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Dispersed general arasaponin tablet and its prepn and application

A technology of Panax notoginseng saponins and dispersible tablets, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc. It can solve the problems of reduced dissolution rate, precipitation of drug crystals, and influence on drug absorption, etc., to achieve fast absorption , quality standard improvement, and the effect of stable storage quality

Inactive Publication Date: 2003-01-01
YUNNAN PHYTOPHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the solid dispersion prepared by the drug and PEG is stored for a long time, there will be aging phenomena such as precipitation of drug crystals and decreased dissolution rate, which will affect the absorption of the drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Calculated according to the preparation of 1000 tablets, the weight composition of the raw materials is: 50g of Panax notoginseng saponins, 150g of lactose, 100g of mannitol, 35g of cross-linked polyvinylpyrrolidone, an appropriate amount of 95% ethanol, and 3g of magnesium stearate, making 1000 tablets in total. Tablet specifications: Each tablet contains 50mg of Panax notoginseng saponins, and the theoretical tablet weight is about 338mg. Pass the raw and auxiliary materials through a 100-mesh sieve respectively, weigh Panax notoginseng saponins, lactose, mannitol and cross-linked PVP according to the prescription amount, and mix them evenly; use 90% ethanol as a wetting agent to make a soft material, granulate with a 24-mesh sieve, wet The granules were dried at 60°C for 1.5 hours, sized with a 24-mesh sieve, mixed with magnesium stearate, and pressed into tablets with a 10.5 mm punch to obtain the Panax notoginseng saponins dispersible tablet of the present invention...

Embodiment 2

[0036] Except that the weight of the raw materials of Panax notoginseng saponins dispersible tablet of the present invention consists of: Panax notoginseng saponins 50, lactose 50, mannitol 50, cross-linked polyvinylpyrrolidone (cross-linked PVP) 15, 95% ethanol in an appropriate amount, magnesium stearate Except 1g, other processes are with embodiment 1.

Embodiment 3

[0038] Except that the weight of the raw materials of Panax notoginseng saponins dispersible tablet of the present invention consists of: Panax notoginseng saponins 100, lactose 250, mannitol 150, cross-linked polyvinylpyrrolidone (cross-linked PVP) 50, 95% ethanol in an appropriate amount, magnesium stearate Except 8g, other processes are with embodiment 1.

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PUM

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Abstract

The present invention relates to one kind of cardiac and cerebral vascular diseases treating compound medicine. The notoginseng total saponin dispersing tablet is prepared with the material includes notoginseng total saponin, lactose, mannitol, crosslinked polyvinyl pyrrolidone, ethanol and magnesium stearate. The preparation process includes 100-mesh sieving, weighing the above-mentioned raw materials, mixing, moistening with ethanol, palletizing, drying, tableting and other steps. The compound medicine has high preventing and treating effect on apoplexy, hemiplegia, cerebral infarction, cerebral embolism, etc.

Description

Technical field [0001] The invention relates to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, in particular to a pharmaceutical composition made of plants and Chinese herbal medicines as main raw materials. Background technique [0002] With the improvement of people's living standards and changes in lifestyles, cardiovascular and cerebrovascular diseases have become the primary disease that seriously endangers people's health, and the incidence rate is increasing year by year. At present, most of the available drugs are western medicines, and there are few traditional Chinese medicines, and most of the traditional Chinese medicine preparations are traditional or common dosage forms. In order to better develop our country's traditional Chinese medicine resources, improve the internal quality and market competitiveness of Chinese medicine preparations, it will be of great practical significance to reform the dosage f...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/704A61P9/10
Inventor 王先明周敏
Owner YUNNAN PHYTOPHARML
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