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Traditional Chinese medicine composition for treating stroke and sequela thereof and preparation method thereof

A technology of composition and sequelae, which is applied in the direction of drug combination, pharmaceutical formula, drug delivery, etc., and can solve the problems of large dosage, many impurities, and poor taste

Active Publication Date: 2015-03-25
通化卫京药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the actual use process, it is found that its limitations, such as long-term storage is prone to precipitation, poor stability, many impurities, large dosage, poor taste, etc.

Method used

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  • Traditional Chinese medicine composition for treating stroke and sequela thereof and preparation method thereof
  • Traditional Chinese medicine composition for treating stroke and sequela thereof and preparation method thereof
  • Traditional Chinese medicine composition for treating stroke and sequela thereof and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097]1. Take the pulverized Scutellaria chinensis, add 75% ethanol to heat and reflux for extraction 3 times, each time add solvent 6 times the weight of the medicinal material, each time for 1.5 hours; combine the extracts, high-speed centrifugation, take the clarified liquid, and the volume of the resin is equivalent to the crude drug 3 times the macroporous resin column, wash with water first, discard the washing solution, then elute with 3 times the column volume of 60% ethanol, and collect the eluent; the eluent is concentrated under reduced pressure and dried to obtain the extract things.

[0098] 2. Take the crushed safflower, add 20% ethanol with 4 times the weight of the medicinal materials, heat and reflux to extract twice, each time for 2 hours, concentrate the extract under reduced pressure, fine filter, take the filtrate and put it on the polyamide chromatographic column, rinse it with water first, then wash it with water The solution was discarded, eluted with 2...

Embodiment 2

[0102] 1. The extract of Ulus radix is ​​prepared by the following method: take the pulverized Uxa, add 60% ethanol to heat and reflux for extraction 4 times, each time add 5 times the amount of solvent by the weight of the medicinal material, each time for 0.5 hour; combine the extracts, concentrate Filtrate, take the macroporous resin column whose volume of resin on the filtrate is equivalent to 4 times of the crude drug, rinse with water first, discard the washing solution, then elute with 40% ethanol of 4 times the column volume, collect the eluent; the eluent is decompressed Concentrate and dry to obtain the extract of Siberia chinensis.

[0103] 2. Take crushed safflower, add 2 times the weight of the medicinal material, heat and reflux for extraction for 3 hours, concentrate the extract under reduced pressure, centrifuge, take the clear liquid and put it on the polyamide chromatographic column, rinse it with water first, discard the washing liquid, and use 10% Elution w...

Embodiment 3

[0107] 1. The extract of Ulus chinensis is prepared by the following method: take the pulverized Uxa sativa, add 95% ethanol to heat and reflux to extract twice, add 7 times the amount of solvent by the weight of the medicinal material each time, for 2 hours each time; combine the extracts, and centrifuge , take the macroporous resin column whose resin volume on the clarified liquid is equivalent to 2 times of the crude drug, first wash with water, discard the washing liquid, and then elute with 80% ethanol with 2 times the column volume, collect the eluent; the eluent is decompressed Concentrate and dry to obtain the extract of Siberia chinensis.

[0108] 2. Take the crushed safflower, add 30% ethanol which is 6 times the weight of the medicinal material, and heat and reflux for extraction 3 times, each time for 1 hour, the extract is concentrated under reduced pressure, filtered, and the filtrate is put on a polyamide chromatographic column, rinsed with water first, Discard ...

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Abstract

The invention provides a preparation method of a medicine for treating cerebral stroke and sequela thereof. Traditional Chinese medicine components of different properties are specifically extracted in a classified manner; therefore, compared with the prior art, the preparation process disclosed by the invention is more reasonable; the content of effective components of the prepared medicine is greatly increased; the medicine can be prepared into an injection; and the injection is easily used in the stroke acute stage. The traditional Chinese medicine component disclosed by the invention is prepared from the following medicinal raw materials in parts by weight: 10-40 parts of herba siegesbeckiae extract, 1-3 parts of safflower carthamus extract, and 1-3 parts of medicinal cyathula root extract.

Description

Technical field: [0001] The invention provides a preparation method of a medicine for treating cerebral apoplexy and its sequelae. Through targeted classification and extraction of Chinese medicine components with different properties, the preparation process of the invention is more reasonable than the prior art, greatly improving the preparation process. The active ingredient content of the medicine can be prepared into an injection form, which is beneficial to medication in the acute stage of apoplexy. Background technique: [0002] Stroke, also known as cerebral apoplexy, is a common disease that occurs in middle-aged and elderly people. According to the nature of the disease, it is divided into hemorrhagic stroke and ischemic stroke. According to the 2004 global investigation of the causes of disease death, stroke is one of the three major causes of death worldwide, and ranks second in the global list of deadly diseases, second only to heart disease. In 2008, about 9 ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/286A61P9/10A61P25/00
CPCA61K9/0019A61K9/0053A61K9/08A61K9/28A61K36/21A61K36/28A61K36/286A61K2236/331A61K2236/333A61K2236/39A61K2236/50A61K2236/51A61K2236/53A61K2300/00
Inventor 王洪飞曾英姿李林昌武丹
Owner 通化卫京药业股份有限公司
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