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Drug composition for treating depressive disorders, preparation method and application of drug composition

A composition and technology for depression, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve life-threatening hypertension, crisis, no longer widely used and other problems, and achieve clear drug effect Effect

Inactive Publication Date: 2013-01-09
TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(2) Monoamine oxidase inhibitors (MAOI): because these drugs can interact with certain foods and drugs, resulting in life-threatening hypertensive crisis, they are no longer widely used

Method used

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  • Drug composition for treating depressive disorders, preparation method and application of drug composition
  • Drug composition for treating depressive disorders, preparation method and application of drug composition
  • Drug composition for treating depressive disorders, preparation method and application of drug composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation of embodiment 1 medicine of the present invention

[0036] 220g Bupleurum, 330g Salvia, 330g Turmeric, 120g Gardenia, 450g Suanzaoren, 450g Yanhusuo, 220g Shichangpu;

[0037]Preparation method: Distill the above seven flavors, Bupleurum, Curcuma, and Shichangpu with water for 8 hours, extract the volatile oil, wrap it with β-cyclodextrin (5g of β-cyclodextrin per 1ml of volatile oil), and dry at low temperature; crush Corydalis and Salvia miltiorrhiza into coarse powder, add Reflux extraction with 70% ethanol twice, 5 times each time, 2 hours each time, filter, and recover ethanol; the above-mentioned Bupleurum, Curcuma, Shichangpu residues and other two flavors such as gardenia were decocted three times, 1 hour each time , combined the decoction and filtered, the filtrate was centrifuged, the supernatant was combined with the above-mentioned ethanol extract, concentrated to a relative density of about 1.30 (70-80°C, thermal measurement), added an appro...

Embodiment 2

[0038] The preparation of embodiment 2 medicine mixture of the present invention

[0039] Bupleurum 165g, Salvia 390g, Gardenia (fried) 165g, Turmeric 195g, Shichangpu 135g, Corydalis (vinegar) 180g, Suanzaoren (fried) 270g, benzoic acid 3g. Make l000ml.

[0040] The above seven flavors, turmeric, bupleurum, and calamus are distilled to extract the aromatic water, collect 300ml of aromatic water, and set aside; continue to add 4 times the amount of water to decoct the dregs of the medicine for 1 hour, and the liquid is set aside. Add water to decoct the other four flavors such as Salvia miltiorrhiza for three times. Add 5 times the amount of water for the first time and decoct for 1 hour. Decoction, filter, concentrate the filtrate to a clear paste with a relative density of 1.20-1.30 (40-50°C), add ethanol to make the alcohol content reach 55%, let it stand for 12-24 hours, take the supernatant, and recover Ethanol, add 3g of benzoic acid, mix well, add the above aromatic w...

Embodiment 3

[0041] Embodiment 3 preparation of medicine of the present invention

[0042] Take raw materials:

[0043] Bupleurum 11g, Salvia miltiorrhiza 16.5g, Curcuma 16.5g, Gardenia 6g, Suanzaoren 22.5g, Corydalis 22.5g, Shichangpu 11g, directly add water to decoct, concentrate, and prepare oral liquid.

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Abstract

The invention provides a drug composition for treating depressive disorders. The drug composition is prepared by following raw materials of, by weight, 11-33 parts of bupleurum, 16.5-49.5 parts of red-rooted salvia roots, 16.5-49.5 parts of turmeric root tubers, 6-18 parts of cape jasmine fruits, 22.5-67.5 parts of wild jujube seeds, 22.5-67.5 parts of fumitories and 11-33 parts of grassleaf sweetflag rhizome. The invention further provides a preparation method and an application of the drug composition. The raw materials of the drug composition are selected according to the principle that the raw materials have effects of soothing the liver, resolving depression, promoting circulation, removing stasis, eliminating phlegm and turbidness, calming the heart and soothing the nerves, the drug composition aims at treating excess symptoms of liver depression, blood stasis and phlegm turbidness of post stroke depression (PSD) in acute stages and subacute stages, and the drug composition is explicit in drug effect and controllable and provides a new drug-using choice.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating depression, which belongs to the field of medicines. Background technique [0002] Depression is an affective mental disorder characterized by low mood caused by various reasons. It is a group of clinical symptoms or states centered on self-experience of depressed mood. Mental disorders characterized by high prevalence, high relapse rate, and high burden rate. With the development of social economy and the change of people's life style, its incidence is on the rise. According to reports, about 25% of women in the general population have experienced depression in their lifetime experience, and about 10% of men have experienced depression. According to the "2002 World Health Organization Report" issued by the World Health Organization, depression has become the fourth largest disease in the world, and by 2020, depression may become the second largest disease after heart disease. Depres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P25/24A61P25/20
Inventor 刘福友陈卫银宋英唐熠
Owner TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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