

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Abstract

The invention discloses a medicament for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. The medicament is prepared from ginseng, radix salviae miltiorrhizae and ligustrazine according to certain weight proportion. The medicament can be prepared into any dosage forms but preferable freeze-drying powder injection, and the method comprises the following steps: extracting the ginseng and the radix salviae miltiorrhizae to obtain active components of general ginsenoside, total salvianolic acid and the like, and then adding the ligustrazine to prepare the freeze-drying powder injection. The medicament has the function of supplementing qi and activating blood circulation, is applied to treating the cardiovascular and cerebrovascular diseases, in particular to treating ischemic cerebrovascular diseases such as cerebral thrombosis, cerebral ischemia, cerebral infarction and the like, and is specifically applied to treating qi-deficiency and blood stasis syndromes during meridian acute stage of stroke, including hemiplegia, deviated mouth and tongue, aphasia, and tired hypodynamia.

Description

technical field [0001] The invention relates to a medicine for treating cardiovascular and cerebrovascular diseases and a preparation method thereof, especially for treating ischemic encephalopathy, and belongs to the field of traditional Chinese medicine. Background technique [0002] Cerebral ischemia, also known as ischemic stroke and cerebral infarction, is a type of disease caused by ischemia and hypoxia caused by cerebral blood flow disorder, resulting in localized brain necrosis or encephalomalacia. Ischemic brain injury includes primary injury during the ischemic period and secondary injury during the reperfusion period. The initial link in the pathological process is ischemia, and the restoration of blood perfusion in the brain tissue is the basis of its treatment, but the subsequent reperfusion Perfusion injury is inevitable. Cerebral ischemia-reperfusion injury refers to the phenomenon that brain cells are damaged due to cerebral ischemia, and the ischemic injury...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K9/19A61P9/10A61K31/4965
Inventor 张保献胡杰
Owner ZHEJIANG WECOME MEDICINE IND
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